Development Level

Tbio 9,742 | 11,445
Tdark 3,902 | 6,588
Tchem 1,365 | 1,598
Tclin 444 | 613

Collection

RFA-RM-18-021 236 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 71 | 99
GPCR: IDG Consortium (Targets) 59 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 15 | 25

IMPC Phenotype

preweaning lethality, complete... 939 | 979
preweaning lethality, incomple... 462 | 499
abnormal behavior 273 | 298
embryonic lethality prior to t... 270 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 183 | 207
enlarged heart 175 | 210
abnormal bone structure 165 | 187
decreased vertical activity 162 | 208
increased lean body mass 156 | 172
decreased body weight 150 | 161
abnormal heart morphology 136 | 162
hyperactivity 135 | 148
decreased bone mineral content 128 | 151
hypoactivity 115 | 132
increased total body fat amoun... 115 | 134
decreased lean body mass 113 | 135
decreased bone mineral density 112 | 126
decreased circulating glucose ... 111 | 126
increased circulating alkaline... 111 | 122
male infertility 107 | 123
embryonic growth retardation 103 | 106
increased startle reflex 102 | 112
decreased grip strength 99 | 116
increased bone mineral content 96 | 108
abnormal seminal vesicle morph... 91 | 114
decreased body length 91 | 101
increased or absent threshold ... 90 | 101
short tibia 88 | 97
decreased circulating choleste... 86 | 93
increased mean corpuscular hem... 86 | 96
prenatal lethality prior to he... 85 | 87
cataract 83 | 92
increased mean corpuscular vol... 83 | 92
decreased circulating serum al... 75 | 82
decreased prepulse inhibition 75 | 82
decreased mean corpuscular vol... 74 | 79
abnormal lens morphology 72 | 81
decreased lymphocyte cell numb... 70 | 83
increased fasted circulating g... 70 | 76
decreased circulating triglyce... 68 | 79
increased bone mineral density 67 | 72
increased circulating HDL chol... 67 | 80
abnormal retina morphology 66 | 71
decreased startle reflex 66 | 75
impaired glucose tolerance 66 | 75
decreased leukocyte cell numbe... 65 | 73
decreased circulating HDL chol... 64 | 68
improved glucose tolerance 64 | 79
decreased circulating insulin ... 63 | 76
abnormal eye morphology 62 | 68
decreased hemoglobin content 60 | 68
increased heart weight 60 | 62
small superior vagus ganglion 60 | 74
abnormal gait 59 | 69
abnormal behavioral response t... 58 | 66
abnormal coat-hair pigmentatio... 57 | 64
abnormal sleep behavior 57 | 70
increased circulating choleste... 57 | 66
decreased erythrocyte cell num... 56 | 62
decreased fasted circulating g... 56 | 65
edema 56 | 59
increased circulating sodium l... 56 | 71
abnormal kidney morphology 54 | 65
small testis 54 | 58
increased monocyte cell number 53 | 63
abnormal spleen morphology 51 | 55
decreased caudal vertebrae num... 51 | 53
female infertility 49 | 60
decreased mean corpuscular hem... 48 | 50
thrombocytopenia 48 | 56
decreased circulating total pr... 47 | 49
abnormal neural tube closure 45 | 46
decreased blood urea nitrogen ... 45 | 51
hydrometra 45 | 53
increased blood urea nitrogen ... 45 | 48
abnormal skin morphology 44 | 50
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 42 | 46
decreased hematocrit 42 | 46
increased hematocrit 42 | 46
increased leukocyte cell numbe... 41 | 47
enlarged spleen 40 | 41
increased mean platelet volume 40 | 45
increased neutrophil cell numb... 40 | 46
abnormal testis morphology 39 | 43
increased hemoglobin content 39 | 45
decreased red blood cell distr... 38 | 41
increased circulating triglyce... 38 | 42
decreased neutrophil cell numb... 37 | 42
increased grip strength 36 | 41
tremors 36 | 39
abnormal bone mineralization 35 | 38
decreased circulating LDL chol... 35 | 38
increased mean corpuscular hem... 35 | 36
abnormal cranium morphology 34 | 36
abnormal epididymis morphology 34 | 42
decreased circulating creatini... 34 | 39
increased erythrocyte cell num... 33 | 39

