Development Level

Tbio 9,928 | 11,445
Tdark 3,964 | 6,588
Tchem 1,386 | 1,598
Tclin 475 | 613

Collection

RFA-RM-18-021 250 | 328
Kinase: IDG Consortium (Target... 115 | 125
GPCR: IDG Consortium (Targets) 73 | 126
Ion Channel: IDG Consortium (T... 73 | 99
Kinase: IDG Consortium (Comple... 32 | 37
GPCR: IDG Consortium (Complete... 17 | 25

IMPC Phenotype

preweaning lethality, complete... 938 | 979
preweaning lethality, incomple... 459 | 499
embryonic lethality prior to t... 270 | 278
abnormal behavior 267 | 298
embryonic lethality prior to o... 236 | 239
abnormal embryo size 209 | 220
decreased total body fat amoun... 182 | 207
enlarged heart 178 | 210
abnormal bone structure 172 | 187
decreased vertical activity 159 | 208
increased lean body mass 152 | 172
decreased body weight 149 | 161
abnormal heart morphology 141 | 162
decreased bone mineral content 132 | 151
hyperactivity 129 | 148
decreased lean body mass 120 | 135
increased total body fat amoun... 120 | 134
decreased circulating glucose ... 113 | 126
increased circulating alkaline... 112 | 122
decreased bone mineral density 110 | 126
hypoactivity 110 | 132
male infertility 108 | 123
increased startle reflex 104 | 112
embryonic growth retardation 100 | 106
decreased grip strength 99 | 116
abnormal seminal vesicle morph... 93 | 114
increased bone mineral content 93 | 108
decreased body length 92 | 101
increased or absent threshold ... 92 | 101
short tibia 90 | 97
decreased circulating choleste... 87 | 93
increased mean corpuscular hem... 87 | 96
cataract 84 | 92
prenatal lethality prior to he... 84 | 87
increased mean corpuscular vol... 83 | 92
abnormal lens morphology 76 | 81
decreased prepulse inhibition 76 | 82
decreased lymphocyte cell numb... 74 | 83
decreased mean corpuscular vol... 74 | 79
decreased circulating triglyce... 72 | 79
decreased circulating serum al... 70 | 82
increased circulating HDL chol... 70 | 80
increased fasted circulating g... 70 | 76
impaired glucose tolerance 68 | 75
increased bone mineral density 68 | 72
improved glucose tolerance 67 | 79
decreased circulating HDL chol... 66 | 68
decreased leukocyte cell numbe... 66 | 73
decreased startle reflex 66 | 75
abnormal retina morphology 63 | 71
abnormal eye morphology 62 | 68
small superior vagus ganglion 62 | 74
abnormal sleep behavior 61 | 70
decreased circulating insulin ... 61 | 76
abnormal gait 60 | 69
decreased hemoglobin content 60 | 68
abnormal coat-hair pigmentatio... 59 | 64
increased circulating sodium l... 59 | 71
decreased erythrocyte cell num... 58 | 62
increased circulating choleste... 58 | 66
edema 57 | 59
decreased fasted circulating g... 56 | 65
abnormal behavioral response t... 55 | 66
increased heart weight 55 | 62
abnormal kidney morphology 53 | 65
increased monocyte cell number 53 | 63
small testis 51 | 58
thrombocytopenia 51 | 56
decreased blood urea nitrogen ... 50 | 51
decreased caudal vertebrae num... 50 | 53
abnormal spleen morphology 48 | 55
female infertility 48 | 60
decreased mean corpuscular hem... 47 | 50
abnormal neural tube closure 45 | 46
hydrometra 45 | 53
decreased circulating alanine ... 44 | 47
decreased circulating total pr... 44 | 49
increased blood urea nitrogen ... 44 | 48
abnormal skin morphology 43 | 50
decreased circulating alkaline... 43 | 46
increased neutrophil cell numb... 42 | 46
decreased hematocrit 41 | 46
increased hematocrit 41 | 46
increased hemoglobin content 40 | 45
increased leukocyte cell numbe... 40 | 47
decreased neutrophil cell numb... 39 | 42
tremors 39 | 39
abnormal testis morphology 38 | 43
decreased red blood cell distr... 38 | 41
increased circulating triglyce... 38 | 42
increased mean platelet volume 38 | 45
increased erythrocyte cell num... 37 | 39
abnormal bone mineralization 36 | 38
abnormal epididymis morphology 36 | 42
enlarged spleen 36 | 41
increased circulating chloride... 36 | 41
increased grip strength 36 | 41
decreased circulating LDL chol... 34 | 38
decreased circulating creatini... 34 | 39
increased mean corpuscular hem... 34 | 36

