Development Level

Tbio 9,434 | 10,625
Tdark 4,505 | 7,003
Tchem 1,654 | 1,890
Tclin 501 | 602

Collection

Eligible Kinase Proteins 123 | 134
Eligible Ion Channel Proteins 92 | 117
Eligible non-olfactory GPCR Proteins 81 | 145

IMPC Term

preweaning lethality, complete... 611 | 633
preweaning lethality, incomple... 241 | 260
abnormal behavior 213 | 226
embryonic lethality prior to t... 184 | 187
decreased lean body mass 183 | 195
decreased total body fat amoun... 180 | 186
decreased body weight 167 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 144 | 157
abnormal bone structure 121 | 131
increased or absent threshold ... 118 | 128
decreased bone mineral density 117 | 126
increased circulating alkaline... 115 | 119
decreased grip strength 113 | 123
abnormal embryo size 108 | 112
decreased circulating glucose ... 108 | 121
hyperactivity 103 | 108
decreased body length 102 | 108
increased lean body mass 99 | 107
enlarged heart 97 | 111
abnormal retina morphology 95 | 100
increased mean corpuscular hem... 92 | 93
increased bone mineral content 89 | 92
increased mean corpuscular vol... 87 | 91
decreased circulating choleste... 82 | 85
hypoactivity 81 | 89
short tibia 78 | 82
decreased circulating triglyce... 77 | 83
increased grip strength 75 | 83
decreased circulating HDL chol... 74 | 77
decreased circulating serum al... 71 | 79
abnormal lens morphology 68 | 73
increased fasted circulating g... 64 | 68
decreased circulating insulin ... 63 | 75
prenatal lethality prior to he... 63 | 64
increased circulating sodium l... 62 | 71
decreased lumbar vertebrae num... 60 | 62
abnormal retinal pigmentation 59 | 61
increased sacral vertebrae num... 59 | 62
abnormal sleep behavior 58 | 63
decreased rib number 57 | 59
increased circulating HDL chol... 55 | 63
abnormal bone mineralization 53 | 55
increased total body fat amoun... 53 | 57
male infertility 53 | 62
abnormal coat/hair pigmentatio... 50 | 54
decreased leukocyte cell numbe... 50 | 54
decreased prepulse inhibition 50 | 52
impaired glucose tolerance 50 | 52
increased bone mineral density 50 | 52
increased circulating choleste... 49 | 53
abnormal gait 48 | 51
decreased circulating alanine ... 48 | 53
decreased hemoglobin content 48 | 53
decreased mean corpuscular vol... 48 | 50
decreased startle reflex 47 | 48
decreased caudal vertebrae num... 45 | 49
improved glucose tolerance 45 | 56
increased exploration in new e... 45 | 56
abnormal behavioral response t... 44 | 52
decreased fasted circulating g... 44 | 49
thrombocytopenia 44 | 46
abnormal heart morphology 43 | 51
decreased erythrocyte cell num... 43 | 43
increased blood urea nitrogen ... 42 | 44
increased body weight 41 | 42
increased hemoglobin content 41 | 45
decreased circulating alkaline... 39 | 41
decreased circulating free fat... 38 | 39
increased circulating chloride... 38 | 43
increased rib number 38 | 41
abnormal eye morphology 37 | 38
abnormal seminal vesicle morph... 37 | 47
decreased circulating total pr... 37 | 41
decreased eosinophil cell numb... 37 | 41
decreased heart weight 37 | 44
decreased circulating LDL chol... 36 | 37
increased startle reflex 36 | 38
abnormal neural tube closure 35 | 37
decreased neutrophil cell numb... 35 | 37
increased leukocyte cell numbe... 35 | 37
small testis 34 | 37
tremors 34 | 34
abnormal spleen morphology 32 | 36
decreased mean corpuscular hem... 32 | 34
increased heart weight 32 | 37
abnormal cranium morphology 31 | 32
decreased T cell number 31 | 31
increased hematocrit 31 | 36
limb grasping 31 | 35
cardiovascular system phenotyp... 30 | 35
decreased circulating calcium ... 30 | 33
increased circulating calcium ... 30 | 32
increased circulating potassiu... 30 | 31
abnormal testis morphology 29 | 30
decreased blood urea nitrogen ... 29 | 31
decreased circulating chloride... 29 | 32
decreased circulating creatini... 29 | 31
decreased circulating fructosa... 29 | 31
decreased NK T cell number 28 | 28

