Development Level

Tbio 9,478 | 11,445
Tdark 3,761 | 6,588
Tchem 1,310 | 1,598
Tclin 440 | 613

Collection

RFA-RM-18-021 219 | 328
Kinase: IDG Consortium (Target... 112 | 125
Ion Channel: IDG Consortium (T... 63 | 99
GPCR: IDG Consortium (Targets) 49 | 126
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 18 | 25

IMPC Phenotype

preweaning lethality, complete... 930 | 979
preweaning lethality, incomple... 446 | 499
embryonic lethality prior to t... 262 | 278
abnormal behavior 254 | 298
embryonic lethality prior to o... 235 | 239
abnormal embryo size 208 | 220
decreased total body fat amoun... 180 | 207
enlarged heart 168 | 210
abnormal bone structure 163 | 187
increased lean body mass 152 | 172
decreased vertical activity 151 | 208
decreased body weight 148 | 161
abnormal heart morphology 130 | 162
decreased bone mineral content 130 | 151
hyperactivity 127 | 148
decreased lean body mass 118 | 135
increased total body fat amoun... 115 | 134
increased circulating alkaline... 110 | 122
decreased circulating glucose ... 108 | 126
hypoactivity 106 | 132
decreased bone mineral density 105 | 126
increased startle reflex 101 | 112
embryonic growth retardation 98 | 106
male infertility 96 | 123
decreased body length 94 | 101
decreased grip strength 94 | 116
increased bone mineral content 94 | 108
increased or absent threshold ... 88 | 101
abnormal seminal vesicle morph... 86 | 114
increased mean corpuscular hem... 86 | 96
short tibia 86 | 97
decreased circulating choleste... 85 | 93
cataract 82 | 92
increased mean corpuscular vol... 82 | 92
prenatal lethality prior to he... 79 | 87
decreased prepulse inhibition 76 | 82
abnormal lens morphology 74 | 81
decreased mean corpuscular vol... 73 | 79
decreased circulating serum al... 70 | 82
decreased lymphocyte cell numb... 70 | 83
decreased startle reflex 67 | 75
increased bone mineral density 67 | 72
abnormal retina morphology 66 | 71
decreased circulating triglyce... 66 | 79
increased fasted circulating g... 65 | 76
decreased circulating HDL chol... 64 | 68
increased circulating HDL chol... 64 | 80
decreased leukocyte cell numbe... 63 | 73
impaired glucose tolerance 62 | 75
improved glucose tolerance 62 | 79
small superior vagus ganglion 62 | 74
abnormal sleep behavior 60 | 70
decreased circulating insulin ... 60 | 76
abnormal eye morphology 59 | 68
abnormal behavioral response t... 58 | 66
abnormal gait 58 | 69
increased circulating sodium l... 58 | 71
edema 57 | 59
abnormal coat-hair pigmentatio... 56 | 64
decreased erythrocyte cell num... 56 | 62
decreased hemoglobin content 56 | 68
increased heart weight 56 | 62
increased circulating choleste... 54 | 66
small testis 53 | 58
abnormal kidney morphology 52 | 65
decreased fasted circulating g... 52 | 65
increased monocyte cell number 50 | 63
decreased caudal vertebrae num... 49 | 53
thrombocytopenia 49 | 56
decreased mean corpuscular hem... 47 | 50
abnormal neural tube closure 45 | 46
abnormal spleen morphology 45 | 55
decreased circulating alanine ... 45 | 47
decreased circulating total pr... 44 | 49
female infertility 44 | 60
decreased blood urea nitrogen ... 43 | 51
hydrometra 43 | 53
increased hematocrit 43 | 46
increased blood urea nitrogen ... 42 | 48
increased hemoglobin content 41 | 45
increased leukocyte cell numbe... 41 | 47
abnormal skin morphology 39 | 50
abnormal testis morphology 39 | 43
decreased circulating alkaline... 39 | 46
decreased hematocrit 39 | 46
decreased red blood cell distr... 38 | 41
enlarged spleen 38 | 41
increased circulating triglyce... 38 | 42
increased neutrophil cell numb... 38 | 46
increased mean platelet volume 37 | 45
decreased circulating LDL chol... 36 | 38
tremors 36 | 39
increased erythrocyte cell num... 35 | 39
increased grip strength 35 | 41
abnormal bone mineralization 34 | 38
abnormal cranium morphology 34 | 36
decreased neutrophil cell numb... 34 | 42
limb grasping 34 | 41
abnormal epididymis morphology 33 | 42
increased mean corpuscular hem... 33 | 36

