Development Level

Tbio 8,846 | 10,625
Tdark 4,190 | 7,003
Tchem 1,564 | 1,890
Tclin 432 | 602

Collection

Kinase: IDG Consortium (Targets) 110 | 125
Ion Channel: IDG Consortium (Targets) 69 | 102
GPCR: IDG Consortium (Targets) 62 | 127
Kinase: IDG Consortium (Complete/Control) 32 | 37
GPCR: IDG Consortium (Complete/Control) 18 | 26

IMPC Phenotype

preweaning lethality, complete... 601 | 633
preweaning lethality, incomple... 233 | 260
abnormal behavior 203 | 226
embryonic lethality prior to t... 182 | 187
decreased lean body mass 177 | 195
decreased total body fat amoun... 171 | 186
decreased body weight 161 | 174
embryonic lethality prior to o... 147 | 148
decreased bone mineral content 141 | 157
abnormal bone structure 117 | 131
decreased bone mineral density 111 | 126
increased or absent threshold ... 111 | 128
increased circulating alkaline... 109 | 119
abnormal embryo size 106 | 112
decreased body length 101 | 108
decreased grip strength 99 | 123
decreased circulating glucose ... 98 | 121
hyperactivity 97 | 108
increased lean body mass 94 | 107
abnormal retina morphology 92 | 100
enlarged heart 92 | 111
increased bone mineral content 85 | 92
increased mean corpuscular vol... 84 | 91
increased mean corpuscular hem... 83 | 93
decreased circulating choleste... 78 | 85
hypoactivity 78 | 89
short tibia 73 | 82
increased grip strength 72 | 83
decreased circulating HDL chol... 70 | 77
decreased circulating triglyce... 70 | 83
decreased circulating serum al... 69 | 79
abnormal lens morphology 66 | 73
prenatal lethality prior to he... 60 | 64
decreased circulating insulin ... 59 | 75
increased fasted circulating g... 59 | 68
abnormal retinal pigmentation 57 | 61
decreased lumbar vertebrae num... 57 | 62
increased sacral vertebrae num... 56 | 62
increased circulating sodium l... 54 | 71
male infertility 54 | 62
abnormal bone mineralization 52 | 55
decreased rib number 52 | 59
abnormal sleep behavior 51 | 63
decreased prepulse inhibition 50 | 52
increased bone mineral density 48 | 52
abnormal coat-hair pigmentatio... 47 | 54
decreased hemoglobin content 47 | 53
decreased mean corpuscular vol... 47 | 50
impaired glucose tolerance 47 | 52
increased circulating HDL chol... 47 | 63
increased total body fat amoun... 47 | 57
decreased circulating alanine ... 46 | 53
decreased leukocyte cell numbe... 46 | 54
decreased startle reflex 46 | 48
improved glucose tolerance 45 | 56
increased exploration in new e... 45 | 56
abnormal behavioral response t... 44 | 52
abnormal gait 43 | 51
decreased caudal vertebrae num... 43 | 49
increased circulating choleste... 43 | 53
abnormal heart morphology 42 | 51
decreased fasted circulating g... 40 | 49
decreased circulating total pr... 39 | 41
decreased erythrocyte cell num... 39 | 43
decreased heart weight 39 | 44
increased body weight 39 | 42
thrombocytopenia 39 | 46
increased blood urea nitrogen ... 38 | 44
increased hemoglobin content 38 | 45
abnormal neural tube closure 35 | 37
decreased circulating LDL chol... 35 | 37
decreased neutrophil cell numb... 35 | 37
increased rib number 35 | 41
increased startle reflex 35 | 38
small testis 35 | 37
decreased circulating free fat... 34 | 39
decreased eosinophil cell numb... 34 | 41
increased leukocyte cell numbe... 34 | 37
abnormal eye morphology 33 | 38
decreased circulating alkaline... 33 | 41
increased circulating chloride... 33 | 43
abnormal seminal vesicle morph... 32 | 47
decreased mean corpuscular hem... 32 | 34
increased heart weight 32 | 37
tremors 31 | 34
abnormal cranium morphology 30 | 32
cardiovascular system phenotyp... 30 | 35
decreased circulating chloride... 30 | 32
decreased circulating creatini... 30 | 31
limb grasping 30 | 35
abnormal testis morphology 29 | 30
decreased circulating fructosa... 29 | 31
increased circulating calcium ... 29 | 32
increased hematocrit 29 | 36
abnormal spleen morphology 28 | 36
decreased T cell number 28 | 31
decreased circulating calcium ... 28 | 33
decreased threshold for audito... 28 | 32
increased circulating potassiu... 28 | 31
embryonic growth retardation 27 | 28

