Development Level

Tbio 8,588 | 10,625
Tdark 4,033 | 7,003
Tchem 1,514 | 1,890
Tclin 408 | 602

Collection

Kinase: IDG Consortium (Targets) 106 | 125
Ion Channel: IDG Consortium (Targets) 69 | 102
GPCR: IDG Consortium (Targets) 54 | 127
Kinase: IDG Consortium (Complete/Control) 30 | 37
GPCR: IDG Consortium (Complete/Control) 16 | 26

IMPC Phenotype

preweaning lethality, complete... 595 | 633
preweaning lethality, incomple... 228 | 260
abnormal behavior 204 | 226
decreased lean body mass 179 | 195
embryonic lethality prior to t... 178 | 187
decreased total body fat amoun... 164 | 186
decreased body weight 158 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 138 | 157
abnormal bone structure 113 | 131
decreased bone mineral density 110 | 126
increased or absent threshold ... 109 | 128
increased circulating alkaline... 108 | 119
abnormal embryo size 104 | 112
decreased body length 101 | 108
decreased grip strength 99 | 123
hyperactivity 99 | 108
decreased circulating glucose ... 98 | 121
increased lean body mass 94 | 107
abnormal retina morphology 89 | 100
enlarged heart 86 | 111
increased bone mineral content 85 | 92
increased mean corpuscular hem... 85 | 93
increased mean corpuscular vol... 79 | 91
decreased circulating choleste... 76 | 85
hypoactivity 75 | 89
decreased circulating triglyce... 70 | 83
short tibia 70 | 82
decreased circulating serum al... 69 | 79
increased grip strength 68 | 83
decreased circulating HDL chol... 67 | 77
increased fasted circulating g... 64 | 68
abnormal lens morphology 63 | 73
prenatal lethality prior to he... 58 | 64
decreased lumbar vertebrae num... 56 | 62
increased sacral vertebrae num... 56 | 62
abnormal retinal pigmentation 55 | 61
decreased circulating insulin ... 55 | 75
increased circulating sodium l... 55 | 71
decreased rib number 52 | 59
abnormal bone mineralization 51 | 55
increased circulating HDL chol... 51 | 63
abnormal sleep behavior 49 | 63
increased total body fat amoun... 49 | 57
increased bone mineral density 48 | 52
abnormal coat-hair pigmentatio... 47 | 54
decreased mean corpuscular vol... 47 | 50
decreased prepulse inhibition 47 | 52
decreased hemoglobin content 46 | 53
male infertility 46 | 62
abnormal gait 44 | 51
increased circulating choleste... 44 | 53
increased exploration in new e... 44 | 56
decreased circulating alanine ... 43 | 53
decreased leukocyte cell numbe... 43 | 54
decreased startle reflex 43 | 48
abnormal behavioral response t... 42 | 52
impaired glucose tolerance 42 | 52
improved glucose tolerance 41 | 56
increased blood urea nitrogen ... 41 | 44
decreased caudal vertebrae num... 40 | 49
decreased erythrocyte cell num... 40 | 43
thrombocytopenia 40 | 46
decreased circulating total pr... 39 | 41
abnormal heart morphology 38 | 51
increased body weight 38 | 42
increased hemoglobin content 38 | 45
decreased fasted circulating g... 37 | 49
increased circulating chloride... 36 | 43
abnormal neural tube closure 35 | 37
decreased heart weight 35 | 44
increased rib number 35 | 41
decreased circulating LDL chol... 34 | 37
decreased eosinophil cell numb... 34 | 41
abnormal eye morphology 33 | 38
decreased circulating free fat... 33 | 39
decreased neutrophil cell numb... 33 | 37
increased startle reflex 33 | 38
abnormal seminal vesicle morph... 32 | 47
abnormal spleen morphology 32 | 36
decreased mean corpuscular hem... 32 | 34
increased leukocyte cell numbe... 32 | 37
small testis 32 | 37
abnormal cranium morphology 30 | 32
decreased circulating alkaline... 30 | 41
increased heart weight 30 | 37
cardiovascular system phenotyp... 29 | 35
decreased circulating fructosa... 29 | 31
increased hematocrit 29 | 36
tremors 29 | 34
increased circulating calcium ... 28 | 32
limb grasping 28 | 35
decreased T cell number 27 | 31
decreased blood urea nitrogen ... 27 | 31
decreased circulating calcium ... 27 | 33
decreased circulating chloride... 27 | 32
decreased circulating creatini... 27 | 31
embryonic growth retardation 27 | 28
increased circulating potassiu... 27 | 31
abnormal testis morphology 26 | 30