Disease

Carcinoma 9,442 | 11,493
ovarian cancer 7,879 | 8,520
osteosarcoma 7,148 | 7,950
medulloblastoma, large-cell 5,568 | 6,241
psoriasis 5,455 | 6,694
glioblastoma 5,206 | 5,792
atypical teratoid / rhabdoid tumor 4,599 | 5,112
lung cancer 4,245 | 4,740
ependymoma 4,144 | 4,679
group 3 medulloblastoma 3,671 | 4,104
adult high grade glioma 3,291 | 3,801
Breast cancer 3,238 | 3,578
malignant mesothelioma 3,011 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,989 | 3,291
primitive neuroectodermal tumor 2,726 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,677 | 2,989
Astrocytoma, Pilocytic 2,656 | 3,081
invasive ductal carcinoma 2,643 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,638 | 2,955
non-small cell lung cancer 2,577 | 2,890
oligodendroglioma 2,524 | 2,850
lung carcinoma 2,394 | 2,843
lung adenocarcinoma 2,337 | 2,716
astrocytic glioma 2,310 | 2,597
Kidney cancer 2,206 | 2,613
pancreatic cancer 2,158 | 2,398
Cancer 2,126 | 2,499
subependymal giant cell astrocytoma 2,038 | 2,287
interstitial cystitis 1,937 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,828 | 1,962
tuberculosis 1,784 | 2,010
Pick disease 1,742 | 1,894
pituitary cancer 1,705 | 1,972
group 4 medulloblastoma 1,695 | 1,855
ductal carcinoma in situ 1,575 | 1,745
ulcerative colitis 1,563 | 1,819
cystic fibrosis 1,522 | 1,696
breast carcinoma 1,461 | 1,638
adrenocortical carcinoma 1,295 | 1,428
Multiple myeloma 1,293 | 1,332
diabetes mellitus 1,292 | 1,728
colon cancer 1,285 | 1,478
Autosomal recessive predisposition 1,245 | 1,442
juvenile dermatomyositis 1,117 | 1,187
acute quadriplegic myopathy 1,101 | 1,158
astrocytoma 1,060 | 1,146
Rheumatoid arthritis 1,058 | 1,191
spina bifida 1,019 | 1,074
primary pancreatic ductal adenocarcinoma 1,012 | 1,109
pediatric high grade glioma 983 | 1,064
dermatomyositis 930 | 966
Intellectual disability 929 | 1,016
nasopharyngeal carcinoma 927 | 1,058
Schizophrenia 906 | 1,160
cutaneous lupus erythematosus 867 | 1,057
active Crohn's disease 820 | 922
Atopic dermatitis 789 | 952
non primary Sjogren syndrome sicca 775 | 891
acute myeloid leukemia 747 | 783
Waldenstrons macroglobulinemia 732 | 765
gastric carcinoma 728 | 807
Epilepsy 692 | 792
esophageal adenocarcinoma 677 | 737
active ulcerative colitis 674 | 764
medulloblastoma 652 | 720
Liver Cirrhosis, Experimental 643 | 769
progressive supranuclear palsy 640 | 676
primary Sjogren syndrome 624 | 735
aldosterone-producing adenoma 617 | 665
Dull intelligence 596 | 645
Low intelligence 596 | 645
Mental Retardation 596 | 645
Mental deficiency 596 | 645
Poor school performance 596 | 645
Cognitive delay 561 | 608
Global developmental delay 561 | 608
Mental and motor retardation 561 | 608
Alzheimer's disease 557 | 658
Obesity 542 | 678
Duchenne muscular dystrophy 535 | 601
Muscle hypotonia 534 | 571
Seizures 531 | 596
Bipolar Disorder 528 | 666
pancreatic carcinoma 519 | 562
Melanoma 518 | 711
hepatocellular carcinoma 508 | 547
Short stature 488 | 531
Endometriosis 472 | 540
fibroadenoma 472 | 559
Liver cancer 470 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 468 | 510
Down syndrome 449 | 499
chronic rhinosinusitis 448 | 512
Prostatic Neoplasms 444 | 495
gastric cancer 429 | 459
sonic hedgehog group medulloblastoma 423 | 467
posterior fossa group A ependymoma 416 | 468
Amyotrophic lateral sclerosis 413 | 451
Breast Neoplasms 401 | 445
tuberculosis and treatment for 6 months 397 | 409

Tissue

Endocrine System 15,231 | 18,159
Female tissues 15,104 | 17,400
Digestive Tract 15,088 | 17,369
Skin and soft tissues 15,067 | 17,230
Male tissues 14,975 | 17,142
Blood and immune system 14,911 | 16,909
Liver and Pancreas 14,839 | 16,750
Nervous System 14,836 | 16,725
Urinary Tract 14,798 | 16,678
Respiratory system 14,668 | 16,393
Cardiovascular System 13,947 | 15,192

Target Family

Non-IDG 8,952 | 12,091
Enzyme 3,570 | 4,145
Transcription Factor 1,175 | 1,400
Kinase 587 | 634
Transporter 381 | 473
Epigenetic 233 | 242
Ion Channel 233 | 344
GPCR 222 | 408
Nuclear Receptor 43 | 48
TF/Epigenetic 36 | 38
oGPCR 21 | 421

HCA RNA Cell Line

HTCEpi 15,453 | 15,453
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29