Development Level

Tbio 9,607 | 11,445
Tdark 3,773 | 6,588
Tchem 1,352 | 1,598
Tclin 447 | 613

Collection

RFA-RM-18-021 233 | 328
Kinase: IDG Consortium (Target... 112 | 125
Ion Channel: IDG Consortium (T... 68 | 99
GPCR: IDG Consortium (Targets) 59 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 13 | 25

IMPC Phenotype

preweaning lethality, complete... 931 | 979
preweaning lethality, incomple... 451 | 499
embryonic lethality prior to t... 265 | 278
abnormal behavior 260 | 298
embryonic lethality prior to o... 235 | 239
abnormal embryo size 209 | 220
decreased total body fat amoun... 177 | 207
enlarged heart 170 | 210
abnormal bone structure 162 | 187
decreased vertical activity 155 | 208
increased lean body mass 153 | 172
decreased body weight 149 | 161
abnormal heart morphology 133 | 162
hyperactivity 128 | 148
decreased bone mineral content 126 | 151
hypoactivity 116 | 132
decreased lean body mass 114 | 135
increased total body fat amoun... 113 | 134
increased circulating alkaline... 110 | 122
decreased circulating glucose ... 106 | 126
decreased bone mineral density 105 | 126
increased startle reflex 102 | 112
embryonic growth retardation 100 | 106
male infertility 98 | 123
decreased grip strength 95 | 116
increased bone mineral content 94 | 108
abnormal seminal vesicle morph... 90 | 114
decreased body length 88 | 101
increased mean corpuscular hem... 87 | 96
increased or absent threshold ... 86 | 101
short tibia 86 | 97
cataract 85 | 92
decreased circulating choleste... 85 | 93
increased mean corpuscular vol... 84 | 92
prenatal lethality prior to he... 80 | 87
abnormal lens morphology 77 | 81
decreased circulating serum al... 74 | 82
decreased mean corpuscular vol... 72 | 79
increased fasted circulating g... 71 | 76
decreased prepulse inhibition 70 | 82
decreased circulating triglyce... 69 | 79
decreased lymphocyte cell numb... 68 | 83
abnormal retina morphology 65 | 71
impaired glucose tolerance 65 | 75
increased circulating HDL chol... 65 | 80
decreased startle reflex 64 | 75
increased bone mineral density 64 | 72
abnormal eye morphology 63 | 68
small superior vagus ganglion 63 | 74
decreased leukocyte cell numbe... 62 | 73
decreased circulating HDL chol... 61 | 68
decreased circulating insulin ... 61 | 76
improved glucose tolerance 61 | 79
abnormal sleep behavior 60 | 70
decreased hemoglobin content 59 | 68
abnormal coat-hair pigmentatio... 58 | 64
decreased erythrocyte cell num... 57 | 62
decreased fasted circulating g... 56 | 65
increased heart weight 56 | 62
abnormal behavioral response t... 55 | 66
edema 55 | 59
increased circulating sodium l... 55 | 71
abnormal gait 54 | 69
abnormal kidney morphology 53 | 65
increased circulating choleste... 53 | 66
increased monocyte cell number 52 | 63
small testis 51 | 58
decreased caudal vertebrae num... 50 | 53
thrombocytopenia 50 | 56
decreased mean corpuscular hem... 48 | 50
female infertility 47 | 60
decreased blood urea nitrogen ... 46 | 51
abnormal spleen morphology 45 | 55
decreased circulating total pr... 45 | 49
hydrometra 45 | 53
abnormal neural tube closure 44 | 46
abnormal skin morphology 44 | 50
decreased circulating alanine ... 41 | 47
decreased circulating alkaline... 41 | 46
decreased hematocrit 41 | 46
increased blood urea nitrogen ... 41 | 48
increased leukocyte cell numbe... 41 | 47
decreased neutrophil cell numb... 39 | 42
increased hematocrit 39 | 46
increased hemoglobin content 39 | 45
abnormal testis morphology 38 | 43
decreased red blood cell distr... 38 | 41
increased mean platelet volume 38 | 45
enlarged spleen 37 | 41
increased neutrophil cell numb... 37 | 46
tremors 37 | 39
abnormal bone mineralization 36 | 38
increased circulating triglyce... 36 | 42
decreased circulating LDL chol... 35 | 38
increased grip strength 35 | 41
abnormal cranium morphology 34 | 36
decreased circulating creatini... 34 | 39
increased circulating creatini... 33 | 38
limb grasping 33 | 41
increased mean corpuscular hem... 32 | 36