Disease

Carcinoma 9,227 | 11,493
ovarian cancer 7,799 | 8,520
osteosarcoma 7,048 | 7,950
medulloblastoma, large-cell 5,516 | 6,241
psoriasis 5,207 | 6,694
glioblastoma 5,174 | 5,792
atypical teratoid / rhabdoid tumor 4,574 | 5,112
lung cancer 4,192 | 4,740
ependymoma 4,108 | 4,679
group 3 medulloblastoma 3,641 | 4,104
adult high grade glioma 3,253 | 3,801
Breast cancer 3,184 | 3,578
malignant mesothelioma 3,035 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,935 | 3,291
primitive neuroectodermal tumor 2,706 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,656 | 2,989
invasive ductal carcinoma 2,620 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,613 | 2,955
Astrocytoma, Pilocytic 2,595 | 3,081
oligodendroglioma 2,518 | 2,850
non-small cell lung cancer 2,458 | 2,890
lung carcinoma 2,310 | 2,843
astrocytic glioma 2,298 | 2,597
lung adenocarcinoma 2,284 | 2,716
Kidney cancer 2,180 | 2,613
pancreatic cancer 2,077 | 2,398
subependymal giant cell astrocytoma 2,030 | 2,287
Cancer 2,018 | 2,499
interstitial cystitis 1,833 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,799 | 1,962
tuberculosis 1,770 | 2,010
Pick disease 1,751 | 1,894
group 4 medulloblastoma 1,692 | 1,855
pituitary cancer 1,672 | 1,972
ulcerative colitis 1,536 | 1,819
ductal carcinoma in situ 1,532 | 1,745
cystic fibrosis 1,495 | 1,696
breast carcinoma 1,427 | 1,638
Multiple myeloma 1,298 | 1,332
adrenocortical carcinoma 1,298 | 1,428
colon cancer 1,285 | 1,478
diabetes mellitus 1,258 | 1,728
Autosomal recessive predisposition 1,207 | 1,442
juvenile dermatomyositis 1,123 | 1,187
acute quadriplegic myopathy 1,113 | 1,158
astrocytoma 1,059 | 1,146
primary pancreatic ductal adenocarcinoma 1,010 | 1,109
Rheumatoid arthritis 1,002 | 1,191
pediatric high grade glioma 969 | 1,064
spina bifida 958 | 1,074
Intellectual disability 914 | 1,016
dermatomyositis 896 | 966
Schizophrenia 893 | 1,160
nasopharyngeal carcinoma 872 | 1,058
cutaneous lupus erythematosus 818 | 1,057
active Crohn's disease 779 | 922
Atopic dermatitis 776 | 952
non primary Sjogren syndrome sicca 773 | 891
acute myeloid leukemia 739 | 783
Waldenstrons macroglobulinemia 738 | 765
gastric carcinoma 724 | 807
Epilepsy 672 | 792
Liver Cirrhosis, Experimental 650 | 769
medulloblastoma 647 | 720
active ulcerative colitis 638 | 764
progressive supranuclear palsy 635 | 676
aldosterone-producing adenoma 614 | 665
esophageal adenocarcinoma 612 | 737
primary Sjogren syndrome 612 | 735
Dull intelligence 579 | 645
Low intelligence 579 | 645
Mental Retardation 579 | 645
Mental deficiency 579 | 645
Poor school performance 579 | 645
Cognitive delay 560 | 608
Global developmental delay 560 | 608
Mental and motor retardation 560 | 608
Alzheimer's disease 551 | 658
Duchenne muscular dystrophy 551 | 601
Obesity 538 | 678
Muscle hypotonia 530 | 571
Melanoma 518 | 711
Seizures 515 | 596
Bipolar Disorder 505 | 666
pancreatic carcinoma 504 | 562
hepatocellular carcinoma 496 | 547
Liver cancer 493 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 479 | 510
Short stature 478 | 531
fibroadenoma 475 | 559
Endometriosis 457 | 540
Down syndrome 449 | 499
chronic rhinosinusitis 425 | 512
Prostatic Neoplasms 423 | 495
gastric cancer 421 | 459
sonic hedgehog group medulloblastoma 420 | 467
posterior fossa group A ependymoma 417 | 468
Amyotrophic lateral sclerosis 414 | 451
tuberculosis and treatment for 6 months 398 | 409
Breast Neoplasms 394 | 445

Tissue

Endocrine System 14,814 | 18,159
Female tissues 14,688 | 17,400
Digestive Tract 14,687 | 17,369
Skin and soft tissues 14,671 | 17,230
Male tissues 14,614 | 17,142
Blood and immune system 14,541 | 16,909
Nervous System 14,528 | 16,725
Liver and Pancreas 14,503 | 16,750
Urinary Tract 14,453 | 16,678
Respiratory system 14,359 | 16,393
Cardiovascular System 13,778 | 15,192

Target Family

Non-IDG 8,686 | 12,091
Enzyme 3,470 | 4,145
Transcription Factor 1,151 | 1,400
Kinase 573 | 634
Transporter 360 | 473
Epigenetic 226 | 242
Ion Channel 218 | 344
GPCR 217 | 408
Nuclear Receptor 38 | 48
TF/Epigenetic 36 | 38
oGPCR 14 | 421

HCA RNA Cell Line

LHCN-M2 14,989 | 14,989
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endosomal/lysosomal potassium channel TMEM175 TMEM175 Tbio Non-IDG -0.65375 3.76 42
WASH complex subunit 2C WASHC2C Tbio Non-IDG -0.83634 0.00000 45
Transmembrane protein 170A TMEM170A Tdark Non-IDG 0.00000 1.18 3
Protein AF-9 MLLT3 Tbio Non-IDG -1.99555 93.8 210
Scm-like with four MBT domains protein 1 SFMBT1 Tbio Epigenetic -2.06810 112.0 113
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.18 96
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.24396 15.5 189
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.72004 3.69 184
Solute carrier organic anion transporter family member 3A1 SLCO3A1 Tbio Transporter -1.39614 24.1 46
Latexin LXN Tbio Enzyme -2.54426 344.4 419