Development Level

Tbio 9,725 | 11,651
Tdark 3,895 | 6,593
Tchem 1,152 | 1,388
Tclin 460 | 612

Collection

RFA-RM-18-021 249 | 328
Kinase: IDG Consortium (Target... 117 | 125
Ion Channel: IDG Consortium (T... 75 | 99
GPCR: IDG Consortium (Targets) 67 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 17 | 25

IMPC Phenotype

preweaning lethality, complete... 934 | 979
preweaning lethality, incomple... 450 | 499
abnormal behavior 270 | 298
embryonic lethality prior to t... 266 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 208 | 220
decreased total body fat amoun... 182 | 207
enlarged heart 170 | 210
decreased vertical activity 162 | 208
abnormal bone structure 161 | 187
decreased body weight 149 | 161
increased lean body mass 149 | 172
abnormal heart morphology 133 | 162
hyperactivity 131 | 148
decreased bone mineral content 129 | 151
decreased lean body mass 118 | 135
increased total body fat amoun... 117 | 134
hypoactivity 114 | 132
decreased bone mineral density 110 | 126
decreased circulating glucose ... 110 | 126
increased circulating alkaline... 110 | 122
increased startle reflex 102 | 112
male infertility 101 | 123
embryonic growth retardation 100 | 106
decreased grip strength 96 | 116
abnormal seminal vesicle morph... 93 | 114
increased bone mineral content 93 | 108
increased or absent threshold ... 93 | 101
decreased body length 91 | 101
increased mean corpuscular hem... 86 | 96
short tibia 86 | 97
cataract 84 | 92
increased mean corpuscular vol... 84 | 92
decreased circulating choleste... 82 | 93
prenatal lethality prior to he... 80 | 87
abnormal lens morphology 75 | 81
decreased mean corpuscular vol... 73 | 79
decreased circulating serum al... 72 | 82
decreased prepulse inhibition 72 | 82
decreased circulating triglyce... 70 | 79
increased fasted circulating g... 70 | 76
decreased startle reflex 68 | 75
decreased lymphocyte cell numb... 67 | 83
increased bone mineral density 67 | 72
decreased circulating insulin ... 66 | 76
increased circulating HDL chol... 66 | 80
decreased leukocyte cell numbe... 65 | 73
improved glucose tolerance 65 | 79
small superior vagus ganglion 65 | 74
abnormal eye morphology 64 | 68
abnormal retina morphology 64 | 71
impaired glucose tolerance 64 | 75
decreased circulating HDL chol... 61 | 68
abnormal sleep behavior 58 | 70
decreased hemoglobin content 58 | 68
abnormal gait 57 | 69
increased circulating choleste... 56 | 66
increased circulating sodium l... 56 | 71
abnormal coat-hair pigmentatio... 55 | 64
increased heart weight 55 | 62
abnormal behavioral response t... 54 | 66
abnormal kidney morphology 54 | 65
decreased fasted circulating g... 54 | 65
decreased erythrocyte cell num... 53 | 62
edema 53 | 59
small testis 52 | 58
abnormal spleen morphology 51 | 55
decreased caudal vertebrae num... 49 | 53
increased monocyte cell number 49 | 63
thrombocytopenia 49 | 56
decreased blood urea nitrogen ... 48 | 51
decreased mean corpuscular hem... 47 | 50
female infertility 47 | 60
decreased circulating alanine ... 45 | 47
hydrometra 45 | 53
abnormal neural tube closure 44 | 46
decreased circulating total pr... 43 | 49
abnormal skin morphology 42 | 50
increased blood urea nitrogen ... 42 | 48
decreased circulating alkaline... 41 | 46
increased hematocrit 41 | 46
increased leukocyte cell numbe... 41 | 47
decreased hematocrit 40 | 46
increased hemoglobin content 40 | 45
increased neutrophil cell numb... 40 | 46
abnormal epididymis morphology 39 | 42
abnormal testis morphology 39 | 43
enlarged spleen 39 | 41
increased mean platelet volume 38 | 45
decreased red blood cell distr... 37 | 41
limb grasping 37 | 41
decreased circulating LDL chol... 36 | 38
increased circulating triglyce... 36 | 42
abnormal bone mineralization 35 | 38
decreased neutrophil cell numb... 35 | 42
increased grip strength 35 | 41
abnormal cranium morphology 34 | 36
enlarged lymph nodes 34 | 37
tremors 34 | 39
decreased circulating aspartat... 33 | 34

