Development Level

Tbio 10,134 | 11,651
Tdark 3,935 | 6,593
Tchem 1,211 | 1,388
Tclin 472 | 612

Collection

Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 67 | 99
GPCR: IDG Consortium (Targets) 64 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 937 | 979
preweaning lethality, incomple... 447 | 499
abnormal behavior 273 | 298
embryonic lethality prior to t... 272 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 210 | 220
decreased total body fat amoun... 194 | 207
enlarged heart 174 | 210
abnormal bone structure 172 | 187
increased lean body mass 159 | 172
decreased vertical activity 158 | 208
decreased body weight 154 | 161
abnormal heart morphology 136 | 162
hyperactivity 133 | 148
decreased bone mineral content 130 | 151
decreased lean body mass 123 | 135
increased total body fat amoun... 122 | 134
hypoactivity 117 | 132
increased circulating alkaline... 117 | 122
decreased circulating glucose ... 114 | 126
decreased bone mineral density 112 | 126
male infertility 105 | 123
decreased grip strength 102 | 116
embryonic growth retardation 102 | 106
increased startle reflex 102 | 112
increased bone mineral content 98 | 108
increased or absent threshold ... 95 | 101
decreased body length 92 | 101
increased mean corpuscular hem... 90 | 96
abnormal seminal vesicle morph... 88 | 114
cataract 88 | 92
decreased circulating choleste... 88 | 93
increased mean corpuscular vol... 88 | 92
short tibia 88 | 97
prenatal lethality prior to he... 85 | 87
decreased prepulse inhibition 78 | 82
abnormal lens morphology 77 | 81
decreased lymphocyte cell numb... 75 | 83
increased circulating HDL chol... 74 | 80
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 73 | 79
decreased circulating serum al... 72 | 82
impaired glucose tolerance 69 | 75
decreased startle reflex 68 | 75
increased fasted circulating g... 68 | 76
decreased circulating HDL chol... 67 | 68
decreased leukocyte cell numbe... 67 | 73
increased bone mineral density 67 | 72
abnormal retina morphology 66 | 71
improved glucose tolerance 65 | 79
small superior vagus ganglion 65 | 74
abnormal sleep behavior 62 | 70
increased circulating choleste... 62 | 66
abnormal eye morphology 61 | 68
abnormal gait 61 | 69
decreased circulating insulin ... 61 | 76
decreased hemoglobin content 61 | 68
increased circulating sodium l... 61 | 71
abnormal behavioral response t... 60 | 66
abnormal coat-hair pigmentatio... 60 | 64
increased heart weight 60 | 62
decreased erythrocyte cell num... 59 | 62
decreased fasted circulating g... 59 | 65
edema 56 | 59
thrombocytopenia 54 | 56
increased monocyte cell number 53 | 63
small testis 52 | 58
abnormal kidney morphology 51 | 65
decreased caudal vertebrae num... 50 | 53
abnormal spleen morphology 48 | 55
female infertility 48 | 60
hydrometra 48 | 53
decreased blood urea nitrogen ... 47 | 51
decreased mean corpuscular hem... 47 | 50
decreased circulating alanine ... 46 | 47
abnormal neural tube closure 44 | 46
decreased circulating alkaline... 44 | 46
increased blood urea nitrogen ... 44 | 48
decreased circulating total pr... 43 | 49
decreased hematocrit 43 | 46
increased leukocyte cell numbe... 43 | 47
increased neutrophil cell numb... 43 | 46
abnormal skin morphology 42 | 50
increased hematocrit 41 | 46
increased hemoglobin content 41 | 45
increased mean platelet volume 41 | 45
decreased red blood cell distr... 39 | 41
increased circulating triglyce... 39 | 42
tremors 39 | 39
abnormal bone mineralization 38 | 38
abnormal testis morphology 38 | 43
enlarged spleen 37 | 41
increased circulating chloride... 37 | 41
increased erythrocyte cell num... 37 | 39
decreased circulating LDL chol... 36 | 38
decreased neutrophil cell numb... 36 | 42
increased circulating creatini... 36 | 38
increased grip strength 36 | 41
limb grasping 36 | 41
decreased circulating creatini... 35 | 39