Disease

Carcinoma 9,599 | 11,493
ovarian cancer 7,892 | 8,520
osteosarcoma 7,274 | 7,950
medulloblastoma, large-cell 5,536 | 6,241
psoriasis 5,514 | 6,694
glioblastoma 5,203 | 5,792
atypical teratoid / rhabdoid tumor 4,567 | 5,112
lung cancer 4,277 | 4,740
ependymoma 4,096 | 4,679
group 3 medulloblastoma 3,667 | 4,104
adult high grade glioma 3,300 | 3,801
Breast cancer 3,193 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,979 | 3,291
malignant mesothelioma 2,962 | 3,232
primitive neuroectodermal tumor 2,707 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,685 | 2,989
invasive ductal carcinoma 2,671 | 2,951
Astrocytoma, Pilocytic 2,659 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 2,655 | 2,955
non-small cell lung cancer 2,587 | 2,890
oligodendroglioma 2,468 | 2,850
lung carcinoma 2,447 | 2,843
lung adenocarcinoma 2,366 | 2,716
astrocytic glioma 2,271 | 2,597
Kidney cancer 2,226 | 2,613
Cancer 2,207 | 2,499
pancreatic cancer 2,148 | 2,398
subependymal giant cell astrocytoma 2,064 | 2,287
interstitial cystitis 2,004 | 2,312
tuberculosis 1,875 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,872 | 1,962
Pick disease 1,723 | 1,894
pituitary cancer 1,687 | 1,972
group 4 medulloblastoma 1,682 | 1,855
ulcerative colitis 1,637 | 1,819
ductal carcinoma in situ 1,550 | 1,745
cystic fibrosis 1,463 | 1,696
breast carcinoma 1,457 | 1,638
diabetes mellitus 1,380 | 1,728
Multiple myeloma 1,302 | 1,332
adrenocortical carcinoma 1,297 | 1,428
colon cancer 1,287 | 1,478
Autosomal recessive predisposition 1,286 | 1,442
juvenile dermatomyositis 1,143 | 1,187
acute quadriplegic myopathy 1,100 | 1,158
Rheumatoid arthritis 1,097 | 1,191
astrocytoma 1,076 | 1,146
primary pancreatic ductal adenocarcinoma 1,022 | 1,109
spina bifida 998 | 1,074
pediatric high grade glioma 963 | 1,064
dermatomyositis 942 | 966
nasopharyngeal carcinoma 934 | 1,058
cutaneous lupus erythematosus 933 | 1,057
Schizophrenia 932 | 1,160
Intellectual disability 930 | 1,016
active Crohn's disease 811 | 922
non primary Sjogren syndrome sicca 808 | 891
Atopic dermatitis 777 | 952
Waldenstrons macroglobulinemia 752 | 765
acute myeloid leukemia 749 | 783
gastric carcinoma 724 | 807
Epilepsy 703 | 792
Liver Cirrhosis, Experimental 703 | 769
primary Sjogren syndrome 695 | 735
esophageal adenocarcinoma 666 | 737
active ulcerative colitis 661 | 764
medulloblastoma 639 | 720
progressive supranuclear palsy 636 | 676
aldosterone-producing adenoma 603 | 665
Dull intelligence 596 | 645
Low intelligence 596 | 645
Mental Retardation 596 | 645
Mental deficiency 596 | 645
Poor school performance 596 | 645
Cognitive delay 574 | 608
Global developmental delay 574 | 608
Mental and motor retardation 574 | 608
Obesity 569 | 678
Alzheimer's disease 558 | 658
Melanoma 550 | 711
Duchenne muscular dystrophy 549 | 601
Muscle hypotonia 541 | 571
Seizures 537 | 596
Bipolar Disorder 524 | 666
pancreatic carcinoma 524 | 562
hepatocellular carcinoma 523 | 547
Liver cancer 496 | 604
Short stature 492 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 476 | 510
Endometriosis 466 | 540
fibroadenoma 462 | 559
Multiple Sclerosis 458 | 540
Down syndrome 447 | 499
Prostatic Neoplasms 445 | 495
chronic rhinosinusitis 430 | 512
gastric cancer 428 | 459
posterior fossa group A ependymoma 417 | 468
sonic hedgehog group medulloblastoma 412 | 467
mucosa-associated lymphoid tissue lymphoma 409 | 484
tuberculosis and treatment for 6 months 405 | 409

Tissue

Endocrine System 15,464 | 18,159
Digestive Tract 15,231 | 17,369
Female tissues 15,209 | 17,400
Skin and soft tissues 15,171 | 17,230
Blood and immune system 15,088 | 16,909
Male tissues 15,076 | 17,142
Liver and Pancreas 14,974 | 16,750
Nervous System 14,922 | 16,725
Urinary Tract 14,902 | 16,678
Respiratory system 14,755 | 16,393
Cardiovascular System 13,971 | 15,192

Target Family

Non-IDG 9,203 | 12,091
Enzyme 3,577 | 4,145
Transcription Factor 1,176 | 1,400
Kinase 578 | 634
Transporter 385 | 473
GPCR 259 | 408
Ion Channel 246 | 344
Epigenetic 229 | 242
Nuclear Receptor 39 | 48
TF/Epigenetic 34 | 38
oGPCR 27 | 421

HCA RNA Cell Line

Daudi 15,753 | 15,753
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39