Development Level

Tbio 8,824 | 10,625
Tdark 4,017 | 7,003
Tchem 1,590 | 1,890
Tclin 432 | 602

Collection

Kinase: IDG Consortium (Targets) 106 | 125
Ion Channel: IDG Consortium (Targets) 65 | 102
GPCR: IDG Consortium (Targets) 62 | 127
Kinase: IDG Consortium (Complete/Control) 33 | 37
GPCR: IDG Consortium (Complete/Control) 20 | 26

IMPC Phenotype

preweaning lethality, complete... 595 | 633
preweaning lethality, incomple... 229 | 260
abnormal behavior 203 | 226
decreased lean body mass 178 | 195
embryonic lethality prior to t... 178 | 187
decreased total body fat amoun... 168 | 186
decreased body weight 161 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 137 | 157
abnormal bone structure 116 | 131
decreased bone mineral density 113 | 126
increased or absent threshold ... 113 | 128
increased circulating alkaline... 108 | 119
decreased grip strength 106 | 123
abnormal embryo size 104 | 112
decreased circulating glucose ... 100 | 121
decreased body length 99 | 108
hyperactivity 96 | 108
abnormal retina morphology 93 | 100
increased lean body mass 92 | 107
enlarged heart 88 | 111
increased mean corpuscular hem... 88 | 93
increased mean corpuscular vol... 86 | 91
increased bone mineral content 82 | 92
decreased circulating choleste... 78 | 85
hypoactivity 76 | 89
short tibia 75 | 82
decreased circulating HDL chol... 71 | 77
decreased circulating triglyce... 70 | 83
increased grip strength 68 | 83
decreased circulating serum al... 67 | 79
abnormal lens morphology 66 | 73
increased fasted circulating g... 60 | 68
prenatal lethality prior to he... 59 | 64
decreased lumbar vertebrae num... 57 | 62
increased circulating HDL chol... 57 | 63
abnormal retinal pigmentation 56 | 61
increased sacral vertebrae num... 56 | 62
abnormal bone mineralization 53 | 55
decreased circulating insulin ... 53 | 75
increased circulating sodium l... 53 | 71
decreased rib number 52 | 59
increased total body fat amoun... 52 | 57
abnormal sleep behavior 51 | 63
male infertility 51 | 62
decreased leukocyte cell numbe... 49 | 54
abnormal coat-hair pigmentatio... 48 | 54
increased bone mineral density 47 | 52
increased circulating choleste... 47 | 53
decreased hemoglobin content 46 | 53
decreased mean corpuscular vol... 46 | 50
decreased circulating alanine ... 45 | 53
decreased prepulse inhibition 45 | 52
increased exploration in new e... 45 | 56
abnormal behavioral response t... 44 | 52
abnormal gait 44 | 51
impaired glucose tolerance 44 | 52
improved glucose tolerance 43 | 56
thrombocytopenia 43 | 46
decreased caudal vertebrae num... 42 | 49
decreased erythrocyte cell num... 42 | 43
decreased startle reflex 42 | 48
increased hemoglobin content 40 | 45
decreased fasted circulating g... 39 | 49
decreased heart weight 38 | 44
increased body weight 38 | 42
abnormal heart morphology 37 | 51
decreased circulating total pr... 37 | 41
increased circulating chloride... 37 | 43
decreased neutrophil cell numb... 35 | 37
increased blood urea nitrogen ... 35 | 44
abnormal neural tube closure 34 | 37
decreased circulating LDL chol... 34 | 37
decreased circulating free fat... 34 | 39
abnormal seminal vesicle morph... 33 | 47
increased rib number 33 | 41
abnormal eye morphology 32 | 38
abnormal spleen morphology 32 | 36
decreased circulating alkaline... 32 | 41
increased heart weight 32 | 37
increased leukocyte cell numbe... 32 | 37
decreased eosinophil cell numb... 31 | 41
increased hematocrit 31 | 36
increased startle reflex 31 | 38
tremors 31 | 34
cardiovascular system phenotyp... 30 | 35
decreased circulating creatini... 30 | 31
decreased mean corpuscular hem... 30 | 34
small testis 30 | 37
abnormal cranium morphology 29 | 32
limb grasping 29 | 35
decreased T cell number 28 | 31
decreased circulating chloride... 28 | 32
decreased circulating fructosa... 28 | 31
decreased circulating calcium ... 27 | 33
embryonic growth retardation 27 | 28
increased circulating potassiu... 27 | 31
decreased NK T cell number 26 | 28
decreased blood urea nitrogen ... 26 | 31
increased circulating calcium ... 26 | 32

