Development Level

Tbio 9,146 | 10,625
Tdark 4,309 | 7,003
Tchem 1,602 | 1,890
Tclin 458 | 602

Collection

Kinase: IDG Consortium (Targets) 116 | 125
Ion Channel: IDG Consortium (Targets) 84 | 102
GPCR: IDG Consortium (Targets) 65 | 127
Kinase: IDG Consortium (Complete/Control) 33 | 37
GPCR: IDG Consortium (Complete/Control) 19 | 26

IMPC Phenotype

preweaning lethality, complete... 607 | 633
preweaning lethality, incomple... 238 | 260
abnormal behavior 210 | 226
embryonic lethality prior to t... 185 | 187
decreased lean body mass 179 | 195
decreased total body fat amoun... 170 | 186
decreased body weight 168 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 139 | 157
abnormal bone structure 116 | 131
increased or absent threshold ... 114 | 128
decreased bone mineral density 113 | 126
increased circulating alkaline... 112 | 119
abnormal embryo size 107 | 112
decreased grip strength 106 | 123
decreased body length 102 | 108
decreased circulating glucose ... 102 | 121
hyperactivity 101 | 108
increased lean body mass 95 | 107
abnormal retina morphology 93 | 100
enlarged heart 92 | 111
increased mean corpuscular hem... 87 | 93
increased bone mineral content 85 | 92
increased mean corpuscular vol... 83 | 91
hypoactivity 81 | 89
decreased circulating choleste... 80 | 85
decreased circulating triglyce... 76 | 83
short tibia 76 | 82
increased grip strength 75 | 83
decreased circulating serum al... 72 | 79
decreased circulating HDL chol... 71 | 77
abnormal lens morphology 66 | 73
increased circulating sodium l... 65 | 71
decreased circulating insulin ... 63 | 75
prenatal lethality prior to he... 62 | 64
increased fasted circulating g... 60 | 68
decreased lumbar vertebrae num... 58 | 62
increased sacral vertebrae num... 57 | 62
abnormal retinal pigmentation 55 | 61
abnormal bone mineralization 54 | 55
decreased rib number 54 | 59
abnormal sleep behavior 53 | 63
increased circulating HDL chol... 51 | 63
increased total body fat amoun... 50 | 57
decreased prepulse inhibition 49 | 52
increased exploration in new e... 49 | 56
male infertility 49 | 62
abnormal coat-hair pigmentatio... 47 | 54
decreased circulating alanine ... 47 | 53
decreased hemoglobin content 47 | 53
decreased leukocyte cell numbe... 47 | 54
increased bone mineral density 47 | 52
decreased mean corpuscular vol... 46 | 50
abnormal gait 45 | 51
decreased startle reflex 45 | 48
impaired glucose tolerance 45 | 52
increased circulating choleste... 45 | 53
decreased caudal vertebrae num... 44 | 49
abnormal behavioral response t... 43 | 52
decreased fasted circulating g... 43 | 49
improved glucose tolerance 43 | 56
thrombocytopenia 42 | 46
decreased erythrocyte cell num... 41 | 43
increased body weight 41 | 42
abnormal heart morphology 40 | 51
decreased circulating total pr... 40 | 41
increased blood urea nitrogen ... 40 | 44
increased hemoglobin content 40 | 45
increased circulating chloride... 39 | 43
decreased eosinophil cell numb... 38 | 41
abnormal eye morphology 37 | 38
abnormal seminal vesicle morph... 37 | 47
decreased circulating alkaline... 37 | 41
decreased circulating free fat... 37 | 39
decreased heart weight 37 | 44
increased rib number 37 | 41
abnormal neural tube closure 35 | 37
decreased neutrophil cell numb... 35 | 37
increased leukocyte cell numbe... 35 | 37
increased startle reflex 35 | 38
decreased circulating LDL chol... 34 | 37
increased hematocrit 32 | 36
tremors 32 | 34
abnormal cranium morphology 31 | 32
cardiovascular system phenotyp... 31 | 35
decreased mean corpuscular hem... 31 | 34
abnormal spleen morphology 30 | 36
decreased circulating fructosa... 30 | 31
increased heart weight 30 | 37
limb grasping 30 | 35
small testis 30 | 37
decreased T cell number 29 | 31
decreased circulating calcium ... 29 | 33
decreased circulating chloride... 29 | 32
increased circulating potassiu... 29 | 31
decreased B cell number 28 | 30
decreased circulating creatini... 28 | 31
decreased blood urea nitrogen ... 27 | 31
embryonic growth retardation 27 | 28
increased circulating calcium ... 27 | 32

