Development Level

Tbio 9,719 | 11,445
Tdark 3,799 | 6,588
Tchem 1,367 | 1,598
Tclin 461 | 613

Collection

RFA-RM-18-021 237 | 328
Kinase: IDG Consortium (Target... 113 | 125
Ion Channel: IDG Consortium (T... 67 | 99
GPCR: IDG Consortium (Targets) 64 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 934 | 979
preweaning lethality, incomple... 449 | 499
embryonic lethality prior to t... 271 | 278
abnormal behavior 264 | 298
embryonic lethality prior to o... 235 | 239
abnormal embryo size 209 | 220
decreased total body fat amoun... 184 | 207
enlarged heart 177 | 210
decreased vertical activity 164 | 208
abnormal bone structure 162 | 187
increased lean body mass 154 | 172
decreased body weight 148 | 161
abnormal heart morphology 139 | 162
hyperactivity 131 | 148
decreased bone mineral content 125 | 151
decreased lean body mass 120 | 135
increased total body fat amoun... 118 | 134
decreased circulating glucose ... 112 | 126
hypoactivity 109 | 132
embryonic growth retardation 104 | 106
decreased bone mineral density 103 | 126
increased circulating alkaline... 103 | 122
increased startle reflex 103 | 112
decreased grip strength 99 | 116
male infertility 97 | 123
increased bone mineral content 95 | 108
abnormal seminal vesicle morph... 93 | 114
increased or absent threshold ... 91 | 101
increased mean corpuscular hem... 89 | 96
decreased body length 88 | 101
increased mean corpuscular vol... 86 | 92
short tibia 86 | 97
prenatal lethality prior to he... 85 | 87
cataract 82 | 92
decreased circulating choleste... 81 | 93
abnormal lens morphology 76 | 81
decreased prepulse inhibition 76 | 82
decreased mean corpuscular vol... 72 | 79
decreased circulating triglyce... 71 | 79
decreased lymphocyte cell numb... 69 | 83
increased fasted circulating g... 69 | 76
increased bone mineral density 68 | 72
decreased leukocyte cell numbe... 67 | 73
increased circulating HDL chol... 67 | 80
decreased circulating serum al... 65 | 82
impaired glucose tolerance 65 | 75
abnormal sleep behavior 64 | 70
abnormal eye morphology 63 | 68
abnormal retina morphology 63 | 71
decreased startle reflex 63 | 75
increased circulating sodium l... 63 | 71
decreased circulating HDL chol... 62 | 68
decreased hemoglobin content 61 | 68
small superior vagus ganglion 61 | 74
decreased circulating insulin ... 60 | 76
abnormal coat-hair pigmentatio... 59 | 64
abnormal gait 59 | 69
decreased erythrocyte cell num... 59 | 62
improved glucose tolerance 59 | 79
abnormal behavioral response t... 58 | 66
increased circulating choleste... 58 | 66
increased heart weight 57 | 62
abnormal kidney morphology 55 | 65
decreased fasted circulating g... 55 | 65
edema 54 | 59
increased monocyte cell number 52 | 63
thrombocytopenia 52 | 56
small testis 50 | 58
decreased caudal vertebrae num... 48 | 53
decreased mean corpuscular hem... 48 | 50
abnormal spleen morphology 46 | 55
decreased blood urea nitrogen ... 46 | 51
hydrometra 46 | 53
decreased circulating alanine ... 44 | 47
decreased hematocrit 44 | 46
female infertility 44 | 60
abnormal neural tube closure 43 | 46
decreased circulating total pr... 43 | 49
abnormal skin morphology 41 | 50
decreased circulating alkaline... 41 | 46
increased hematocrit 41 | 46
increased hemoglobin content 41 | 45
increased neutrophil cell numb... 41 | 46
increased blood urea nitrogen ... 40 | 48
increased leukocyte cell numbe... 39 | 47
increased mean platelet volume 39 | 45
decreased red blood cell distr... 38 | 41
decreased neutrophil cell numb... 37 | 42
increased circulating chloride... 37 | 41
tremors 37 | 39
abnormal bone mineralization 36 | 38
abnormal testis morphology 36 | 43
increased circulating triglyce... 36 | 42
increased erythrocyte cell num... 36 | 39
enlarged spleen 35 | 41
increased mean corpuscular hem... 35 | 36
limb grasping 35 | 41
decreased circulating LDL chol... 34 | 38
increased grip strength 34 | 41
prolonged QT interval 33 | 38

