Development Level

Tbio 9,199 | 10,625
Tdark 4,380 | 7,003
Tchem 1,601 | 1,890
Tclin 487 | 602

Collection

Kinase: IDG Consortium (Targets) 114 | 125
Ion Channel: IDG Consortium (Targets) 84 | 102
GPCR: IDG Consortium (Targets) 68 | 128
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 15 | 24

IMPC Phenotype

preweaning lethality, complete... 610 | 633
preweaning lethality, incomple... 243 | 260
abnormal behavior 216 | 226
embryonic lethality prior to t... 185 | 187
decreased lean body mass 184 | 195
decreased total body fat amoun... 174 | 186
decreased body weight 167 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 147 | 157
abnormal bone structure 120 | 131
decreased bone mineral density 119 | 126
increased or absent threshold ... 115 | 128
increased circulating alkaline... 111 | 119
abnormal embryo size 108 | 112
decreased grip strength 105 | 123
decreased body length 103 | 108
hyperactivity 103 | 108
decreased circulating glucose ... 101 | 121
increased lean body mass 96 | 107
abnormal retina morphology 94 | 100
enlarged heart 91 | 111
increased mean corpuscular hem... 88 | 93
increased bone mineral content 86 | 92
increased mean corpuscular vol... 85 | 91
hypoactivity 83 | 89
decreased circulating choleste... 79 | 85
decreased circulating triglyce... 75 | 83
short tibia 75 | 82
decreased circulating serum al... 74 | 79
increased grip strength 73 | 83
decreased circulating HDL chol... 72 | 77
abnormal lens morphology 66 | 73
increased fasted circulating g... 63 | 68
prenatal lethality prior to he... 61 | 64
decreased lumbar vertebrae num... 60 | 62
increased circulating sodium l... 60 | 71
decreased circulating insulin ... 59 | 75
increased sacral vertebrae num... 59 | 62
decreased rib number 56 | 59
abnormal retinal pigmentation 55 | 61
abnormal bone mineralization 54 | 55
male infertility 53 | 62
abnormal sleep behavior 52 | 63
increased circulating HDL chol... 52 | 63
increased total body fat amoun... 52 | 57
abnormal gait 49 | 51
decreased leukocyte cell numbe... 49 | 54
abnormal coat-hair pigmentatio... 48 | 54
decreased prepulse inhibition 48 | 52
impaired glucose tolerance 48 | 52
increased bone mineral density 48 | 52
increased exploration in new e... 48 | 56
decreased circulating alanine ... 47 | 53
decreased hemoglobin content 47 | 53
decreased mean corpuscular vol... 47 | 50
increased circulating choleste... 46 | 53
abnormal behavioral response t... 45 | 52
decreased startle reflex 45 | 48
improved glucose tolerance 45 | 56
decreased caudal vertebrae num... 44 | 49
decreased fasted circulating g... 43 | 49
thrombocytopenia 43 | 46
abnormal heart morphology 42 | 51
decreased erythrocyte cell num... 41 | 43
increased body weight 41 | 42
decreased heart weight 40 | 44
increased blood urea nitrogen ... 40 | 44
decreased circulating total pr... 39 | 41
increased circulating chloride... 39 | 43
increased hemoglobin content 39 | 45
decreased eosinophil cell numb... 38 | 41
increased rib number 38 | 41
abnormal seminal vesicle morph... 37 | 47
abnormal eye morphology 36 | 38
decreased circulating alkaline... 36 | 41
abnormal neural tube closure 35 | 37
decreased circulating LDL chol... 35 | 37
increased startle reflex 35 | 38
decreased circulating free fat... 34 | 39
increased leukocyte cell numbe... 34 | 37
limb grasping 34 | 35
decreased neutrophil cell numb... 33 | 37
increased heart weight 33 | 37
small testis 33 | 37
abnormal cranium morphology 31 | 32
abnormal spleen morphology 31 | 36
decreased mean corpuscular hem... 31 | 34
cardiovascular system phenotyp... 30 | 35
tremors 30 | 34
decreased T cell number 29 | 31
decreased circulating calcium ... 29 | 33
decreased circulating fructosa... 29 | 31
abnormal testis morphology 28 | 30
decreased blood urea nitrogen ... 28 | 31
female infertility 28 | 34
increased circulating calcium ... 28 | 32
decreased circulating chloride... 27 | 32
embryonic growth retardation 27 | 28
increased hematocrit 27 | 36
decreased circulating aspartat... 26 | 27

