Development Level

Tbio 9,279 | 10,625
Tdark 4,386 | 7,003
Tchem 1,629 | 1,890
Tclin 488 | 602

Collection

Kinase: IDG Consortium (Targets) 114 | 125
Ion Channel: IDG Consortium (Targets) 80 | 102
GPCR: IDG Consortium (Targets) 68 | 127
Kinase: IDG Consortium (Complete/Control) 35 | 37
GPCR: IDG Consortium (Complete/Control) 19 | 26

IMPC Phenotype

preweaning lethality, complete... 610 | 633
preweaning lethality, incomple... 235 | 260
abnormal behavior 213 | 226
decreased lean body mass 183 | 195
embryonic lethality prior to t... 183 | 187
decreased total body fat amoun... 170 | 186
decreased body weight 165 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 146 | 157
abnormal bone structure 122 | 131
increased or absent threshold ... 119 | 128
decreased bone mineral density 116 | 126
decreased grip strength 110 | 123
increased circulating alkaline... 110 | 119
decreased circulating glucose ... 108 | 121
abnormal embryo size 104 | 112
decreased body length 103 | 108
hyperactivity 103 | 108
increased lean body mass 96 | 107
enlarged heart 95 | 111
abnormal retina morphology 92 | 100
increased mean corpuscular hem... 91 | 93
increased bone mineral content 86 | 92
increased mean corpuscular vol... 86 | 91
decreased circulating choleste... 81 | 85
hypoactivity 78 | 89
short tibia 78 | 82
decreased circulating triglyce... 74 | 83
decreased circulating serum al... 73 | 79
decreased circulating HDL chol... 72 | 77
increased grip strength 72 | 83
abnormal lens morphology 68 | 73
decreased circulating insulin ... 66 | 75
increased circulating sodium l... 63 | 71
increased fasted circulating g... 63 | 68
prenatal lethality prior to he... 63 | 64
decreased lumbar vertebrae num... 60 | 62
increased sacral vertebrae num... 59 | 62
abnormal retinal pigmentation 57 | 61
abnormal sleep behavior 57 | 63
decreased rib number 56 | 59
abnormal bone mineralization 54 | 55
increased circulating HDL chol... 54 | 63
male infertility 53 | 62
increased total body fat amoun... 51 | 57
increased bone mineral density 50 | 52
increased exploration in new e... 50 | 56
decreased hemoglobin content 49 | 53
abnormal coat-hair pigmentatio... 48 | 54
decreased leukocyte cell numbe... 48 | 54
decreased mean corpuscular vol... 47 | 50
decreased prepulse inhibition 47 | 52
impaired glucose tolerance 47 | 52
abnormal gait 46 | 51
decreased circulating alanine ... 46 | 53
abnormal behavioral response t... 45 | 52
decreased caudal vertebrae num... 45 | 49
decreased fasted circulating g... 45 | 49
increased circulating choleste... 45 | 53
thrombocytopenia 45 | 46
decreased startle reflex 44 | 48
improved glucose tolerance 44 | 56
abnormal heart morphology 43 | 51
decreased erythrocyte cell num... 42 | 43
increased blood urea nitrogen ... 41 | 44
increased hemoglobin content 41 | 45
decreased circulating total pr... 40 | 41
decreased heart weight 40 | 44
abnormal seminal vesicle morph... 39 | 47
increased circulating chloride... 39 | 43
increased body weight 38 | 42
abnormal eye morphology 37 | 38
decreased circulating alkaline... 37 | 41
increased rib number 36 | 41
decreased neutrophil cell numb... 35 | 37
abnormal neural tube closure 34 | 37
decreased circulating LDL chol... 34 | 37
decreased circulating free fat... 34 | 39
tremors 34 | 34
decreased eosinophil cell numb... 33 | 41
increased heart weight 33 | 37
increased hematocrit 33 | 36
increased startle reflex 33 | 38
abnormal spleen morphology 32 | 36
decreased mean corpuscular hem... 32 | 34
increased leukocyte cell numbe... 32 | 37
small testis 32 | 37
abnormal cranium morphology 31 | 32
cardiovascular system phenotyp... 30 | 35
decreased circulating calcium ... 30 | 33
decreased circulating fructosa... 30 | 31
decreased T cell number 29 | 31
decreased circulating creatini... 29 | 31
limb grasping 29 | 35
decreased B cell number 28 | 30
decreased blood urea nitrogen ... 28 | 31
decreased circulating chloride... 28 | 32
female infertility 28 | 34
abnormal epididymis morphology 27 | 31
increased circulating calcium ... 27 | 32

