Development Level

Tbio 10,805 | 11,651
Tdark 4,357 | 6,593
Tchem 1,312 | 1,388
Tclin 565 | 612

Collection

RFA-RM-18-021 291 | 328
Kinase: IDG Consortium (Target... 124 | 125
GPCR: IDG Consortium (Targets) 94 | 126
Ion Channel: IDG Consortium (T... 87 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 965 | 979
preweaning lethality, incomple... 486 | 499
abnormal behavior 283 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 216 | 220
decreased total body fat amoun... 203 | 207
enlarged heart 190 | 210
decreased vertical activity 183 | 208
abnormal bone structure 180 | 187
increased lean body mass 167 | 172
decreased body weight 157 | 161
abnormal heart morphology 148 | 162
hyperactivity 143 | 148
decreased bone mineral content 140 | 151
decreased lean body mass 129 | 135
increased total body fat amoun... 128 | 134
hypoactivity 126 | 132
decreased circulating glucose ... 122 | 126
decreased bone mineral density 117 | 126
increased circulating alkaline... 117 | 122
male infertility 112 | 123
increased startle reflex 111 | 112
decreased grip strength 108 | 116
increased bone mineral content 104 | 108
abnormal seminal vesicle morph... 103 | 114
embryonic growth retardation 103 | 106
decreased body length 99 | 101
increased or absent threshold ... 98 | 101
short tibia 94 | 97
increased mean corpuscular hem... 92 | 96
cataract 89 | 92
decreased circulating choleste... 89 | 93
increased mean corpuscular vol... 87 | 92
prenatal lethality prior to he... 84 | 87
decreased prepulse inhibition 79 | 82
abnormal lens morphology 78 | 81
decreased lymphocyte cell numb... 78 | 83
decreased circulating serum al... 77 | 82
decreased mean corpuscular vol... 76 | 79
decreased circulating triglyce... 75 | 79
decreased startle reflex 74 | 75
increased fasted circulating g... 73 | 76
improved glucose tolerance 72 | 79
increased bone mineral density 72 | 72
decreased circulating insulin ... 71 | 76
decreased leukocyte cell numbe... 71 | 73
increased circulating HDL chol... 70 | 80
impaired glucose tolerance 69 | 75
abnormal eye morphology 68 | 68
abnormal sleep behavior 68 | 70
increased circulating sodium l... 68 | 71
small superior vagus ganglion 68 | 74
abnormal retina morphology 67 | 71
abnormal gait 66 | 69
decreased circulating HDL chol... 64 | 68
abnormal behavioral response t... 63 | 66
decreased fasted circulating g... 63 | 65
decreased hemoglobin content 63 | 68
abnormal coat-hair pigmentatio... 61 | 64
abnormal kidney morphology 61 | 65
increased heart weight 61 | 62
increased circulating choleste... 59 | 66
edema 58 | 59
decreased erythrocyte cell num... 57 | 62
increased monocyte cell number 56 | 63
female infertility 55 | 60
small testis 55 | 58
thrombocytopenia 53 | 56
abnormal spleen morphology 52 | 55
decreased caudal vertebrae num... 51 | 53
decreased mean corpuscular hem... 49 | 50
abnormal skin morphology 48 | 50
decreased circulating total pr... 48 | 49
hydrometra 47 | 53
abnormal neural tube closure 46 | 46
decreased blood urea nitrogen ... 46 | 51
decreased circulating alkaline... 46 | 46
decreased circulating alanine ... 44 | 47
increased blood urea nitrogen ... 44 | 48
increased hematocrit 44 | 46
increased hemoglobin content 44 | 45
decreased hematocrit 43 | 46
increased leukocyte cell numbe... 43 | 47
increased neutrophil cell numb... 43 | 46
abnormal testis morphology 42 | 43
increased circulating chloride... 41 | 41
increased circulating triglyce... 41 | 42
increased mean platelet volume 41 | 45
limb grasping 41 | 41
decreased neutrophil cell numb... 40 | 42
decreased red blood cell distr... 40 | 41
enlarged spleen 40 | 41
tremors 39 | 39
abnormal bone mineralization 38 | 38
abnormal epididymis morphology 38 | 42
increased grip strength 38 | 41
decreased circulating creatini... 37 | 39
decreased circulating LDL chol... 36 | 38
increased erythrocyte cell num... 36 | 39

