Development Level

Tbio 9,681 | 11,445
Tdark 3,901 | 6,588
Tchem 1,337 | 1,598
Tclin 457 | 613

Collection

RFA-RM-18-021 238 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 69 | 99
GPCR: IDG Consortium (Targets) 63 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 16 | 25

IMPC Phenotype

preweaning lethality, complete... 941 | 979
preweaning lethality, incomple... 446 | 499
embryonic lethality prior to t... 267 | 278
abnormal behavior 266 | 298
embryonic lethality prior to o... 236 | 239
abnormal embryo size 205 | 220
decreased total body fat amoun... 180 | 207
enlarged heart 165 | 210
abnormal bone structure 163 | 187
decreased vertical activity 155 | 208
increased lean body mass 153 | 172
decreased body weight 151 | 161
hyperactivity 136 | 148
abnormal heart morphology 129 | 162
decreased bone mineral content 129 | 151
decreased lean body mass 117 | 135
increased total body fat amoun... 114 | 134
hypoactivity 113 | 132
decreased circulating glucose ... 110 | 126
decreased bone mineral density 107 | 126
increased circulating alkaline... 107 | 122
increased startle reflex 103 | 112
embryonic growth retardation 99 | 106
male infertility 98 | 123
decreased grip strength 96 | 116
increased bone mineral content 95 | 108
increased or absent threshold ... 89 | 101
increased mean corpuscular hem... 88 | 96
short tibia 88 | 97
decreased body length 86 | 101
abnormal seminal vesicle morph... 85 | 114
increased mean corpuscular vol... 83 | 92
cataract 82 | 92
prenatal lethality prior to he... 81 | 87
decreased circulating choleste... 80 | 93
decreased prepulse inhibition 76 | 82
abnormal lens morphology 73 | 81
decreased circulating serum al... 71 | 82
decreased circulating triglyce... 71 | 79
decreased lymphocyte cell numb... 71 | 83
decreased mean corpuscular vol... 70 | 79
increased bone mineral density 68 | 72
decreased startle reflex 67 | 75
increased fasted circulating g... 67 | 76
impaired glucose tolerance 65 | 75
increased circulating HDL chol... 65 | 80
decreased leukocyte cell numbe... 64 | 73
improved glucose tolerance 64 | 79
abnormal eye morphology 63 | 68
abnormal gait 63 | 69
abnormal retina morphology 63 | 71
small superior vagus ganglion 63 | 74
decreased circulating insulin ... 62 | 76
decreased circulating HDL chol... 60 | 68
decreased hemoglobin content 59 | 68
abnormal sleep behavior 58 | 70
increased heart weight 58 | 62
abnormal coat-hair pigmentatio... 57 | 64
increased circulating choleste... 57 | 66
increased circulating sodium l... 57 | 71
abnormal behavioral response t... 56 | 66
decreased erythrocyte cell num... 56 | 62
abnormal kidney morphology 53 | 65
edema 53 | 59
increased monocyte cell number 52 | 63
small testis 52 | 58
decreased fasted circulating g... 51 | 65
decreased caudal vertebrae num... 49 | 53
female infertility 49 | 60
thrombocytopenia 49 | 56
abnormal spleen morphology 48 | 55
decreased mean corpuscular hem... 46 | 50
decreased circulating total pr... 44 | 49
abnormal neural tube closure 43 | 46
decreased circulating alkaline... 43 | 46
hydrometra 43 | 53
decreased blood urea nitrogen ... 42 | 51
decreased circulating alanine ... 42 | 47
increased hematocrit 41 | 46
abnormal skin morphology 40 | 50
abnormal testis morphology 40 | 43
decreased hematocrit 40 | 46
increased blood urea nitrogen ... 40 | 48
increased hemoglobin content 40 | 45
increased leukocyte cell numbe... 40 | 47
enlarged spleen 39 | 41
increased circulating triglyce... 39 | 42
increased neutrophil cell numb... 39 | 46
decreased red blood cell distr... 38 | 41
increased mean platelet volume 38 | 45
decreased neutrophil cell numb... 36 | 42
increased grip strength 36 | 41
abnormal bone mineralization 35 | 38
limb grasping 35 | 41
tremors 35 | 39
decreased circulating LDL chol... 34 | 38
anophthalmia 33 | 33
decreased circulating creatini... 33 | 39
increased circulating chloride... 33 | 41
increased mean corpuscular hem... 33 | 36

