Development Level

Tbio 9,745 | 11,651
Tdark 3,666 | 6,593
Tchem 1,189 | 1,388
Tclin 441 | 612

Collection

RFA-RM-18-021 225 | 328
Kinase: IDG Consortium (Target... 108 | 125
Ion Channel: IDG Consortium (T... 64 | 99
GPCR: IDG Consortium (Targets) 61 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 930 | 979
preweaning lethality, incomple... 439 | 499
abnormal behavior 266 | 298
embryonic lethality prior to t... 262 | 278
embryonic lethality prior to o... 235 | 239
abnormal embryo size 205 | 220
decreased total body fat amoun... 177 | 207
enlarged heart 172 | 210
abnormal bone structure 163 | 187
increased lean body mass 152 | 172
decreased body weight 150 | 161
decreased vertical activity 149 | 208
abnormal heart morphology 135 | 162
hyperactivity 127 | 148
decreased bone mineral content 125 | 151
decreased lean body mass 119 | 135
increased total body fat amoun... 115 | 134
hypoactivity 108 | 132
decreased bone mineral density 107 | 126
decreased circulating glucose ... 107 | 126
increased circulating alkaline... 106 | 122
increased startle reflex 102 | 112
male infertility 101 | 123
embryonic growth retardation 99 | 106
decreased grip strength 98 | 116
increased bone mineral content 90 | 108
short tibia 89 | 97
decreased body length 88 | 101
increased mean corpuscular hem... 88 | 96
abnormal seminal vesicle morph... 87 | 114
increased mean corpuscular vol... 87 | 92
decreased circulating choleste... 85 | 93
increased or absent threshold ... 85 | 101
cataract 82 | 92
prenatal lethality prior to he... 81 | 87
abnormal lens morphology 75 | 81
decreased prepulse inhibition 73 | 82
decreased mean corpuscular vol... 71 | 79
decreased circulating triglyce... 70 | 79
decreased lymphocyte cell numb... 70 | 83
increased circulating HDL chol... 68 | 80
increased bone mineral density 67 | 72
decreased circulating serum al... 66 | 82
decreased leukocyte cell numbe... 66 | 73
increased fasted circulating g... 66 | 76
decreased circulating HDL chol... 64 | 68
improved glucose tolerance 64 | 79
abnormal retina morphology 63 | 71
abnormal eye morphology 61 | 68
decreased startle reflex 61 | 75
impaired glucose tolerance 61 | 75
small superior vagus ganglion 60 | 74
decreased erythrocyte cell num... 59 | 62
decreased hemoglobin content 59 | 68
abnormal sleep behavior 57 | 70
abnormal coat-hair pigmentatio... 56 | 64
decreased circulating insulin ... 56 | 76
increased circulating choleste... 56 | 66
abnormal gait 55 | 69
abnormal behavioral response t... 54 | 66
increased circulating sodium l... 54 | 71
increased monocyte cell number 54 | 63
edema 53 | 59
increased heart weight 53 | 62
decreased fasted circulating g... 52 | 65
abnormal spleen morphology 51 | 55
thrombocytopenia 51 | 56
decreased caudal vertebrae num... 50 | 53
abnormal kidney morphology 49 | 65
small testis 49 | 58
abnormal skin morphology 46 | 50
decreased mean corpuscular hem... 45 | 50
female infertility 44 | 60
abnormal neural tube closure 43 | 46
decreased circulating total pr... 43 | 49
hydrometra 43 | 53
decreased circulating alanine ... 42 | 47
decreased hematocrit 42 | 46
increased leukocyte cell numbe... 41 | 47
decreased blood urea nitrogen ... 40 | 51
decreased circulating alkaline... 40 | 46
increased blood urea nitrogen ... 40 | 48
increased hematocrit 40 | 46
increased hemoglobin content 40 | 45
increased neutrophil cell numb... 39 | 46
decreased red blood cell distr... 38 | 41
increased mean platelet volume 38 | 45
abnormal bone mineralization 37 | 38
decreased neutrophil cell numb... 37 | 42
tremors 37 | 39
enlarged spleen 36 | 41
abnormal testis morphology 35 | 43
decreased circulating LDL chol... 35 | 38
decreased circulating creatini... 35 | 39
increased circulating triglyce... 35 | 42
increased grip strength 35 | 41
limb grasping 35 | 41
abnormal epididymis morphology 34 | 42
increased circulating chloride... 34 | 41
increased erythrocyte cell num... 34 | 39

