Development Level

Tbio 8,995 | 10,625
Tdark 4,260 | 7,003
Tchem 1,581 | 1,890
Tclin 435 | 602

Collection

Kinase: IDG Consortium (Targets) 113 | 125
Ion Channel: IDG Consortium (Targets) 72 | 102
GPCR: IDG Consortium (Targets) 59 | 127
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 15 | 26

IMPC Phenotype

preweaning lethality, complete... 603 | 633
preweaning lethality, incomple... 246 | 260
abnormal behavior 205 | 226
embryonic lethality prior to t... 184 | 187
decreased lean body mass 174 | 195
decreased total body fat amoun... 170 | 186
decreased body weight 160 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 140 | 157
abnormal bone structure 116 | 131
decreased bone mineral density 114 | 126
increased or absent threshold ... 114 | 128
increased circulating alkaline... 111 | 119
abnormal embryo size 106 | 112
decreased circulating glucose ... 103 | 121
decreased grip strength 102 | 123
decreased body length 101 | 108
hyperactivity 97 | 108
increased lean body mass 97 | 107
abnormal retina morphology 93 | 100
enlarged heart 92 | 111
increased mean corpuscular hem... 86 | 93
increased bone mineral content 84 | 92
increased mean corpuscular vol... 82 | 91
decreased circulating choleste... 79 | 85
hypoactivity 76 | 89
decreased circulating HDL chol... 72 | 77
decreased circulating serum al... 72 | 79
decreased circulating triglyce... 71 | 83
short tibia 71 | 82
increased grip strength 69 | 83
abnormal lens morphology 63 | 73
increased fasted circulating g... 62 | 68
prenatal lethality prior to he... 62 | 64
decreased lumbar vertebrae num... 61 | 62
decreased circulating insulin ... 60 | 75
increased sacral vertebrae num... 58 | 62
increased circulating sodium l... 56 | 71
abnormal retinal pigmentation 55 | 61
decreased rib number 55 | 59
male infertility 53 | 62
abnormal bone mineralization 52 | 55
abnormal sleep behavior 50 | 63
increased bone mineral density 50 | 52
increased circulating HDL chol... 50 | 63
increased exploration in new e... 50 | 56
decreased prepulse inhibition 49 | 52
increased total body fat amoun... 49 | 57
abnormal coat-hair pigmentatio... 48 | 54
decreased mean corpuscular vol... 48 | 50
decreased hemoglobin content 47 | 53
decreased leukocyte cell numbe... 47 | 54
impaired glucose tolerance 46 | 52
increased circulating choleste... 46 | 53
decreased circulating alanine ... 45 | 53
abnormal behavioral response t... 44 | 52
abnormal gait 44 | 51
decreased caudal vertebrae num... 44 | 49
decreased startle reflex 44 | 48
improved glucose tolerance 43 | 56
increased blood urea nitrogen ... 41 | 44
decreased circulating total pr... 40 | 41
decreased erythrocyte cell num... 40 | 43
decreased fasted circulating g... 40 | 49
thrombocytopenia 40 | 46
abnormal heart morphology 39 | 51
increased body weight 38 | 42
increased hemoglobin content 38 | 45
increased rib number 37 | 41
abnormal eye morphology 36 | 38
abnormal neural tube closure 36 | 37
decreased circulating alkaline... 36 | 41
increased circulating chloride... 36 | 43
abnormal seminal vesicle morph... 35 | 47
decreased circulating free fat... 35 | 39
decreased eosinophil cell numb... 35 | 41
decreased circulating LDL chol... 34 | 37
decreased heart weight 34 | 44
increased startle reflex 34 | 38
small testis 34 | 37
decreased mean corpuscular hem... 33 | 34
decreased neutrophil cell numb... 33 | 37
increased heart weight 33 | 37
increased leukocyte cell numbe... 33 | 37
abnormal cranium morphology 31 | 32
abnormal spleen morphology 31 | 36
increased hematocrit 31 | 36
decreased circulating calcium ... 30 | 33
tremors 30 | 34
decreased circulating fructosa... 29 | 31
increased circulating potassiu... 29 | 31
decreased T cell number 28 | 31
decreased blood urea nitrogen ... 28 | 31
decreased circulating chloride... 28 | 32
decreased circulating creatini... 28 | 31
limb grasping 28 | 35
abnormal rib morphology 27 | 28
abnormal testis morphology 27 | 30
embryonic growth retardation 27 | 28
female infertility 27 | 34

