Development Level

Tbio 9,166 | 10,625
Tdark 4,324 | 7,003
Tchem 1,618 | 1,890
Tclin 466 | 602

Collection

Kinase: IDG Consortium (Targets) 112 | 125
Ion Channel: IDG Consortium (Targets) 76 | 102
GPCR: IDG Consortium (Targets) 73 | 127
Kinase: IDG Consortium (Complete/Control) 31 | 37
GPCR: IDG Consortium (Complete/Control) 17 | 26

IMPC Phenotype

preweaning lethality, complete... 605 | 633
preweaning lethality, incomple... 235 | 260
abnormal behavior 206 | 226
embryonic lethality prior to t... 181 | 187
decreased lean body mass 176 | 195
decreased total body fat amoun... 169 | 186
decreased body weight 158 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 142 | 157
abnormal bone structure 121 | 131
increased or absent threshold ... 118 | 128
decreased bone mineral density 114 | 126
increased circulating alkaline... 113 | 119
abnormal embryo size 105 | 112
decreased circulating glucose ... 105 | 121
decreased grip strength 105 | 123
decreased body length 101 | 108
hyperactivity 97 | 108
abnormal retina morphology 94 | 100
enlarged heart 94 | 111
increased lean body mass 94 | 107
increased mean corpuscular hem... 89 | 93
increased bone mineral content 85 | 92
increased mean corpuscular vol... 83 | 91
decreased circulating choleste... 82 | 85
short tibia 76 | 82
hypoactivity 75 | 89
decreased circulating HDL chol... 74 | 77
decreased circulating triglyce... 73 | 83
abnormal lens morphology 69 | 73
decreased circulating serum al... 69 | 79
increased grip strength 69 | 83
increased fasted circulating g... 63 | 68
prenatal lethality prior to he... 62 | 64
increased circulating sodium l... 60 | 71
decreased circulating insulin ... 59 | 75
decreased lumbar vertebrae num... 58 | 62
abnormal retinal pigmentation 57 | 61
increased sacral vertebrae num... 57 | 62
abnormal sleep behavior 56 | 63
male infertility 56 | 62
abnormal bone mineralization 53 | 55
decreased rib number 53 | 59
increased circulating HDL chol... 53 | 63
decreased prepulse inhibition 51 | 52
increased total body fat amoun... 51 | 57
impaired glucose tolerance 50 | 52
abnormal coat-hair pigmentatio... 49 | 54
decreased hemoglobin content 49 | 53
decreased leukocyte cell numbe... 49 | 54
decreased mean corpuscular vol... 48 | 50
increased bone mineral density 48 | 52
decreased circulating alanine ... 47 | 53
increased circulating choleste... 47 | 53
improved glucose tolerance 46 | 56
decreased startle reflex 45 | 48
increased exploration in new e... 45 | 56
abnormal gait 44 | 51
abnormal behavioral response t... 43 | 52
decreased erythrocyte cell num... 43 | 43
decreased fasted circulating g... 43 | 49
abnormal heart morphology 42 | 51
increased blood urea nitrogen ... 42 | 44
thrombocytopenia 42 | 46
decreased caudal vertebrae num... 41 | 49
increased hemoglobin content 41 | 45
decreased circulating total pr... 38 | 41
decreased heart weight 38 | 44
decreased circulating alkaline... 37 | 41
increased body weight 37 | 42
increased circulating chloride... 37 | 43
increased rib number 37 | 41
abnormal neural tube closure 36 | 37
abnormal seminal vesicle morph... 36 | 47
decreased neutrophil cell numb... 36 | 37
abnormal eye morphology 34 | 38
decreased eosinophil cell numb... 34 | 41
tremors 34 | 34
decreased circulating LDL chol... 33 | 37
decreased circulating free fat... 33 | 39
increased startle reflex 33 | 38
decreased mean corpuscular hem... 32 | 34
increased heart weight 32 | 37
increased leukocyte cell numbe... 32 | 37
abnormal spleen morphology 31 | 36
cardiovascular system phenotyp... 31 | 35
small testis 31 | 37
abnormal cranium morphology 30 | 32
decreased T cell number 30 | 31
decreased blood urea nitrogen ... 30 | 31
decreased circulating chloride... 30 | 32
increased circulating calcium ... 30 | 32
increased circulating potassiu... 30 | 31
decreased circulating fructosa... 29 | 31
increased hematocrit 29 | 36
decreased circulating calcium ... 28 | 33
decreased circulating creatini... 28 | 31
limb grasping 28 | 35
decreased NK T cell number 27 | 28
embryonic growth retardation 27 | 28