Disease

Carcinoma 9,232 | 11,493
ovarian cancer 7,760 | 8,520
osteosarcoma 7,045 | 7,950
medulloblastoma, large-cell 5,498 | 6,241
psoriasis 5,292 | 6,694
glioblastoma 5,147 | 5,792
atypical teratoid / rhabdoid tumor 4,571 | 5,112
lung cancer 4,141 | 4,740
ependymoma 4,089 | 4,679
group 3 medulloblastoma 3,628 | 4,104
adult high grade glioma 3,241 | 3,801
Breast cancer 3,137 | 3,578
malignant mesothelioma 2,940 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,939 | 3,291
primitive neuroectodermal tumor 2,702 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,614 | 2,989
Astrocytoma, Pilocytic 2,605 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 2,584 | 2,955
invasive ductal carcinoma 2,579 | 2,951
oligodendroglioma 2,486 | 2,850
non-small cell lung cancer 2,461 | 2,890
astrocytic glioma 2,278 | 2,597
lung adenocarcinoma 2,268 | 2,716
lung carcinoma 2,267 | 2,843
Kidney cancer 2,135 | 2,613
pancreatic cancer 2,073 | 2,398
Cancer 2,044 | 2,499
subependymal giant cell astrocytoma 2,022 | 2,287
interstitial cystitis 1,836 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,806 | 1,962
tuberculosis 1,715 | 2,010
Pick disease 1,707 | 1,894
group 4 medulloblastoma 1,685 | 1,855
pituitary cancer 1,666 | 1,972
ductal carcinoma in situ 1,513 | 1,745
ulcerative colitis 1,490 | 1,819
cystic fibrosis 1,425 | 1,696
breast carcinoma 1,416 | 1,638
Multiple myeloma 1,290 | 1,332
colon cancer 1,258 | 1,478
adrenocortical carcinoma 1,253 | 1,428
diabetes mellitus 1,248 | 1,728
Autosomal recessive predisposition 1,228 | 1,442
juvenile dermatomyositis 1,087 | 1,187
acute quadriplegic myopathy 1,085 | 1,158
astrocytoma 1,051 | 1,146
Rheumatoid arthritis 1,013 | 1,191
primary pancreatic ductal adenocarcinoma 1,003 | 1,109
spina bifida 997 | 1,074
pediatric high grade glioma 971 | 1,064
Intellectual disability 925 | 1,016
Schizophrenia 895 | 1,160
dermatomyositis 878 | 966
nasopharyngeal carcinoma 876 | 1,058
cutaneous lupus erythematosus 792 | 1,057
active Crohn's disease 780 | 922
non primary Sjogren syndrome sicca 756 | 891
Atopic dermatitis 745 | 952
acute myeloid leukemia 732 | 783
Waldenstrons macroglobulinemia 729 | 765
gastric carcinoma 713 | 807
Epilepsy 681 | 792
active ulcerative colitis 645 | 764
medulloblastoma 636 | 720
esophageal adenocarcinoma 634 | 737
Liver Cirrhosis, Experimental 633 | 769
progressive supranuclear palsy 629 | 676
aldosterone-producing adenoma 604 | 665
primary Sjogren syndrome 598 | 735
Dull intelligence 589 | 645
Low intelligence 589 | 645
Mental Retardation 589 | 645
Mental deficiency 589 | 645
Poor school performance 589 | 645
Cognitive delay 574 | 608
Global developmental delay 574 | 608
Mental and motor retardation 574 | 608
Alzheimer's disease 547 | 658
Obesity 535 | 678
Muscle hypotonia 529 | 571
Seizures 525 | 596
Duchenne muscular dystrophy 509 | 601
Bipolar Disorder 507 | 666
pancreatic carcinoma 494 | 562
hepatocellular carcinoma 486 | 547
Short stature 485 | 531
Melanoma 474 | 711
Liver cancer 472 | 604
fibroadenoma 467 | 559
autosomal dominant Emery-Dreifuss muscular dystrophy 447 | 510
Endometriosis 443 | 540
Prostatic Neoplasms 438 | 495
Down syndrome 437 | 499
chronic rhinosinusitis 427 | 512
gastric cancer 409 | 459
sonic hedgehog group medulloblastoma 409 | 467
Amyotrophic lateral sclerosis 403 | 451
posterior fossa group A ependymoma 402 | 468
tuberculosis and treatment for 6 months 397 | 409
Breast Neoplasms 394 | 445

Tissue

Endocrine System 15,020 | 18,159
Digestive Tract 14,850 | 17,369
Female tissues 14,848 | 17,400
Skin and soft tissues 14,810 | 17,230
Male tissues 14,752 | 17,142
Blood and immune system 14,666 | 16,909
Nervous System 14,650 | 16,725
Liver and Pancreas 14,630 | 16,750
Urinary Tract 14,567 | 16,678
Respiratory system 14,480 | 16,393
Cardiovascular System 13,742 | 15,192

Target Family

Non-IDG 8,796 | 12,091
Enzyme 3,534 | 4,145
Transcription Factor 1,167 | 1,400
Kinase 581 | 634
Transporter 360 | 473
GPCR 237 | 408
Ion Channel 235 | 344
Epigenetic 226 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 34 | 38
oGPCR 20 | 421

HCA RNA Cell Line

MCF7 15,232 | 15,232
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50