Development Level

Tbio 10,386 | 11,445
Tdark 4,202 | 6,588
Tchem 1,457 | 1,598
Tclin 536 | 613

Collection

RFA-RM-18-021 272 | 328
Kinase: IDG Consortium (Target... 120 | 125
Ion Channel: IDG Consortium (T... 83 | 99
GPCR: IDG Consortium (Targets) 76 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 953 | 979
preweaning lethality, incomple... 476 | 499
abnormal behavior 286 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 213 | 220
decreased total body fat amoun... 194 | 207
enlarged heart 190 | 210
decreased vertical activity 178 | 208
abnormal bone structure 176 | 187
increased lean body mass 162 | 172
decreased body weight 155 | 161
abnormal heart morphology 148 | 162
hyperactivity 140 | 148
decreased bone mineral content 134 | 151
decreased lean body mass 126 | 135
increased total body fat amoun... 124 | 134
decreased circulating glucose ... 121 | 126
hypoactivity 120 | 132
increased circulating alkaline... 119 | 122
decreased bone mineral density 113 | 126
male infertility 111 | 123
decreased grip strength 108 | 116
increased startle reflex 108 | 112
embryonic growth retardation 103 | 106
increased bone mineral content 101 | 108
abnormal seminal vesicle morph... 99 | 114
decreased body length 97 | 101
increased or absent threshold ... 95 | 101
short tibia 91 | 97
decreased circulating choleste... 90 | 93
increased mean corpuscular hem... 90 | 96
increased mean corpuscular vol... 90 | 92
cataract 85 | 92
prenatal lethality prior to he... 85 | 87
decreased circulating serum al... 79 | 82
decreased prepulse inhibition 79 | 82
abnormal lens morphology 77 | 81
decreased lymphocyte cell numb... 76 | 83
decreased circulating triglyce... 75 | 79
decreased mean corpuscular vol... 75 | 79
increased circulating HDL chol... 73 | 80
increased fasted circulating g... 72 | 76
increased bone mineral density 71 | 72
decreased startle reflex 70 | 75
impaired glucose tolerance 70 | 75
decreased circulating insulin ... 69 | 76
decreased leukocyte cell numbe... 69 | 73
improved glucose tolerance 69 | 79
abnormal sleep behavior 67 | 70
abnormal eye morphology 66 | 68
decreased circulating HDL chol... 66 | 68
abnormal retina morphology 65 | 71
abnormal gait 64 | 69
increased circulating sodium l... 64 | 71
small superior vagus ganglion 63 | 74
decreased fasted circulating g... 62 | 65
decreased hemoglobin content 62 | 68
increased circulating choleste... 61 | 66
abnormal behavioral response t... 59 | 66
decreased erythrocyte cell num... 59 | 62
increased heart weight 59 | 62
abnormal kidney morphology 58 | 65
abnormal coat-hair pigmentatio... 57 | 64
edema 57 | 59
increased monocyte cell number 57 | 63
small testis 53 | 58
female infertility 52 | 60
thrombocytopenia 52 | 56
decreased caudal vertebrae num... 51 | 53
decreased blood urea nitrogen ... 49 | 51
decreased circulating total pr... 49 | 49
abnormal spleen morphology 48 | 55
decreased mean corpuscular hem... 48 | 50
increased blood urea nitrogen ... 46 | 48
decreased circulating alkaline... 45 | 46
hydrometra 45 | 53
abnormal neural tube closure 44 | 46
decreased circulating alanine ... 44 | 47
decreased hematocrit 44 | 46
increased hematocrit 44 | 46
increased leukocyte cell numbe... 44 | 47
increased hemoglobin content 43 | 45
increased neutrophil cell numb... 43 | 46
abnormal skin morphology 42 | 50
increased circulating triglyce... 42 | 42
increased mean platelet volume 41 | 45
decreased neutrophil cell numb... 40 | 42
decreased red blood cell distr... 39 | 41
increased circulating chloride... 39 | 41
tremors 39 | 39
abnormal testis morphology 38 | 43
limb grasping 38 | 41
abnormal bone mineralization 37 | 38
decreased circulating creatini... 36 | 39
enlarged spleen 36 | 41
increased erythrocyte cell num... 36 | 39
decreased circulating LDL chol... 35 | 38
increased grip strength 35 | 41
increased mean corpuscular hem... 35 | 36

