Development Level

Tbio 9,899 | 11,445
Tdark 3,946 | 6,588
Tchem 1,378 | 1,598
Tclin 467 | 613

Collection

RFA-RM-18-021 259 | 328
Kinase: IDG Consortium (Target... 118 | 125
Ion Channel: IDG Consortium (T... 82 | 99
GPCR: IDG Consortium (Targets) 64 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 942 | 979
preweaning lethality, incomple... 459 | 499
abnormal behavior 268 | 298
embryonic lethality prior to t... 268 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 210 | 220
decreased total body fat amoun... 185 | 207
enlarged heart 180 | 210
abnormal bone structure 165 | 187
decreased vertical activity 163 | 208
decreased body weight 157 | 161
increased lean body mass 155 | 172
abnormal heart morphology 141 | 162
hyperactivity 131 | 148
decreased bone mineral content 127 | 151
decreased lean body mass 122 | 135
increased total body fat amoun... 119 | 134
hypoactivity 116 | 132
decreased circulating glucose ... 113 | 126
increased circulating alkaline... 112 | 122
decreased bone mineral density 109 | 126
increased startle reflex 107 | 112
decreased grip strength 101 | 116
male infertility 101 | 123
embryonic growth retardation 100 | 106
increased bone mineral content 97 | 108
increased or absent threshold ... 93 | 101
abnormal seminal vesicle morph... 91 | 114
decreased body length 90 | 101
short tibia 89 | 97
increased mean corpuscular hem... 87 | 96
decreased circulating choleste... 86 | 93
cataract 85 | 92
increased mean corpuscular vol... 83 | 92
prenatal lethality prior to he... 83 | 87
decreased prepulse inhibition 77 | 82
abnormal lens morphology 76 | 81
decreased lymphocyte cell numb... 74 | 83
decreased circulating serum al... 73 | 82
decreased circulating triglyce... 72 | 79
increased bone mineral density 70 | 72
decreased mean corpuscular vol... 69 | 79
decreased startle reflex 68 | 75
increased fasted circulating g... 68 | 76
abnormal eye morphology 67 | 68
decreased circulating insulin ... 66 | 76
increased circulating HDL chol... 66 | 80
abnormal retina morphology 65 | 71
decreased leukocyte cell numbe... 65 | 73
increased circulating sodium l... 65 | 71
improved glucose tolerance 64 | 79
small superior vagus ganglion 64 | 74
decreased circulating HDL chol... 63 | 68
impaired glucose tolerance 63 | 75
abnormal sleep behavior 61 | 70
decreased hemoglobin content 59 | 68
abnormal gait 58 | 69
edema 58 | 59
abnormal behavioral response t... 57 | 66
abnormal kidney morphology 57 | 65
decreased erythrocyte cell num... 57 | 62
abnormal coat-hair pigmentatio... 56 | 64
decreased fasted circulating g... 56 | 65
increased circulating choleste... 56 | 66
increased heart weight 56 | 62
increased monocyte cell number 54 | 63
decreased caudal vertebrae num... 52 | 53
small testis 50 | 58
thrombocytopenia 50 | 56
abnormal spleen morphology 49 | 55
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
female infertility 46 | 60
hydrometra 46 | 53
abnormal neural tube closure 45 | 46
decreased blood urea nitrogen ... 44 | 51
decreased circulating alanine ... 44 | 47
increased hematocrit 43 | 46
abnormal skin morphology 42 | 50
decreased circulating alkaline... 42 | 46
increased blood urea nitrogen ... 42 | 48
increased leukocyte cell numbe... 42 | 47
increased neutrophil cell numb... 42 | 46
decreased hematocrit 40 | 46
increased hemoglobin content 40 | 45
enlarged spleen 39 | 41
increased circulating chloride... 39 | 41
increased mean platelet volume 39 | 45
decreased neutrophil cell numb... 38 | 42
tremors 38 | 39
abnormal bone mineralization 37 | 38
decreased red blood cell distr... 37 | 41
increased grip strength 37 | 41
abnormal epididymis morphology 36 | 42
abnormal testis morphology 36 | 43
increased circulating triglyce... 36 | 42
limb grasping 36 | 41
abnormal cranium morphology 35 | 36
decreased circulating LDL chol... 35 | 38
increased erythrocyte cell num... 35 | 39

