Development Level

Tbio 9,469 | 11,178
Tdark 3,893 | 6,569
Tchem 1,558 | 1,885
Tclin 456 | 612

Collection

Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 69 | 99
GPCR: IDG Consortium (Targets) 63 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 16 | 25

IMPC Phenotype

preweaning lethality, complete... 941 | 979
preweaning lethality, incomple... 446 | 499
embryonic lethality prior to t... 267 | 278
abnormal behavior 266 | 298
embryonic lethality prior to o... 236 | 239
abnormal embryo size 205 | 220
decreased total body fat amoun... 180 | 207
enlarged heart 165 | 210
abnormal bone structure 163 | 187
decreased vertical activity 155 | 208
increased lean body mass 153 | 172
decreased body weight 151 | 161
hyperactivity 136 | 148
abnormal heart morphology 129 | 162
decreased bone mineral content 129 | 151
decreased lean body mass 117 | 135
increased total body fat amoun... 114 | 134
hypoactivity 113 | 132
decreased circulating glucose ... 110 | 126
decreased bone mineral density 107 | 126
increased circulating alkaline... 107 | 122
increased startle reflex 103 | 112
embryonic growth retardation 99 | 106
male infertility 98 | 123
decreased grip strength 96 | 116
increased bone mineral content 95 | 108
increased or absent threshold ... 89 | 101
increased mean corpuscular hem... 88 | 96
short tibia 88 | 97
decreased body length 86 | 101
abnormal seminal vesicle morph... 85 | 114
increased mean corpuscular vol... 83 | 92
cataract 82 | 92
prenatal lethality prior to he... 81 | 87
decreased circulating choleste... 80 | 93
decreased prepulse inhibition 76 | 82
abnormal lens morphology 73 | 81
decreased circulating serum al... 71 | 82
decreased circulating triglyce... 71 | 79
decreased lymphocyte cell numb... 71 | 83
decreased mean corpuscular vol... 70 | 79
increased bone mineral density 68 | 72
decreased startle reflex 67 | 75
increased fasted circulating g... 67 | 76
impaired glucose tolerance 65 | 75
increased circulating HDL chol... 65 | 80
decreased leukocyte cell numbe... 64 | 73
improved glucose tolerance 64 | 79
abnormal eye morphology 63 | 68
abnormal gait 63 | 69
abnormal retina morphology 63 | 71
small superior vagus ganglion 63 | 74
decreased circulating insulin ... 62 | 76
decreased circulating HDL chol... 60 | 68
decreased hemoglobin content 59 | 68
abnormal sleep behavior 58 | 70
increased heart weight 58 | 62
abnormal coat-hair pigmentatio... 57 | 64
increased circulating choleste... 57 | 66
increased circulating sodium l... 57 | 71
abnormal behavioral response t... 56 | 66
decreased erythrocyte cell num... 56 | 62
abnormal kidney morphology 53 | 65
edema 53 | 59
increased monocyte cell number 52 | 63
small testis 52 | 58
decreased fasted circulating g... 51 | 65
decreased caudal vertebrae num... 49 | 53
female infertility 49 | 60
thrombocytopenia 49 | 56
abnormal spleen morphology 48 | 55
decreased mean corpuscular hem... 46 | 50
decreased circulating total pr... 44 | 49
abnormal neural tube closure 43 | 46
decreased circulating alkaline... 43 | 46
hydrometra 43 | 53
decreased blood urea nitrogen ... 42 | 51
decreased circulating alanine ... 42 | 47
increased hematocrit 41 | 46
abnormal skin morphology 40 | 50
abnormal testis morphology 40 | 43
decreased hematocrit 40 | 46
increased blood urea nitrogen ... 40 | 48
increased hemoglobin content 40 | 45
increased leukocyte cell numbe... 40 | 47
enlarged spleen 39 | 41
increased circulating triglyce... 39 | 42
increased neutrophil cell numb... 39 | 46
decreased red blood cell distr... 38 | 41
increased mean platelet volume 38 | 45
decreased neutrophil cell numb... 36 | 42
increased grip strength 36 | 41
abnormal bone mineralization 35 | 38
limb grasping 35 | 41
tremors 35 | 39
decreased circulating LDL chol... 34 | 38
anophthalmia 33 | 33
decreased circulating creatini... 33 | 39
increased circulating chloride... 33 | 41
increased mean corpuscular hem... 33 | 36