Disease

Carcinoma 9,228 | 11,493
ovarian cancer 7,755 | 8,520
osteosarcoma 7,062 | 7,950
medulloblastoma, large-cell 5,453 | 6,241
psoriasis 5,275 | 6,694
glioblastoma 5,094 | 5,792
atypical teratoid / rhabdoid tumor 4,506 | 5,112
lung cancer 4,151 | 4,740
ependymoma 4,018 | 4,679
group 3 medulloblastoma 3,598 | 4,104
adult high grade glioma 3,211 | 3,801
Breast cancer 3,128 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,945 | 3,291
malignant mesothelioma 2,942 | 3,232
primitive neuroectodermal tumor 2,663 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,616 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,589 | 2,955
Astrocytoma, Pilocytic 2,573 | 3,081
invasive ductal carcinoma 2,555 | 2,951
oligodendroglioma 2,457 | 2,850
non-small cell lung cancer 2,443 | 2,890
lung carcinoma 2,269 | 2,843
lung adenocarcinoma 2,264 | 2,716
astrocytic glioma 2,243 | 2,597
pancreatic cancer 2,101 | 2,398
Kidney cancer 2,099 | 2,613
Cancer 2,083 | 2,499
subependymal giant cell astrocytoma 2,000 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,875 | 1,962
interstitial cystitis 1,857 | 2,312
tuberculosis 1,747 | 2,010
Pick disease 1,695 | 1,894
group 4 medulloblastoma 1,669 | 1,855
pituitary cancer 1,645 | 1,972
ductal carcinoma in situ 1,511 | 1,745
ulcerative colitis 1,510 | 1,819
breast carcinoma 1,414 | 1,638
cystic fibrosis 1,405 | 1,696
diabetes mellitus 1,300 | 1,728
Multiple myeloma 1,290 | 1,332
colon cancer 1,262 | 1,478
adrenocortical carcinoma 1,259 | 1,428
Autosomal recessive predisposition 1,255 | 1,442
juvenile dermatomyositis 1,112 | 1,187
acute quadriplegic myopathy 1,091 | 1,158
astrocytoma 1,056 | 1,146
primary pancreatic ductal adenocarcinoma 1,014 | 1,109
Rheumatoid arthritis 1,013 | 1,191
spina bifida 995 | 1,074
pediatric high grade glioma 955 | 1,064
Intellectual disability 934 | 1,016
Schizophrenia 899 | 1,160
dermatomyositis 886 | 966
nasopharyngeal carcinoma 862 | 1,058
active Crohn's disease 815 | 922
cutaneous lupus erythematosus 815 | 1,057
non primary Sjogren syndrome sicca 776 | 891
Atopic dermatitis 743 | 952
Waldenstrons macroglobulinemia 726 | 765
acute myeloid leukemia 726 | 783
gastric carcinoma 709 | 807
Epilepsy 679 | 792
Liver Cirrhosis, Experimental 672 | 769
active ulcerative colitis 660 | 764
medulloblastoma 632 | 720
progressive supranuclear palsy 632 | 676
esophageal adenocarcinoma 627 | 737
aldosterone-producing adenoma 605 | 665
Dull intelligence 600 | 645
Low intelligence 600 | 645
Mental Retardation 600 | 645
Mental deficiency 600 | 645
Poor school performance 600 | 645
primary Sjogren syndrome 598 | 735
Cognitive delay 573 | 608
Global developmental delay 573 | 608
Mental and motor retardation 573 | 608
Obesity 555 | 678
Alzheimer's disease 549 | 658
Duchenne muscular dystrophy 530 | 601
Muscle hypotonia 527 | 571
Seizures 518 | 596
Bipolar Disorder 509 | 666
hepatocellular carcinoma 499 | 547
pancreatic carcinoma 499 | 562
Melanoma 496 | 711
Short stature 479 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 463 | 510
fibroadenoma 463 | 559
Endometriosis 453 | 540
Prostatic Neoplasms 452 | 495
Liver cancer 451 | 604
Down syndrome 447 | 499
chronic rhinosinusitis 419 | 512
Amyotrophic lateral sclerosis 415 | 451
sonic hedgehog group medulloblastoma 410 | 467
posterior fossa group A ependymoma 409 | 468
gastric cancer 408 | 459
tuberculosis and treatment for 6 months 399 | 409
Breast Neoplasms 398 | 445

Tissue

Endocrine System 14,961 | 18,159
Digestive Tract 14,822 | 17,369
Female tissues 14,797 | 17,400
Skin and soft tissues 14,769 | 17,230
Male tissues 14,711 | 17,142
Blood and immune system 14,627 | 16,909
Liver and Pancreas 14,620 | 16,750
Nervous System 14,596 | 16,725
Urinary Tract 14,556 | 16,678
Respiratory system 14,416 | 16,393
Cardiovascular System 13,711 | 15,192

Target Family

Non-IDG 8,789 | 12,091
Enzyme 3,555 | 4,145
Transcription Factor 1,138 | 1,400
Kinase 569 | 634
Transporter 383 | 473
Epigenetic 225 | 242
Ion Channel 219 | 344
GPCR 212 | 408
Nuclear Receptor 44 | 48
TF/Epigenetic 36 | 38
oGPCR 9 | 421

HCA RNA Cell Line

Hep G2 15,179 | 15,179
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endosomal/lysosomal potassium channel TMEM175 TMEM175 Tbio Non-IDG -0.65375 3.76 42
WASH complex subunit 2C WASHC2C Tbio Non-IDG -0.83634 0.00000 45
Transmembrane protein 170A TMEM170A Tdark Non-IDG 0.00000 1.18 3
Protein AF-9 MLLT3 Tbio Non-IDG -1.99555 93.8 210
Scm-like with four MBT domains protein 1 SFMBT1 Tbio Epigenetic -2.06810 112.0 113
Guanine deaminase GDA Tbio Enzyme -1.48687 32.3 196
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.18 96
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.24396 15.5 189
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.72004 3.69 184
Latexin LXN Tbio Enzyme -2.54426 344.4 419