Development Level

Tbio 10,375 | 11,651
Tdark 4,114 | 6,593
Tchem 1,252 | 1,388
Tclin 492 | 612

Collection

RFA-RM-18-021 246 | 328
Kinase: IDG Consortium (Target... 118 | 125
Ion Channel: IDG Consortium (T... 71 | 99
GPCR: IDG Consortium (Targets) 65 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 944 | 979
preweaning lethality, incomple... 458 | 499
abnormal behavior 275 | 298
embryonic lethality prior to t... 273 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 193 | 207
enlarged heart 182 | 210
decreased vertical activity 173 | 208
abnormal bone structure 164 | 187
increased lean body mass 159 | 172
decreased body weight 152 | 161
abnormal heart morphology 145 | 162
hyperactivity 138 | 148
decreased bone mineral content 133 | 151
decreased lean body mass 121 | 135
hypoactivity 118 | 132
increased total body fat amoun... 118 | 134
decreased circulating glucose ... 115 | 126
decreased bone mineral density 110 | 126
increased circulating alkaline... 110 | 122
male infertility 107 | 123
embryonic growth retardation 102 | 106
increased startle reflex 102 | 112
decreased grip strength 99 | 116
increased bone mineral content 97 | 108
abnormal seminal vesicle morph... 96 | 114
decreased body length 91 | 101
increased mean corpuscular hem... 90 | 96
short tibia 90 | 97
decreased circulating choleste... 88 | 93
increased or absent threshold ... 87 | 101
increased mean corpuscular vol... 86 | 92
prenatal lethality prior to he... 85 | 87
cataract 79 | 92
decreased prepulse inhibition 76 | 82
decreased circulating triglyce... 75 | 79
decreased mean corpuscular vol... 75 | 79
abnormal lens morphology 74 | 81
decreased circulating serum al... 74 | 82
decreased lymphocyte cell numb... 74 | 83
increased circulating HDL chol... 71 | 80
decreased circulating insulin ... 68 | 76
decreased leukocyte cell numbe... 68 | 73
increased bone mineral density 68 | 72
increased fasted circulating g... 67 | 76
impaired glucose tolerance 66 | 75
improved glucose tolerance 66 | 79
decreased startle reflex 65 | 75
small superior vagus ganglion 65 | 74
abnormal eye morphology 64 | 68
abnormal retina morphology 64 | 71
abnormal sleep behavior 64 | 70
decreased circulating HDL chol... 64 | 68
decreased hemoglobin content 62 | 68
increased circulating sodium l... 62 | 71
abnormal gait 61 | 69
increased circulating choleste... 61 | 66
abnormal behavioral response t... 59 | 66
abnormal coat-hair pigmentatio... 58 | 64
decreased erythrocyte cell num... 58 | 62
increased heart weight 58 | 62
abnormal kidney morphology 57 | 65
edema 57 | 59
increased monocyte cell number 55 | 63
decreased fasted circulating g... 54 | 65
small testis 54 | 58
thrombocytopenia 54 | 56
decreased caudal vertebrae num... 51 | 53
female infertility 50 | 60
abnormal spleen morphology 49 | 55
decreased blood urea nitrogen ... 47 | 51
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 46 | 50
hydrometra 46 | 53
abnormal neural tube closure 45 | 46
decreased circulating alanine ... 45 | 47
abnormal skin morphology 44 | 50
increased leukocyte cell numbe... 44 | 47
decreased circulating alkaline... 43 | 46
increased hematocrit 43 | 46
decreased hematocrit 42 | 46
increased blood urea nitrogen ... 41 | 48
increased circulating triglyce... 41 | 42
increased hemoglobin content 41 | 45
increased neutrophil cell numb... 41 | 46
decreased neutrophil cell numb... 40 | 42
increased mean platelet volume 40 | 45
abnormal testis morphology 39 | 43
decreased red blood cell distr... 38 | 41
enlarged spleen 38 | 41
tremors 37 | 39
abnormal bone mineralization 36 | 38
abnormal epididymis morphology 36 | 42
decreased circulating LDL chol... 36 | 38
increased grip strength 36 | 41
increased erythrocyte cell num... 35 | 39
decreased circulating creatini... 34 | 39
increased circulating chloride... 34 | 41
increased mean corpuscular hem... 34 | 36

