Development Level

Tbio 9,215 | 10,625
Tdark 4,293 | 7,003
Tchem 1,630 | 1,890
Tclin 487 | 602

Collection

Kinase: IDG Consortium (Targets) 109 | 125
Ion Channel: IDG Consortium (Targets) 81 | 102
GPCR: IDG Consortium (Targets) 64 | 128
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 20 | 24

IMPC Phenotype

preweaning lethality, complete... 610 | 633
preweaning lethality, incomple... 236 | 260
abnormal behavior 214 | 226
decreased lean body mass 183 | 195
embryonic lethality prior to t... 182 | 187
decreased total body fat amoun... 169 | 186
decreased body weight 166 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 145 | 157
abnormal bone structure 121 | 131
decreased bone mineral density 119 | 126
increased or absent threshold ... 117 | 128
increased circulating alkaline... 114 | 119
decreased grip strength 111 | 123
decreased circulating glucose ... 107 | 121
abnormal embryo size 105 | 112
hyperactivity 103 | 108
decreased body length 101 | 108
enlarged heart 99 | 111
increased lean body mass 96 | 107
abnormal retina morphology 92 | 100
increased mean corpuscular hem... 90 | 93
increased bone mineral content 85 | 92
increased mean corpuscular vol... 85 | 91
decreased circulating choleste... 80 | 85
hypoactivity 80 | 89
short tibia 77 | 82
decreased circulating triglyce... 75 | 83
decreased circulating serum al... 72 | 79
decreased circulating HDL chol... 71 | 77
increased grip strength 71 | 83
abnormal lens morphology 69 | 73
increased fasted circulating g... 62 | 68
prenatal lethality prior to he... 61 | 64
increased circulating sodium l... 60 | 71
decreased circulating insulin ... 59 | 75
decreased lumbar vertebrae num... 59 | 62
increased sacral vertebrae num... 56 | 62
abnormal retinal pigmentation 55 | 61
abnormal sleep behavior 54 | 63
decreased rib number 54 | 59
increased circulating HDL chol... 54 | 63
increased total body fat amoun... 53 | 57
abnormal bone mineralization 52 | 55
male infertility 52 | 62
decreased leukocyte cell numbe... 50 | 54
increased bone mineral density 49 | 52
abnormal coat-hair pigmentatio... 48 | 54
decreased prepulse inhibition 48 | 52
decreased hemoglobin content 47 | 53
impaired glucose tolerance 47 | 52
increased circulating choleste... 47 | 53
increased exploration in new e... 47 | 56
decreased mean corpuscular vol... 46 | 50
decreased startle reflex 46 | 48
abnormal gait 45 | 51
abnormal heart morphology 45 | 51
abnormal behavioral response t... 44 | 52
decreased caudal vertebrae num... 44 | 49
decreased fasted circulating g... 44 | 49
improved glucose tolerance 44 | 56
decreased circulating alanine ... 43 | 53
decreased erythrocyte cell num... 43 | 43
thrombocytopenia 42 | 46
increased hemoglobin content 41 | 45
abnormal seminal vesicle morph... 40 | 47
decreased circulating alkaline... 40 | 41
increased body weight 40 | 42
decreased circulating total pr... 39 | 41
increased blood urea nitrogen ... 39 | 44
decreased heart weight 38 | 44
increased circulating chloride... 37 | 43
increased rib number 37 | 41
decreased circulating free fat... 36 | 39
decreased neutrophil cell numb... 36 | 37
abnormal eye morphology 35 | 38
small testis 35 | 37
abnormal neural tube closure 34 | 37
increased heart weight 34 | 37
tremors 34 | 34
decreased circulating LDL chol... 33 | 37
decreased eosinophil cell numb... 33 | 41
increased leukocyte cell numbe... 33 | 37
increased startle reflex 33 | 38
increased hematocrit 32 | 36
abnormal cranium morphology 30 | 32
abnormal spleen morphology 30 | 36
decreased blood urea nitrogen ... 30 | 31
decreased circulating calcium ... 30 | 33
decreased circulating creatini... 30 | 31
decreased circulating fructosa... 30 | 31
decreased mean corpuscular hem... 30 | 34
abnormal testis morphology 29 | 30
cardiovascular system phenotyp... 29 | 35
decreased T cell number 29 | 31
limb grasping 29 | 35
abnormal epididymis morphology 28 | 31
decreased circulating chloride... 28 | 32
decreased threshold for audito... 28 | 32
decreased NK T cell number 27 | 28

