Development Level

Tbio 9,587 | 10,625
Tdark 4,571 | 7,003
Tchem 1,708 | 1,890
Tclin 493 | 602

Collection

Kinase: IDG Consortium (Targets) 115 | 125
GPCR: IDG Consortium (Targets) 80 | 127
Ion Channel: IDG Consortium (Targets) 79 | 102
Kinase: IDG Consortium (Complete/Control) 33 | 37
GPCR: IDG Consortium (Complete/Control) 21 | 26

IMPC Phenotype

preweaning lethality, complete... 612 | 633
preweaning lethality, incomple... 247 | 260
abnormal behavior 219 | 226
decreased lean body mass 185 | 195
embryonic lethality prior to t... 184 | 187
decreased total body fat amoun... 175 | 186
decreased body weight 170 | 174
embryonic lethality prior to o... 147 | 148
decreased bone mineral content 145 | 157
abnormal bone structure 121 | 131
decreased bone mineral density 118 | 126
increased or absent threshold ... 117 | 128
decreased grip strength 113 | 123
increased circulating alkaline... 113 | 119
decreased circulating glucose ... 109 | 121
abnormal embryo size 107 | 112
decreased body length 104 | 108
hyperactivity 101 | 108
enlarged heart 100 | 111
increased lean body mass 98 | 107
abnormal retina morphology 95 | 100
increased mean corpuscular hem... 90 | 93
increased bone mineral content 88 | 92
increased mean corpuscular vol... 87 | 91
hypoactivity 86 | 89
decreased circulating choleste... 80 | 85
short tibia 79 | 82
decreased circulating triglyce... 76 | 83
decreased circulating serum al... 74 | 79
increased grip strength 74 | 83
decreased circulating HDL chol... 72 | 77
abnormal lens morphology 68 | 73
decreased circulating insulin ... 66 | 75
increased fasted circulating g... 65 | 68
increased circulating sodium l... 63 | 71
prenatal lethality prior to he... 62 | 64
decreased lumbar vertebrae num... 59 | 62
increased sacral vertebrae num... 59 | 62
male infertility 59 | 62
abnormal retinal pigmentation 58 | 61
increased circulating HDL chol... 58 | 63
abnormal sleep behavior 57 | 63
abnormal bone mineralization 54 | 55
decreased rib number 54 | 59
abnormal coat-hair pigmentatio... 51 | 54
decreased leukocyte cell numbe... 51 | 54
increased circulating choleste... 51 | 53
increased exploration in new e... 51 | 56
increased total body fat amoun... 51 | 57
increased bone mineral density 50 | 52
decreased circulating alanine ... 49 | 53
decreased hemoglobin content 49 | 53
decreased caudal vertebrae num... 48 | 49
abnormal gait 47 | 51
decreased mean corpuscular vol... 47 | 50
decreased prepulse inhibition 47 | 52
impaired glucose tolerance 46 | 52
abnormal heart morphology 45 | 51
improved glucose tolerance 45 | 56
abnormal behavioral response t... 44 | 52
decreased fasted circulating g... 44 | 49
decreased startle reflex 44 | 48
decreased erythrocyte cell num... 43 | 43
thrombocytopenia 43 | 46
abnormal seminal vesicle morph... 42 | 47
decreased heart weight 41 | 44
increased blood urea nitrogen ... 41 | 44
increased body weight 41 | 42
increased hemoglobin content 41 | 45
decreased circulating total pr... 40 | 41
increased circulating chloride... 39 | 43
increased rib number 39 | 41
decreased eosinophil cell numb... 38 | 41
abnormal neural tube closure 37 | 37
abnormal eye morphology 36 | 38
decreased circulating LDL chol... 36 | 37
decreased circulating alkaline... 36 | 41
decreased circulating free fat... 36 | 39
decreased neutrophil cell numb... 36 | 37
increased startle reflex 36 | 38
increased leukocyte cell numbe... 35 | 37
small testis 35 | 37
abnormal spleen morphology 33 | 36
increased heart weight 33 | 37
cardiovascular system phenotyp... 32 | 35
decreased T cell number 31 | 31
decreased mean corpuscular hem... 31 | 34
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
tremors 31 | 34
abnormal cranium morphology 30 | 32
decreased blood urea nitrogen ... 30 | 31
decreased circulating calcium ... 30 | 33
decreased circulating chloride... 30 | 32
decreased circulating fructosa... 30 | 31
female infertility 30 | 34
increased hematocrit 30 | 36
limb grasping 30 | 35
decreased threshold for audito... 29 | 32
abnormal testis morphology 28 | 30

