Development Level

Tbio 9,762 | 11,651
Tdark 3,830 | 6,593
Tchem 1,177 | 1,388
Tclin 440 | 612

Collection

RFA-RM-18-021 231 | 328
Kinase: IDG Consortium (Target... 112 | 125
Ion Channel: IDG Consortium (T... 66 | 99
GPCR: IDG Consortium (Targets) 61 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 18 | 25

IMPC Phenotype

preweaning lethality, complete... 935 | 979
preweaning lethality, incomple... 446 | 499
embryonic lethality prior to t... 268 | 278
abnormal behavior 260 | 298
embryonic lethality prior to o... 235 | 239
abnormal embryo size 207 | 220
decreased total body fat amoun... 183 | 207
enlarged heart 176 | 210
abnormal bone structure 164 | 187
decreased vertical activity 158 | 208
increased lean body mass 155 | 172
decreased body weight 150 | 161
abnormal heart morphology 139 | 162
decreased bone mineral content 132 | 151
hyperactivity 128 | 148
decreased lean body mass 117 | 135
hypoactivity 113 | 132
increased total body fat amoun... 113 | 134
increased circulating alkaline... 109 | 122
decreased circulating glucose ... 106 | 126
decreased bone mineral density 105 | 126
increased startle reflex 105 | 112
male infertility 105 | 123
embryonic growth retardation 99 | 106
decreased grip strength 98 | 116
increased bone mineral content 93 | 108
decreased body length 90 | 101
abnormal seminal vesicle morph... 89 | 114
increased or absent threshold ... 87 | 101
short tibia 85 | 97
cataract 84 | 92
decreased circulating choleste... 84 | 93
increased mean corpuscular hem... 83 | 96
increased mean corpuscular vol... 83 | 92
prenatal lethality prior to he... 80 | 87
decreased prepulse inhibition 76 | 82
abnormal lens morphology 74 | 81
decreased lymphocyte cell numb... 72 | 83
decreased circulating serum al... 71 | 82
decreased mean corpuscular vol... 70 | 79
increased bone mineral density 67 | 72
abnormal retina morphology 66 | 71
decreased circulating triglyce... 66 | 79
increased fasted circulating g... 66 | 76
decreased startle reflex 65 | 75
impaired glucose tolerance 65 | 75
improved glucose tolerance 64 | 79
increased circulating HDL chol... 64 | 80
decreased circulating HDL chol... 63 | 68
small superior vagus ganglion 62 | 74
decreased circulating insulin ... 61 | 76
decreased leukocyte cell numbe... 61 | 73
abnormal eye morphology 60 | 68
abnormal sleep behavior 60 | 70
abnormal behavioral response t... 58 | 66
abnormal gait 57 | 69
decreased hemoglobin content 57 | 68
decreased erythrocyte cell num... 56 | 62
edema 56 | 59
increased heart weight 56 | 62
abnormal coat-hair pigmentatio... 55 | 64
increased circulating sodium l... 55 | 71
small testis 55 | 58
increased circulating choleste... 54 | 66
decreased fasted circulating g... 53 | 65
increased monocyte cell number 53 | 63
abnormal kidney morphology 52 | 65
decreased caudal vertebrae num... 50 | 53
female infertility 48 | 60
thrombocytopenia 48 | 56
abnormal spleen morphology 46 | 55
decreased mean corpuscular hem... 46 | 50
decreased circulating total pr... 45 | 49
abnormal neural tube closure 44 | 46
decreased circulating alanine ... 44 | 47
hydrometra 43 | 53
abnormal skin morphology 42 | 50
increased blood urea nitrogen ... 42 | 48
increased leukocyte cell numbe... 42 | 47
abnormal testis morphology 41 | 43
increased neutrophil cell numb... 41 | 46
decreased blood urea nitrogen ... 40 | 51
decreased hematocrit 40 | 46
increased hematocrit 40 | 46
decreased circulating alkaline... 39 | 46
increased mean platelet volume 39 | 45
enlarged spleen 38 | 41
increased hemoglobin content 38 | 45
decreased red blood cell distr... 37 | 41
increased circulating triglyce... 37 | 42
tremors 37 | 39
decreased circulating LDL chol... 36 | 38
increased grip strength 36 | 41
limb grasping 36 | 41
abnormal bone mineralization 35 | 38
decreased circulating creatini... 35 | 39
decreased neutrophil cell numb... 35 | 42
increased mean corpuscular hem... 35 | 36
abnormal epididymis morphology 34 | 42
increased erythrocyte cell num... 34 | 39