Disease

ovarian cancer 7,845 | 8,491
osteosarcoma 7,146 | 7,933
medulloblastoma, large-cell 5,673 | 6,234
psoriasis 5,500 | 6,685
glioblastoma 5,122 | 5,572
lung cancer 4,086 | 4,473
atypical teratoid / rhabdoid tumor 4,049 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,978 | 3,289
malignant mesothelioma 2,963 | 3,163
Breast cancer 2,843 | 3,098
primitive neuroectodermal tumor 2,809 | 3,031
pilocytic astrocytoma 2,748 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 2,690 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,665 | 2,956
invasive ductal carcinoma 2,656 | 2,950
oligodendroglioma 2,624 | 2,849
pediatric high grade glioma 2,489 | 2,712
non-small cell lung cancer 2,448 | 2,798
lung carcinoma 2,407 | 2,844
lung adenocarcinoma 2,342 | 2,714
ependymoma 2,341 | 2,514
subependymal giant cell astrocytoma 2,112 | 2,287
group 3 medulloblastoma 2,079 | 2,254
astrocytic glioma 2,074 | 2,241
pancreatic cancer 2,050 | 2,300
Cancer 2,027 | 2,346
interstitial cystitis 1,922 | 2,299
adult high grade glioma 1,879 | 2,148
Carcinoma 1,831 | 2,147
ulcerative colitis 1,784 | 2,087
Pick disease 1,777 | 1,893
pituitary cancer 1,770 | 1,972
group 4 medulloblastoma 1,750 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,653 | 1,795
ductal carcinoma in situ 1,575 | 1,745
cystic fibrosis 1,465 | 1,670
breast carcinoma 1,442 | 1,614
medulloblastoma 1,408 | 1,524
astrocytoma 1,390 | 1,493
tuberculosis 1,387 | 1,563
posterior fossa group B ependymoma 1,378 | 1,530
sonic hedgehog group medulloblastoma 1,362 | 1,482
posterior fossa group A ependymoma 1,342 | 1,511
colon cancer 1,295 | 1,475
diabetes mellitus 1,287 | 1,663
adrenocortical carcinoma 1,282 | 1,427
Multiple myeloma 1,281 | 1,327
primary pancreatic ductal adenocarcinoma 1,184 | 1,271
juvenile dermatomyositis 1,109 | 1,189
acute quadriplegic myopathy 1,099 | 1,157
Rheumatoid Arthritis 1,047 | 1,170
atypical teratoid/rhabdoid tumor 1,007 | 1,095
spina bifida 982 | 1,064
dermatomyositis 929 | 966
nasopharyngeal carcinoma 896 | 1,056
cutaneous lupus erythematosus 842 | 1,056
active Crohn's disease 797 | 918
Atopic dermatitis 775 | 944
gastric carcinoma 764 | 832
non primary Sjogren syndrome sicca 741 | 840
acute myeloid leukemia 739 | 785
Waldenstrons macroglobulinemia 725 | 764
primary Sjogren syndrome 657 | 788
tuberculosis and treatment for 6 months 647 | 686
progressive supranuclear palsy 635 | 674
esophageal adenocarcinoma 626 | 737
aldosterone-producing adenoma 620 | 664
Alzheimer's disease 558 | 644
Duchenne muscular dystrophy 541 | 602
Intellectual disability 535 | 573
pancreatic carcinoma 511 | 567
Obesity 508 | 616
Down syndrome 504 | 548
hepatocellular carcinoma 501 | 550
fibroadenoma 491 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 473 | 499
Endometriosis 470 | 535
chronic rhinosinusitis 438 | 512
Prostatic Neoplasms 421 | 471
Schizophrenia 413 | 503
IGA Glomerulonephritis 405 | 454
active ulcerative colitis 403 | 477
Amyotrophic Lateral Sclerosis 396 | 432
Multiple Sclerosis 394 | 498
gastric cancer 391 | 436
mucosa-associated lymphoid tissue lymphoma 376 | 480
Mammary Neoplasms 368 | 410
Neurodegenerative disease 355 | 383
inflammatory breast cancer 343 | 404
non-small cell lung carcinoma 336 | 413
Parkinson's disease 314 | 364
Kidney disease 313 | 397
glioblastoma multiforme 312 | 347
sarcoidosis 305 | 368
Polycystic Ovary Syndrome 303 | 334
hereditary spastic paraplegia 302 | 313
Epilepsy 299 | 346
tuberculosis and treatment for 3 months 294 | 327
urothelial carcinoma 281 | 318
nephrosclerosis 268 | 329

Tissue

Nervous System 15,454 | 18,560
Female tissues 15,433 | 18,646
Digestive Tract 15,413 | 18,472
Endocrine System 15,406 | 18,511
Urinary Tract 15,365 | 18,443
Liver and Pancreas 15,350 | 18,135
Male tissues 15,334 | 17,968
Cardiovascular System 15,314 | 17,957
Blood and immune system 15,303 | 17,994
Skin and soft tissues 15,255 | 18,114
Respiratory system 15,143 | 17,483

Target Family

Non-IDG 9,001 | 11,969
Enzyme 3,568 | 4,146
Transcription Factor 1,281 | 1,400
Kinase 590 | 634
Transporter 390 | 473
Ion Channel 274 | 341
GPCR 251 | 408
Epigenetic 223 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 33 | 38
oGPCR 11 | 421

HCA RNA Cell Line

HEK 293 15,667 | 15,667
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66