Disease

ovarian cancer 8,003 | 8,491
osteosarcoma 7,371 | 7,933
psoriasis 5,797 | 6,685
medulloblastoma, large-cell 5,746 | 6,234
glioblastoma 5,207 | 5,572
lung cancer 4,259 | 4,473
atypical teratoid / rhabdoid tumor 4,049 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,137 | 3,289
malignant mesothelioma 3,010 | 3,163
Breast cancer 2,909 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 2,842 | 2,988
pilocytic astrocytoma 2,815 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 2,804 | 2,956
invasive ductal carcinoma 2,792 | 2,950
primitive neuroectodermal tumor 2,787 | 3,031
non-small cell lung cancer 2,639 | 2,798
oligodendroglioma 2,615 | 2,849
lung carcinoma 2,592 | 2,844
pediatric high grade glioma 2,510 | 2,712
lung adenocarcinoma 2,500 | 2,714
ependymoma 2,352 | 2,514
pancreatic cancer 2,174 | 2,300
Cancer 2,160 | 2,346
interstitial cystitis 2,123 | 2,299
subependymal giant cell astrocytoma 2,121 | 2,287
group 3 medulloblastoma 2,094 | 2,254
astrocytic glioma 2,065 | 2,241
ulcerative colitis 1,968 | 2,087
adult high grade glioma 1,951 | 2,148
Carcinoma 1,830 | 2,147
pituitary cancer 1,789 | 1,972
Pick disease 1,786 | 1,893
group 4 medulloblastoma 1,747 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,709 | 1,795
ductal carcinoma in situ 1,640 | 1,745
cystic fibrosis 1,546 | 1,670
breast carcinoma 1,520 | 1,614
tuberculosis 1,489 | 1,563
astrocytoma 1,421 | 1,493
medulloblastoma 1,397 | 1,524
posterior fossa group B ependymoma 1,394 | 1,530
colon cancer 1,390 | 1,475
sonic hedgehog group medulloblastoma 1,370 | 1,482
diabetes mellitus 1,364 | 1,663
posterior fossa group A ependymoma 1,359 | 1,511
adrenocortical carcinoma 1,358 | 1,427
Multiple myeloma 1,293 | 1,327
primary pancreatic ductal adenocarcinoma 1,229 | 1,271
juvenile dermatomyositis 1,159 | 1,189
acute quadriplegic myopathy 1,117 | 1,157
Rheumatoid Arthritis 1,091 | 1,170
atypical teratoid/rhabdoid tumor 1,017 | 1,095
spina bifida 1,012 | 1,064
cutaneous lupus erythematosus 973 | 1,056
nasopharyngeal carcinoma 966 | 1,056
dermatomyositis 947 | 966
active Crohn's disease 874 | 918
Atopic dermatitis 832 | 944
gastric carcinoma 788 | 832
non primary Sjogren syndrome sicca 761 | 840
acute myeloid leukemia 758 | 785
Waldenstrons macroglobulinemia 753 | 764
primary Sjogren syndrome 752 | 788
esophageal adenocarcinoma 685 | 737
tuberculosis and treatment for 6 months 670 | 686
progressive supranuclear palsy 644 | 674
aldosterone-producing adenoma 638 | 664
Alzheimer's disease 574 | 644
Duchenne muscular dystrophy 573 | 602
Obesity 556 | 616
pancreatic carcinoma 541 | 567
Intellectual disability 538 | 573
hepatocellular carcinoma 531 | 550
fibroadenoma 520 | 557
Down syndrome 515 | 548
Endometriosis 497 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 481 | 499
chronic rhinosinusitis 469 | 512
Prostatic Neoplasms 445 | 471
active ulcerative colitis 444 | 477
IGA Glomerulonephritis 441 | 454
mucosa-associated lymphoid tissue lymphoma 440 | 480
Multiple Sclerosis 422 | 498
gastric cancer 417 | 436
Schizophrenia 412 | 503
Amyotrophic Lateral Sclerosis 403 | 432
Mammary Neoplasms 381 | 410
inflammatory breast cancer 371 | 404
Neurodegenerative disease 356 | 383
non-small cell lung carcinoma 353 | 413
Kidney disease 348 | 397
sarcoidosis 343 | 368
glioblastoma multiforme 321 | 347
Parkinson's disease 317 | 364
Polycystic Ovary Syndrome 310 | 334
tuberculosis and treatment for 3 months 309 | 327
nephrosclerosis 306 | 329
hereditary spastic paraplegia 302 | 313
urothelial carcinoma 302 | 318
Asthma 295 | 349

Tissue

Nervous System 16,108 | 18,560
Female tissues 16,089 | 18,646
Digestive Tract 16,084 | 18,472
Endocrine System 16,075 | 18,511
Urinary Tract 16,027 | 18,443
Liver and Pancreas 15,984 | 18,135
Male tissues 15,956 | 17,968
Blood and immune system 15,949 | 17,994
Cardiovascular System 15,916 | 17,957
Skin and soft tissues 15,893 | 18,114
Respiratory system 15,743 | 17,483

Target Family

Non-IDG 9,522 | 11,969
Enzyme 3,703 | 4,146
Transcription Factor 1,262 | 1,400
Kinase 595 | 634
Transporter 410 | 473
GPCR 286 | 408
Ion Channel 249 | 341
Epigenetic 227 | 242
Nuclear Receptor 46 | 48
TF/Epigenetic 35 | 38
oGPCR 24 | 421

HCA RNA Cell Line

NB-4 16,359 | 16,359
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66