Disease

Carcinoma 10,074 | 11,493
ovarian cancer 8,142 | 8,520
osteosarcoma 7,514 | 7,950
medulloblastoma, large-cell 5,870 | 6,241
psoriasis 5,840 | 6,694
glioblastoma 5,512 | 5,792
atypical teratoid / rhabdoid tumor 4,871 | 5,112
lung cancer 4,466 | 4,740
ependymoma 4,406 | 4,679
group 3 medulloblastoma 3,895 | 4,104
adult high grade glioma 3,556 | 3,801
Breast cancer 3,386 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,129 | 3,291
malignant mesothelioma 3,122 | 3,232
Astrocytoma, Pilocytic 2,894 | 3,081
primitive neuroectodermal tumor 2,891 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,833 | 2,989
invasive ductal carcinoma 2,808 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,792 | 2,955
non-small cell lung cancer 2,729 | 2,890
oligodendroglioma 2,700 | 2,850
lung carcinoma 2,619 | 2,843
lung adenocarcinoma 2,517 | 2,716
astrocytic glioma 2,459 | 2,597
Kidney cancer 2,364 | 2,613
Cancer 2,313 | 2,499
pancreatic cancer 2,268 | 2,398
subependymal giant cell astrocytoma 2,191 | 2,287
interstitial cystitis 2,128 | 2,312
tuberculosis 1,922 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,895 | 1,962
Pick disease 1,831 | 1,894
pituitary cancer 1,823 | 1,972
group 4 medulloblastoma 1,773 | 1,855
ulcerative colitis 1,697 | 1,819
ductal carcinoma in situ 1,634 | 1,745
cystic fibrosis 1,569 | 1,696
breast carcinoma 1,548 | 1,638
diabetes mellitus 1,439 | 1,728
colon cancer 1,376 | 1,478
adrenocortical carcinoma 1,368 | 1,428
Autosomal recessive predisposition 1,320 | 1,442
Multiple myeloma 1,312 | 1,332
juvenile dermatomyositis 1,163 | 1,187
acute quadriplegic myopathy 1,132 | 1,158
Rheumatoid arthritis 1,128 | 1,191
astrocytoma 1,119 | 1,146
primary pancreatic ductal adenocarcinoma 1,069 | 1,109
spina bifida 1,033 | 1,074
Schizophrenia 1,028 | 1,160
pediatric high grade glioma 1,019 | 1,064
Intellectual disability 974 | 1,016
nasopharyngeal carcinoma 967 | 1,058
cutaneous lupus erythematosus 962 | 1,057
dermatomyositis 954 | 966
active Crohn's disease 860 | 922
Atopic dermatitis 833 | 952
non primary Sjogren syndrome sicca 819 | 891
acute myeloid leukemia 771 | 783
gastric carcinoma 768 | 807
Waldenstrons macroglobulinemia 760 | 765
Epilepsy 747 | 792
Liver Cirrhosis, Experimental 738 | 769
primary Sjogren syndrome 707 | 735
active ulcerative colitis 704 | 764
medulloblastoma 695 | 720
esophageal adenocarcinoma 693 | 737
progressive supranuclear palsy 653 | 676
aldosterone-producing adenoma 643 | 665
Dull intelligence 617 | 645
Low intelligence 617 | 645
Mental Retardation 617 | 645
Mental deficiency 617 | 645
Poor school performance 617 | 645
Obesity 609 | 678
Alzheimer's disease 603 | 658
Cognitive delay 591 | 608
Global developmental delay 591 | 608
Mental and motor retardation 591 | 608
Melanoma 588 | 711
Bipolar Disorder 587 | 666
Duchenne muscular dystrophy 577 | 601
Seizures 565 | 596
Muscle hypotonia 550 | 571
pancreatic carcinoma 544 | 562
hepatocellular carcinoma 534 | 547
Liver cancer 533 | 604
fibroadenoma 519 | 559
Short stature 507 | 531
Endometriosis 495 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 494 | 510
Multiple Sclerosis 485 | 540
Down syndrome 480 | 499
Prostatic Neoplasms 464 | 495
chronic rhinosinusitis 464 | 512
gastric cancer 444 | 459
sonic hedgehog group medulloblastoma 443 | 467
posterior fossa group A ependymoma 442 | 468
mucosa-associated lymphoid tissue lymphoma 433 | 484
Amyotrophic lateral sclerosis 430 | 451

Tissue

Endocrine System 16,273 | 18,159
Digestive Tract 15,994 | 17,369
Female tissues 15,961 | 17,400
Skin and soft tissues 15,926 | 17,230
Male tissues 15,819 | 17,142
Blood and immune system 15,755 | 16,909
Nervous System 15,692 | 16,725
Liver and Pancreas 15,656 | 16,750
Urinary Tract 15,599 | 16,678
Respiratory system 15,445 | 16,393
Cardiovascular System 14,530 | 15,192

Target Family

Non-IDG 9,666 | 12,091
Enzyme 3,704 | 4,145
Transcription Factor 1,280 | 1,400
Kinase 603 | 634
Transporter 406 | 473
Ion Channel 285 | 344
GPCR 281 | 408
Epigenetic 231 | 242
Nuclear Receptor 45 | 48
oGPCR 43 | 421
TF/Epigenetic 37 | 38

HCA RNA Cell Line

HMC-1 16,581 | 16,581
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39