Development Level

Tbio 10,210 | 11,651
Tdark 4,025 | 6,593
Tchem 1,228 | 1,388
Tclin 497 | 612

Collection

RFA-RM-18-021 253 | 328
Kinase: IDG Consortium (Target... 116 | 125
Ion Channel: IDG Consortium (T... 78 | 99
GPCR: IDG Consortium (Targets) 67 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 944 | 979
preweaning lethality, incomple... 456 | 499
abnormal behavior 275 | 298
embryonic lethality prior to t... 272 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 191 | 207
enlarged heart 179 | 210
abnormal bone structure 174 | 187
decreased vertical activity 172 | 208
increased lean body mass 159 | 172
decreased body weight 152 | 161
abnormal heart morphology 141 | 162
hyperactivity 138 | 148
decreased bone mineral content 135 | 151
decreased lean body mass 127 | 135
increased total body fat amoun... 123 | 134
hypoactivity 116 | 132
decreased circulating glucose ... 114 | 126
decreased bone mineral density 113 | 126
increased circulating alkaline... 111 | 122
increased startle reflex 106 | 112
decreased grip strength 105 | 116
embryonic growth retardation 103 | 106
male infertility 102 | 123
increased bone mineral content 98 | 108
decreased body length 96 | 101
abnormal seminal vesicle morph... 95 | 114
increased or absent threshold ... 91 | 101
short tibia 91 | 97
increased mean corpuscular hem... 90 | 96
cataract 87 | 92
decreased circulating choleste... 87 | 93
increased mean corpuscular vol... 86 | 92
prenatal lethality prior to he... 85 | 87
abnormal lens morphology 75 | 81
decreased circulating serum al... 75 | 82
decreased prepulse inhibition 75 | 82
decreased mean corpuscular vol... 73 | 79
decreased circulating triglyce... 72 | 79
decreased lymphocyte cell numb... 72 | 83
increased circulating HDL chol... 72 | 80
increased bone mineral density 70 | 72
increased fasted circulating g... 70 | 76
decreased circulating insulin ... 69 | 76
decreased startle reflex 68 | 75
impaired glucose tolerance 68 | 75
decreased leukocyte cell numbe... 67 | 73
small superior vagus ganglion 66 | 74
decreased circulating HDL chol... 65 | 68
improved glucose tolerance 65 | 79
abnormal eye morphology 64 | 68
abnormal retina morphology 64 | 71
abnormal sleep behavior 64 | 70
increased circulating sodium l... 64 | 71
decreased hemoglobin content 62 | 68
abnormal gait 60 | 69
decreased fasted circulating g... 60 | 65
abnormal behavioral response t... 58 | 66
abnormal coat-hair pigmentatio... 58 | 64
decreased erythrocyte cell num... 58 | 62
increased circulating choleste... 58 | 66
increased heart weight 57 | 62
edema 55 | 59
thrombocytopenia 55 | 56
abnormal kidney morphology 54 | 65
small testis 52 | 58
decreased caudal vertebrae num... 51 | 53
female infertility 49 | 60
increased monocyte cell number 49 | 63
abnormal spleen morphology 48 | 55
decreased blood urea nitrogen ... 47 | 51
decreased mean corpuscular hem... 47 | 50
decreased circulating total pr... 46 | 49
hydrometra 46 | 53
decreased circulating alanine ... 45 | 47
abnormal neural tube closure 44 | 46
decreased hematocrit 44 | 46
decreased circulating alkaline... 43 | 46
increased blood urea nitrogen ... 43 | 48
increased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
abnormal skin morphology 42 | 50
increased hemoglobin content 41 | 45
abnormal testis morphology 40 | 43
decreased red blood cell distr... 40 | 41
increased leukocyte cell numbe... 40 | 47
increased circulating triglyce... 39 | 42
tremors 39 | 39
decreased neutrophil cell numb... 38 | 42
increased circulating chloride... 38 | 41
increased mean platelet volume 38 | 45
abnormal bone mineralization 37 | 38
abnormal epididymis morphology 37 | 42
enlarged spleen 37 | 41
increased erythrocyte cell num... 36 | 39
decreased circulating LDL chol... 35 | 38
decreased circulating creatini... 35 | 39
increased grip strength 35 | 41
increased mean corpuscular hem... 35 | 36