Disease

Carcinoma 9,552 | 11,493
ovarian cancer 7,911 | 8,520
osteosarcoma 7,226 | 7,950
medulloblastoma, large-cell 5,610 | 6,241
psoriasis 5,499 | 6,694
glioblastoma 5,259 | 5,792
atypical teratoid / rhabdoid tumor 4,618 | 5,112
lung cancer 4,297 | 4,740
ependymoma 4,178 | 4,679
group 3 medulloblastoma 3,701 | 4,104
adult high grade glioma 3,334 | 3,801
Breast cancer 3,233 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,028 | 3,291
malignant mesothelioma 3,024 | 3,232
primitive neuroectodermal tumor 2,730 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,729 | 2,989
Astrocytoma, Pilocytic 2,709 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 2,689 | 2,955
invasive ductal carcinoma 2,688 | 2,951
non-small cell lung cancer 2,591 | 2,890
oligodendroglioma 2,533 | 2,850
lung carcinoma 2,447 | 2,843
lung adenocarcinoma 2,368 | 2,716
astrocytic glioma 2,316 | 2,597
Kidney cancer 2,210 | 2,613
Cancer 2,197 | 2,499
pancreatic cancer 2,172 | 2,398
subependymal giant cell astrocytoma 2,088 | 2,287
interstitial cystitis 1,989 | 2,312
tuberculosis 1,842 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,839 | 1,962
Pick disease 1,743 | 1,894
pituitary cancer 1,721 | 1,972
group 4 medulloblastoma 1,704 | 1,855
ulcerative colitis 1,627 | 1,819
ductal carcinoma in situ 1,573 | 1,745
cystic fibrosis 1,487 | 1,696
breast carcinoma 1,470 | 1,638
diabetes mellitus 1,397 | 1,728
adrenocortical carcinoma 1,321 | 1,428
colon cancer 1,309 | 1,478
Multiple myeloma 1,308 | 1,332
Autosomal recessive predisposition 1,271 | 1,442
juvenile dermatomyositis 1,147 | 1,187
Rheumatoid arthritis 1,108 | 1,191
acute quadriplegic myopathy 1,108 | 1,158
astrocytoma 1,083 | 1,146
primary pancreatic ductal adenocarcinoma 1,044 | 1,109
spina bifida 994 | 1,074
pediatric high grade glioma 982 | 1,064
Schizophrenia 948 | 1,160
dermatomyositis 944 | 966
Intellectual disability 939 | 1,016
nasopharyngeal carcinoma 916 | 1,058
cutaneous lupus erythematosus 905 | 1,057
active Crohn's disease 825 | 922
non primary Sjogren syndrome sicca 799 | 891
Atopic dermatitis 782 | 952
acute myeloid leukemia 745 | 783
Waldenstrons macroglobulinemia 744 | 765
gastric carcinoma 744 | 807
Epilepsy 694 | 792
Liver Cirrhosis, Experimental 685 | 769
primary Sjogren syndrome 677 | 735
active ulcerative colitis 672 | 764
esophageal adenocarcinoma 659 | 737
medulloblastoma 651 | 720
progressive supranuclear palsy 634 | 676
aldosterone-producing adenoma 613 | 665
Dull intelligence 599 | 645
Low intelligence 599 | 645
Mental Retardation 599 | 645
Mental deficiency 599 | 645
Poor school performance 599 | 645
Obesity 579 | 678
Cognitive delay 574 | 608
Global developmental delay 574 | 608
Mental and motor retardation 574 | 608
Alzheimer's disease 566 | 658
Duchenne muscular dystrophy 554 | 601
Muscle hypotonia 537 | 571
Bipolar Disorder 536 | 666
Seizures 529 | 596
Melanoma 523 | 711
hepatocellular carcinoma 518 | 547
pancreatic carcinoma 515 | 562
Short stature 490 | 531
fibroadenoma 490 | 559
Liver cancer 488 | 604
Endometriosis 478 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 478 | 510
Down syndrome 459 | 499
Multiple Sclerosis 450 | 540
Prostatic Neoplasms 447 | 495
chronic rhinosinusitis 436 | 512
gastric cancer 425 | 459
sonic hedgehog group medulloblastoma 422 | 467
posterior fossa group A ependymoma 420 | 468
Amyotrophic lateral sclerosis 409 | 451
mucosa-associated lymphoid tissue lymphoma 408 | 484

Tissue

Endocrine System 15,464 | 18,159
Female tissues 15,238 | 17,400
Digestive Tract 15,235 | 17,369
Skin and soft tissues 15,186 | 17,230
Male tissues 15,110 | 17,142
Blood and immune system 15,093 | 16,909
Nervous System 14,993 | 16,725
Liver and Pancreas 14,969 | 16,750
Urinary Tract 14,923 | 16,678
Respiratory system 14,809 | 16,393
Cardiovascular System 14,023 | 15,192

Target Family

Non-IDG 9,199 | 12,091
Enzyme 3,595 | 4,145
Transcription Factor 1,184 | 1,400
Kinase 585 | 634
Transporter 373 | 473
GPCR 246 | 408
Ion Channel 232 | 344
Epigenetic 229 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38
oGPCR 25 | 421

HCA RNA Cell Line

HDLM-2 15,752 | 15,752
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50