Disease

ovarian cancer 7,624 | 8,491
osteosarcoma 7,018 | 7,933
medulloblastoma, large-cell 5,358 | 6,234
psoriasis 5,224 | 6,685
glioblastoma 4,877 | 5,572
lung cancer 4,026 | 4,473
atypical teratoid / rhabdoid tumor 3,790 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,882 | 3,289
malignant mesothelioma 2,808 | 3,163
Breast cancer 2,705 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 2,608 | 2,988
primitive neuroectodermal tumor 2,606 | 3,031
invasive ductal carcinoma 2,570 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,563 | 2,956
pilocytic astrocytoma 2,557 | 3,086
non-small cell lung cancer 2,430 | 2,798
oligodendroglioma 2,391 | 2,849
pediatric high grade glioma 2,349 | 2,712
lung carcinoma 2,343 | 2,844
lung adenocarcinoma 2,257 | 2,714
ependymoma 2,190 | 2,514
Cancer 2,013 | 2,346
pancreatic cancer 2,008 | 2,300
subependymal giant cell astrocytoma 1,992 | 2,287
group 3 medulloblastoma 1,961 | 2,254
interstitial cystitis 1,904 | 2,299
astrocytic glioma 1,902 | 2,241
ulcerative colitis 1,820 | 2,087
adult high grade glioma 1,767 | 2,148
Carcinoma 1,675 | 2,147
Pick disease 1,675 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,674 | 1,795
group 4 medulloblastoma 1,630 | 1,875
pituitary cancer 1,620 | 1,972
ductal carcinoma in situ 1,505 | 1,745
tuberculosis 1,419 | 1,563
cystic fibrosis 1,391 | 1,670
breast carcinoma 1,382 | 1,614
astrocytoma 1,356 | 1,493
medulloblastoma 1,318 | 1,524
Multiple myeloma 1,291 | 1,327
sonic hedgehog group medulloblastoma 1,276 | 1,482
diabetes mellitus 1,274 | 1,663
adrenocortical carcinoma 1,268 | 1,427
colon cancer 1,252 | 1,475
posterior fossa group A ependymoma 1,234 | 1,511
posterior fossa group B ependymoma 1,230 | 1,530
primary pancreatic ductal adenocarcinoma 1,167 | 1,271
juvenile dermatomyositis 1,122 | 1,189
acute quadriplegic myopathy 1,093 | 1,157
Rheumatoid Arthritis 1,060 | 1,170
spina bifida 954 | 1,064
dermatomyositis 929 | 966
atypical teratoid/rhabdoid tumor 924 | 1,095
cutaneous lupus erythematosus 885 | 1,056
nasopharyngeal carcinoma 877 | 1,056
active Crohn's disease 771 | 918
Waldenstrons macroglobulinemia 749 | 764
gastric carcinoma 736 | 832
Atopic dermatitis 735 | 944
acute myeloid leukemia 730 | 785
primary Sjogren syndrome 725 | 788
non primary Sjogren syndrome sicca 719 | 840
tuberculosis and treatment for 6 months 654 | 686
esophageal adenocarcinoma 627 | 737
progressive supranuclear palsy 615 | 674
aldosterone-producing adenoma 594 | 664
Duchenne muscular dystrophy 541 | 602
Alzheimer's disease 533 | 644
pancreatic carcinoma 522 | 567
hepatocellular carcinoma 518 | 550
Intellectual disability 508 | 573
Obesity 496 | 616
Down syndrome 485 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 465 | 499
fibroadenoma 458 | 557
Endometriosis 442 | 535
IGA Glomerulonephritis 432 | 454
chronic rhinosinusitis 420 | 512
mucosa-associated lymphoid tissue lymphoma 416 | 480
Prostatic Neoplasms 414 | 471
gastric cancer 400 | 436
active ulcerative colitis 393 | 477
Amyotrophic Lateral Sclerosis 387 | 432
Multiple Sclerosis 384 | 498
Schizophrenia 370 | 503
Mammary Neoplasms 357 | 410
Neurodegenerative disease 340 | 383
inflammatory breast cancer 332 | 404
sarcoidosis 325 | 368
non-small cell lung carcinoma 314 | 413
Kidney disease 312 | 397
hereditary spastic paraplegia 300 | 313
tuberculosis and treatment for 3 months 297 | 327
Polycystic Ovary Syndrome 287 | 334
glioblastoma multiforme 287 | 347
Parkinson's disease 279 | 364
nephrosclerosis 277 | 329
urothelial carcinoma 271 | 318
interstitial lung disease 264 | 292

Tissue

Nervous System 14,668 | 18,560
Female tissues 14,649 | 18,646
Digestive Tract 14,643 | 18,472
Endocrine System 14,635 | 18,511
Urinary Tract 14,601 | 18,443
Liver and Pancreas 14,584 | 18,135
Blood and immune system 14,576 | 17,994
Male tissues 14,566 | 17,968
Cardiovascular System 14,555 | 17,957
Skin and soft tissues 14,493 | 18,114
Respiratory system 14,423 | 17,483

Target Family

Non-IDG 8,599 | 11,969
Enzyme 3,472 | 4,146
Transcription Factor 1,117 | 1,400
Kinase 558 | 634
Transporter 356 | 473
GPCR 230 | 408
Epigenetic 220 | 242
Ion Channel 213 | 341
Nuclear Receptor 42 | 48
TF/Epigenetic 34 | 38
oGPCR 22 | 421

HCA RNA Cell Line

HL-60 14,863 | 14,863
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66