Disease

ovarian cancer 7,867 | 8,491
osteosarcoma 7,238 | 7,933
medulloblastoma, large-cell 5,618 | 6,234
psoriasis 5,513 | 6,685
glioblastoma 5,094 | 5,572
lung cancer 4,133 | 4,473
atypical teratoid / rhabdoid tumor 3,972 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,028 | 3,289
malignant mesothelioma 2,949 | 3,163
Breast cancer 2,836 | 3,098
pilocytic astrocytoma 2,755 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 2,730 | 2,988
primitive neuroectodermal tumor 2,730 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 2,700 | 2,956
invasive ductal carcinoma 2,688 | 2,950
oligodendroglioma 2,567 | 2,849
non-small cell lung cancer 2,521 | 2,798
lung carcinoma 2,483 | 2,844
pediatric high grade glioma 2,474 | 2,712
lung adenocarcinoma 2,391 | 2,714
ependymoma 2,304 | 2,514
Cancer 2,110 | 2,346
pancreatic cancer 2,107 | 2,300
subependymal giant cell astrocytoma 2,098 | 2,287
group 3 medulloblastoma 2,065 | 2,254
interstitial cystitis 2,033 | 2,299
astrocytic glioma 2,020 | 2,241
ulcerative colitis 1,895 | 2,087
adult high grade glioma 1,880 | 2,148
Carcinoma 1,805 | 2,147
Pick disease 1,759 | 1,893
pituitary cancer 1,737 | 1,972
group 4 medulloblastoma 1,730 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,674 | 1,795
ductal carcinoma in situ 1,573 | 1,745
cystic fibrosis 1,470 | 1,670
breast carcinoma 1,450 | 1,614
tuberculosis 1,450 | 1,563
astrocytoma 1,416 | 1,493
medulloblastoma 1,370 | 1,524
posterior fossa group B ependymoma 1,337 | 1,530
posterior fossa group A ependymoma 1,329 | 1,511
sonic hedgehog group medulloblastoma 1,328 | 1,482
adrenocortical carcinoma 1,313 | 1,427
colon cancer 1,311 | 1,475
diabetes mellitus 1,299 | 1,663
Multiple myeloma 1,293 | 1,327
primary pancreatic ductal adenocarcinoma 1,208 | 1,271
juvenile dermatomyositis 1,145 | 1,189
acute quadriplegic myopathy 1,102 | 1,157
Rheumatoid Arthritis 1,088 | 1,170
atypical teratoid/rhabdoid tumor 989 | 1,095
spina bifida 985 | 1,064
dermatomyositis 944 | 966
nasopharyngeal carcinoma 928 | 1,056
cutaneous lupus erythematosus 919 | 1,056
active Crohn's disease 828 | 918
Atopic dermatitis 768 | 944
gastric carcinoma 768 | 832
primary Sjogren syndrome 752 | 788
acute myeloid leukemia 748 | 785
Waldenstrons macroglobulinemia 741 | 764
non primary Sjogren syndrome sicca 735 | 840
tuberculosis and treatment for 6 months 665 | 686
esophageal adenocarcinoma 658 | 737
progressive supranuclear palsy 640 | 674
aldosterone-producing adenoma 614 | 664
Alzheimer's disease 555 | 644
Duchenne muscular dystrophy 550 | 602
pancreatic carcinoma 538 | 567
Intellectual disability 531 | 573
hepatocellular carcinoma 526 | 550
Obesity 517 | 616
Down syndrome 505 | 548
fibroadenoma 493 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 466 | 499
Endometriosis 460 | 535
chronic rhinosinusitis 436 | 512
IGA Glomerulonephritis 432 | 454
active ulcerative colitis 421 | 477
Multiple Sclerosis 419 | 498
Prostatic Neoplasms 419 | 471
mucosa-associated lymphoid tissue lymphoma 411 | 480
gastric cancer 409 | 436
Schizophrenia 403 | 503
Amyotrophic Lateral Sclerosis 390 | 432
Mammary Neoplasms 366 | 410
inflammatory breast cancer 352 | 404
Neurodegenerative disease 349 | 383
non-small cell lung carcinoma 345 | 413
sarcoidosis 338 | 368
Kidney disease 336 | 397
glioblastoma multiforme 320 | 347
Parkinson's disease 309 | 364
tuberculosis and treatment for 3 months 306 | 327
Polycystic Ovary Syndrome 302 | 334
hereditary spastic paraplegia 302 | 313
urothelial carcinoma 295 | 318
nephrosclerosis 282 | 329
Epilepsy 278 | 346

Tissue

Nervous System 15,555 | 18,560
Female tissues 15,533 | 18,646
Endocrine System 15,524 | 18,511
Digestive Tract 15,523 | 18,472
Urinary Tract 15,468 | 18,443
Liver and Pancreas 15,445 | 18,135
Male tissues 15,423 | 17,968
Blood and immune system 15,410 | 17,994
Cardiovascular System 15,388 | 17,957
Skin and soft tissues 15,348 | 18,114
Respiratory system 15,237 | 17,483

Target Family

Non-IDG 9,173 | 11,969
Enzyme 3,597 | 4,146
Transcription Factor 1,208 | 1,400
Kinase 578 | 634
Transporter 384 | 473
GPCR 264 | 408
Ion Channel 256 | 341
Epigenetic 223 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 34 | 38
oGPCR 23 | 421

HCA RNA Cell Line

REH 15,782 | 15,782
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131