Disease

Carcinoma 10,406 | 11,493
ovarian cancer 8,248 | 8,520
osteosarcoma 7,546 | 7,950
psoriasis 6,030 | 6,694
medulloblastoma, large-cell 6,002 | 6,241
glioblastoma 5,632 | 5,792
atypical teratoid / rhabdoid tumor 4,973 | 5,112
lung cancer 4,562 | 4,740
ependymoma 4,541 | 4,679
group 3 medulloblastoma 3,981 | 4,104
adult high grade glioma 3,642 | 3,801
Breast cancer 3,452 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,179 | 3,291
malignant mesothelioma 3,156 | 3,232
Astrocytoma, Pilocytic 2,985 | 3,081
primitive neuroectodermal tumor 2,961 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,887 | 2,989
invasive ductal carcinoma 2,863 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,861 | 2,955
oligodendroglioma 2,792 | 2,850
non-small cell lung cancer 2,756 | 2,890
lung carcinoma 2,683 | 2,843
lung adenocarcinoma 2,564 | 2,716
astrocytic glioma 2,541 | 2,597
Kidney cancer 2,473 | 2,613
Cancer 2,327 | 2,499
pancreatic cancer 2,299 | 2,398
subependymal giant cell astrocytoma 2,230 | 2,287
interstitial cystitis 2,168 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,913 | 1,962
pituitary cancer 1,907 | 1,972
tuberculosis 1,902 | 2,010
Pick disease 1,867 | 1,894
group 4 medulloblastoma 1,813 | 1,855
ulcerative colitis 1,706 | 1,819
ductal carcinoma in situ 1,686 | 1,745
cystic fibrosis 1,626 | 1,696
breast carcinoma 1,577 | 1,638
diabetes mellitus 1,461 | 1,728
colon cancer 1,412 | 1,478
adrenocortical carcinoma 1,393 | 1,428
Autosomal recessive predisposition 1,368 | 1,442
Multiple myeloma 1,310 | 1,332
juvenile dermatomyositis 1,172 | 1,187
acute quadriplegic myopathy 1,149 | 1,158
Rheumatoid arthritis 1,135 | 1,191
astrocytoma 1,128 | 1,146
primary pancreatic ductal adenocarcinoma 1,082 | 1,109
Schizophrenia 1,066 | 1,160
spina bifida 1,041 | 1,074
pediatric high grade glioma 1,039 | 1,064
Intellectual disability 989 | 1,016
nasopharyngeal carcinoma 988 | 1,058
cutaneous lupus erythematosus 976 | 1,057
dermatomyositis 958 | 966
active Crohn's disease 873 | 922
Atopic dermatitis 852 | 952
non primary Sjogren syndrome sicca 847 | 891
gastric carcinoma 789 | 807
acute myeloid leukemia 771 | 783
Epilepsy 768 | 792
Waldenstrons macroglobulinemia 756 | 765
Liver Cirrhosis, Experimental 724 | 769
active ulcerative colitis 721 | 764
medulloblastoma 703 | 720
primary Sjogren syndrome 702 | 735
esophageal adenocarcinoma 700 | 737
progressive supranuclear palsy 662 | 676
Melanoma 652 | 711
aldosterone-producing adenoma 648 | 665
Dull intelligence 626 | 645
Low intelligence 626 | 645
Mental Retardation 626 | 645
Mental deficiency 626 | 645
Poor school performance 626 | 645
Obesity 625 | 678
Alzheimer's disease 623 | 658
Bipolar Disorder 610 | 666
Cognitive delay 599 | 608
Global developmental delay 599 | 608
Mental and motor retardation 599 | 608
Duchenne muscular dystrophy 591 | 601
Seizures 579 | 596
Liver cancer 573 | 604
Muscle hypotonia 560 | 571
pancreatic carcinoma 543 | 562
fibroadenoma 536 | 559
hepatocellular carcinoma 530 | 547
Short stature 518 | 531
Endometriosis 510 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 506 | 510
Down syndrome 485 | 499
Multiple Sclerosis 482 | 540
chronic rhinosinusitis 482 | 512
Prostatic Neoplasms 467 | 495
sonic hedgehog group medulloblastoma 458 | 467
posterior fossa group A ependymoma 450 | 468
gastric cancer 447 | 459
Amyotrophic lateral sclerosis 439 | 451
mucosa-associated lymphoid tissue lymphoma 437 | 484

Tissue

Endocrine System 16,662 | 18,159
Female tissues 16,331 | 17,400
Digestive Tract 16,319 | 17,369
Skin and soft tissues 16,237 | 17,230
Male tissues 16,146 | 17,142
Nervous System 16,008 | 16,725
Blood and immune system 16,005 | 16,909
Liver and Pancreas 15,931 | 16,750
Urinary Tract 15,891 | 16,678
Respiratory system 15,670 | 16,393
Cardiovascular System 14,748 | 15,192

Target Family

Non-IDG 9,870 | 12,091
Enzyme 3,809 | 4,145
Transcription Factor 1,311 | 1,400
Kinase 618 | 634
Transporter 418 | 473
GPCR 329 | 408
Ion Channel 305 | 344
Epigenetic 235 | 242
oGPCR 60 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

HCA RNA Cell Line

NTERA-2 17,039 | 17,039
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83