Development Level

Tbio 9,972 | 11,445
Tdark 3,936 | 6,588
Tchem 1,404 | 1,598
Tclin 497 | 613

Collection

RFA-RM-18-021 249 | 328
Kinase: IDG Consortium (Target... 111 | 125
Ion Channel: IDG Consortium (T... 79 | 99
GPCR: IDG Consortium (Targets) 63 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 948 | 979
preweaning lethality, incomple... 451 | 499
abnormal behavior 277 | 298
embryonic lethality prior to t... 267 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 182 | 207
enlarged heart 179 | 210
decreased vertical activity 169 | 208
abnormal bone structure 168 | 187
increased lean body mass 156 | 172
decreased body weight 152 | 161
abnormal heart morphology 138 | 162
hyperactivity 135 | 148
decreased bone mineral content 132 | 151
decreased lean body mass 123 | 135
increased total body fat amoun... 121 | 134
hypoactivity 115 | 132
decreased bone mineral density 114 | 126
increased circulating alkaline... 113 | 122
decreased circulating glucose ... 112 | 126
decreased grip strength 103 | 116
increased startle reflex 103 | 112
embryonic growth retardation 102 | 106
male infertility 102 | 123
increased bone mineral content 97 | 108
abnormal seminal vesicle morph... 94 | 114
short tibia 93 | 97
increased or absent threshold ... 90 | 101
decreased body length 89 | 101
increased mean corpuscular hem... 88 | 96
increased mean corpuscular vol... 87 | 92
decreased circulating choleste... 86 | 93
cataract 83 | 92
prenatal lethality prior to he... 83 | 87
abnormal lens morphology 75 | 81
decreased prepulse inhibition 75 | 82
decreased circulating triglyce... 73 | 79
decreased lymphocyte cell numb... 73 | 83
decreased circulating serum al... 72 | 82
decreased mean corpuscular vol... 70 | 79
increased circulating HDL chol... 70 | 80
increased fasted circulating g... 69 | 76
decreased startle reflex 68 | 75
decreased leukocyte cell numbe... 67 | 73
impaired glucose tolerance 67 | 75
increased bone mineral density 67 | 72
small superior vagus ganglion 67 | 74
decreased circulating HDL chol... 64 | 68
improved glucose tolerance 64 | 79
abnormal retina morphology 63 | 71
abnormal eye morphology 62 | 68
abnormal sleep behavior 61 | 70
decreased circulating insulin ... 61 | 76
decreased hemoglobin content 60 | 68
increased circulating sodium l... 60 | 71
abnormal behavioral response t... 58 | 66
abnormal gait 58 | 69
decreased erythrocyte cell num... 58 | 62
abnormal coat-hair pigmentatio... 57 | 64
decreased fasted circulating g... 57 | 65
increased circulating choleste... 57 | 66
increased heart weight 57 | 62
edema 55 | 59
small testis 55 | 58
abnormal kidney morphology 54 | 65
increased monocyte cell number 54 | 63
decreased caudal vertebrae num... 52 | 53
thrombocytopenia 51 | 56
female infertility 50 | 60
abnormal spleen morphology 47 | 55
decreased blood urea nitrogen ... 47 | 51
decreased circulating total pr... 46 | 49
hydrometra 46 | 53
decreased mean corpuscular hem... 45 | 50
abnormal neural tube closure 44 | 46
abnormal skin morphology 44 | 50
decreased circulating alkaline... 44 | 46
decreased hematocrit 43 | 46
increased hematocrit 43 | 46
abnormal testis morphology 42 | 43
decreased circulating alanine ... 42 | 47
increased blood urea nitrogen ... 42 | 48
increased neutrophil cell numb... 42 | 46
increased leukocyte cell numbe... 41 | 47
increased hemoglobin content 40 | 45
decreased red blood cell distr... 39 | 41
increased circulating triglyce... 39 | 42
tremors 39 | 39
abnormal epididymis morphology 38 | 42
decreased neutrophil cell numb... 38 | 42
increased mean platelet volume 38 | 45
enlarged spleen 37 | 41
increased circulating chloride... 37 | 41
abnormal bone mineralization 36 | 38
decreased circulating creatini... 35 | 39
increased erythrocyte cell num... 35 | 39
increased grip strength 35 | 41
limb grasping 35 | 41
increased mean corpuscular hem... 34 | 36