Disease

ovarian cancer 7,729 | 8,491
osteosarcoma 7,003 | 7,933
medulloblastoma, large-cell 5,484 | 6,234
psoriasis 5,259 | 6,685
glioblastoma 4,961 | 5,572
lung cancer 4,041 | 4,473
atypical teratoid / rhabdoid tumor 3,899 | 4,369
malignant mesothelioma 2,968 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 2,916 | 3,289
Breast cancer 2,791 | 3,098
primitive neuroectodermal tumor 2,671 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,634 | 2,988
pilocytic astrocytoma 2,625 | 3,086
invasive ductal carcinoma 2,620 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,593 | 2,956
oligodendroglioma 2,501 | 2,849
pediatric high grade glioma 2,410 | 2,712
non-small cell lung cancer 2,408 | 2,798
lung carcinoma 2,344 | 2,844
lung adenocarcinoma 2,284 | 2,714
ependymoma 2,253 | 2,514
pancreatic cancer 2,024 | 2,300
subependymal giant cell astrocytoma 2,008 | 2,287
group 3 medulloblastoma 2,006 | 2,254
astrocytic glioma 1,975 | 2,241
Cancer 1,935 | 2,346
interstitial cystitis 1,877 | 2,299
adult high grade glioma 1,799 | 2,148
ulcerative colitis 1,799 | 2,087
Carcinoma 1,758 | 2,147
Pick disease 1,729 | 1,893
group 4 medulloblastoma 1,691 | 1,875
pituitary cancer 1,683 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,626 | 1,795
ductal carcinoma in situ 1,535 | 1,745
cystic fibrosis 1,495 | 1,670
breast carcinoma 1,409 | 1,614
astrocytoma 1,362 | 1,493
tuberculosis 1,357 | 1,563
medulloblastoma 1,328 | 1,524
posterior fossa group B ependymoma 1,327 | 1,530
sonic hedgehog group medulloblastoma 1,317 | 1,482
posterior fossa group A ependymoma 1,287 | 1,511
Multiple myeloma 1,282 | 1,327
adrenocortical carcinoma 1,280 | 1,427
colon cancer 1,275 | 1,475
diabetes mellitus 1,207 | 1,663
primary pancreatic ductal adenocarcinoma 1,174 | 1,271
juvenile dermatomyositis 1,119 | 1,189
acute quadriplegic myopathy 1,091 | 1,157
Rheumatoid Arthritis 998 | 1,170
spina bifida 964 | 1,064
atypical teratoid/rhabdoid tumor 957 | 1,095
dermatomyositis 888 | 966
nasopharyngeal carcinoma 883 | 1,056
cutaneous lupus erythematosus 844 | 1,056
active Crohn's disease 795 | 918
Atopic dermatitis 759 | 944
gastric carcinoma 742 | 832
acute myeloid leukemia 729 | 785
Waldenstrons macroglobulinemia 725 | 764
non primary Sjogren syndrome sicca 722 | 840
primary Sjogren syndrome 663 | 788
tuberculosis and treatment for 6 months 652 | 686
esophageal adenocarcinoma 629 | 737
progressive supranuclear palsy 628 | 674
aldosterone-producing adenoma 608 | 664
Alzheimer's disease 551 | 644
Duchenne muscular dystrophy 537 | 602
pancreatic carcinoma 515 | 567
Intellectual disability 507 | 573
hepatocellular carcinoma 507 | 550
Obesity 490 | 616
Down syndrome 483 | 548
fibroadenoma 470 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 464 | 499
Endometriosis 450 | 535
chronic rhinosinusitis 436 | 512
IGA Glomerulonephritis 412 | 454
Prostatic Neoplasms 406 | 471
active ulcerative colitis 398 | 477
Amyotrophic Lateral Sclerosis 395 | 432
gastric cancer 395 | 436
mucosa-associated lymphoid tissue lymphoma 386 | 480
Schizophrenia 380 | 503
Multiple Sclerosis 374 | 498
Mammary Neoplasms 368 | 410
Neurodegenerative disease 354 | 383
inflammatory breast cancer 345 | 404
non-small cell lung carcinoma 328 | 413
glioblastoma multiforme 309 | 347
hereditary spastic paraplegia 303 | 313
Parkinson's disease 298 | 364
Kidney disease 294 | 397
Polycystic Ovary Syndrome 290 | 334
sarcoidosis 288 | 368
tuberculosis and treatment for 3 months 288 | 327
urothelial carcinoma 278 | 318
Epilepsy 269 | 346
interstitial lung disease 266 | 292

Tissue

Nervous System 14,892 | 18,560
Female tissues 14,876 | 18,646
Digestive Tract 14,874 | 18,472
Endocrine System 14,860 | 18,511
Urinary Tract 14,830 | 18,443
Liver and Pancreas 14,816 | 18,135
Cardiovascular System 14,789 | 17,957
Blood and immune system 14,781 | 17,994
Male tissues 14,781 | 17,968
Skin and soft tissues 14,734 | 18,114
Respiratory system 14,645 | 17,483

Target Family

Non-IDG 8,682 | 11,969
Enzyme 3,489 | 4,146
Transcription Factor 1,165 | 1,400
Kinase 570 | 634
Transporter 364 | 473
GPCR 229 | 408
Ion Channel 226 | 341
Epigenetic 219 | 242
Nuclear Receptor 38 | 48
TF/Epigenetic 33 | 38
oGPCR 17 | 421

HCA RNA Cell Line

HBF TERT88 15,032 | 15,032
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50