Development Level

Tbio 10,573 | 11,651
Tdark 4,191 | 6,593
Tchem 1,279 | 1,388
Tclin 504 | 612

Collection

Kinase: IDG Consortium (Target... 118 | 125
GPCR: IDG Consortium (Targets) 79 | 126
Ion Channel: IDG Consortium (T... 77 | 99
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 952 | 979
preweaning lethality, incomple... 472 | 499
abnormal behavior 288 | 298
embryonic lethality prior to t... 272 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 213 | 220
decreased total body fat amoun... 188 | 207
enlarged heart 185 | 210
decreased vertical activity 176 | 208
abnormal bone structure 171 | 187
increased lean body mass 157 | 172
decreased body weight 155 | 161
abnormal heart morphology 143 | 162
decreased bone mineral content 137 | 151
hyperactivity 137 | 148
hypoactivity 125 | 132
decreased lean body mass 124 | 135
increased total body fat amoun... 120 | 134
decreased bone mineral density 117 | 126
decreased circulating glucose ... 114 | 126
male infertility 114 | 123
increased circulating alkaline... 113 | 122
increased startle reflex 109 | 112
decreased grip strength 104 | 116
embryonic growth retardation 104 | 106
increased bone mineral content 99 | 108
abnormal seminal vesicle morph... 96 | 114
increased or absent threshold ... 93 | 101
decreased body length 91 | 101
increased mean corpuscular hem... 90 | 96
short tibia 90 | 97
increased mean corpuscular vol... 88 | 92
cataract 86 | 92
decreased circulating choleste... 86 | 93
prenatal lethality prior to he... 85 | 87
abnormal lens morphology 77 | 81
decreased lymphocyte cell numb... 76 | 83
decreased prepulse inhibition 76 | 82
decreased circulating serum al... 75 | 82
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 73 | 79
increased circulating HDL chol... 73 | 80
increased fasted circulating g... 73 | 76
increased bone mineral density 70 | 72
decreased circulating insulin ... 68 | 76
decreased leukocyte cell numbe... 68 | 73
improved glucose tolerance 68 | 79
decreased startle reflex 67 | 75
small superior vagus ganglion 67 | 74
impaired glucose tolerance 66 | 75
abnormal retina morphology 65 | 71
abnormal sleep behavior 65 | 70
abnormal eye morphology 63 | 68
decreased circulating HDL chol... 63 | 68
increased circulating choleste... 63 | 66
increased circulating sodium l... 63 | 71
abnormal gait 62 | 69
abnormal coat-hair pigmentatio... 60 | 64
decreased hemoglobin content 60 | 68
decreased erythrocyte cell num... 59 | 62
abnormal kidney morphology 58 | 65
decreased fasted circulating g... 58 | 65
increased heart weight 56 | 62
small testis 56 | 58
abnormal behavioral response t... 55 | 66
edema 54 | 59
increased monocyte cell number 54 | 63
thrombocytopenia 53 | 56
abnormal spleen morphology 52 | 55
female infertility 52 | 60
decreased caudal vertebrae num... 51 | 53
decreased blood urea nitrogen ... 48 | 51
hydrometra 47 | 53
abnormal neural tube closure 46 | 46
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
decreased circulating alanine ... 45 | 47
increased blood urea nitrogen ... 45 | 48
abnormal skin morphology 44 | 50
increased leukocyte cell numbe... 44 | 47
increased neutrophil cell numb... 44 | 46
decreased circulating alkaline... 43 | 46
decreased hematocrit 42 | 46
abnormal testis morphology 41 | 43
increased hemoglobin content 41 | 45
increased mean platelet volume 41 | 45
decreased neutrophil cell numb... 39 | 42
enlarged spleen 39 | 41
increased circulating triglyce... 39 | 42
increased hematocrit 39 | 46
decreased red blood cell distr... 38 | 41
increased grip strength 38 | 41
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
tremors 37 | 39
abnormal epididymis morphology 36 | 42
increased circulating chloride... 36 | 41
enlarged lymph nodes 35 | 37
increased erythrocyte cell num... 35 | 39
limb grasping 35 | 41

