Development Level

Tbio 9,980 | 11,178
Tdark 4,124 | 6,569
Tchem 1,659 | 1,885
Tclin 512 | 612

Collection

Kinase: IDG Consortium (Target... 118 | 125
Ion Channel: IDG Consortium (T... 84 | 99
GPCR: IDG Consortium (Targets) 75 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 949 | 979
preweaning lethality, incomple... 466 | 499
abnormal behavior 275 | 298
embryonic lethality prior to t... 270 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 195 | 207
enlarged heart 189 | 210
abnormal bone structure 174 | 187
decreased vertical activity 173 | 208
increased lean body mass 163 | 172
decreased body weight 154 | 161
abnormal heart morphology 145 | 162
decreased bone mineral content 137 | 151
hyperactivity 137 | 148
decreased lean body mass 126 | 135
increased total body fat amoun... 125 | 134
decreased bone mineral density 116 | 126
decreased circulating glucose ... 116 | 126
increased circulating alkaline... 116 | 122
hypoactivity 115 | 132
increased startle reflex 108 | 112
decreased grip strength 104 | 116
male infertility 102 | 123
embryonic growth retardation 101 | 106
increased bone mineral content 99 | 108
abnormal seminal vesicle morph... 97 | 114
decreased body length 96 | 101
increased or absent threshold ... 94 | 101
increased mean corpuscular hem... 91 | 96
short tibia 91 | 97
decreased circulating choleste... 89 | 93
increased mean corpuscular vol... 87 | 92
cataract 86 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 79 | 83
abnormal lens morphology 77 | 81
decreased prepulse inhibition 77 | 82
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 73 | 79
decreased startle reflex 73 | 75
decreased circulating serum al... 72 | 82
increased circulating HDL chol... 70 | 80
impaired glucose tolerance 69 | 75
increased bone mineral density 69 | 72
increased fasted circulating g... 69 | 76
decreased leukocyte cell numbe... 68 | 73
small superior vagus ganglion 68 | 74
abnormal eye morphology 67 | 68
abnormal retina morphology 66 | 71
abnormal sleep behavior 66 | 70
decreased circulating HDL chol... 66 | 68
decreased circulating insulin ... 64 | 76
improved glucose tolerance 64 | 79
abnormal gait 62 | 69
increased circulating sodium l... 62 | 71
decreased hemoglobin content 61 | 68
increased circulating choleste... 60 | 66
abnormal coat-hair pigmentatio... 59 | 64
decreased erythrocyte cell num... 59 | 62
decreased fasted circulating g... 59 | 65
edema 59 | 59
increased heart weight 58 | 62
increased monocyte cell number 58 | 63
abnormal kidney morphology 56 | 65
small testis 56 | 58
abnormal behavioral response t... 55 | 66
thrombocytopenia 52 | 56
abnormal spleen morphology 51 | 55
decreased caudal vertebrae num... 51 | 53
hydrometra 50 | 53
abnormal skin morphology 49 | 50
decreased blood urea nitrogen ... 47 | 51
decreased mean corpuscular hem... 47 | 50
female infertility 47 | 60
decreased circulating alanine ... 45 | 47
increased blood urea nitrogen ... 45 | 48
abnormal neural tube closure 44 | 46
decreased circulating alkaline... 44 | 46
decreased circulating total pr... 44 | 49
decreased hematocrit 44 | 46
increased neutrophil cell numb... 44 | 46
increased leukocyte cell numbe... 43 | 47
increased hematocrit 42 | 46
abnormal testis morphology 41 | 43
enlarged spleen 41 | 41
increased hemoglobin content 41 | 45
decreased neutrophil cell numb... 40 | 42
increased circulating triglyce... 39 | 42
increased mean platelet volume 39 | 45
tremors 39 | 39
decreased red blood cell distr... 38 | 41
increased circulating chloride... 38 | 41
decreased circulating LDL chol... 37 | 38
increased erythrocyte cell num... 37 | 39
increased grip strength 37 | 41
limb grasping 37 | 41
abnormal bone mineralization 36 | 38
abnormal epididymis morphology 36 | 42
decreased circulating creatini... 36 | 39

