Development Level

Tbio 10,745 | 11,445
Tdark 4,469 | 6,588
Tchem 1,520 | 1,598
Tclin 567 | 613

Collection

RFA-RM-18-021 282 | 328
Kinase: IDG Consortium (Target... 122 | 125
Ion Channel: IDG Consortium (T... 86 | 99
GPCR: IDG Consortium (Targets) 81 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 967 | 979
preweaning lethality, incomple... 486 | 499
abnormal behavior 291 | 298
embryonic lethality prior to t... 275 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 217 | 220
decreased total body fat amoun... 202 | 207
enlarged heart 200 | 210
decreased vertical activity 190 | 208
abnormal bone structure 179 | 187
increased lean body mass 167 | 172
decreased body weight 159 | 161
abnormal heart morphology 154 | 162
decreased bone mineral content 143 | 151
hyperactivity 143 | 148
decreased lean body mass 130 | 135
increased total body fat amoun... 128 | 134
hypoactivity 127 | 132
decreased circulating glucose ... 122 | 126
decreased bone mineral density 119 | 126
increased circulating alkaline... 118 | 122
male infertility 115 | 123
decreased grip strength 113 | 116
abnormal seminal vesicle morph... 109 | 114
increased startle reflex 109 | 112
increased bone mineral content 104 | 108
embryonic growth retardation 103 | 106
increased or absent threshold ... 99 | 101
decreased body length 98 | 101
short tibia 95 | 97
increased mean corpuscular hem... 94 | 96
decreased circulating choleste... 92 | 93
cataract 90 | 92
increased mean corpuscular vol... 90 | 92
prenatal lethality prior to he... 86 | 87
decreased lymphocyte cell numb... 81 | 83
decreased circulating serum al... 80 | 82
abnormal lens morphology 79 | 81
decreased mean corpuscular vol... 79 | 79
decreased prepulse inhibition 79 | 82
decreased circulating triglyce... 78 | 79
increased circulating HDL chol... 77 | 80
improved glucose tolerance 76 | 79
increased fasted circulating g... 73 | 76
small superior vagus ganglion 73 | 74
decreased circulating insulin ... 72 | 76
impaired glucose tolerance 72 | 75
decreased startle reflex 71 | 75
abnormal retina morphology 70 | 71
decreased leukocyte cell numbe... 70 | 73
increased bone mineral density 70 | 72
abnormal eye morphology 68 | 68
abnormal gait 68 | 69
decreased circulating HDL chol... 67 | 68
abnormal sleep behavior 66 | 70
increased circulating sodium l... 66 | 71
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
decreased hemoglobin content 65 | 68
increased circulating choleste... 65 | 66
abnormal coat-hair pigmentatio... 62 | 64
abnormal behavioral response t... 61 | 66
decreased erythrocyte cell num... 61 | 62
increased monocyte cell number 61 | 63
increased heart weight 60 | 62
edema 59 | 59
small testis 56 | 58
female infertility 55 | 60
abnormal spleen morphology 54 | 55
thrombocytopenia 54 | 56
decreased caudal vertebrae num... 53 | 53
hydrometra 52 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased circulating total pr... 49 | 49
decreased mean corpuscular hem... 48 | 50
increased blood urea nitrogen ... 47 | 48
abnormal neural tube closure 46 | 46
decreased circulating alanine ... 46 | 47
decreased circulating alkaline... 46 | 46
increased leukocyte cell numbe... 46 | 47
decreased hematocrit 45 | 46
increased hematocrit 44 | 46
increased neutrophil cell numb... 44 | 46
abnormal testis morphology 43 | 43
increased hemoglobin content 42 | 45
decreased neutrophil cell numb... 41 | 42
enlarged spleen 41 | 41
increased mean platelet volume 41 | 45
abnormal epididymis morphology 40 | 42
increased circulating chloride... 40 | 41
increased circulating triglyce... 40 | 42
decreased red blood cell distr... 39 | 41
increased grip strength 39 | 41
limb grasping 39 | 41
tremors 39 | 39
abnormal bone mineralization 38 | 38
decreased circulating LDL chol... 37 | 38
decreased circulating creatini... 37 | 39
increased circulating creatini... 37 | 38