Disease

Carcinoma 9,357 | 11,493
ovarian cancer 7,784 | 8,520
osteosarcoma 7,208 | 7,950
medulloblastoma, large-cell 5,505 | 6,241
psoriasis 5,328 | 6,694
glioblastoma 5,180 | 5,792
atypical teratoid / rhabdoid tumor 4,561 | 5,112
lung cancer 4,240 | 4,740
ependymoma 4,066 | 4,679
group 3 medulloblastoma 3,623 | 4,104
adult high grade glioma 3,267 | 3,801
Breast cancer 3,135 | 3,578
malignant mesothelioma 2,935 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,929 | 3,291
primitive neuroectodermal tumor 2,680 | 3,035
Astrocytoma, Pilocytic 2,640 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,624 | 2,989
invasive ductal carcinoma 2,601 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,569 | 2,955
non-small cell lung cancer 2,527 | 2,890
oligodendroglioma 2,473 | 2,850
lung carcinoma 2,367 | 2,843
lung adenocarcinoma 2,287 | 2,716
astrocytic glioma 2,274 | 2,597
Kidney cancer 2,185 | 2,613
Cancer 2,140 | 2,499
pancreatic cancer 2,121 | 2,398
subependymal giant cell astrocytoma 2,052 | 2,287
interstitial cystitis 1,921 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,852 | 1,962
tuberculosis 1,834 | 2,010
Pick disease 1,717 | 1,894
pituitary cancer 1,660 | 1,972
group 4 medulloblastoma 1,657 | 1,855
ulcerative colitis 1,590 | 1,819
ductal carcinoma in situ 1,507 | 1,745
cystic fibrosis 1,406 | 1,696
breast carcinoma 1,392 | 1,638
diabetes mellitus 1,333 | 1,728
adrenocortical carcinoma 1,308 | 1,428
Multiple myeloma 1,306 | 1,332
colon cancer 1,260 | 1,478
Autosomal recessive predisposition 1,252 | 1,442
juvenile dermatomyositis 1,116 | 1,187
acute quadriplegic myopathy 1,092 | 1,158
Rheumatoid arthritis 1,084 | 1,191
astrocytoma 1,064 | 1,146
primary pancreatic ductal adenocarcinoma 1,002 | 1,109
spina bifida 978 | 1,074
pediatric high grade glioma 966 | 1,064
dermatomyositis 936 | 966
Schizophrenia 921 | 1,160
Intellectual disability 916 | 1,016
cutaneous lupus erythematosus 898 | 1,057
nasopharyngeal carcinoma 876 | 1,058
active Crohn's disease 805 | 922
non primary Sjogren syndrome sicca 780 | 891
acute myeloid leukemia 757 | 783
Waldenstrons macroglobulinemia 751 | 765
Atopic dermatitis 735 | 952
gastric carcinoma 707 | 807
Epilepsy 696 | 792
Liver Cirrhosis, Experimental 696 | 769
primary Sjogren syndrome 671 | 735
active ulcerative colitis 652 | 764
esophageal adenocarcinoma 637 | 737
medulloblastoma 636 | 720
progressive supranuclear palsy 630 | 676
aldosterone-producing adenoma 603 | 665
Dull intelligence 588 | 645
Low intelligence 588 | 645
Mental Retardation 588 | 645
Mental deficiency 588 | 645
Poor school performance 588 | 645
Cognitive delay 569 | 608
Global developmental delay 569 | 608
Mental and motor retardation 569 | 608
Alzheimer's disease 560 | 658
Obesity 546 | 678
pancreatic carcinoma 538 | 562
Duchenne muscular dystrophy 533 | 601
Seizures 530 | 596
Melanoma 527 | 711
Muscle hypotonia 526 | 571
hepatocellular carcinoma 524 | 547
Bipolar Disorder 505 | 666
Liver cancer 487 | 604
Short stature 483 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 463 | 510
Endometriosis 457 | 540
fibroadenoma 450 | 559
Down syndrome 436 | 499
gastric cancer 436 | 459
Prostatic Neoplasms 435 | 495
chronic rhinosinusitis 419 | 512
Multiple Sclerosis 414 | 540
mucosa-associated lymphoid tissue lymphoma 414 | 484
Amyotrophic lateral sclerosis 412 | 451
tuberculosis and treatment for 6 months 403 | 409
sonic hedgehog group medulloblastoma 402 | 467

Tissue

Endocrine System 15,084 | 18,159
Digestive Tract 14,904 | 17,369
Female tissues 14,899 | 17,400
Skin and soft tissues 14,871 | 17,230
Male tissues 14,776 | 17,142
Blood and immune system 14,767 | 16,909
Liver and Pancreas 14,678 | 16,750
Nervous System 14,648 | 16,725
Urinary Tract 14,629 | 16,678
Respiratory system 14,526 | 16,393
Cardiovascular System 13,816 | 15,192

Target Family

Non-IDG 8,915 | 12,091
Enzyme 3,546 | 4,145
Transcription Factor 1,142 | 1,400
Kinase 577 | 634
Transporter 371 | 473
Ion Channel 234 | 344
GPCR 233 | 408
Epigenetic 226 | 242
Nuclear Receptor 38 | 48
TF/Epigenetic 33 | 38
oGPCR 31 | 421

HCA RNA Cell Line

HEL 15,346 | 15,346
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29