Disease

ovarian cancer 7,783 | 8,491
osteosarcoma 7,188 | 7,933
medulloblastoma, large-cell 5,480 | 6,234
psoriasis 5,469 | 6,685
glioblastoma 4,970 | 5,572
lung cancer 4,078 | 4,473
atypical teratoid / rhabdoid tumor 3,859 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,950 | 3,289
malignant mesothelioma 2,875 | 3,163
Breast cancer 2,763 | 3,098
primitive neuroectodermal tumor 2,674 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,662 | 2,988
invasive ductal carcinoma 2,643 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,638 | 2,956
pilocytic astrocytoma 2,631 | 3,086
non-small cell lung cancer 2,491 | 2,798
oligodendroglioma 2,446 | 2,849
lung carcinoma 2,432 | 2,844
pediatric high grade glioma 2,393 | 2,712
lung adenocarcinoma 2,345 | 2,714
ependymoma 2,237 | 2,514
Cancer 2,061 | 2,346
pancreatic cancer 2,052 | 2,300
subependymal giant cell astrocytoma 2,046 | 2,287
group 3 medulloblastoma 2,014 | 2,254
interstitial cystitis 1,986 | 2,299
astrocytic glioma 1,950 | 2,241
ulcerative colitis 1,869 | 2,087
adult high grade glioma 1,825 | 2,148
Carcinoma 1,777 | 2,147
Pick disease 1,709 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,699 | 1,795
group 4 medulloblastoma 1,683 | 1,875
pituitary cancer 1,674 | 1,972
ductal carcinoma in situ 1,536 | 1,745
tuberculosis 1,439 | 1,563
cystic fibrosis 1,431 | 1,670
breast carcinoma 1,421 | 1,614
astrocytoma 1,367 | 1,493
medulloblastoma 1,324 | 1,524
diabetes mellitus 1,317 | 1,663
sonic hedgehog group medulloblastoma 1,302 | 1,482
posterior fossa group B ependymoma 1,292 | 1,530
Multiple myeloma 1,287 | 1,327
posterior fossa group A ependymoma 1,281 | 1,511
adrenocortical carcinoma 1,279 | 1,427
colon cancer 1,275 | 1,475
primary pancreatic ductal adenocarcinoma 1,164 | 1,271
juvenile dermatomyositis 1,135 | 1,189
acute quadriplegic myopathy 1,092 | 1,157
Rheumatoid Arthritis 1,073 | 1,170
spina bifida 978 | 1,064
atypical teratoid/rhabdoid tumor 976 | 1,095
dermatomyositis 937 | 966
nasopharyngeal carcinoma 927 | 1,056
cutaneous lupus erythematosus 926 | 1,056
active Crohn's disease 801 | 918
Atopic dermatitis 762 | 944
non primary Sjogren syndrome sicca 747 | 840
Waldenstrons macroglobulinemia 745 | 764
gastric carcinoma 742 | 832
primary Sjogren syndrome 742 | 788
acute myeloid leukemia 738 | 785
tuberculosis and treatment for 6 months 665 | 686
esophageal adenocarcinoma 663 | 737
progressive supranuclear palsy 630 | 674
aldosterone-producing adenoma 598 | 664
Alzheimer's disease 542 | 644
Duchenne muscular dystrophy 542 | 602
pancreatic carcinoma 525 | 567
hepatocellular carcinoma 523 | 550
Intellectual disability 517 | 573
Obesity 513 | 616
Down syndrome 487 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 465 | 499
fibroadenoma 458 | 557
Endometriosis 455 | 535
IGA Glomerulonephritis 428 | 454
chronic rhinosinusitis 427 | 512
Prostatic Neoplasms 420 | 471
Multiple Sclerosis 419 | 498
mucosa-associated lymphoid tissue lymphoma 407 | 480
gastric cancer 403 | 436
active ulcerative colitis 400 | 477
Amyotrophic Lateral Sclerosis 384 | 432
Schizophrenia 383 | 503
Mammary Neoplasms 368 | 410
inflammatory breast cancer 359 | 404
Neurodegenerative disease 341 | 383
sarcoidosis 337 | 368
non-small cell lung carcinoma 336 | 413
Kidney disease 333 | 397
tuberculosis and treatment for 3 months 308 | 327
hereditary spastic paraplegia 303 | 313
Polycystic Ovary Syndrome 300 | 334
glioblastoma multiforme 298 | 347
Parkinson's disease 290 | 364
nephrosclerosis 287 | 329
Epilepsy 278 | 346
urothelial carcinoma 276 | 318

Tissue

Nervous System 15,347 | 18,560
Female tissues 15,331 | 18,646
Digestive Tract 15,320 | 18,472
Endocrine System 15,319 | 18,511
Urinary Tract 15,271 | 18,443
Liver and Pancreas 15,244 | 18,135
Blood and immune system 15,220 | 17,994
Male tissues 15,206 | 17,968
Cardiovascular System 15,189 | 17,957
Skin and soft tissues 15,147 | 18,114
Respiratory system 15,023 | 17,483

Target Family

Non-IDG 9,072 | 11,969
Enzyme 3,551 | 4,146
Transcription Factor 1,172 | 1,400
Kinase 571 | 634
Transporter 385 | 473
GPCR 259 | 408
Ion Channel 242 | 341
Epigenetic 223 | 242
Nuclear Receptor 39 | 48
TF/Epigenetic 33 | 38
oGPCR 27 | 421

HCA RNA Cell Line

Daudi 15,574 | 15,574
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50