Disease

Carcinoma 9,694 | 11,192
ovarian cancer 7,833 | 8,297
osteosarcoma 7,206 | 7,766
medulloblastoma, large-cell 5,684 | 6,086
psoriasis 5,574 | 6,514
glioblastoma 5,353 | 5,635
atypical teratoid / rhabdoid tumor 4,707 | 4,971
lung cancer 4,293 | 4,607
ependymoma 4,273 | 4,559
group 3 medulloblastoma 3,774 | 4,002
adult high grade glioma 3,439 | 3,701
Breast cancer 3,219 | 3,469
malignant mesothelioma 2,995 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 2,993 | 3,204
Astrocytoma, Pilocytic 2,822 | 3,006
primitive neuroectodermal tumor 2,815 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,696 | 2,902
invasive ductal carcinoma 2,668 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 2,665 | 2,872
oligodendroglioma 2,626 | 2,768
non-small cell lung cancer 2,582 | 2,799
lung carcinoma 2,492 | 2,755
astrocytic glioma 2,398 | 2,530
lung adenocarcinoma 2,374 | 2,627
Kidney cancer 2,307 | 2,548
pancreatic cancer 2,149 | 2,322
Cancer 2,145 | 2,388
subependymal giant cell astrocytoma 2,118 | 2,230
interstitial cystitis 2,015 | 2,237
tuberculosis 1,843 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,814 | 1,911
Pick disease 1,789 | 1,856
pituitary cancer 1,755 | 1,915
group 4 medulloblastoma 1,712 | 1,806
ulcerative colitis 1,617 | 1,765
ductal carcinoma in situ 1,550 | 1,686
cystic fibrosis 1,492 | 1,629
breast carcinoma 1,458 | 1,589
diabetes mellitus 1,366 | 1,683
colon cancer 1,302 | 1,428
adrenocortical carcinoma 1,299 | 1,385
Multiple myeloma 1,276 | 1,296
Autosomal recessive predisposition 1,261 | 1,407
juvenile dermatomyositis 1,114 | 1,147
acute quadriplegic myopathy 1,094 | 1,133
Rheumatoid arthritis 1,093 | 1,156
astrocytoma 1,085 | 1,113
primary pancreatic ductal adenocarcinoma 1,013 | 1,071
spina bifida 1,007 | 1,053
pediatric high grade glioma 993 | 1,035
Schizophrenia 988 | 1,136
Intellectual disability 939 | 998
dermatomyositis 923 | 941
nasopharyngeal carcinoma 915 | 1,024
cutaneous lupus erythematosus 910 | 1,016
active Crohn's disease 802 | 882
non primary Sjogren syndrome sicca 787 | 861
Atopic dermatitis 771 | 915
gastric carcinoma 734 | 781
acute myeloid leukemia 733 | 760
Waldenstrons macroglobulinemia 724 | 742
Epilepsy 721 | 775
Liver Cirrhosis, Experimental 671 | 733
primary Sjogren syndrome 668 | 710
active ulcerative colitis 663 | 736
medulloblastoma 656 | 702
esophageal adenocarcinoma 641 | 696
progressive supranuclear palsy 636 | 656
aldosterone-producing adenoma 605 | 646
Dull intelligence 598 | 634
Low intelligence 598 | 634
Mental Retardation 598 | 634
Mental deficiency 598 | 634
Poor school performance 598 | 634
Alzheimer's disease 588 | 640
Cognitive delay 572 | 596
Global developmental delay 572 | 596
Mental and motor retardation 572 | 596
Melanoma 570 | 689
Obesity 568 | 655
Bipolar Disorder 564 | 646
Duchenne muscular dystrophy 552 | 587
Seizures 548 | 584
Muscle hypotonia 537 | 562
pancreatic carcinoma 525 | 555
Liver cancer 519 | 589
hepatocellular carcinoma 514 | 536
Short stature 480 | 514
fibroadenoma 480 | 538
Endometriosis 475 | 521
autosomal dominant Emery-Dreifuss muscular dystrophy 473 | 492
Down syndrome 462 | 480
Multiple Sclerosis 452 | 527
chronic rhinosinusitis 438 | 505
Prostatic Neoplasms 434 | 472
gastric cancer 424 | 445
sonic hedgehog group medulloblastoma 423 | 459
posterior fossa group A ependymoma 420 | 456
Amyotrophic lateral sclerosis 414 | 437
mucosa-associated lymphoid tissue lymphoma 408 | 473

Tissue

Endocrine System 15,977 | 18,159
Female tissues 15,696 | 17,400
Digestive Tract 15,694 | 17,369
Skin and soft tissues 15,642 | 17,230
Male tissues 15,568 | 17,142
Blood and immune system 15,487 | 16,909
Nervous System 15,447 | 16,725
Liver and Pancreas 15,373 | 16,750
Urinary Tract 15,336 | 16,678
Respiratory system 15,185 | 16,393
Cardiovascular System 14,324 | 15,192

Target Family

Non-IDG 9,513 | 12,091
Enzyme 3,665 | 4,145
Transcription Factor 1,189 | 1,400
Kinase 592 | 634
Transporter 392 | 473
GPCR 282 | 408
Ion Channel 282 | 344
Epigenetic 228 | 242
oGPCR 56 | 421
Nuclear Receptor 40 | 48
TF/Epigenetic 36 | 38

HCA RNA Cell Line

Karpas-707 16,275 | 16,275
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 9 MAGEA9B Tbio Non-IDG -1.32496 23.3 213
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153