Disease

ovarian cancer 7,620 | 8,491
osteosarcoma 6,879 | 7,933
medulloblastoma, large-cell 5,350 | 6,234
psoriasis 5,000 | 6,685
glioblastoma 4,850 | 5,572
lung cancer 3,956 | 4,473
atypical teratoid / rhabdoid tumor 3,783 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,878 | 3,289
malignant mesothelioma 2,877 | 3,163
Breast cancer 2,731 | 3,098
primitive neuroectodermal tumor 2,619 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,596 | 2,988
invasive ductal carcinoma 2,560 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,554 | 2,956
pilocytic astrocytoma 2,530 | 3,086
oligodendroglioma 2,438 | 2,849
non-small cell lung cancer 2,354 | 2,798
pediatric high grade glioma 2,336 | 2,712
lung carcinoma 2,254 | 2,844
ependymoma 2,215 | 2,514
lung adenocarcinoma 2,211 | 2,714
pancreatic cancer 1,990 | 2,300
subependymal giant cell astrocytoma 1,978 | 2,287
group 3 medulloblastoma 1,959 | 2,254
astrocytic glioma 1,939 | 2,241
Cancer 1,898 | 2,346
interstitial cystitis 1,805 | 2,299
adult high grade glioma 1,760 | 2,148
ulcerative colitis 1,751 | 2,087
Pick disease 1,698 | 1,893
group 4 medulloblastoma 1,672 | 1,875
Carcinoma 1,656 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 1,615 | 1,795
pituitary cancer 1,603 | 1,972
ductal carcinoma in situ 1,492 | 1,745
cystic fibrosis 1,414 | 1,670
breast carcinoma 1,372 | 1,614
tuberculosis 1,340 | 1,563
astrocytoma 1,339 | 1,493
medulloblastoma 1,297 | 1,524
sonic hedgehog group medulloblastoma 1,281 | 1,482
Multiple myeloma 1,280 | 1,327
posterior fossa group B ependymoma 1,270 | 1,530
adrenocortical carcinoma 1,248 | 1,427
posterior fossa group A ependymoma 1,247 | 1,511
colon cancer 1,230 | 1,475
diabetes mellitus 1,171 | 1,663
primary pancreatic ductal adenocarcinoma 1,141 | 1,271
juvenile dermatomyositis 1,118 | 1,189
acute quadriplegic myopathy 1,085 | 1,157
Rheumatoid Arthritis 972 | 1,170
atypical teratoid/rhabdoid tumor 940 | 1,095
spina bifida 933 | 1,064
dermatomyositis 886 | 966
nasopharyngeal carcinoma 855 | 1,056
cutaneous lupus erythematosus 802 | 1,056
active Crohn's disease 783 | 918
gastric carcinoma 734 | 832
acute myeloid leukemia 729 | 785
Waldenstrons macroglobulinemia 720 | 764
non primary Sjogren syndrome sicca 713 | 840
Atopic dermatitis 712 | 944
primary Sjogren syndrome 646 | 788
tuberculosis and treatment for 6 months 643 | 686
progressive supranuclear palsy 620 | 674
esophageal adenocarcinoma 615 | 737
aldosterone-producing adenoma 600 | 664
Alzheimer's disease 528 | 644
Duchenne muscular dystrophy 522 | 602
pancreatic carcinoma 506 | 567
Intellectual disability 505 | 573
hepatocellular carcinoma 498 | 550
Down syndrome 483 | 548
Obesity 468 | 616
autosomal dominant Emery-Dreifuss muscular dystrophy 459 | 499
fibroadenoma 450 | 557
Endometriosis 437 | 535
IGA Glomerulonephritis 411 | 454
chronic rhinosinusitis 406 | 512
Prostatic Neoplasms 405 | 471
gastric cancer 393 | 436
active ulcerative colitis 388 | 477
Amyotrophic Lateral Sclerosis 385 | 432
mucosa-associated lymphoid tissue lymphoma 368 | 480
Mammary Neoplasms 363 | 410
Schizophrenia 359 | 503
Multiple Sclerosis 356 | 498
Neurodegenerative disease 338 | 383
inflammatory breast cancer 332 | 404
non-small cell lung carcinoma 309 | 413
glioblastoma multiforme 303 | 347
hereditary spastic paraplegia 300 | 313
tuberculosis and treatment for 3 months 296 | 327
sarcoidosis 287 | 368
Parkinson's disease 286 | 364
Kidney disease 285 | 397
Polycystic Ovary Syndrome 284 | 334
urothelial carcinoma 269 | 318
interstitial lung disease 256 | 292
Epilepsy 250 | 346

Tissue

Nervous System 14,404 | 18,560
Female tissues 14,387 | 18,646
Digestive Tract 14,386 | 18,472
Endocrine System 14,370 | 18,511
Liver and Pancreas 14,347 | 18,135
Urinary Tract 14,342 | 18,443
Blood and immune system 14,329 | 17,994
Male tissues 14,329 | 17,968
Cardiovascular System 14,316 | 17,957
Skin and soft tissues 14,239 | 18,114
Respiratory system 14,211 | 17,483

Target Family

Non-IDG 8,436 | 11,969
Enzyme 3,383 | 4,146
Transcription Factor 1,099 | 1,400
Kinase 555 | 634
Transporter 350 | 473
Epigenetic 219 | 242
GPCR 210 | 408
Ion Channel 203 | 341
Nuclear Receptor 37 | 48
TF/Epigenetic 33 | 38
oGPCR 18 | 421

HCA RNA Cell Line

HUVEC TERT2 14,543 | 14,543
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50