Development Level

Tbio 10,386 | 11,445
Tdark 4,145 | 6,588
Tchem 1,461 | 1,598
Tclin 523 | 613

Collection

RFA-RM-18-021 268 | 328
Kinase: IDG Consortium (Target... 115 | 125
GPCR: IDG Consortium (Targets) 83 | 126
Ion Channel: IDG Consortium (T... 79 | 99
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 952 | 979
preweaning lethality, incomple... 475 | 499
abnormal behavior 284 | 298
embryonic lethality prior to t... 273 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 214 | 220
decreased total body fat amoun... 195 | 207
enlarged heart 190 | 210
abnormal bone structure 177 | 187
decreased vertical activity 177 | 208
increased lean body mass 160 | 172
decreased body weight 153 | 161
abnormal heart morphology 144 | 162
hyperactivity 139 | 148
decreased bone mineral content 136 | 151
decreased lean body mass 124 | 135
increased total body fat amoun... 122 | 134
hypoactivity 120 | 132
increased circulating alkaline... 115 | 122
decreased bone mineral density 114 | 126
decreased circulating glucose ... 113 | 126
decreased grip strength 105 | 116
increased startle reflex 105 | 112
embryonic growth retardation 102 | 106
male infertility 102 | 123
increased bone mineral content 100 | 108
abnormal seminal vesicle morph... 99 | 114
short tibia 96 | 97
decreased body length 94 | 101
increased or absent threshold ... 93 | 101
decreased circulating choleste... 88 | 93
increased mean corpuscular hem... 88 | 96
cataract 87 | 92
increased mean corpuscular vol... 85 | 92
prenatal lethality prior to he... 84 | 87
abnormal lens morphology 77 | 81
decreased prepulse inhibition 77 | 82
decreased lymphocyte cell numb... 76 | 83
decreased mean corpuscular vol... 75 | 79
decreased circulating serum al... 74 | 82
decreased circulating triglyce... 74 | 79
increased circulating HDL chol... 73 | 80
increased fasted circulating g... 72 | 76
decreased startle reflex 70 | 75
increased bone mineral density 70 | 72
small superior vagus ganglion 70 | 74
decreased circulating insulin ... 68 | 76
decreased leukocyte cell numbe... 68 | 73
impaired glucose tolerance 68 | 75
improved glucose tolerance 68 | 79
abnormal retina morphology 66 | 71
decreased circulating HDL chol... 66 | 68
abnormal eye morphology 65 | 68
abnormal gait 65 | 69
abnormal sleep behavior 64 | 70
increased circulating choleste... 61 | 66
increased circulating sodium l... 61 | 71
abnormal behavioral response t... 60 | 66
decreased hemoglobin content 59 | 68
edema 59 | 59
abnormal coat-hair pigmentatio... 58 | 64
abnormal kidney morphology 58 | 65
decreased erythrocyte cell num... 58 | 62
decreased fasted circulating g... 58 | 65
increased heart weight 58 | 62
increased monocyte cell number 57 | 63
small testis 55 | 58
abnormal spleen morphology 52 | 55
thrombocytopenia 52 | 56
hydrometra 51 | 53
decreased caudal vertebrae num... 50 | 53
female infertility 50 | 60
decreased blood urea nitrogen ... 48 | 51
decreased mean corpuscular hem... 47 | 50
abnormal neural tube closure 46 | 46
abnormal skin morphology 46 | 50
decreased circulating alkaline... 45 | 46
decreased circulating total pr... 45 | 49
increased blood urea nitrogen ... 44 | 48
increased leukocyte cell numbe... 44 | 47
decreased circulating alanine ... 43 | 47
decreased hematocrit 42 | 46
increased neutrophil cell numb... 42 | 46
abnormal testis morphology 41 | 43
increased hematocrit 41 | 46
enlarged spleen 40 | 41
increased circulating triglyce... 40 | 42
increased mean platelet volume 40 | 45
decreased neutrophil cell numb... 39 | 42
tremors 39 | 39
increased circulating chloride... 38 | 41
increased hemoglobin content 38 | 45
abnormal bone mineralization 37 | 38
decreased red blood cell distr... 37 | 41
abnormal epididymis morphology 36 | 42
decreased circulating LDL chol... 36 | 38
increased grip strength 36 | 41
decreased circulating creatini... 35 | 39
limb grasping 35 | 41
increased mean corpuscular hem... 34 | 36

