Development Level

Tbio 9,593 | 10,625
Tdark 4,523 | 7,003
Tchem 1,701 | 1,890
Tclin 513 | 602

Collection

Kinase: IDG Consortium (Targets) 112 | 125
GPCR: IDG Consortium (Targets) 83 | 127
Ion Channel: IDG Consortium (Targets) 81 | 102
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 21 | 26

IMPC Phenotype

preweaning lethality, complete... 613 | 633
preweaning lethality, incomple... 250 | 260
abnormal behavior 219 | 226
embryonic lethality prior to t... 184 | 187
decreased lean body mass 183 | 195
decreased total body fat amoun... 181 | 186
decreased body weight 166 | 174
embryonic lethality prior to o... 147 | 148
decreased bone mineral content 146 | 157
abnormal bone structure 128 | 131
increased or absent threshold ... 118 | 128
increased circulating alkaline... 115 | 119
decreased bone mineral density 114 | 126
decreased grip strength 110 | 123
abnormal embryo size 108 | 112
decreased circulating glucose ... 105 | 121
decreased body length 103 | 108
enlarged heart 103 | 111
hyperactivity 102 | 108
increased lean body mass 101 | 107
abnormal retina morphology 95 | 100
increased bone mineral content 88 | 92
increased mean corpuscular hem... 88 | 93
increased mean corpuscular vol... 85 | 91
decreased circulating choleste... 81 | 85
hypoactivity 80 | 89
short tibia 80 | 82
decreased circulating triglyce... 77 | 83
decreased circulating HDL chol... 74 | 77
decreased circulating serum al... 73 | 79
abnormal lens morphology 70 | 73
increased grip strength 70 | 83
decreased circulating insulin ... 67 | 75
increased fasted circulating g... 64 | 68
prenatal lethality prior to he... 62 | 64
increased circulating sodium l... 61 | 71
decreased lumbar vertebrae num... 60 | 62
increased sacral vertebrae num... 58 | 62
abnormal retinal pigmentation 57 | 61
abnormal sleep behavior 57 | 63
decreased rib number 55 | 59
increased circulating HDL chol... 54 | 63
abnormal bone mineralization 53 | 55
male infertility 52 | 62
increased exploration in new e... 51 | 56
increased total body fat amoun... 51 | 57
decreased leukocyte cell numbe... 50 | 54
impaired glucose tolerance 50 | 52
increased circulating choleste... 50 | 53
abnormal coat-hair pigmentatio... 49 | 54
decreased prepulse inhibition 49 | 52
improved glucose tolerance 49 | 56
increased bone mineral density 49 | 52
abnormal gait 48 | 51
decreased mean corpuscular vol... 48 | 50
decreased circulating alanine ... 47 | 53
decreased hemoglobin content 47 | 53
abnormal behavioral response t... 46 | 52
decreased caudal vertebrae num... 46 | 49
abnormal heart morphology 45 | 51
decreased startle reflex 45 | 48
decreased fasted circulating g... 44 | 49
thrombocytopenia 43 | 46
increased blood urea nitrogen ... 42 | 44
increased body weight 42 | 42
decreased erythrocyte cell num... 41 | 43
decreased circulating alkaline... 40 | 41
increased hemoglobin content 40 | 45
abnormal seminal vesicle morph... 39 | 47
decreased circulating total pr... 39 | 41
decreased eosinophil cell numb... 39 | 41
increased circulating chloride... 39 | 43
abnormal eye morphology 37 | 38
decreased heart weight 37 | 44
increased rib number 37 | 41
abnormal neural tube closure 36 | 37
decreased circulating LDL chol... 35 | 37
decreased circulating free fat... 35 | 39
increased heart weight 35 | 37
increased startle reflex 35 | 38
small testis 35 | 37
increased leukocyte cell numbe... 34 | 37
tremors 34 | 34
abnormal spleen morphology 33 | 36
decreased mean corpuscular hem... 33 | 34
decreased neutrophil cell numb... 33 | 37
abnormal cranium morphology 31 | 32
cardiovascular system phenotyp... 31 | 35
increased hematocrit 31 | 36
decreased blood urea nitrogen ... 30 | 31
decreased circulating calcium ... 30 | 33
decreased circulating fructosa... 30 | 31
increased circulating calcium ... 30 | 32
increased circulating potassiu... 30 | 31
decreased T cell number 29 | 31
decreased threshold for audito... 29 | 32
abnormal testis morphology 28 | 30
decreased circulating chloride... 28 | 32
decreased circulating creatini... 28 | 31
limb grasping 28 | 35