Disease

Carcinoma 9,680 | 11,493
ovarian cancer 7,974 | 8,520
osteosarcoma 7,322 | 7,950
medulloblastoma, large-cell 5,674 | 6,241
psoriasis 5,563 | 6,694
glioblastoma 5,342 | 5,792
atypical teratoid / rhabdoid tumor 4,683 | 5,112
lung cancer 4,335 | 4,740
ependymoma 4,242 | 4,679
group 3 medulloblastoma 3,759 | 4,104
adult high grade glioma 3,408 | 3,801
Breast cancer 3,262 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,056 | 3,291
malignant mesothelioma 3,028 | 3,232
Astrocytoma, Pilocytic 2,785 | 3,081
primitive neuroectodermal tumor 2,763 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,752 | 2,989
invasive ductal carcinoma 2,716 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,715 | 2,955
non-small cell lung cancer 2,618 | 2,890
oligodendroglioma 2,591 | 2,850
lung carcinoma 2,497 | 2,843
lung adenocarcinoma 2,410 | 2,716
astrocytic glioma 2,364 | 2,597
Cancer 2,255 | 2,499
Kidney cancer 2,240 | 2,613
pancreatic cancer 2,198 | 2,398
subependymal giant cell astrocytoma 2,116 | 2,287
interstitial cystitis 2,050 | 2,312
tuberculosis 1,881 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,857 | 1,962
Pick disease 1,773 | 1,894
pituitary cancer 1,749 | 1,972
group 4 medulloblastoma 1,719 | 1,855
ulcerative colitis 1,654 | 1,819
ductal carcinoma in situ 1,587 | 1,745
cystic fibrosis 1,504 | 1,696
breast carcinoma 1,485 | 1,638
diabetes mellitus 1,364 | 1,728
adrenocortical carcinoma 1,330 | 1,428
colon cancer 1,323 | 1,478
Multiple myeloma 1,308 | 1,332
Autosomal recessive predisposition 1,284 | 1,442
juvenile dermatomyositis 1,153 | 1,187
Rheumatoid arthritis 1,113 | 1,191
acute quadriplegic myopathy 1,111 | 1,158
astrocytoma 1,104 | 1,146
primary pancreatic ductal adenocarcinoma 1,056 | 1,109
spina bifida 1,004 | 1,074
pediatric high grade glioma 992 | 1,064
Schizophrenia 963 | 1,160
dermatomyositis 949 | 966
Intellectual disability 945 | 1,016
nasopharyngeal carcinoma 934 | 1,058
cutaneous lupus erythematosus 927 | 1,057
active Crohn's disease 838 | 922
non primary Sjogren syndrome sicca 795 | 891
Atopic dermatitis 782 | 952
acute myeloid leukemia 759 | 783
Waldenstrons macroglobulinemia 748 | 765
gastric carcinoma 748 | 807
Liver Cirrhosis, Experimental 707 | 769
primary Sjogren syndrome 706 | 735
Epilepsy 701 | 792
active ulcerative colitis 687 | 764
medulloblastoma 667 | 720
esophageal adenocarcinoma 661 | 737
progressive supranuclear palsy 647 | 676
aldosterone-producing adenoma 619 | 665
Dull intelligence 604 | 645
Low intelligence 604 | 645
Mental Retardation 604 | 645
Mental deficiency 604 | 645
Poor school performance 604 | 645
Cognitive delay 576 | 608
Global developmental delay 576 | 608
Mental and motor retardation 576 | 608
Alzheimer's disease 573 | 658
Obesity 573 | 678
Duchenne muscular dystrophy 557 | 601
Melanoma 544 | 711
Muscle hypotonia 542 | 571
pancreatic carcinoma 537 | 562
Seizures 534 | 596
Bipolar Disorder 533 | 666
hepatocellular carcinoma 526 | 547
Short stature 500 | 531
Liver cancer 497 | 604
fibroadenoma 497 | 559
autosomal dominant Emery-Dreifuss muscular dystrophy 477 | 510
Endometriosis 470 | 540
Down syndrome 463 | 499
Multiple Sclerosis 461 | 540
Prostatic Neoplasms 444 | 495
chronic rhinosinusitis 439 | 512
gastric cancer 435 | 459
posterior fossa group A ependymoma 424 | 468
sonic hedgehog group medulloblastoma 424 | 467
mucosa-associated lymphoid tissue lymphoma 414 | 484
Amyotrophic lateral sclerosis 411 | 451

Tissue

Endocrine System 15,680 | 18,159
Female tissues 15,457 | 17,400
Digestive Tract 15,449 | 17,369
Skin and soft tissues 15,397 | 17,230
Male tissues 15,335 | 17,142
Blood and immune system 15,315 | 16,909
Nervous System 15,231 | 16,725
Liver and Pancreas 15,172 | 16,750
Urinary Tract 15,132 | 16,678
Respiratory system 15,013 | 16,393
Cardiovascular System 14,189 | 15,192

Target Family

Non-IDG 9,302 | 12,091
Enzyme 3,625 | 4,145
Transcription Factor 1,212 | 1,400
Kinase 584 | 634
Transporter 384 | 473
GPCR 264 | 408
Ion Channel 258 | 344
Epigenetic 230 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 35 | 38
oGPCR 24 | 421

HCA RNA Cell Line

REH 15,960 | 15,960
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50