Disease

Carcinoma 10,051 | 11,493
ovarian cancer 8,163 | 8,520
osteosarcoma 7,455 | 7,950
psoriasis 5,928 | 6,694
medulloblastoma, large-cell 5,882 | 6,241
glioblastoma 5,534 | 5,792
atypical teratoid / rhabdoid tumor 4,869 | 5,112
lung cancer 4,490 | 4,740
ependymoma 4,409 | 4,679
group 3 medulloblastoma 3,903 | 4,104
adult high grade glioma 3,575 | 3,801
Breast cancer 3,420 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,145 | 3,291
malignant mesothelioma 3,129 | 3,232
Astrocytoma, Pilocytic 2,911 | 3,081
primitive neuroectodermal tumor 2,902 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,838 | 2,989
invasive ductal carcinoma 2,807 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,801 | 2,955
non-small cell lung cancer 2,742 | 2,890
oligodendroglioma 2,718 | 2,850
lung carcinoma 2,602 | 2,843
lung adenocarcinoma 2,521 | 2,716
astrocytic glioma 2,473 | 2,597
Kidney cancer 2,360 | 2,613
Cancer 2,315 | 2,499
pancreatic cancer 2,277 | 2,398
subependymal giant cell astrocytoma 2,198 | 2,287
interstitial cystitis 2,146 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,898 | 1,962
tuberculosis 1,898 | 2,010
Pick disease 1,841 | 1,894
pituitary cancer 1,837 | 1,972
group 4 medulloblastoma 1,771 | 1,855
ulcerative colitis 1,695 | 1,819
ductal carcinoma in situ 1,655 | 1,745
cystic fibrosis 1,631 | 1,696
breast carcinoma 1,553 | 1,638
diabetes mellitus 1,441 | 1,728
colon cancer 1,379 | 1,478
adrenocortical carcinoma 1,363 | 1,428
Autosomal recessive predisposition 1,312 | 1,442
Multiple myeloma 1,312 | 1,332
juvenile dermatomyositis 1,158 | 1,187
Rheumatoid arthritis 1,135 | 1,191
astrocytoma 1,127 | 1,146
acute quadriplegic myopathy 1,122 | 1,158
primary pancreatic ductal adenocarcinoma 1,071 | 1,109
spina bifida 1,048 | 1,074
pediatric high grade glioma 1,021 | 1,064
Schizophrenia 1,020 | 1,160
nasopharyngeal carcinoma 984 | 1,058
Intellectual disability 972 | 1,016
cutaneous lupus erythematosus 961 | 1,057
dermatomyositis 953 | 966
active Crohn's disease 866 | 922
Atopic dermatitis 858 | 952
non primary Sjogren syndrome sicca 819 | 891
gastric carcinoma 766 | 807
acute myeloid leukemia 760 | 783
Waldenstrons macroglobulinemia 751 | 765
Epilepsy 740 | 792
esophageal adenocarcinoma 715 | 737
active ulcerative colitis 714 | 764
Liver Cirrhosis, Experimental 713 | 769
primary Sjogren syndrome 697 | 735
medulloblastoma 688 | 720
progressive supranuclear palsy 658 | 676
aldosterone-producing adenoma 643 | 665
Dull intelligence 618 | 645
Low intelligence 618 | 645
Mental Retardation 618 | 645
Mental deficiency 618 | 645
Poor school performance 618 | 645
Alzheimer's disease 605 | 658
Obesity 596 | 678
Melanoma 595 | 711
Bipolar Disorder 591 | 666
Cognitive delay 588 | 608
Global developmental delay 588 | 608
Mental and motor retardation 588 | 608
Duchenne muscular dystrophy 578 | 601
Seizures 561 | 596
Muscle hypotonia 555 | 571
Liver cancer 536 | 604
pancreatic carcinoma 535 | 562
hepatocellular carcinoma 530 | 547
fibroadenoma 517 | 559
Endometriosis 507 | 540
Short stature 501 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 494 | 510
Down syndrome 485 | 499
Multiple Sclerosis 472 | 540
Prostatic Neoplasms 469 | 495
chronic rhinosinusitis 468 | 512
sonic hedgehog group medulloblastoma 446 | 467
posterior fossa group A ependymoma 444 | 468
gastric cancer 440 | 459
mucosa-associated lymphoid tissue lymphoma 429 | 484
Amyotrophic lateral sclerosis 426 | 451

Tissue

Endocrine System 16,190 | 18,159
Female tissues 15,973 | 17,400
Digestive Tract 15,972 | 17,369
Skin and soft tissues 15,921 | 17,230
Male tissues 15,790 | 17,142
Blood and immune system 15,731 | 16,909
Nervous System 15,635 | 16,725
Liver and Pancreas 15,610 | 16,750
Urinary Tract 15,563 | 16,678
Respiratory system 15,404 | 16,393
Cardiovascular System 14,514 | 15,192

Target Family

Non-IDG 9,625 | 12,091
Enzyme 3,718 | 4,145
Transcription Factor 1,263 | 1,400
Kinase 593 | 634
Transporter 410 | 473
Ion Channel 284 | 344
GPCR 278 | 408
Epigenetic 232 | 242
Nuclear Receptor 44 | 48
TF/Epigenetic 36 | 38
oGPCR 32 | 421

HCA RNA Cell Line

HaCaT 16,515 | 16,515
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39