Disease

ovarian cancer 8,049 | 8,491
osteosarcoma 7,368 | 7,933
psoriasis 5,877 | 6,685
medulloblastoma, large-cell 5,824 | 6,234
glioblastoma 5,282 | 5,572
lung cancer 4,262 | 4,473
atypical teratoid / rhabdoid tumor 4,114 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,116 | 3,289
malignant mesothelioma 3,039 | 3,163
Breast cancer 2,961 | 3,098
pilocytic astrocytoma 2,885 | 3,086
primitive neuroectodermal tumor 2,869 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,815 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,784 | 2,956
invasive ductal carcinoma 2,778 | 2,950
oligodendroglioma 2,693 | 2,849
non-small cell lung cancer 2,639 | 2,798
lung carcinoma 2,587 | 2,844
pediatric high grade glioma 2,586 | 2,712
lung adenocarcinoma 2,499 | 2,714
ependymoma 2,379 | 2,514
subependymal giant cell astrocytoma 2,179 | 2,287
pancreatic cancer 2,171 | 2,300
Cancer 2,164 | 2,346
interstitial cystitis 2,127 | 2,299
astrocytic glioma 2,111 | 2,241
group 3 medulloblastoma 2,109 | 2,254
adult high grade glioma 1,964 | 2,148
ulcerative colitis 1,944 | 2,087
Carcinoma 1,900 | 2,147
Pick disease 1,826 | 1,893
pituitary cancer 1,823 | 1,972
group 4 medulloblastoma 1,781 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,713 | 1,795
ductal carcinoma in situ 1,640 | 1,745
cystic fibrosis 1,594 | 1,670
breast carcinoma 1,517 | 1,614
tuberculosis 1,463 | 1,563
astrocytoma 1,456 | 1,493
medulloblastoma 1,430 | 1,524
sonic hedgehog group medulloblastoma 1,411 | 1,482
posterior fossa group A ependymoma 1,410 | 1,511
posterior fossa group B ependymoma 1,390 | 1,530
diabetes mellitus 1,371 | 1,663
colon cancer 1,366 | 1,475
adrenocortical carcinoma 1,345 | 1,427
Multiple myeloma 1,298 | 1,327
primary pancreatic ductal adenocarcinoma 1,225 | 1,271
juvenile dermatomyositis 1,150 | 1,189
acute quadriplegic myopathy 1,113 | 1,157
Rheumatoid Arthritis 1,102 | 1,170
atypical teratoid/rhabdoid tumor 1,036 | 1,095
spina bifida 1,030 | 1,064
nasopharyngeal carcinoma 977 | 1,056
cutaneous lupus erythematosus 953 | 1,056
dermatomyositis 948 | 966
active Crohn's disease 856 | 918
Atopic dermatitis 843 | 944
gastric carcinoma 786 | 832
non primary Sjogren syndrome sicca 760 | 840
acute myeloid leukemia 750 | 785
Waldenstrons macroglobulinemia 744 | 764
primary Sjogren syndrome 742 | 788
esophageal adenocarcinoma 712 | 737
tuberculosis and treatment for 6 months 663 | 686
progressive supranuclear palsy 652 | 674
aldosterone-producing adenoma 638 | 664
Alzheimer's disease 589 | 644
Duchenne muscular dystrophy 572 | 602
Intellectual disability 545 | 573
Obesity 536 | 616
pancreatic carcinoma 536 | 567
hepatocellular carcinoma 530 | 550
Down syndrome 529 | 548
fibroadenoma 513 | 557
Endometriosis 496 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 482 | 499
chronic rhinosinusitis 465 | 512
Prostatic Neoplasms 443 | 471
IGA Glomerulonephritis 439 | 454
active ulcerative colitis 435 | 477
Multiple Sclerosis 433 | 498
mucosa-associated lymphoid tissue lymphoma 426 | 480
Schizophrenia 424 | 503
gastric cancer 413 | 436
Amyotrophic Lateral Sclerosis 405 | 432
Mammary Neoplasms 390 | 410
inflammatory breast cancer 373 | 404
Neurodegenerative disease 365 | 383
non-small cell lung carcinoma 361 | 413
sarcoidosis 346 | 368
Kidney disease 341 | 397
glioblastoma multiforme 330 | 347
Parkinson's disease 320 | 364
Polycystic Ovary Syndrome 309 | 334
tuberculosis and treatment for 3 months 309 | 327
hereditary spastic paraplegia 305 | 313
Epilepsy 304 | 346
urothelial carcinoma 298 | 318
nephrosclerosis 295 | 329

Tissue

Nervous System 16,093 | 18,560
Female tissues 16,077 | 18,646
Digestive Tract 16,065 | 18,472
Endocrine System 16,054 | 18,511
Urinary Tract 16,010 | 18,443
Liver and Pancreas 15,976 | 18,135
Male tissues 15,947 | 17,968
Blood and immune system 15,924 | 17,994
Cardiovascular System 15,918 | 17,957
Skin and soft tissues 15,892 | 18,114
Respiratory system 15,744 | 17,483

Target Family

Non-IDG 9,488 | 11,969
Enzyme 3,691 | 4,146
Transcription Factor 1,259 | 1,400
Kinase 586 | 634
Transporter 410 | 473
Ion Channel 281 | 341
GPCR 278 | 408
Epigenetic 226 | 242
Nuclear Receptor 44 | 48
TF/Epigenetic 35 | 38
oGPCR 32 | 421

HCA RNA Cell Line

HaCaT 16,330 | 16,330
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131