Development Level

Tbio 9,326 | 11,445
Tdark 3,688 | 6,588
Tchem 1,288 | 1,598
Tclin 415 | 613

Collection

RFA-RM-18-021 220 | 328
Kinase: IDG Consortium (Target... 108 | 125
Ion Channel: IDG Consortium (T... 66 | 99
GPCR: IDG Consortium (Targets) 54 | 126
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 16 | 25

IMPC Phenotype

preweaning lethality, complete... 924 | 979
preweaning lethality, incomple... 442 | 499
abnormal behavior 268 | 298
embryonic lethality prior to t... 258 | 278
embryonic lethality prior to o... 233 | 239
abnormal embryo size 205 | 220
decreased total body fat amoun... 177 | 207
enlarged heart 164 | 210
abnormal bone structure 159 | 187
increased lean body mass 152 | 172
decreased body weight 149 | 161
decreased vertical activity 147 | 208
hyperactivity 134 | 148
abnormal heart morphology 127 | 162
decreased bone mineral content 126 | 151
decreased lean body mass 117 | 135
increased total body fat amoun... 115 | 134
hypoactivity 112 | 132
decreased bone mineral density 109 | 126
decreased circulating glucose ... 106 | 126
increased circulating alkaline... 105 | 122
increased startle reflex 102 | 112
embryonic growth retardation 99 | 106
increased bone mineral content 94 | 108
decreased grip strength 92 | 116
male infertility 92 | 123
decreased body length 88 | 101
abnormal seminal vesicle morph... 85 | 114
cataract 84 | 92
increased mean corpuscular hem... 84 | 96
short tibia 83 | 97
increased or absent threshold ... 82 | 101
decreased circulating choleste... 81 | 93
increased mean corpuscular vol... 81 | 92
prenatal lethality prior to he... 78 | 87
abnormal lens morphology 75 | 81
decreased prepulse inhibition 74 | 82
decreased circulating serum al... 71 | 82
decreased mean corpuscular vol... 71 | 79
decreased circulating triglyce... 68 | 79
increased bone mineral density 68 | 72
increased fasted circulating g... 68 | 76
decreased startle reflex 67 | 75
decreased lymphocyte cell numb... 66 | 83
increased circulating HDL chol... 65 | 80
abnormal retina morphology 64 | 71
abnormal eye morphology 61 | 68
decreased leukocyte cell numbe... 61 | 73
impaired glucose tolerance 61 | 75
improved glucose tolerance 61 | 79
decreased circulating HDL chol... 59 | 68
decreased hemoglobin content 59 | 68
small superior vagus ganglion 59 | 74
abnormal gait 58 | 69
abnormal behavioral response t... 57 | 66
decreased circulating insulin ... 57 | 76
increased circulating sodium l... 57 | 71
abnormal coat-hair pigmentatio... 56 | 64
abnormal sleep behavior 56 | 70
decreased erythrocyte cell num... 55 | 62
increased heart weight 55 | 62
edema 54 | 59
increased circulating choleste... 53 | 66
decreased caudal vertebrae num... 51 | 53
small testis 51 | 58
abnormal spleen morphology 49 | 55
decreased fasted circulating g... 49 | 65
abnormal kidney morphology 48 | 65
decreased mean corpuscular hem... 48 | 50
increased monocyte cell number 48 | 63
thrombocytopenia 48 | 56
decreased circulating total pr... 46 | 49
decreased blood urea nitrogen ... 45 | 51
increased blood urea nitrogen ... 44 | 48
abnormal neural tube closure 43 | 46
female infertility 43 | 60
abnormal skin morphology 42 | 50
decreased circulating alanine ... 42 | 47
hydrometra 41 | 53
increased neutrophil cell numb... 40 | 46
decreased hematocrit 39 | 46
increased hematocrit 39 | 46
increased hemoglobin content 39 | 45
decreased circulating alkaline... 38 | 46
enlarged spleen 38 | 41
increased leukocyte cell numbe... 38 | 47
increased mean platelet volume 38 | 45
abnormal testis morphology 37 | 43
decreased red blood cell distr... 36 | 41
abnormal bone mineralization 35 | 38
decreased circulating LDL chol... 35 | 38
decreased neutrophil cell numb... 35 | 42
increased circulating triglyce... 35 | 42
tremors 35 | 39
abnormal cranium morphology 34 | 36
enlarged lymph nodes 34 | 37
increased grip strength 34 | 41
decreased circulating creatini... 33 | 39
increased erythrocyte cell num... 33 | 39
increased mean corpuscular hem... 33 | 36