Disease

Carcinoma 9,173 | 11,493
ovarian cancer 7,730 | 8,520
osteosarcoma 7,104 | 7,950
medulloblastoma, large-cell 5,415 | 6,241
psoriasis 5,276 | 6,694
glioblastoma 5,108 | 5,792
atypical teratoid / rhabdoid tumor 4,471 | 5,112
lung cancer 4,226 | 4,740
ependymoma 3,961 | 4,679
group 3 medulloblastoma 3,567 | 4,104
adult high grade glioma 3,206 | 3,801
Breast cancer 3,115 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,911 | 3,291
malignant mesothelioma 2,894 | 3,232
primitive neuroectodermal tumor 2,641 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,631 | 2,989
invasive ductal carcinoma 2,599 | 2,951
Astrocytoma, Pilocytic 2,584 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 2,580 | 2,955
non-small cell lung cancer 2,523 | 2,890
oligodendroglioma 2,416 | 2,850
lung carcinoma 2,358 | 2,843
lung adenocarcinoma 2,279 | 2,716
astrocytic glioma 2,221 | 2,597
Cancer 2,155 | 2,499
Kidney cancer 2,117 | 2,613
pancreatic cancer 2,095 | 2,398
subependymal giant cell astrocytoma 2,011 | 2,287
interstitial cystitis 1,922 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,853 | 1,962
tuberculosis 1,845 | 2,010
Pick disease 1,690 | 1,894
group 4 medulloblastoma 1,637 | 1,855
pituitary cancer 1,633 | 1,972
ulcerative colitis 1,592 | 1,819
ductal carcinoma in situ 1,519 | 1,745
cystic fibrosis 1,424 | 1,696
breast carcinoma 1,419 | 1,638
diabetes mellitus 1,339 | 1,728
Multiple myeloma 1,307 | 1,332
adrenocortical carcinoma 1,286 | 1,428
colon cancer 1,264 | 1,478
Autosomal recessive predisposition 1,245 | 1,442
juvenile dermatomyositis 1,130 | 1,187
acute quadriplegic myopathy 1,101 | 1,158
Rheumatoid arthritis 1,086 | 1,191
astrocytoma 1,070 | 1,146
primary pancreatic ductal adenocarcinoma 1,017 | 1,109
spina bifida 975 | 1,074
pediatric high grade glioma 958 | 1,064
dermatomyositis 935 | 966
Intellectual disability 911 | 1,016
Schizophrenia 907 | 1,160
cutaneous lupus erythematosus 894 | 1,057
nasopharyngeal carcinoma 884 | 1,058
active Crohn's disease 780 | 922
non primary Sjogren syndrome sicca 776 | 891
Waldenstrons macroglobulinemia 757 | 765
Atopic dermatitis 749 | 952
acute myeloid leukemia 743 | 783
gastric carcinoma 716 | 807
Liver Cirrhosis, Experimental 703 | 769
Epilepsy 683 | 792
primary Sjogren syndrome 681 | 735
medulloblastoma 654 | 720
active ulcerative colitis 644 | 764
esophageal adenocarcinoma 630 | 737
progressive supranuclear palsy 620 | 676
aldosterone-producing adenoma 599 | 665
Dull intelligence 587 | 645
Low intelligence 587 | 645
Mental Retardation 587 | 645
Mental deficiency 587 | 645
Poor school performance 587 | 645
Cognitive delay 559 | 608
Global developmental delay 559 | 608
Mental and motor retardation 559 | 608
Alzheimer's disease 551 | 658
Duchenne muscular dystrophy 548 | 601
Obesity 544 | 678
Seizures 524 | 596
pancreatic carcinoma 522 | 562
Muscle hypotonia 521 | 571
hepatocellular carcinoma 519 | 547
Melanoma 509 | 711
Bipolar Disorder 494 | 666
Short stature 477 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 477 | 510
fibroadenoma 462 | 559
Liver cancer 459 | 604
Endometriosis 453 | 540
Down syndrome 444 | 499
Prostatic Neoplasms 438 | 495
gastric cancer 429 | 459
chronic rhinosinusitis 423 | 512
Multiple Sclerosis 422 | 540
mucosa-associated lymphoid tissue lymphoma 419 | 484
Amyotrophic lateral sclerosis 407 | 451
posterior fossa group A ependymoma 406 | 468
sonic hedgehog group medulloblastoma 404 | 467

Tissue

Endocrine System 14,789 | 18,159
Digestive Tract 14,668 | 17,369
Female tissues 14,649 | 17,400
Skin and soft tissues 14,621 | 17,230
Blood and immune system 14,539 | 16,909
Male tissues 14,529 | 17,142
Liver and Pancreas 14,498 | 16,750
Urinary Tract 14,441 | 16,678
Nervous System 14,426 | 16,725
Respiratory system 14,309 | 16,393
Cardiovascular System 13,658 | 15,192

Target Family

Non-IDG 8,731 | 12,091
Enzyme 3,497 | 4,145
Transcription Factor 1,120 | 1,400
Kinase 565 | 634
Transporter 356 | 473
GPCR 230 | 408
Epigenetic 226 | 242
Ion Channel 216 | 344
Nuclear Receptor 42 | 48
TF/Epigenetic 35 | 38
oGPCR 23 | 421

HCA RNA Cell Line

HL-60 15,041 | 15,041
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50