Development Level

Tbio 10,388 | 11,651
Tdark 4,138 | 6,593
Tchem 1,237 | 1,388
Tclin 512 | 612

Collection

RFA-RM-18-021 268 | 328
Kinase: IDG Consortium (Target... 118 | 125
Ion Channel: IDG Consortium (T... 84 | 99
GPCR: IDG Consortium (Targets) 75 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 949 | 979
preweaning lethality, incomple... 466 | 499
abnormal behavior 275 | 298
embryonic lethality prior to t... 270 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 195 | 207
enlarged heart 189 | 210
abnormal bone structure 174 | 187
decreased vertical activity 173 | 208
increased lean body mass 163 | 172
decreased body weight 154 | 161
abnormal heart morphology 145 | 162
decreased bone mineral content 137 | 151
hyperactivity 137 | 148
decreased lean body mass 126 | 135
increased total body fat amoun... 125 | 134
decreased bone mineral density 116 | 126
decreased circulating glucose ... 116 | 126
increased circulating alkaline... 116 | 122
hypoactivity 115 | 132
increased startle reflex 108 | 112
decreased grip strength 104 | 116
male infertility 102 | 123
embryonic growth retardation 101 | 106
increased bone mineral content 99 | 108
abnormal seminal vesicle morph... 97 | 114
decreased body length 96 | 101
increased or absent threshold ... 94 | 101
increased mean corpuscular hem... 91 | 96
short tibia 91 | 97
decreased circulating choleste... 89 | 93
increased mean corpuscular vol... 87 | 92
cataract 86 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 79 | 83
abnormal lens morphology 77 | 81
decreased prepulse inhibition 77 | 82
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 73 | 79
decreased startle reflex 73 | 75
decreased circulating serum al... 72 | 82
increased circulating HDL chol... 70 | 80
impaired glucose tolerance 69 | 75
increased bone mineral density 69 | 72
increased fasted circulating g... 69 | 76
decreased leukocyte cell numbe... 68 | 73
small superior vagus ganglion 68 | 74
abnormal eye morphology 67 | 68
abnormal retina morphology 66 | 71
abnormal sleep behavior 66 | 70
decreased circulating HDL chol... 66 | 68
decreased circulating insulin ... 64 | 76
improved glucose tolerance 64 | 79
abnormal gait 62 | 69
increased circulating sodium l... 62 | 71
decreased hemoglobin content 61 | 68
increased circulating choleste... 60 | 66
abnormal coat-hair pigmentatio... 59 | 64
decreased erythrocyte cell num... 59 | 62
decreased fasted circulating g... 59 | 65
edema 59 | 59
increased heart weight 58 | 62
increased monocyte cell number 58 | 63
abnormal kidney morphology 56 | 65
small testis 56 | 58
abnormal behavioral response t... 55 | 66
thrombocytopenia 52 | 56
abnormal spleen morphology 51 | 55
decreased caudal vertebrae num... 51 | 53
hydrometra 50 | 53
abnormal skin morphology 49 | 50
decreased blood urea nitrogen ... 47 | 51
decreased mean corpuscular hem... 47 | 50
female infertility 47 | 60
decreased circulating alanine ... 45 | 47
increased blood urea nitrogen ... 45 | 48
abnormal neural tube closure 44 | 46
decreased circulating alkaline... 44 | 46
decreased circulating total pr... 44 | 49
decreased hematocrit 44 | 46
increased neutrophil cell numb... 44 | 46
increased leukocyte cell numbe... 43 | 47
increased hematocrit 42 | 46
abnormal testis morphology 41 | 43
enlarged spleen 41 | 41
increased hemoglobin content 41 | 45
decreased neutrophil cell numb... 40 | 42
increased circulating triglyce... 39 | 42
increased mean platelet volume 39 | 45
tremors 39 | 39
decreased red blood cell distr... 38 | 41
increased circulating chloride... 38 | 41
decreased circulating LDL chol... 37 | 38
increased erythrocyte cell num... 37 | 39
increased grip strength 37 | 41
limb grasping 37 | 41
abnormal bone mineralization 36 | 38
abnormal epididymis morphology 36 | 42
decreased circulating creatini... 36 | 39