Disease

Carcinoma 9,362 | 11,493
ovarian cancer 7,840 | 8,520
osteosarcoma 7,088 | 7,950
medulloblastoma, large-cell 5,541 | 6,241
psoriasis 5,308 | 6,694
glioblastoma 5,204 | 5,792
atypical teratoid / rhabdoid tumor 4,591 | 5,112
lung cancer 4,246 | 4,740
ependymoma 4,143 | 4,679
group 3 medulloblastoma 3,657 | 4,104
adult high grade glioma 3,277 | 3,801
Breast cancer 3,211 | 3,578
malignant mesothelioma 3,053 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,946 | 3,291
primitive neuroectodermal tumor 2,704 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,658 | 2,989
Astrocytoma, Pilocytic 2,652 | 3,081
invasive ductal carcinoma 2,649 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,609 | 2,955
oligodendroglioma 2,525 | 2,850
non-small cell lung cancer 2,502 | 2,890
lung carcinoma 2,359 | 2,843
lung adenocarcinoma 2,304 | 2,716
astrocytic glioma 2,301 | 2,597
Kidney cancer 2,212 | 2,613
pancreatic cancer 2,117 | 2,398
Cancer 2,085 | 2,499
subependymal giant cell astrocytoma 2,025 | 2,287
interstitial cystitis 1,895 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,806 | 1,962
tuberculosis 1,776 | 2,010
Pick disease 1,744 | 1,894
pituitary cancer 1,696 | 1,972
group 4 medulloblastoma 1,688 | 1,855
ulcerative colitis 1,567 | 1,819
ductal carcinoma in situ 1,550 | 1,745
cystic fibrosis 1,531 | 1,696
breast carcinoma 1,444 | 1,638
adrenocortical carcinoma 1,299 | 1,428
Multiple myeloma 1,297 | 1,332
colon cancer 1,288 | 1,478
diabetes mellitus 1,267 | 1,728
Autosomal recessive predisposition 1,212 | 1,442
juvenile dermatomyositis 1,127 | 1,187
acute quadriplegic myopathy 1,100 | 1,158
astrocytoma 1,068 | 1,146
primary pancreatic ductal adenocarcinoma 1,024 | 1,109
Rheumatoid arthritis 1,022 | 1,191
spina bifida 985 | 1,074
pediatric high grade glioma 979 | 1,064
Intellectual disability 912 | 1,016
Schizophrenia 907 | 1,160
dermatomyositis 896 | 966
nasopharyngeal carcinoma 888 | 1,058
cutaneous lupus erythematosus 853 | 1,057
active Crohn's disease 805 | 922
Atopic dermatitis 773 | 952
non primary Sjogren syndrome sicca 773 | 891
acute myeloid leukemia 741 | 783
Waldenstrons macroglobulinemia 732 | 765
gastric carcinoma 723 | 807
Epilepsy 682 | 792
Liver Cirrhosis, Experimental 661 | 769
active ulcerative colitis 656 | 764
medulloblastoma 653 | 720
progressive supranuclear palsy 633 | 676
esophageal adenocarcinoma 632 | 737
primary Sjogren syndrome 625 | 735
aldosterone-producing adenoma 613 | 665
Dull intelligence 582 | 645
Low intelligence 582 | 645
Mental Retardation 582 | 645
Mental deficiency 582 | 645
Poor school performance 582 | 645
Cognitive delay 560 | 608
Global developmental delay 560 | 608
Mental and motor retardation 560 | 608
Alzheimer's disease 559 | 658
Duchenne muscular dystrophy 543 | 601
Obesity 543 | 678
Melanoma 529 | 711
Seizures 528 | 596
Muscle hypotonia 524 | 571
Bipolar Disorder 518 | 666
pancreatic carcinoma 515 | 562
hepatocellular carcinoma 508 | 547
Liver cancer 493 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 476 | 510
fibroadenoma 474 | 559
Short stature 471 | 531
Endometriosis 459 | 540
Down syndrome 444 | 499
chronic rhinosinusitis 439 | 512
Prostatic Neoplasms 429 | 495
gastric cancer 422 | 459
sonic hedgehog group medulloblastoma 419 | 467
Amyotrophic lateral sclerosis 416 | 451
posterior fossa group A ependymoma 416 | 468
Multiple Sclerosis 410 | 540
Breast Neoplasms 403 | 445

Tissue

Endocrine System 15,016 | 18,159
Female tissues 14,878 | 17,400
Digestive Tract 14,867 | 17,369
Skin and soft tissues 14,839 | 17,230
Male tissues 14,786 | 17,142
Blood and immune system 14,723 | 16,909
Liver and Pancreas 14,688 | 16,750
Nervous System 14,682 | 16,725
Urinary Tract 14,629 | 16,678
Respiratory system 14,545 | 16,393
Cardiovascular System 13,874 | 15,192

Target Family

Non-IDG 8,811 | 12,091
Enzyme 3,515 | 4,145
Transcription Factor 1,169 | 1,400
Kinase 577 | 634
Transporter 364 | 473
GPCR 229 | 408
Ion Channel 229 | 344
Epigenetic 225 | 242
Nuclear Receptor 38 | 48
TF/Epigenetic 34 | 38
oGPCR 18 | 421

HCA RNA Cell Line

HBF TERT88 15,209 | 15,209
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50