Disease

Carcinoma 9,151 | 11,192
ovarian cancer 7,644 | 8,297
osteosarcoma 6,931 | 7,766
medulloblastoma, large-cell 5,425 | 6,086
psoriasis 5,242 | 6,514
glioblastoma 5,094 | 5,635
atypical teratoid / rhabdoid tumor 4,497 | 4,971
lung cancer 4,105 | 4,607
ependymoma 4,087 | 4,559
group 3 medulloblastoma 3,585 | 4,002
adult high grade glioma 3,231 | 3,701
Breast cancer 3,121 | 3,469
malignant mesothelioma 2,919 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 2,879 | 3,204
primitive neuroectodermal tumor 2,669 | 2,957
Astrocytoma, Pilocytic 2,599 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 2,591 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,553 | 2,872
invasive ductal carcinoma 2,553 | 2,867
oligodendroglioma 2,471 | 2,768
non-small cell lung cancer 2,431 | 2,799
astrocytic glioma 2,275 | 2,530
lung carcinoma 2,265 | 2,755
lung adenocarcinoma 2,236 | 2,627
Kidney cancer 2,160 | 2,548
pancreatic cancer 2,067 | 2,322
Cancer 2,037 | 2,388
subependymal giant cell astrocytoma 2,005 | 2,230
interstitial cystitis 1,829 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,763 | 1,911
tuberculosis 1,726 | 1,963
Pick disease 1,717 | 1,856
group 4 medulloblastoma 1,657 | 1,806
pituitary cancer 1,651 | 1,915
ductal carcinoma in situ 1,499 | 1,686
ulcerative colitis 1,496 | 1,765
cystic fibrosis 1,449 | 1,629
breast carcinoma 1,400 | 1,589
diabetes mellitus 1,262 | 1,683
Multiple myeloma 1,259 | 1,296
colon cancer 1,245 | 1,428
adrenocortical carcinoma 1,239 | 1,385
Autosomal recessive predisposition 1,199 | 1,407
juvenile dermatomyositis 1,079 | 1,147
acute quadriplegic myopathy 1,072 | 1,133
astrocytoma 1,026 | 1,113
Rheumatoid arthritis 1,009 | 1,156
primary pancreatic ductal adenocarcinoma 997 | 1,071
spina bifida 974 | 1,053
pediatric high grade glioma 941 | 1,035
Intellectual disability 916 | 998
dermatomyositis 901 | 941
Schizophrenia 886 | 1,136
nasopharyngeal carcinoma 861 | 1,024
cutaneous lupus erythematosus 810 | 1,016
active Crohn's disease 769 | 882
non primary Sjogren syndrome sicca 764 | 861
Atopic dermatitis 731 | 915
acute myeloid leukemia 721 | 760
gastric carcinoma 717 | 781
Waldenstrons macroglobulinemia 703 | 742
Epilepsy 676 | 775
active ulcerative colitis 642 | 736
medulloblastoma 641 | 702
Liver Cirrhosis, Experimental 619 | 733
progressive supranuclear palsy 618 | 656
esophageal adenocarcinoma 602 | 696
aldosterone-producing adenoma 588 | 646
primary Sjogren syndrome 587 | 710
Dull intelligence 578 | 634
Low intelligence 578 | 634
Mental Retardation 578 | 634
Mental deficiency 578 | 634
Poor school performance 578 | 634
Cognitive delay 559 | 596
Global developmental delay 559 | 596
Mental and motor retardation 559 | 596
Alzheimer's disease 543 | 640
Duchenne muscular dystrophy 522 | 587
Muscle hypotonia 522 | 562
Obesity 522 | 655
Seizures 518 | 584
Melanoma 515 | 689
Bipolar Disorder 507 | 646
pancreatic carcinoma 503 | 555
Liver cancer 495 | 589
hepatocellular carcinoma 488 | 536
Short stature 473 | 514
autosomal dominant Emery-Dreifuss muscular dystrophy 463 | 492
fibroadenoma 461 | 538
Endometriosis 447 | 521
chronic rhinosinusitis 426 | 505
Down syndrome 423 | 480
Prostatic Neoplasms 419 | 472
posterior fossa group A ependymoma 412 | 456
sonic hedgehog group medulloblastoma 412 | 459
gastric cancer 406 | 445
Amyotrophic lateral sclerosis 398 | 437
Multiple Sclerosis 392 | 527
tuberculosis and treatment for 6 months 391 | 399

Tissue

Endocrine System 15,139 | 18,159
Female tissues 14,963 | 17,400
Digestive Tract 14,951 | 17,369
Skin and soft tissues 14,900 | 17,230
Male tissues 14,860 | 17,142
Nervous System 14,755 | 16,725
Blood and immune system 14,749 | 16,909
Liver and Pancreas 14,691 | 16,750
Urinary Tract 14,668 | 16,678
Respiratory system 14,548 | 16,393
Cardiovascular System 13,855 | 15,192

Target Family

Non-IDG 8,930 | 12,091
Enzyme 3,515 | 4,145
Transcription Factor 1,178 | 1,400
Kinase 589 | 634
Transporter 371 | 473
Ion Channel 244 | 344
GPCR 227 | 408
Epigenetic 223 | 242
Nuclear Receptor 39 | 48
TF/Epigenetic 34 | 38
oGPCR 26 | 421

HCA RNA Cell Line

PC-3 15,376 | 15,376
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93