Disease

ovarian cancer 7,932 | 8,492
osteosarcoma 7,291 | 7,933
medulloblastoma, large-cell 5,770 | 6,234
psoriasis 5,670 | 6,685
glioblastoma 5,246 | 5,572
lung cancer 4,180 | 4,473
atypical teratoid / rhabdoid tumor 4,094 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,044 | 3,289
malignant mesothelioma 2,997 | 3,163
Breast cancer 2,866 | 3,099
pilocytic astrocytoma 2,865 | 3,086
primitive neuroectodermal tumor 2,855 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,749 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,723 | 2,956
invasive ductal carcinoma 2,715 | 2,950
oligodendroglioma 2,679 | 2,849
pediatric high grade glioma 2,577 | 2,712
non-small cell lung cancer 2,560 | 2,798
lung carcinoma 2,559 | 2,844
lung adenocarcinoma 2,430 | 2,714
ependymoma 2,385 | 2,514
subependymal giant cell astrocytoma 2,151 | 2,287
pancreatic cancer 2,113 | 2,300
astrocytic glioma 2,101 | 2,241
Cancer 2,091 | 2,346
group 3 medulloblastoma 2,090 | 2,254
interstitial cystitis 2,063 | 2,299
Carcinoma 1,925 | 2,147
adult high grade glioma 1,923 | 2,148
ulcerative colitis 1,903 | 2,087
Pick disease 1,812 | 1,893
pituitary cancer 1,794 | 1,972
group 4 medulloblastoma 1,764 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,685 | 1,795
ductal carcinoma in situ 1,588 | 1,745
cystic fibrosis 1,512 | 1,670
breast carcinoma 1,469 | 1,614
tuberculosis 1,453 | 1,563
astrocytoma 1,445 | 1,493
medulloblastoma 1,419 | 1,524
posterior fossa group A ependymoma 1,380 | 1,511
sonic hedgehog group medulloblastoma 1,377 | 1,482
posterior fossa group B ependymoma 1,362 | 1,530
diabetes mellitus 1,344 | 1,663
colon cancer 1,332 | 1,475
adrenocortical carcinoma 1,322 | 1,427
Multiple myeloma 1,298 | 1,328
primary pancreatic ductal adenocarcinoma 1,191 | 1,271
juvenile dermatomyositis 1,143 | 1,189
acute quadriplegic myopathy 1,109 | 1,157
Rheumatoid Arthritis 1,099 | 1,171
atypical teratoid/rhabdoid tumor 1,021 | 1,095
spina bifida 1,006 | 1,064
dermatomyositis 944 | 967
nasopharyngeal carcinoma 938 | 1,056
cutaneous lupus erythematosus 935 | 1,056
active Crohn's disease 826 | 918
Atopic dermatitis 790 | 944
gastric carcinoma 776 | 832
non primary Sjogren syndrome sicca 756 | 840
acute myeloid leukemia 744 | 785
Waldenstrons macroglobulinemia 741 | 765
primary Sjogren syndrome 735 | 789
esophageal adenocarcinoma 672 | 737
tuberculosis and treatment for 6 months 667 | 686
progressive supranuclear palsy 648 | 674
aldosterone-producing adenoma 617 | 664
Alzheimer's disease 589 | 644
Duchenne muscular dystrophy 559 | 602
Intellectual disability 543 | 573
Obesity 532 | 616
pancreatic carcinoma 532 | 567
hepatocellular carcinoma 526 | 550
Down syndrome 522 | 548
fibroadenoma 496 | 557
Endometriosis 484 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 479 | 499
chronic rhinosinusitis 441 | 512
IGA Glomerulonephritis 433 | 454
Prostatic Neoplasms 429 | 471
Multiple Sclerosis 427 | 498
Schizophrenia 421 | 503
active ulcerative colitis 419 | 477
mucosa-associated lymphoid tissue lymphoma 415 | 480
gastric cancer 411 | 436
Amyotrophic Lateral Sclerosis 409 | 432
Mammary Neoplasms 382 | 410
inflammatory breast cancer 361 | 404
Neurodegenerative disease 360 | 383
non-small cell lung carcinoma 358 | 413
sarcoidosis 341 | 368
glioblastoma multiforme 329 | 347
Kidney disease 323 | 397
Parkinson's disease 322 | 364
Epilepsy 308 | 346
tuberculosis and treatment for 3 months 305 | 327
hereditary spastic paraplegia 304 | 313
Polycystic Ovary Syndrome 301 | 335
nephrosclerosis 290 | 329
Asthma 289 | 349