Disease

Carcinoma 9,568 | 11,493
ovarian cancer 7,904 | 8,520
osteosarcoma 7,173 | 7,950
medulloblastoma, large-cell 5,611 | 6,241
psoriasis 5,487 | 6,694
glioblastoma 5,254 | 5,792
atypical teratoid / rhabdoid tumor 4,650 | 5,112
lung cancer 4,279 | 4,740
ependymoma 4,199 | 4,679
group 3 medulloblastoma 3,709 | 4,104
adult high grade glioma 3,340 | 3,801
Breast cancer 3,251 | 3,578
malignant mesothelioma 3,042 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,004 | 3,291
primitive neuroectodermal tumor 2,760 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,685 | 2,989
Astrocytoma, Pilocytic 2,684 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 2,680 | 2,955
invasive ductal carcinoma 2,665 | 2,951
non-small cell lung cancer 2,571 | 2,890
oligodendroglioma 2,568 | 2,850
lung carcinoma 2,401 | 2,843
lung adenocarcinoma 2,366 | 2,716
astrocytic glioma 2,340 | 2,597
Kidney cancer 2,226 | 2,613
Cancer 2,185 | 2,499
pancreatic cancer 2,173 | 2,398
subependymal giant cell astrocytoma 2,048 | 2,287
interstitial cystitis 1,943 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,833 | 1,962
tuberculosis 1,799 | 2,010
Pick disease 1,743 | 1,894
pituitary cancer 1,734 | 1,972
group 4 medulloblastoma 1,709 | 1,855
ductal carcinoma in situ 1,565 | 1,745
ulcerative colitis 1,562 | 1,819
cystic fibrosis 1,525 | 1,696
breast carcinoma 1,462 | 1,638
diabetes mellitus 1,355 | 1,728
colon cancer 1,305 | 1,478
adrenocortical carcinoma 1,301 | 1,428
Multiple myeloma 1,299 | 1,332
Autosomal recessive predisposition 1,257 | 1,442
juvenile dermatomyositis 1,119 | 1,187
acute quadriplegic myopathy 1,099 | 1,158
Rheumatoid arthritis 1,070 | 1,191
astrocytoma 1,068 | 1,146
primary pancreatic ductal adenocarcinoma 1,038 | 1,109
spina bifida 1,011 | 1,074
pediatric high grade glioma 980 | 1,064
Intellectual disability 943 | 1,016
Schizophrenia 934 | 1,160
dermatomyositis 933 | 966
nasopharyngeal carcinoma 913 | 1,058
cutaneous lupus erythematosus 843 | 1,057
active Crohn's disease 821 | 922
non primary Sjogren syndrome sicca 791 | 891
Atopic dermatitis 778 | 952
acute myeloid leukemia 742 | 783
gastric carcinoma 739 | 807
Waldenstrons macroglobulinemia 728 | 765
Epilepsy 705 | 792
active ulcerative colitis 681 | 764
Liver Cirrhosis, Experimental 664 | 769
medulloblastoma 662 | 720
esophageal adenocarcinoma 657 | 737
progressive supranuclear palsy 646 | 676
primary Sjogren syndrome 619 | 735
aldosterone-producing adenoma 617 | 665
Dull intelligence 600 | 645
Low intelligence 600 | 645
Mental Retardation 600 | 645
Mental deficiency 600 | 645
Poor school performance 600 | 645
Cognitive delay 576 | 608
Global developmental delay 576 | 608
Mental and motor retardation 576 | 608
Obesity 573 | 678
Alzheimer's disease 563 | 658
Duchenne muscular dystrophy 550 | 601
Melanoma 541 | 711
Muscle hypotonia 539 | 571
Seizures 536 | 596
Bipolar Disorder 529 | 666
hepatocellular carcinoma 513 | 547
pancreatic carcinoma 508 | 562
fibroadenoma 498 | 559
Liver cancer 496 | 604
Short stature 490 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 480 | 510
Endometriosis 478 | 540
Down syndrome 458 | 499
Prostatic Neoplasms 452 | 495
chronic rhinosinusitis 435 | 512
gastric cancer 421 | 459
posterior fossa group A ependymoma 420 | 468
sonic hedgehog group medulloblastoma 417 | 467
Amyotrophic lateral sclerosis 415 | 451
Multiple Sclerosis 409 | 540
Breast Neoplasms 408 | 445

Tissue

Endocrine System 15,419 | 18,159
Digestive Tract 15,230 | 17,369
Female tissues 15,223 | 17,400
Skin and soft tissues 15,198 | 17,230
Male tissues 15,107 | 17,142
Blood and immune system 15,035 | 16,909
Liver and Pancreas 14,977 | 16,750
Nervous System 14,970 | 16,725
Urinary Tract 14,922 | 16,678
Respiratory system 14,783 | 16,393
Cardiovascular System 14,023 | 15,192

Target Family

Non-IDG 9,106 | 12,091
Enzyme 3,585 | 4,145
Transcription Factor 1,203 | 1,400
Kinase 584 | 634
Transporter 392 | 473
Ion Channel 250 | 344
GPCR 247 | 408
Epigenetic 229 | 242
Nuclear Receptor 41 | 48
TF/Epigenetic 36 | 38
oGPCR 17 | 421

HCA RNA Cell Line

HeLa 15,690 | 15,690
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29