Disease

Carcinoma 9,941 | 11,493
ovarian cancer 8,042 | 8,520
osteosarcoma 7,376 | 7,950
medulloblastoma, large-cell 5,828 | 6,241
psoriasis 5,722 | 6,694
glioblastoma 5,499 | 5,792
atypical teratoid / rhabdoid tumor 4,838 | 5,112
lung cancer 4,413 | 4,740
ependymoma 4,385 | 4,679
group 3 medulloblastoma 3,869 | 4,104
adult high grade glioma 3,528 | 3,801
Breast cancer 3,317 | 3,578
malignant mesothelioma 3,087 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,072 | 3,291
Astrocytoma, Pilocytic 2,894 | 3,081
primitive neuroectodermal tumor 2,890 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,773 | 2,989
invasive ductal carcinoma 2,744 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,739 | 2,955
oligodendroglioma 2,705 | 2,850
non-small cell lung cancer 2,659 | 2,890
lung carcinoma 2,574 | 2,843
astrocytic glioma 2,463 | 2,597
lung adenocarcinoma 2,451 | 2,716
Kidney cancer 2,363 | 2,613
Cancer 2,241 | 2,499
pancreatic cancer 2,216 | 2,398
subependymal giant cell astrocytoma 2,170 | 2,287
interstitial cystitis 2,083 | 2,312
tuberculosis 1,887 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,860 | 1,962
Pick disease 1,826 | 1,894
pituitary cancer 1,808 | 1,972
group 4 medulloblastoma 1,753 | 1,855
ulcerative colitis 1,664 | 1,819
ductal carcinoma in situ 1,603 | 1,745
cystic fibrosis 1,547 | 1,696
breast carcinoma 1,503 | 1,638
diabetes mellitus 1,408 | 1,728
colon cancer 1,346 | 1,478
adrenocortical carcinoma 1,340 | 1,428
Multiple myeloma 1,312 | 1,332
Autosomal recessive predisposition 1,288 | 1,442
juvenile dermatomyositis 1,151 | 1,187
Rheumatoid arthritis 1,126 | 1,191
acute quadriplegic myopathy 1,118 | 1,158
astrocytoma 1,117 | 1,146
primary pancreatic ductal adenocarcinoma 1,047 | 1,109
spina bifida 1,024 | 1,074
pediatric high grade glioma 1,020 | 1,064
Schizophrenia 1,005 | 1,160
Intellectual disability 955 | 1,016
dermatomyositis 948 | 966
cutaneous lupus erythematosus 944 | 1,057
nasopharyngeal carcinoma 944 | 1,058
active Crohn's disease 836 | 922
non primary Sjogren syndrome sicca 813 | 891
Atopic dermatitis 803 | 952
acute myeloid leukemia 756 | 783
gastric carcinoma 756 | 807
Waldenstrons macroglobulinemia 747 | 765
Epilepsy 735 | 792
Liver Cirrhosis, Experimental 706 | 769
primary Sjogren syndrome 690 | 735
active ulcerative colitis 687 | 764
esophageal adenocarcinoma 675 | 737
medulloblastoma 673 | 720
progressive supranuclear palsy 654 | 676
aldosterone-producing adenoma 622 | 665
Dull intelligence 608 | 645
Low intelligence 608 | 645
Mental Retardation 608 | 645
Mental deficiency 608 | 645
Poor school performance 608 | 645
Alzheimer's disease 604 | 658
Melanoma 590 | 711
Obesity 588 | 678
Cognitive delay 580 | 608
Global developmental delay 580 | 608
Mental and motor retardation 580 | 608
Bipolar Disorder 579 | 666
Duchenne muscular dystrophy 565 | 601
Seizures 557 | 596
Muscle hypotonia 545 | 571
Liver cancer 532 | 604
pancreatic carcinoma 531 | 562
hepatocellular carcinoma 525 | 547
fibroadenoma 500 | 559
Endometriosis 494 | 540
Short stature 493 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 490 | 510
Down syndrome 480 | 499
Multiple Sclerosis 463 | 540
Prostatic Neoplasms 454 | 495
chronic rhinosinusitis 444 | 512
gastric cancer 438 | 459
posterior fossa group A ependymoma 432 | 468
sonic hedgehog group medulloblastoma 431 | 467
Amyotrophic lateral sclerosis 428 | 451
mucosa-associated lymphoid tissue lymphoma 417 | 484

Tissue

Endocrine System 15,977 | 18,159
Female tissues 15,696 | 17,400
Digestive Tract 15,694 | 17,369
Skin and soft tissues 15,642 | 17,230
Male tissues 15,568 | 17,142
Blood and immune system 15,487 | 16,909
Nervous System 15,447 | 16,725
Liver and Pancreas 15,373 | 16,750
Urinary Tract 15,336 | 16,678
Respiratory system 15,185 | 16,393
Cardiovascular System 14,324 | 15,192

Target Family

Non-IDG 9,513 | 12,091
Enzyme 3,665 | 4,145
Transcription Factor 1,189 | 1,400
Kinase 592 | 634
Transporter 392 | 473
GPCR 282 | 408
Ion Channel 282 | 344
Epigenetic 228 | 242
oGPCR 56 | 421
Nuclear Receptor 40 | 48
TF/Epigenetic 36 | 38

HCA RNA Cell Line

Karpas-707 16,275 | 16,275
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50