Disease

Carcinoma 10,392 | 11,493
ovarian cancer 8,282 | 8,520
osteosarcoma 7,621 | 7,950
psoriasis 6,121 | 6,694
medulloblastoma, large-cell 5,961 | 6,241
glioblastoma 5,597 | 5,792
atypical teratoid / rhabdoid tumor 4,927 | 5,112
lung cancer 4,567 | 4,740
ependymoma 4,501 | 4,679
group 3 medulloblastoma 3,949 | 4,104
adult high grade glioma 3,618 | 3,801
Breast cancer 3,466 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,224 | 3,291
malignant mesothelioma 3,182 | 3,232
Astrocytoma, Pilocytic 2,949 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,930 | 2,989
primitive neuroectodermal tumor 2,925 | 3,035
invasive ductal carcinoma 2,897 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,894 | 2,955
non-small cell lung cancer 2,814 | 2,890
oligodendroglioma 2,742 | 2,850
lung carcinoma 2,708 | 2,843
lung adenocarcinoma 2,620 | 2,716
astrocytic glioma 2,504 | 2,597
Kidney cancer 2,401 | 2,613
Cancer 2,379 | 2,499
pancreatic cancer 2,334 | 2,398
subependymal giant cell astrocytoma 2,228 | 2,287
interstitial cystitis 2,203 | 2,312
tuberculosis 1,938 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,922 | 1,962
pituitary cancer 1,897 | 1,972
Pick disease 1,855 | 1,894
group 4 medulloblastoma 1,801 | 1,855
ulcerative colitis 1,750 | 1,819
ductal carcinoma in situ 1,721 | 1,745
cystic fibrosis 1,647 | 1,696
breast carcinoma 1,605 | 1,638
diabetes mellitus 1,500 | 1,728
colon cancer 1,425 | 1,478
adrenocortical carcinoma 1,402 | 1,428
Autosomal recessive predisposition 1,376 | 1,442
Multiple myeloma 1,314 | 1,332
juvenile dermatomyositis 1,173 | 1,187
Rheumatoid arthritis 1,149 | 1,191
acute quadriplegic myopathy 1,140 | 1,158
astrocytoma 1,120 | 1,146
primary pancreatic ductal adenocarcinoma 1,100 | 1,109
Schizophrenia 1,071 | 1,160
spina bifida 1,052 | 1,074
pediatric high grade glioma 1,029 | 1,064
nasopharyngeal carcinoma 1,015 | 1,058
cutaneous lupus erythematosus 1,003 | 1,057
Intellectual disability 993 | 1,016
dermatomyositis 959 | 966
active Crohn's disease 901 | 922
Atopic dermatitis 877 | 952
non primary Sjogren syndrome sicca 840 | 891
gastric carcinoma 790 | 807
acute myeloid leukemia 771 | 783
Waldenstrons macroglobulinemia 759 | 765
Epilepsy 757 | 792
Liver Cirrhosis, Experimental 748 | 769
active ulcerative colitis 741 | 764
esophageal adenocarcinoma 715 | 737
primary Sjogren syndrome 712 | 735
medulloblastoma 698 | 720
progressive supranuclear palsy 663 | 676
aldosterone-producing adenoma 656 | 665
Obesity 640 | 678
Dull intelligence 629 | 645
Low intelligence 629 | 645
Mental Retardation 629 | 645
Mental deficiency 629 | 645
Poor school performance 629 | 645
Alzheimer's disease 616 | 658
Bipolar Disorder 612 | 666
Melanoma 607 | 711
Cognitive delay 597 | 608
Global developmental delay 597 | 608
Mental and motor retardation 597 | 608
Duchenne muscular dystrophy 588 | 601
Seizures 577 | 596
Muscle hypotonia 559 | 571
fibroadenoma 547 | 559
pancreatic carcinoma 546 | 562
Liver cancer 536 | 604
hepatocellular carcinoma 536 | 547
Endometriosis 521 | 540
Short stature 516 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 504 | 510
Multiple Sclerosis 500 | 540
Down syndrome 487 | 499
chronic rhinosinusitis 484 | 512
Prostatic Neoplasms 475 | 495
posterior fossa group A ependymoma 456 | 468
gastric cancer 451 | 459
mucosa-associated lymphoid tissue lymphoma 450 | 484
sonic hedgehog group medulloblastoma 450 | 467
Breast Neoplasms 438 | 445

Tissue

Endocrine System 16,938 | 18,159
Female tissues 16,611 | 17,400
Digestive Tract 16,595 | 17,369
Skin and soft tissues 16,503 | 17,230
Male tissues 16,424 | 17,142
Blood and immune system 16,273 | 16,909
Nervous System 16,186 | 16,725
Liver and Pancreas 16,177 | 16,750
Urinary Tract 16,137 | 16,678
Respiratory system 15,915 | 16,393
Cardiovascular System 14,877 | 15,192

Target Family

Non-IDG 10,109 | 12,091
Enzyme 3,859 | 4,145
Transcription Factor 1,304 | 1,400
Kinase 615 | 634
Transporter 436 | 473
GPCR 314 | 408
Ion Channel 301 | 344
Epigenetic 234 | 242
Nuclear Receptor 47 | 48
oGPCR 45 | 421
TF/Epigenetic 37 | 38

HCA RNA Cell Line

EFO-21 17,301 | 17,301
U-2 OS 17,559 | 17,559
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endosomal/lysosomal potassium channel TMEM175 TMEM175 Tbio Non-IDG -0.65375 3.76 42
WASH complex subunit 2C WASHC2C Tbio Non-IDG -0.83634 0.00000 45
Transmembrane protein 170A TMEM170A Tdark Non-IDG 0.00000 1.18 3
Protein AF-9 MLLT3 Tbio Non-IDG -1.99555 93.8 210
Scm-like with four MBT domains protein 1 SFMBT1 Tbio Epigenetic -2.06810 112.0 113
Guanine deaminase GDA Tbio Enzyme -1.48687 32.3 196
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.18 96
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.24396 15.5 189
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.72004 3.69 184
Solute carrier organic anion transporter family member 3A1 SLCO3A1 Tbio Transporter -1.39614 24.1 46