Development Level

Tbio 9,918 | 10,625
Tdark 4,865 | 7,003
Tchem 1,777 | 1,890
Tclin 556 | 602

Collection

Kinase: IDG Consortium (Targets) 120 | 125
Ion Channel: IDG Consortium (Targets) 89 | 102
GPCR: IDG Consortium (Targets) 81 | 127
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 22 | 26

IMPC Phenotype

preweaning lethality, complete... 624 | 633
preweaning lethality, incomple... 254 | 260
abnormal behavior 224 | 226
decreased lean body mass 188 | 195
embryonic lethality prior to t... 186 | 187
decreased total body fat amoun... 182 | 186
decreased body weight 171 | 174
decreased bone mineral content 151 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 127 | 131
increased or absent threshold ... 125 | 128
decreased bone mineral density 121 | 126
decreased grip strength 118 | 123
increased circulating alkaline... 117 | 119
decreased circulating glucose ... 115 | 121
abnormal embryo size 109 | 112
enlarged heart 108 | 111
decreased body length 106 | 108
hyperactivity 105 | 108
increased lean body mass 103 | 107
abnormal retina morphology 99 | 100
increased mean corpuscular hem... 92 | 93
increased bone mineral content 91 | 92
increased mean corpuscular vol... 89 | 91
hypoactivity 86 | 89
decreased circulating choleste... 84 | 85
decreased circulating triglyce... 81 | 83
short tibia 80 | 82
increased grip strength 77 | 83
decreased circulating HDL chol... 76 | 77
decreased circulating serum al... 76 | 79
abnormal lens morphology 71 | 73
decreased circulating insulin ... 70 | 75
increased fasted circulating g... 67 | 68
increased circulating sodium l... 66 | 71
prenatal lethality prior to he... 64 | 64
abnormal retinal pigmentation 60 | 61
decreased lumbar vertebrae num... 60 | 62
abnormal sleep behavior 59 | 63
increased circulating HDL chol... 59 | 63
increased sacral vertebrae num... 59 | 62
male infertility 58 | 62
decreased rib number 57 | 59
abnormal bone mineralization 55 | 55
improved glucose tolerance 54 | 56
increased exploration in new e... 54 | 56
increased total body fat amoun... 54 | 57
abnormal coat-hair pigmentatio... 52 | 54
increased circulating choleste... 52 | 53
decreased hemoglobin content 51 | 53
decreased leukocyte cell numbe... 51 | 54
decreased prepulse inhibition 51 | 52
impaired glucose tolerance 51 | 52
increased bone mineral density 51 | 52
abnormal gait 50 | 51
abnormal heart morphology 50 | 51
decreased mean corpuscular vol... 50 | 50
decreased circulating alanine ... 49 | 53
decreased fasted circulating g... 49 | 49
abnormal behavioral response t... 48 | 52
decreased caudal vertebrae num... 48 | 49
abnormal seminal vesicle morph... 46 | 47
decreased startle reflex 46 | 48
increased blood urea nitrogen ... 44 | 44
thrombocytopenia 44 | 46
decreased erythrocyte cell num... 43 | 43
increased hemoglobin content 43 | 45
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased heart weight 41 | 44
increased circulating chloride... 41 | 43
increased rib number 40 | 41
decreased eosinophil cell numb... 39 | 41
abnormal eye morphology 38 | 38
decreased circulating free fat... 38 | 39
abnormal neural tube closure 36 | 37
decreased circulating LDL chol... 36 | 37
decreased neutrophil cell numb... 36 | 37
increased leukocyte cell numbe... 36 | 37
increased startle reflex 36 | 38
small testis 36 | 37
abnormal spleen morphology 35 | 36
increased heart weight 35 | 37
tremors 34 | 34
decreased mean corpuscular hem... 33 | 34
increased hematocrit 33 | 36
limb grasping 33 | 35
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
cardiovascular system phenotyp... 31 | 35
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
decreased threshold for audito... 31 | 32
female infertility 31 | 34
increased circulating calcium ... 31 | 32
abnormal epididymis morphology 30 | 31
decreased circulating calcium ... 30 | 33
increased circulating potassiu... 30 | 31

