Development Level

Tbio 9,415 | 10,625
Tdark 4,475 | 7,003
Tchem 1,675 | 1,890
Tclin 483 | 602

Collection

Kinase: IDG Consortium (Targets) 116 | 125
Ion Channel: IDG Consortium (Targets) 72 | 102
GPCR: IDG Consortium (Targets) 66 | 128
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 21 | 24

IMPC Phenotype

preweaning lethality, complete... 605 | 633
preweaning lethality, incomple... 235 | 260
abnormal behavior 209 | 226
decreased lean body mass 185 | 195
embryonic lethality prior to t... 184 | 187
decreased total body fat amoun... 177 | 186
decreased body weight 164 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 146 | 157
abnormal bone structure 119 | 131
increased or absent threshold ... 118 | 128
decreased bone mineral density 114 | 126
increased circulating alkaline... 111 | 119
decreased grip strength 109 | 123
decreased circulating glucose ... 108 | 121
abnormal embryo size 106 | 112
decreased body length 102 | 108
hyperactivity 99 | 108
increased lean body mass 99 | 107
enlarged heart 95 | 111
abnormal retina morphology 93 | 100
increased mean corpuscular hem... 91 | 93
increased bone mineral content 86 | 92
increased mean corpuscular vol... 85 | 91
decreased circulating choleste... 79 | 85
hypoactivity 79 | 89
decreased circulating triglyce... 76 | 83
short tibia 75 | 82
increased grip strength 73 | 83
decreased circulating HDL chol... 71 | 77
decreased circulating serum al... 71 | 79
abnormal lens morphology 70 | 73
decreased circulating insulin ... 67 | 75
increased circulating sodium l... 62 | 71
increased fasted circulating g... 62 | 68
prenatal lethality prior to he... 62 | 64
decreased lumbar vertebrae num... 60 | 62
increased sacral vertebrae num... 59 | 62
abnormal retinal pigmentation 57 | 61
abnormal sleep behavior 57 | 63
increased circulating HDL chol... 56 | 63
male infertility 55 | 62
abnormal bone mineralization 53 | 55
increased total body fat amoun... 53 | 57
decreased rib number 52 | 59
increased bone mineral density 50 | 52
increased circulating choleste... 50 | 53
abnormal coat-hair pigmentatio... 49 | 54
decreased circulating alanine ... 49 | 53
decreased hemoglobin content 49 | 53
decreased prepulse inhibition 49 | 52
decreased leukocyte cell numbe... 48 | 54
decreased mean corpuscular vol... 48 | 50
increased exploration in new e... 48 | 56
abnormal behavioral response t... 46 | 52
abnormal gait 45 | 51
decreased startle reflex 45 | 48
impaired glucose tolerance 45 | 52
improved glucose tolerance 45 | 56
decreased caudal vertebrae num... 44 | 49
thrombocytopenia 44 | 46
abnormal heart morphology 43 | 51
decreased fasted circulating g... 43 | 49
increased hemoglobin content 43 | 45
decreased erythrocyte cell num... 42 | 43
increased body weight 41 | 42
decreased circulating total pr... 40 | 41
increased blood urea nitrogen ... 39 | 44
abnormal seminal vesicle morph... 38 | 47
decreased heart weight 38 | 44
increased rib number 38 | 41
decreased circulating alkaline... 37 | 41
decreased neutrophil cell numb... 37 | 37
increased circulating chloride... 37 | 43
abnormal eye morphology 35 | 38
abnormal neural tube closure 35 | 37
decreased circulating LDL chol... 35 | 37
decreased circulating free fat... 34 | 39
decreased eosinophil cell numb... 34 | 41
increased leukocyte cell numbe... 34 | 37
small testis 33 | 37
cardiovascular system phenotyp... 32 | 35
decreased mean corpuscular hem... 32 | 34
increased heart weight 32 | 37
increased hematocrit 32 | 36
increased startle reflex 32 | 38
tremors 32 | 34
abnormal spleen morphology 31 | 36
decreased T cell number 31 | 31
abnormal cranium morphology 30 | 32
increased circulating calcium ... 30 | 32
decreased circulating fructosa... 29 | 31
decreased circulating calcium ... 28 | 33
decreased circulating chloride... 28 | 32
embryonic growth retardation 28 | 28
female infertility 28 | 34
limb grasping 28 | 35
abnormal epididymis morphology 27 | 31
decreased NK T cell number 27 | 28
increased circulating potassiu... 27 | 31