Disease

ovarian cancer 7,793 | 8,491
osteosarcoma 7,090 | 7,933
medulloblastoma, large-cell 5,556 | 6,234
psoriasis 5,441 | 6,685
glioblastoma 5,014 | 5,572
lung cancer 4,073 | 4,473
atypical teratoid / rhabdoid tumor 3,946 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,975 | 3,289
malignant mesothelioma 2,959 | 3,163
Breast cancer 2,834 | 3,098
primitive neuroectodermal tumor 2,727 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 2,663 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2,662 | 2,988
pilocytic astrocytoma 2,655 | 3,086
invasive ductal carcinoma 2,635 | 2,950
oligodendroglioma 2,545 | 2,849
non-small cell lung cancer 2,473 | 2,798
pediatric high grade glioma 2,439 | 2,712
lung carcinoma 2,388 | 2,844
lung adenocarcinoma 2,345 | 2,714
ependymoma 2,289 | 2,514
pancreatic cancer 2,076 | 2,300
Cancer 2,039 | 2,346
subependymal giant cell astrocytoma 2,031 | 2,287
group 3 medulloblastoma 2,013 | 2,254
astrocytic glioma 2,009 | 2,241
interstitial cystitis 1,925 | 2,299
adult high grade glioma 1,835 | 2,148
ulcerative colitis 1,798 | 2,087
Carcinoma 1,794 | 2,147
Pick disease 1,729 | 1,893
group 4 medulloblastoma 1,723 | 1,875
pituitary cancer 1,721 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,654 | 1,795
ductal carcinoma in situ 1,549 | 1,745
cystic fibrosis 1,489 | 1,670
breast carcinoma 1,425 | 1,614
tuberculosis 1,380 | 1,563
astrocytoma 1,367 | 1,493
medulloblastoma 1,364 | 1,524
posterior fossa group B ependymoma 1,350 | 1,530
sonic hedgehog group medulloblastoma 1,324 | 1,482
posterior fossa group A ependymoma 1,298 | 1,511
diabetes mellitus 1,294 | 1,663
colon cancer 1,293 | 1,475
Multiple myeloma 1,284 | 1,327
adrenocortical carcinoma 1,282 | 1,427
primary pancreatic ductal adenocarcinoma 1,187 | 1,271
juvenile dermatomyositis 1,111 | 1,189
acute quadriplegic myopathy 1,090 | 1,157
Rheumatoid Arthritis 1,045 | 1,170
spina bifida 993 | 1,064
atypical teratoid/rhabdoid tumor 975 | 1,095
dermatomyositis 928 | 966
nasopharyngeal carcinoma 907 | 1,056
cutaneous lupus erythematosus 836 | 1,056
active Crohn's disease 811 | 918
Atopic dermatitis 766 | 944
gastric carcinoma 758 | 832
non primary Sjogren syndrome sicca 741 | 840
acute myeloid leukemia 731 | 785
Waldenstrons macroglobulinemia 721 | 764
primary Sjogren syndrome 656 | 788
tuberculosis and treatment for 6 months 655 | 686
esophageal adenocarcinoma 654 | 737
progressive supranuclear palsy 640 | 674
aldosterone-producing adenoma 612 | 664
Alzheimer's disease 557 | 644
Duchenne muscular dystrophy 544 | 602
Intellectual disability 529 | 573
Obesity 513 | 616
hepatocellular carcinoma 513 | 550
pancreatic carcinoma 509 | 567
Down syndrome 499 | 548
fibroadenoma 494 | 557
Endometriosis 469 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 468 | 499
chronic rhinosinusitis 432 | 512
Prostatic Neoplasms 426 | 471
active ulcerative colitis 415 | 477
IGA Glomerulonephritis 411 | 454
gastric cancer 395 | 436
Amyotrophic Lateral Sclerosis 394 | 432
Schizophrenia 392 | 503
mucosa-associated lymphoid tissue lymphoma 378 | 480
Mammary Neoplasms 373 | 410
Multiple Sclerosis 369 | 498
Neurodegenerative disease 348 | 383
inflammatory breast cancer 348 | 404
non-small cell lung carcinoma 337 | 413
glioblastoma multiforme 311 | 347
Kidney disease 306 | 397
sarcoidosis 305 | 368
Parkinson's disease 304 | 364
Polycystic Ovary Syndrome 301 | 334
hereditary spastic paraplegia 300 | 313
tuberculosis and treatment for 3 months 291 | 327
Epilepsy 280 | 346
urothelial carcinoma 275 | 318
nephrosclerosis 265 | 329

Tissue

Nervous System 15,305 | 18,560
Female tissues 15,279 | 18,646
Digestive Tract 15,272 | 18,472
Endocrine System 15,269 | 18,511
Urinary Tract 15,220 | 18,443
Liver and Pancreas 15,211 | 18,135
Male tissues 15,188 | 17,968
Blood and immune system 15,156 | 17,994
Cardiovascular System 15,147 | 17,957
Skin and soft tissues 15,110 | 18,114
Respiratory system 14,996 | 17,483

Target Family

Non-IDG 8,978 | 11,969
Enzyme 3,559 | 4,146
Transcription Factor 1,199 | 1,400
Kinase 578 | 634
Transporter 392 | 473
GPCR 247 | 408
Ion Channel 247 | 341
Epigenetic 222 | 242
Nuclear Receptor 41 | 48
TF/Epigenetic 35 | 38
oGPCR 17 | 421

HCA RNA Cell Line

HeLa 15,515 | 15,515
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66