Disease

Carcinoma 9,383 | 11,493
ovarian cancer 7,851 | 8,520
osteosarcoma 7,092 | 7,950
medulloblastoma, large-cell 5,562 | 6,241
psoriasis 5,386 | 6,694
glioblastoma 5,234 | 5,792
atypical teratoid / rhabdoid tumor 4,622 | 5,112
lung cancer 4,215 | 4,740
ependymoma 4,194 | 4,679
group 3 medulloblastoma 3,674 | 4,104
adult high grade glioma 3,315 | 3,801
Breast cancer 3,216 | 3,578
malignant mesothelioma 3,008 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,951 | 3,291
primitive neuroectodermal tumor 2,738 | 3,035
Astrocytoma, Pilocytic 2,668 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,664 | 2,989
invasive ductal carcinoma 2,627 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,625 | 2,955
oligodendroglioma 2,543 | 2,850
non-small cell lung cancer 2,507 | 2,890
lung carcinoma 2,341 | 2,843
astrocytic glioma 2,334 | 2,597
lung adenocarcinoma 2,312 | 2,716
Kidney cancer 2,209 | 2,613
pancreatic cancer 2,132 | 2,398
Cancer 2,129 | 2,499
subependymal giant cell astrocytoma 2,056 | 2,287
interstitial cystitis 1,890 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,806 | 1,962
tuberculosis 1,768 | 2,010
Pick disease 1,749 | 1,894
pituitary cancer 1,700 | 1,972
group 4 medulloblastoma 1,699 | 1,855
ductal carcinoma in situ 1,552 | 1,745
ulcerative colitis 1,542 | 1,819
cystic fibrosis 1,505 | 1,696
breast carcinoma 1,442 | 1,638
diabetes mellitus 1,300 | 1,728
Multiple myeloma 1,295 | 1,332
colon cancer 1,287 | 1,478
adrenocortical carcinoma 1,279 | 1,428
Autosomal recessive predisposition 1,225 | 1,442
juvenile dermatomyositis 1,117 | 1,187
acute quadriplegic myopathy 1,097 | 1,158
astrocytoma 1,056 | 1,146
Rheumatoid arthritis 1,041 | 1,191
primary pancreatic ductal adenocarcinoma 1,032 | 1,109
spina bifida 992 | 1,074
pediatric high grade glioma 967 | 1,064
Intellectual disability 930 | 1,016
dermatomyositis 926 | 966
Schizophrenia 904 | 1,160
nasopharyngeal carcinoma 892 | 1,058
cutaneous lupus erythematosus 842 | 1,057
active Crohn's disease 800 | 922
non primary Sjogren syndrome sicca 786 | 891
Atopic dermatitis 764 | 952
acute myeloid leukemia 743 | 783
gastric carcinoma 739 | 807
Waldenstrons macroglobulinemia 725 | 765
Epilepsy 690 | 792
active ulcerative colitis 665 | 764
medulloblastoma 658 | 720
Liver Cirrhosis, Experimental 650 | 769
esophageal adenocarcinoma 637 | 737
progressive supranuclear palsy 634 | 676
primary Sjogren syndrome 609 | 735
aldosterone-producing adenoma 604 | 665
Dull intelligence 587 | 645
Low intelligence 587 | 645
Mental Retardation 587 | 645
Mental deficiency 587 | 645
Poor school performance 587 | 645
Cognitive delay 569 | 608
Global developmental delay 569 | 608
Mental and motor retardation 569 | 608
Alzheimer's disease 559 | 658
Obesity 539 | 678
Duchenne muscular dystrophy 536 | 601
Muscle hypotonia 529 | 571
Melanoma 528 | 711
Seizures 527 | 596
Bipolar Disorder 524 | 666
pancreatic carcinoma 509 | 562
Liver cancer 506 | 604
hepatocellular carcinoma 499 | 547
Short stature 486 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 481 | 510
fibroadenoma 477 | 559
Endometriosis 465 | 540
Prostatic Neoplasms 438 | 495
Down syndrome 437 | 499
chronic rhinosinusitis 431 | 512
posterior fossa group A ependymoma 424 | 468
gastric cancer 420 | 459
sonic hedgehog group medulloblastoma 420 | 467
Amyotrophic lateral sclerosis 412 | 451
Multiple Sclerosis 402 | 540
tuberculosis and treatment for 6 months 401 | 409

Tissue

Endocrine System 15,139 | 18,159
Female tissues 14,963 | 17,400
Digestive Tract 14,951 | 17,369
Skin and soft tissues 14,900 | 17,230
Male tissues 14,860 | 17,142
Nervous System 14,755 | 16,725
Blood and immune system 14,749 | 16,909
Liver and Pancreas 14,691 | 16,750
Urinary Tract 14,668 | 16,678
Respiratory system 14,548 | 16,393
Cardiovascular System 13,855 | 15,192

Target Family

Non-IDG 8,930 | 12,091
Enzyme 3,515 | 4,145
Transcription Factor 1,178 | 1,400
Kinase 589 | 634
Transporter 371 | 473
Ion Channel 244 | 344
GPCR 227 | 408
Epigenetic 223 | 242
Nuclear Receptor 39 | 48
TF/Epigenetic 34 | 38
oGPCR 26 | 421

HCA RNA Cell Line

PC-3 15,376 | 15,376
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29