Disease

ovarian cancer 8,168 | 8,491
osteosarcoma 7,533 | 7,933
psoriasis 6,073 | 6,685
medulloblastoma, large-cell 5,903 | 6,234
glioblastoma 5,342 | 5,572
lung cancer 4,329 | 4,473
atypical teratoid / rhabdoid tumor 4,164 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,194 | 3,289
malignant mesothelioma 3,090 | 3,163
Breast cancer 2,994 | 3,098
pilocytic astrocytoma 2,922 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 2,906 | 2,988
primitive neuroectodermal tumor 2,890 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 2,876 | 2,956
invasive ductal carcinoma 2,867 | 2,950
oligodendroglioma 2,716 | 2,849
non-small cell lung cancer 2,706 | 2,798
lung carcinoma 2,692 | 2,844
lung adenocarcinoma 2,598 | 2,714
pediatric high grade glioma 2,593 | 2,712
ependymoma 2,411 | 2,514
pancreatic cancer 2,233 | 2,300
Cancer 2,221 | 2,346
subependymal giant cell astrocytoma 2,209 | 2,287
interstitial cystitis 2,184 | 2,299
group 3 medulloblastoma 2,150 | 2,254
astrocytic glioma 2,145 | 2,241
adult high grade glioma 2,007 | 2,148
ulcerative colitis 2,006 | 2,087
Carcinoma 1,927 | 2,147
pituitary cancer 1,884 | 1,972
Pick disease 1,840 | 1,893
group 4 medulloblastoma 1,799 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,736 | 1,795
ductal carcinoma in situ 1,706 | 1,745
cystic fibrosis 1,610 | 1,670
breast carcinoma 1,570 | 1,614
tuberculosis 1,493 | 1,563
medulloblastoma 1,454 | 1,524
posterior fossa group B ependymoma 1,449 | 1,530
astrocytoma 1,445 | 1,493
posterior fossa group A ependymoma 1,432 | 1,511
diabetes mellitus 1,430 | 1,663
sonic hedgehog group medulloblastoma 1,417 | 1,482
colon cancer 1,411 | 1,475
adrenocortical carcinoma 1,383 | 1,427
Multiple myeloma 1,299 | 1,327
primary pancreatic ductal adenocarcinoma 1,255 | 1,271
juvenile dermatomyositis 1,165 | 1,189
acute quadriplegic myopathy 1,131 | 1,157
Rheumatoid Arthritis 1,120 | 1,170
atypical teratoid/rhabdoid tumor 1,059 | 1,095
spina bifida 1,032 | 1,064
nasopharyngeal carcinoma 1,008 | 1,056
cutaneous lupus erythematosus 994 | 1,056
dermatomyositis 954 | 966
active Crohn's disease 891 | 918
Atopic dermatitis 863 | 944
gastric carcinoma 809 | 832
non primary Sjogren syndrome sicca 780 | 840
acute myeloid leukemia 759 | 785
primary Sjogren syndrome 759 | 788
Waldenstrons macroglobulinemia 752 | 764
esophageal adenocarcinoma 712 | 737
tuberculosis and treatment for 6 months 669 | 686
progressive supranuclear palsy 656 | 674
aldosterone-producing adenoma 651 | 664
Alzheimer's disease 599 | 644
Duchenne muscular dystrophy 582 | 602
Obesity 577 | 616
Intellectual disability 556 | 573
pancreatic carcinoma 547 | 567
fibroadenoma 543 | 557
hepatocellular carcinoma 537 | 550
Down syndrome 532 | 548
Endometriosis 510 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 499
chronic rhinosinusitis 481 | 512
Multiple Sclerosis 456 | 498
active ulcerative colitis 455 | 477
Schizophrenia 453 | 503
Prostatic Neoplasms 449 | 471
mucosa-associated lymphoid tissue lymphoma 448 | 480
IGA Glomerulonephritis 441 | 454
gastric cancer 424 | 436
Amyotrophic Lateral Sclerosis 416 | 432
Mammary Neoplasms 401 | 410
inflammatory breast cancer 381 | 404
non-small cell lung carcinoma 380 | 413
Neurodegenerative disease 369 | 383
Kidney disease 365 | 397
sarcoidosis 351 | 368
Parkinson's disease 334 | 364
glioblastoma multiforme 330 | 347
nephrosclerosis 320 | 329
Polycystic Ovary Syndrome 318 | 334
Epilepsy 316 | 346
Asthma 314 | 349
tuberculosis and treatment for 3 months 314 | 327
urothelial carcinoma 307 | 318

Tissue

Nervous System 16,847 | 18,560
Female tissues 16,834 | 18,646
Endocrine System 16,812 | 18,511
Digestive Tract 16,804 | 18,472
Urinary Tract 16,750 | 18,443
Liver and Pancreas 16,679 | 18,135
Male tissues 16,622 | 17,968
Blood and immune system 16,610 | 17,994
Cardiovascular System 16,609 | 17,957
Skin and soft tissues 16,607 | 18,114
Respiratory system 16,364 | 17,483

Target Family

Non-IDG 9,973 | 11,969
Enzyme 3,831 | 4,146
Transcription Factor 1,301 | 1,400
Kinase 609 | 634
Transporter 436 | 473
GPCR 313 | 408
Ion Channel 298 | 341
Epigenetic 228 | 242
Nuclear Receptor 47 | 48
oGPCR 44 | 421
TF/Epigenetic 36 | 38

HCA RNA Cell Line

EFO-21 17,116 | 17,116
U-2 OS 17,365 | 17,365
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66