Disease

ovarian cancer 7,888 | 8,491
osteosarcoma 7,299 | 7,933
psoriasis 5,665 | 6,685
medulloblastoma, large-cell 5,606 | 6,234
glioblastoma 5,063 | 5,572
lung cancer 4,158 | 4,473
atypical teratoid / rhabdoid tumor 3,960 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,037 | 3,289
malignant mesothelioma 2,962 | 3,163
Breast cancer 2,831 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 2,740 | 2,988
primitive neuroectodermal tumor 2,723 | 3,031
pilocytic astrocytoma 2,707 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 2,696 | 2,956
invasive ductal carcinoma 2,693 | 2,950
non-small cell lung cancer 2,543 | 2,798
oligodendroglioma 2,534 | 2,849
lung carcinoma 2,485 | 2,844
pediatric high grade glioma 2,438 | 2,712
lung adenocarcinoma 2,418 | 2,714
ependymoma 2,288 | 2,514
pancreatic cancer 2,129 | 2,300
Cancer 2,114 | 2,346
subependymal giant cell astrocytoma 2,104 | 2,287
group 3 medulloblastoma 2,054 | 2,254
interstitial cystitis 2,029 | 2,299
astrocytic glioma 1,991 | 2,241
ulcerative colitis 1,915 | 2,087
adult high grade glioma 1,881 | 2,148
Carcinoma 1,801 | 2,147
Pick disease 1,729 | 1,893
group 4 medulloblastoma 1,715 | 1,875
pituitary cancer 1,714 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,706 | 1,795
ductal carcinoma in situ 1,579 | 1,745
cystic fibrosis 1,485 | 1,670
breast carcinoma 1,462 | 1,614
tuberculosis 1,453 | 1,563
astrocytoma 1,412 | 1,493
medulloblastoma 1,371 | 1,524
sonic hedgehog group medulloblastoma 1,339 | 1,482
diabetes mellitus 1,332 | 1,663
posterior fossa group B ependymoma 1,330 | 1,530
adrenocortical carcinoma 1,325 | 1,427
posterior fossa group A ependymoma 1,321 | 1,511
colon cancer 1,309 | 1,475
Multiple myeloma 1,292 | 1,327
primary pancreatic ductal adenocarcinoma 1,208 | 1,271
juvenile dermatomyositis 1,135 | 1,189
acute quadriplegic myopathy 1,097 | 1,157
Rheumatoid Arthritis 1,087 | 1,170
spina bifida 1,008 | 1,064
atypical teratoid/rhabdoid tumor 983 | 1,095
cutaneous lupus erythematosus 944 | 1,056
dermatomyositis 943 | 966
nasopharyngeal carcinoma 940 | 1,056
active Crohn's disease 838 | 918
Atopic dermatitis 792 | 944
gastric carcinoma 775 | 832
acute myeloid leukemia 750 | 785
Waldenstrons macroglobulinemia 747 | 764
non primary Sjogren syndrome sicca 745 | 840
primary Sjogren syndrome 742 | 788
esophageal adenocarcinoma 685 | 737
tuberculosis and treatment for 6 months 665 | 686
progressive supranuclear palsy 634 | 674
aldosterone-producing adenoma 617 | 664
Duchenne muscular dystrophy 557 | 602
Alzheimer's disease 556 | 644
pancreatic carcinoma 539 | 567
hepatocellular carcinoma 532 | 550
Intellectual disability 529 | 573
Obesity 528 | 616
Down syndrome 502 | 548
fibroadenoma 494 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 468 | 499
Endometriosis 462 | 535
chronic rhinosinusitis 443 | 512
IGA Glomerulonephritis 435 | 454
mucosa-associated lymphoid tissue lymphoma 434 | 480
Prostatic Neoplasms 433 | 471
active ulcerative colitis 418 | 477
Multiple Sclerosis 416 | 498
gastric cancer 416 | 436
Schizophrenia 401 | 503
Amyotrophic Lateral Sclerosis 395 | 432
Mammary Neoplasms 381 | 410
inflammatory breast cancer 368 | 404
Neurodegenerative disease 354 | 383
non-small cell lung carcinoma 343 | 413
sarcoidosis 335 | 368
Kidney disease 334 | 397
glioblastoma multiforme 320 | 347
Polycystic Ovary Syndrome 311 | 334
tuberculosis and treatment for 3 months 311 | 327
Parkinson's disease 307 | 364
hereditary spastic paraplegia 302 | 313
urothelial carcinoma 291 | 318
nephrosclerosis 287 | 329
Epilepsy 283 | 346

Tissue

Nervous System 15,807 | 18,560
Female tissues 15,798 | 18,646
Endocrine System 15,775 | 18,511
Digestive Tract 15,768 | 18,472
Urinary Tract 15,713 | 18,443
Liver and Pancreas 15,668 | 18,135
Male tissues 15,653 | 17,968
Blood and immune system 15,642 | 17,994
Cardiovascular System 15,619 | 17,957
Skin and soft tissues 15,594 | 18,114
Respiratory system 15,443 | 17,483

Target Family

Non-IDG 9,340 | 11,969
Enzyme 3,627 | 4,146
Transcription Factor 1,240 | 1,400
Kinase 592 | 634
Transporter 392 | 473
GPCR 262 | 408
Ion Channel 247 | 341
Epigenetic 224 | 242
oGPCR 46 | 421
Nuclear Receptor 43 | 48
TF/Epigenetic 35 | 38

HCA RNA Cell Line

K-562 16,048 | 16,048
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66