Disease

Carcinoma 10,021 | 11,493
ovarian cancer 8,113 | 8,520
osteosarcoma 7,457 | 7,950
psoriasis 5,848 | 6,694
medulloblastoma, large-cell 5,802 | 6,241
glioblastoma 5,453 | 5,792
atypical teratoid / rhabdoid tumor 4,785 | 5,112
lung cancer 4,469 | 4,740
ependymoma 4,344 | 4,679
group 3 medulloblastoma 3,839 | 4,104
adult high grade glioma 3,495 | 3,801
Breast cancer 3,350 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,166 | 3,291
malignant mesothelioma 3,099 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,866 | 2,989
Astrocytoma, Pilocytic 2,848 | 3,081
invasive ductal carcinoma 2,822 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,821 | 2,955
primitive neuroectodermal tumor 2,820 | 3,035
non-small cell lung cancer 2,737 | 2,890
oligodendroglioma 2,639 | 2,850
lung carcinoma 2,608 | 2,843
lung adenocarcinoma 2,522 | 2,716
astrocytic glioma 2,406 | 2,597
Cancer 2,312 | 2,499
Kidney cancer 2,299 | 2,613
pancreatic cancer 2,267 | 2,398
interstitial cystitis 2,143 | 2,312
subependymal giant cell astrocytoma 2,139 | 2,287
tuberculosis 1,928 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,892 | 1,962
pituitary cancer 1,803 | 1,972
Pick disease 1,800 | 1,894
group 4 medulloblastoma 1,734 | 1,855
ulcerative colitis 1,718 | 1,819
ductal carcinoma in situ 1,656 | 1,745
cystic fibrosis 1,582 | 1,696
breast carcinoma 1,556 | 1,638
diabetes mellitus 1,436 | 1,728
colon cancer 1,403 | 1,478
adrenocortical carcinoma 1,377 | 1,428
Autosomal recessive predisposition 1,317 | 1,442
Multiple myeloma 1,308 | 1,332
juvenile dermatomyositis 1,167 | 1,187
acute quadriplegic myopathy 1,126 | 1,158
Rheumatoid arthritis 1,120 | 1,191
astrocytoma 1,111 | 1,146
primary pancreatic ductal adenocarcinoma 1,076 | 1,109
spina bifida 1,032 | 1,074
pediatric high grade glioma 1,011 | 1,064
Schizophrenia 987 | 1,160
cutaneous lupus erythematosus 981 | 1,057
nasopharyngeal carcinoma 972 | 1,058
Intellectual disability 957 | 1,016
dermatomyositis 952 | 966
active Crohn's disease 884 | 922
Atopic dermatitis 847 | 952
non primary Sjogren syndrome sicca 821 | 891
acute myeloid leukemia 770 | 783
gastric carcinoma 768 | 807
Waldenstrons macroglobulinemia 760 | 765
active ulcerative colitis 723 | 764
Liver Cirrhosis, Experimental 722 | 769
Epilepsy 718 | 792
primary Sjogren syndrome 706 | 735
esophageal adenocarcinoma 688 | 737
medulloblastoma 674 | 720
progressive supranuclear palsy 651 | 676
aldosterone-producing adenoma 643 | 665
Obesity 612 | 678
Dull intelligence 611 | 645
Low intelligence 611 | 645
Mental Retardation 611 | 645
Mental deficiency 611 | 645
Poor school performance 611 | 645
Alzheimer's disease 594 | 658
Cognitive delay 582 | 608
Global developmental delay 582 | 608
Mental and motor retardation 582 | 608
Duchenne muscular dystrophy 579 | 601
Melanoma 571 | 711
Bipolar Disorder 564 | 666
Seizures 551 | 596
Muscle hypotonia 545 | 571
pancreatic carcinoma 540 | 562
hepatocellular carcinoma 531 | 547
fibroadenoma 524 | 559
Endometriosis 507 | 540
Liver cancer 505 | 604
Short stature 505 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 493 | 510
chronic rhinosinusitis 472 | 512
Down syndrome 470 | 499
Prostatic Neoplasms 469 | 495
Multiple Sclerosis 467 | 540
gastric cancer 444 | 459
mucosa-associated lymphoid tissue lymphoma 443 | 484
posterior fossa group A ependymoma 438 | 468
sonic hedgehog group medulloblastoma 435 | 467
Amyotrophic lateral sclerosis 424 | 451

Tissue

Endocrine System 16,234 | 18,159
Digestive Tract 15,964 | 17,369
Female tissues 15,938 | 17,400
Skin and soft tissues 15,876 | 17,230
Male tissues 15,824 | 17,142
Blood and immune system 15,746 | 16,909
Liver and Pancreas 15,619 | 16,750
Nervous System 15,599 | 16,725
Urinary Tract 15,577 | 16,678
Respiratory system 15,422 | 16,393
Cardiovascular System 14,509 | 15,192

Target Family

Non-IDG 9,659 | 12,091
Enzyme 3,733 | 4,145
Transcription Factor 1,266 | 1,400
Kinase 602 | 634
Transporter 410 | 473
GPCR 286 | 408
Ion Channel 252 | 344
Epigenetic 233 | 242
Nuclear Receptor 46 | 48
TF/Epigenetic 36 | 38
oGPCR 24 | 421

HCA RNA Cell Line

NB-4 16,547 | 16,547
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50