Disease

Carcinoma 9,795 | 11,493
ovarian cancer 7,997 | 8,520
osteosarcoma 7,383 | 7,950
psoriasis 5,716 | 6,694
medulloblastoma, large-cell 5,663 | 6,241
glioblastoma 5,310 | 5,792
atypical teratoid / rhabdoid tumor 4,674 | 5,112
lung cancer 4,368 | 4,740
ependymoma 4,206 | 4,679
group 3 medulloblastoma 3,742 | 4,104
adult high grade glioma 3,379 | 3,801
Breast cancer 3,271 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,064 | 3,291
malignant mesothelioma 3,047 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,763 | 2,989
primitive neuroectodermal tumor 2,756 | 3,035
Astrocytoma, Pilocytic 2,735 | 3,081
invasive ductal carcinoma 2,722 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,711 | 2,955
non-small cell lung cancer 2,639 | 2,890
oligodendroglioma 2,558 | 2,850
lung carcinoma 2,500 | 2,843
lung adenocarcinoma 2,438 | 2,716
astrocytic glioma 2,324 | 2,597
Cancer 2,256 | 2,499
Kidney cancer 2,242 | 2,613
pancreatic cancer 2,218 | 2,398
subependymal giant cell astrocytoma 2,122 | 2,287
interstitial cystitis 2,048 | 2,312
tuberculosis 1,892 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,890 | 1,962
Pick disease 1,743 | 1,894
pituitary cancer 1,727 | 1,972
group 4 medulloblastoma 1,710 | 1,855
ulcerative colitis 1,672 | 1,819
ductal carcinoma in situ 1,595 | 1,745
cystic fibrosis 1,519 | 1,696
breast carcinoma 1,496 | 1,638
diabetes mellitus 1,399 | 1,728
adrenocortical carcinoma 1,343 | 1,428
colon cancer 1,322 | 1,478
Autosomal recessive predisposition 1,311 | 1,442
Multiple myeloma 1,308 | 1,332
juvenile dermatomyositis 1,143 | 1,187
Rheumatoid arthritis 1,116 | 1,191
astrocytoma 1,111 | 1,146
acute quadriplegic myopathy 1,106 | 1,158
primary pancreatic ductal adenocarcinoma 1,055 | 1,109
spina bifida 1,027 | 1,074
pediatric high grade glioma 986 | 1,064
Schizophrenia 970 | 1,160
cutaneous lupus erythematosus 952 | 1,057
dermatomyositis 948 | 966
nasopharyngeal carcinoma 946 | 1,058
Intellectual disability 936 | 1,016
active Crohn's disease 847 | 922
Atopic dermatitis 807 | 952
non primary Sjogren syndrome sicca 804 | 891
acute myeloid leukemia 761 | 783
Waldenstrons macroglobulinemia 754 | 765
gastric carcinoma 754 | 807
Liver Cirrhosis, Experimental 712 | 769
Epilepsy 710 | 792
primary Sjogren syndrome 697 | 735
active ulcerative colitis 688 | 764
esophageal adenocarcinoma 688 | 737
medulloblastoma 668 | 720
progressive supranuclear palsy 640 | 676
aldosterone-producing adenoma 622 | 665
Dull intelligence 596 | 645
Low intelligence 596 | 645
Mental Retardation 596 | 645
Mental deficiency 596 | 645
Poor school performance 596 | 645
Obesity 586 | 678
Cognitive delay 573 | 608
Global developmental delay 573 | 608
Mental and motor retardation 573 | 608
Alzheimer's disease 569 | 658
Duchenne muscular dystrophy 563 | 601
Melanoma 555 | 711
Bipolar Disorder 547 | 666
Muscle hypotonia 540 | 571
pancreatic carcinoma 538 | 562
Seizures 536 | 596
hepatocellular carcinoma 531 | 547
Liver cancer 503 | 604
fibroadenoma 498 | 559
Short stature 492 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 480 | 510
Endometriosis 472 | 540
Down syndrome 460 | 499
Prostatic Neoplasms 459 | 495
Multiple Sclerosis 456 | 540
chronic rhinosinusitis 446 | 512
gastric cancer 443 | 459
mucosa-associated lymphoid tissue lymphoma 437 | 484
sonic hedgehog group medulloblastoma 434 | 467
posterior fossa group A ependymoma 422 | 468
Amyotrophic lateral sclerosis 416 | 451

Tissue

Endocrine System 15,923 | 18,159
Digestive Tract 15,637 | 17,369
Female tissues 15,631 | 17,400
Skin and soft tissues 15,586 | 17,230
Male tissues 15,475 | 17,142
Blood and immune system 15,436 | 16,909
Liver and Pancreas 15,337 | 16,750
Nervous System 15,298 | 16,725
Urinary Tract 15,262 | 16,678
Respiratory system 15,105 | 16,393
Cardiovascular System 14,287 | 15,192

Target Family

Non-IDG 9,476 | 12,091
Enzyme 3,653 | 4,145
Transcription Factor 1,243 | 1,400
Kinase 598 | 634
Transporter 392 | 473
GPCR 264 | 408
Ion Channel 250 | 344
Epigenetic 231 | 242
oGPCR 47 | 421
Nuclear Receptor 43 | 48
TF/Epigenetic 36 | 38

HCA RNA Cell Line

K-562 16,233 | 16,233
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50