Disease

ovarian cancer 7,845 | 8,491
osteosarcoma 7,228 | 7,933
medulloblastoma, large-cell 5,624 | 6,234
psoriasis 5,518 | 6,685
glioblastoma 5,089 | 5,572
lung cancer 4,147 | 4,473
atypical teratoid / rhabdoid tumor 3,958 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,011 | 3,289
malignant mesothelioma 2,966 | 3,163
Breast cancer 2,837 | 3,098
pilocytic astrocytoma 2,735 | 3,086
primitive neuroectodermal tumor 2,728 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,720 | 2,988
invasive ductal carcinoma 2,691 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,682 | 2,956
oligodendroglioma 2,565 | 2,849
non-small cell lung cancer 2,520 | 2,798
lung carcinoma 2,486 | 2,844
pediatric high grade glioma 2,473 | 2,712
lung adenocarcinoma 2,386 | 2,714
ependymoma 2,295 | 2,514
pancreatic cancer 2,093 | 2,300
subependymal giant cell astrocytoma 2,092 | 2,287
Cancer 2,089 | 2,346
group 3 medulloblastoma 2,061 | 2,254
astrocytic glioma 2,023 | 2,241
interstitial cystitis 2,003 | 2,299
adult high grade glioma 1,866 | 2,148
ulcerative colitis 1,859 | 2,087
Carcinoma 1,794 | 2,147
Pick disease 1,752 | 1,893
pituitary cancer 1,747 | 1,972
group 4 medulloblastoma 1,729 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,682 | 1,795
ductal carcinoma in situ 1,579 | 1,745
cystic fibrosis 1,474 | 1,670
breast carcinoma 1,452 | 1,614
tuberculosis 1,437 | 1,563
astrocytoma 1,397 | 1,493
medulloblastoma 1,372 | 1,524
sonic hedgehog group medulloblastoma 1,346 | 1,482
posterior fossa group B ependymoma 1,331 | 1,530
posterior fossa group A ependymoma 1,325 | 1,511
adrenocortical carcinoma 1,312 | 1,427
colon cancer 1,312 | 1,475
diabetes mellitus 1,306 | 1,663
Multiple myeloma 1,294 | 1,327
primary pancreatic ductal adenocarcinoma 1,200 | 1,271
juvenile dermatomyositis 1,135 | 1,189
acute quadriplegic myopathy 1,099 | 1,157
Rheumatoid Arthritis 1,083 | 1,170
spina bifida 997 | 1,064
atypical teratoid/rhabdoid tumor 992 | 1,095
dermatomyositis 939 | 966
cutaneous lupus erythematosus 921 | 1,056
nasopharyngeal carcinoma 912 | 1,056
active Crohn's disease 821 | 918
Atopic dermatitis 780 | 944
gastric carcinoma 770 | 832
acute myeloid leukemia 745 | 785
Waldenstrons macroglobulinemia 743 | 764
primary Sjogren syndrome 739 | 788
non primary Sjogren syndrome sicca 736 | 840
esophageal adenocarcinoma 664 | 737
tuberculosis and treatment for 6 months 658 | 686
progressive supranuclear palsy 636 | 674
aldosterone-producing adenoma 617 | 664
Duchenne muscular dystrophy 556 | 602
Alzheimer's disease 542 | 644
pancreatic carcinoma 530 | 567
Intellectual disability 526 | 573
hepatocellular carcinoma 526 | 550
Obesity 511 | 616
Down syndrome 508 | 548
fibroadenoma 483 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 471 | 499
Endometriosis 463 | 535
IGA Glomerulonephritis 433 | 454
chronic rhinosinusitis 433 | 512
active ulcerative colitis 421 | 477
Prostatic Neoplasms 418 | 471
gastric cancer 413 | 436
Multiple Sclerosis 408 | 498
mucosa-associated lymphoid tissue lymphoma 408 | 480
Amyotrophic Lateral Sclerosis 401 | 432
Schizophrenia 396 | 503
Mammary Neoplasms 371 | 410
inflammatory breast cancer 360 | 404
Neurodegenerative disease 350 | 383
sarcoidosis 340 | 368
non-small cell lung carcinoma 336 | 413
Kidney disease 319 | 397
glioblastoma multiforme 314 | 347
Parkinson's disease 306 | 364
tuberculosis and treatment for 3 months 304 | 327
hereditary spastic paraplegia 303 | 313
Polycystic Ovary Syndrome 299 | 334
urothelial carcinoma 287 | 318
Epilepsy 281 | 346
nephrosclerosis 279 | 329

Tissue

Nervous System 15,408 | 18,560
Female tissues 15,383 | 18,646
Digestive Tract 15,370 | 18,472
Endocrine System 15,370 | 18,511
Urinary Tract 15,320 | 18,443
Liver and Pancreas 15,314 | 18,135
Male tissues 15,295 | 17,968
Blood and immune system 15,275 | 17,994
Cardiovascular System 15,258 | 17,957
Skin and soft tissues 15,200 | 18,114
Respiratory system 15,109 | 17,483

Target Family

Non-IDG 9,060 | 11,969
Enzyme 3,567 | 4,146
Transcription Factor 1,202 | 1,400
Kinase 576 | 634
Transporter 381 | 473
Ion Channel 260 | 341
GPCR 257 | 408
Epigenetic 227 | 242
Nuclear Receptor 39 | 48
TF/Epigenetic 35 | 38
oGPCR 21 | 421

HCA RNA Cell Line

MOLT-4 15,625 | 15,625
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66