Disease

Carcinoma 9,593 | 11,493
ovarian cancer 7,954 | 8,520
osteosarcoma 7,316 | 7,950
medulloblastoma, large-cell 5,681 | 6,241
psoriasis 5,566 | 6,694
glioblastoma 5,330 | 5,792
atypical teratoid / rhabdoid tumor 4,682 | 5,112
lung cancer 4,355 | 4,740
ependymoma 4,219 | 4,679
group 3 medulloblastoma 3,766 | 4,104
adult high grade glioma 3,388 | 3,801
Breast cancer 3,266 | 3,578
malignant mesothelioma 3,051 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,040 | 3,291
primitive neuroectodermal tumor 2,762 | 3,035
Astrocytoma, Pilocytic 2,759 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,744 | 2,989
invasive ductal carcinoma 2,720 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,700 | 2,955
non-small cell lung cancer 2,613 | 2,890
oligodendroglioma 2,590 | 2,850
lung carcinoma 2,502 | 2,843
lung adenocarcinoma 2,408 | 2,716
astrocytic glioma 2,363 | 2,597
Cancer 2,236 | 2,499
Kidney cancer 2,234 | 2,613
pancreatic cancer 2,187 | 2,398
subependymal giant cell astrocytoma 2,110 | 2,287
interstitial cystitis 2,024 | 2,312
tuberculosis 1,868 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,861 | 1,962
Pick disease 1,765 | 1,894
pituitary cancer 1,760 | 1,972
group 4 medulloblastoma 1,717 | 1,855
ulcerative colitis 1,623 | 1,819
ductal carcinoma in situ 1,592 | 1,745
cystic fibrosis 1,506 | 1,696
breast carcinoma 1,487 | 1,638
diabetes mellitus 1,368 | 1,728
adrenocortical carcinoma 1,331 | 1,428
colon cancer 1,325 | 1,478
Multiple myeloma 1,309 | 1,332
Autosomal recessive predisposition 1,277 | 1,442
juvenile dermatomyositis 1,143 | 1,187
Rheumatoid arthritis 1,112 | 1,191
acute quadriplegic myopathy 1,108 | 1,158
astrocytoma 1,088 | 1,146
primary pancreatic ductal adenocarcinoma 1,052 | 1,109
spina bifida 1,015 | 1,074
pediatric high grade glioma 997 | 1,064
Schizophrenia 960 | 1,160
dermatomyositis 945 | 966
Intellectual disability 934 | 1,016
cutaneous lupus erythematosus 930 | 1,057
nasopharyngeal carcinoma 918 | 1,058
active Crohn's disease 831 | 922
non primary Sjogren syndrome sicca 795 | 891
Atopic dermatitis 793 | 952
acute myeloid leukemia 757 | 783
Waldenstrons macroglobulinemia 751 | 765
gastric carcinoma 751 | 807
Liver Cirrhosis, Experimental 711 | 769
Epilepsy 707 | 792
primary Sjogren syndrome 693 | 735
active ulcerative colitis 685 | 764
medulloblastoma 673 | 720
esophageal adenocarcinoma 667 | 737
progressive supranuclear palsy 642 | 676
aldosterone-producing adenoma 622 | 665
Dull intelligence 597 | 645
Low intelligence 597 | 645
Mental Retardation 597 | 645
Mental deficiency 597 | 645
Poor school performance 597 | 645
Cognitive delay 581 | 608
Global developmental delay 581 | 608
Mental and motor retardation 581 | 608
Obesity 563 | 678
Duchenne muscular dystrophy 562 | 601
Alzheimer's disease 558 | 658
Muscle hypotonia 548 | 571
Seizures 543 | 596
Bipolar Disorder 542 | 666
Melanoma 532 | 711
pancreatic carcinoma 529 | 562
hepatocellular carcinoma 526 | 547
Liver cancer 496 | 604
Short stature 493 | 531
fibroadenoma 487 | 559
autosomal dominant Emery-Dreifuss muscular dystrophy 482 | 510
Endometriosis 472 | 540
Down syndrome 467 | 499
Multiple Sclerosis 447 | 540
Prostatic Neoplasms 442 | 495
gastric cancer 440 | 459
chronic rhinosinusitis 436 | 512
sonic hedgehog group medulloblastoma 429 | 467
posterior fossa group A ependymoma 421 | 468
Amyotrophic lateral sclerosis 419 | 451
mucosa-associated lymphoid tissue lymphoma 411 | 484

Tissue

Endocrine System 15,544 | 18,159
Digestive Tract 15,355 | 17,369
Female tissues 15,335 | 17,400
Skin and soft tissues 15,289 | 17,230
Male tissues 15,221 | 17,142
Blood and immune system 15,189 | 16,909
Nervous System 15,122 | 16,725
Liver and Pancreas 15,093 | 16,750
Urinary Tract 15,040 | 16,678
Respiratory system 14,922 | 16,393
Cardiovascular System 14,124 | 15,192

Target Family

Non-IDG 9,197 | 12,091
Enzyme 3,593 | 4,145
Transcription Factor 1,205 | 1,400
Kinase 582 | 634
Transporter 381 | 473
Ion Channel 264 | 344
GPCR 257 | 408
Epigenetic 233 | 242
Nuclear Receptor 39 | 48
TF/Epigenetic 36 | 38
oGPCR 22 | 421

HCA RNA Cell Line

MOLT-4 15,809 | 15,809
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39