Disease

Carcinoma 9,025 | 11,493
ovarian cancer 7,730 | 8,520
osteosarcoma 6,962 | 7,950
medulloblastoma, large-cell 5,405 | 6,241
glioblastoma 5,086 | 5,792
psoriasis 5,046 | 6,694
atypical teratoid / rhabdoid tumor 4,469 | 5,112
lung cancer 4,141 | 4,740
ependymoma 4,022 | 4,679
group 3 medulloblastoma 3,585 | 4,104
adult high grade glioma 3,185 | 3,801
Breast cancer 3,132 | 3,578
malignant mesothelioma 2,954 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,907 | 3,291
primitive neuroectodermal tumor 2,651 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,619 | 2,989
invasive ductal carcinoma 2,590 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,571 | 2,955
Astrocytoma, Pilocytic 2,557 | 3,081
oligodendroglioma 2,461 | 2,850
non-small cell lung cancer 2,443 | 2,890
lung carcinoma 2,267 | 2,843
astrocytic glioma 2,251 | 2,597
lung adenocarcinoma 2,232 | 2,716
Kidney cancer 2,102 | 2,613
pancreatic cancer 2,079 | 2,398
Cancer 2,039 | 2,499
subependymal giant cell astrocytoma 1,995 | 2,287
interstitial cystitis 1,820 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,791 | 1,962
tuberculosis 1,755 | 2,010
Pick disease 1,713 | 1,894
group 4 medulloblastoma 1,656 | 1,855
pituitary cancer 1,617 | 1,972
ulcerative colitis 1,526 | 1,819
ductal carcinoma in situ 1,509 | 1,745
cystic fibrosis 1,447 | 1,696
breast carcinoma 1,407 | 1,638
Multiple myeloma 1,296 | 1,332
adrenocortical carcinoma 1,266 | 1,428
colon cancer 1,241 | 1,478
diabetes mellitus 1,225 | 1,728
Autosomal recessive predisposition 1,166 | 1,442
juvenile dermatomyositis 1,126 | 1,187
acute quadriplegic myopathy 1,094 | 1,158
astrocytoma 1,059 | 1,146
Rheumatoid arthritis 995 | 1,191
primary pancreatic ductal adenocarcinoma 995 | 1,109
pediatric high grade glioma 956 | 1,064
spina bifida 949 | 1,074
Intellectual disability 895 | 1,016
dermatomyositis 894 | 966
nasopharyngeal carcinoma 862 | 1,058
Schizophrenia 852 | 1,160
cutaneous lupus erythematosus 808 | 1,057
active Crohn's disease 792 | 922
non primary Sjogren syndrome sicca 764 | 891
acute myeloid leukemia 740 | 783
Waldenstrons macroglobulinemia 727 | 765
Atopic dermatitis 724 | 952
gastric carcinoma 715 | 807
Epilepsy 653 | 792
Liver Cirrhosis, Experimental 639 | 769
active ulcerative colitis 639 | 764
medulloblastoma 629 | 720
progressive supranuclear palsy 626 | 676
esophageal adenocarcinoma 618 | 737
primary Sjogren syndrome 608 | 735
aldosterone-producing adenoma 605 | 665
Dull intelligence 569 | 645
Low intelligence 569 | 645
Mental Retardation 569 | 645
Mental deficiency 569 | 645
Poor school performance 569 | 645
Cognitive delay 552 | 608
Global developmental delay 552 | 608
Mental and motor retardation 552 | 608
Alzheimer's disease 534 | 658
Duchenne muscular dystrophy 528 | 601
Obesity 526 | 678
Muscle hypotonia 510 | 571
pancreatic carcinoma 505 | 562
Seizures 502 | 596
hepatocellular carcinoma 498 | 547
Bipolar Disorder 495 | 666
autosomal dominant Emery-Dreifuss muscular dystrophy 471 | 510
Melanoma 469 | 711
Short stature 467 | 531
Liver cancer 462 | 604
fibroadenoma 454 | 559
Endometriosis 447 | 540
Down syndrome 446 | 499
Prostatic Neoplasms 429 | 495
gastric cancer 419 | 459
sonic hedgehog group medulloblastoma 414 | 467
posterior fossa group A ependymoma 411 | 468
chronic rhinosinusitis 409 | 512
Amyotrophic lateral sclerosis 406 | 451
tuberculosis and treatment for 6 months 396 | 409
Breast Neoplasms 394 | 445

Tissue

Endocrine System 14,550 | 18,159
Digestive Tract 14,439 | 17,369
Female tissues 14,439 | 17,400
Skin and soft tissues 14,409 | 17,230
Male tissues 14,382 | 17,142
Blood and immune system 14,333 | 16,909
Liver and Pancreas 14,295 | 16,750
Nervous System 14,295 | 16,725
Urinary Tract 14,260 | 16,678
Respiratory system 14,187 | 16,393
Cardiovascular System 13,635 | 15,192

Target Family

Non-IDG 8,565 | 12,091
Enzyme 3,408 | 4,145
Transcription Factor 1,103 | 1,400
Kinase 561 | 634
Transporter 350 | 473
Epigenetic 225 | 242
GPCR 210 | 408
Ion Channel 206 | 344
Nuclear Receptor 37 | 48
TF/Epigenetic 34 | 38
oGPCR 18 | 421

HCA RNA Cell Line

HUVEC TERT2 14,717 | 14,717
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29