Disease

ovarian cancer 7,769 | 8,491
osteosarcoma 7,061 | 7,933
medulloblastoma, large-cell 5,509 | 6,234
psoriasis 5,407 | 6,685
glioblastoma 4,964 | 5,572
lung cancer 4,040 | 4,473
atypical teratoid / rhabdoid tumor 3,897 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,960 | 3,289
malignant mesothelioma 2,935 | 3,163
Breast cancer 2,818 | 3,098
primitive neuroectodermal tumor 2,692 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,653 | 2,988
pilocytic astrocytoma 2,628 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 2,621 | 2,956
invasive ductal carcinoma 2,612 | 2,950
oligodendroglioma 2,499 | 2,849
non-small cell lung cancer 2,478 | 2,798
pediatric high grade glioma 2,422 | 2,712
lung carcinoma 2,378 | 2,844
lung adenocarcinoma 2,313 | 2,714
ependymoma 2,268 | 2,514
pancreatic cancer 2,062 | 2,300
subependymal giant cell astrocytoma 2,020 | 2,287
group 3 medulloblastoma 2,008 | 2,254
astrocytic glioma 1,993 | 2,241
Cancer 1,984 | 2,346
interstitial cystitis 1,918 | 2,299
adult high grade glioma 1,805 | 2,148
ulcerative colitis 1,803 | 2,087
Carcinoma 1,741 | 2,147
Pick disease 1,727 | 1,893
group 4 medulloblastoma 1,701 | 1,875
pituitary cancer 1,690 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,647 | 1,795
ductal carcinoma in situ 1,558 | 1,745
cystic fibrosis 1,487 | 1,670
breast carcinoma 1,424 | 1,614
tuberculosis 1,383 | 1,563
astrocytoma 1,345 | 1,493
medulloblastoma 1,334 | 1,524
posterior fossa group B ependymoma 1,333 | 1,530
sonic hedgehog group medulloblastoma 1,319 | 1,482
Multiple myeloma 1,278 | 1,327
adrenocortical carcinoma 1,278 | 1,427
posterior fossa group A ependymoma 1,274 | 1,511
colon cancer 1,272 | 1,475
diabetes mellitus 1,225 | 1,663
primary pancreatic ductal adenocarcinoma 1,162 | 1,271
juvenile dermatomyositis 1,109 | 1,189
acute quadriplegic myopathy 1,092 | 1,157
Rheumatoid Arthritis 1,030 | 1,170
spina bifida 999 | 1,064
atypical teratoid/rhabdoid tumor 969 | 1,095
dermatomyositis 921 | 966
nasopharyngeal carcinoma 920 | 1,056
cutaneous lupus erythematosus 859 | 1,056
active Crohn's disease 811 | 918
Atopic dermatitis 775 | 944
gastric carcinoma 747 | 832
acute myeloid leukemia 736 | 785
non primary Sjogren syndrome sicca 726 | 840
Waldenstrons macroglobulinemia 724 | 764
esophageal adenocarcinoma 674 | 737
primary Sjogren syndrome 662 | 788
tuberculosis and treatment for 6 months 646 | 686
progressive supranuclear palsy 634 | 674
aldosterone-producing adenoma 612 | 664
Alzheimer's disease 545 | 644
Duchenne muscular dystrophy 529 | 602
pancreatic carcinoma 519 | 567
Intellectual disability 515 | 573
hepatocellular carcinoma 507 | 550
Down syndrome 489 | 548
Obesity 488 | 616
fibroadenoma 468 | 557
Endometriosis 462 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 458 | 499
chronic rhinosinusitis 445 | 512
Prostatic Neoplasms 419 | 471
IGA Glomerulonephritis 407 | 454
active ulcerative colitis 407 | 477
gastric cancer 401 | 436
Amyotrophic Lateral Sclerosis 395 | 432
Schizophrenia 382 | 503
mucosa-associated lymphoid tissue lymphoma 375 | 480
Mammary Neoplasms 368 | 410
Multiple Sclerosis 351 | 498
Neurodegenerative disease 351 | 383
inflammatory breast cancer 350 | 404
non-small cell lung carcinoma 332 | 413
Parkinson's disease 306 | 364
glioblastoma multiforme 299 | 347
hereditary spastic paraplegia 298 | 313
Polycystic Ovary Syndrome 293 | 334
sarcoidosis 293 | 368
tuberculosis and treatment for 3 months 291 | 327
urothelial carcinoma 283 | 318
Epilepsy 273 | 346
nephrosclerosis 265 | 329
Kidney disease 264 | 397

Tissue

Nervous System 15,100 | 18,560
Digestive Tract 15,090 | 18,472
Female tissues 15,083 | 18,646
Endocrine System 15,064 | 18,511
Liver and Pancreas 15,031 | 18,135
Urinary Tract 15,030 | 18,443
Male tissues 14,998 | 17,968
Blood and immune system 14,994 | 17,994
Cardiovascular System 14,979 | 17,957
Skin and soft tissues 14,932 | 18,114
Respiratory system 14,851 | 17,483

Target Family

Non-IDG 8,819 | 11,969
Enzyme 3,542 | 4,146
Transcription Factor 1,171 | 1,400
Kinase 581 | 634
Transporter 381 | 473
Ion Channel 229 | 341
Epigenetic 227 | 242
GPCR 222 | 408
Nuclear Receptor 43 | 48
TF/Epigenetic 35 | 38
oGPCR 21 | 421

HCA RNA Cell Line

HTCEpi 15,271 | 15,271
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50