Tissue

Nervous System 15,861 | 18,561
Female tissues 15,849 | 18,647
Digestive Tract 15,819 | 18,473
Endocrine System 15,818 | 18,512
Urinary Tract 15,771 | 18,444
Liver and Pancreas 15,725 | 18,136
Male tissues 15,703 | 17,969
Blood and immune system 15,694 | 17,995
Cardiovascular System 15,668 | 17,958
Skin and soft tissues 15,641 | 18,115
Respiratory system 15,503 | 17,484

Target Family

Non-IDG 9,380 | 11,969
Enzyme 3,640 | 4,146
Transcription Factor 1,185 | 1,400
Kinase 585 | 634
Transporter 392 | 473
GPCR 281 | 408
Ion Channel 278 | 341
Epigenetic 222 | 242
oGPCR 56 | 421
Nuclear Receptor 40 | 48
TF/Epigenetic 35 | 38

HCA RNA Cell Line

Karpas-707 16,094 | 16,094
U-2 OS 17,366 | 17,366
EFO-21 17,117 | 17,117
SCLC-21H 16,946 | 16,946
NTERA-2 16,846 | 16,846
U-266/70 16,556 | 16,556
BEWO 16,541 | 16,541
SH-SY5Y 16,521 | 16,521
HMC-1 16,394 | 16,394
NB-4 16,360 | 16,360
HaCaT 16,331 | 16,331
U-2197 16,301 | 16,301
U-266/84 16,257 | 16,257
U-251 MG 16,195 | 16,195
U-87 MG 16,106 | 16,106
U-698 16,093 | 16,093
WM-115 16,065 | 16,065
K-562 16,049 | 16,049
T-47d 16,037 | 16,037
U-937 15,988 | 15,988
AF22 15,979 | 15,979
SK-MEL-30 15,962 | 15,962
A-431 15,947 | 15,947
CAPAN-2 15,918 | 15,918
RPMI-8226 15,832 | 15,832
SK-BR-3 15,827 | 15,827
REH 15,783 | 15,783
U-138 MG 15,734 | 15,734
HEK 293 15,668 | 15,668
THP-1 15,652 | 15,652
MOLT-4 15,626 | 15,626
HDLM-2 15,579 | 15,579
Daudi 15,575 | 15,575
RH-30 15,520 | 15,520
HeLa 15,516 | 15,516
RT4 15,502 | 15,502
AN3-CA 15,463 | 15,463
BJ hTERT+ SV40 Large T+ 15,430 | 15,430
BJ hTERT+ SV40 Large T+ RasG12... 15,312 | 15,312
BJ 15,277 | 15,277
HTCEpi 15,272 | 15,272
CACO-2 15,255 | 15,255
PC-3 15,204 | 15,204
BJ hTERT+ 15,182 | 15,182
HEL 15,175 | 15,175
SiHa 15,107 | 15,107
RPTEC TERT1 15,102 | 15,102
MCF7 15,049 | 15,049
HBF TERT88 15,033 | 15,033
Hep G2 15,000 | 15,000
A549 14,995 | 14,995
HL-60 14,864 | 14,864
LHCN-M2 14,817 | 14,817
ASC TERT1 14,671 | 14,671
HUVEC TERT2 14,544 | 14,544
TIME 14,297 | 14,297

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
NACHT, LRR and PYD domains-containing protein 14 NLRP14 Tbio Non-IDG -1.33032 17.6 30
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240