Development Level

Tbio 10,262 | 11,651
Tdark 4,105 | 6,593
Tchem 1,247 | 1,388
Tclin 488 | 612

Collection

RFA-RM-18-021 255 | 328
Kinase: IDG Consortium (Target... 118 | 125
Ion Channel: IDG Consortium (T... 75 | 99
GPCR: IDG Consortium (Targets) 71 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 944 | 979
preweaning lethality, incomple... 463 | 499
abnormal behavior 271 | 298
embryonic lethality prior to t... 268 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 179 | 210
abnormal bone structure 171 | 187
decreased vertical activity 158 | 208
increased lean body mass 155 | 172
decreased body weight 153 | 161
abnormal heart morphology 140 | 162
decreased bone mineral content 131 | 151
hyperactivity 131 | 148
decreased lean body mass 119 | 135
increased total body fat amoun... 118 | 134
hypoactivity 116 | 132
decreased bone mineral density 112 | 126
decreased circulating glucose ... 111 | 126
increased circulating alkaline... 110 | 122
male infertility 109 | 123
increased startle reflex 107 | 112
embryonic growth retardation 101 | 106
increased bone mineral content 100 | 108
decreased grip strength 98 | 116
increased or absent threshold ... 93 | 101
decreased body length 91 | 101
short tibia 91 | 97
increased mean corpuscular hem... 89 | 96
abnormal seminal vesicle morph... 88 | 114
cataract 88 | 92
increased mean corpuscular vol... 87 | 92
decreased circulating choleste... 86 | 93
prenatal lethality prior to he... 81 | 87
abnormal lens morphology 78 | 81
decreased lymphocyte cell numb... 76 | 83
decreased prepulse inhibition 75 | 82
decreased circulating serum al... 73 | 82
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 72 | 79
decreased circulating insulin ... 71 | 76
decreased startle reflex 69 | 75
increased bone mineral density 69 | 72
increased fasted circulating g... 69 | 76
improved glucose tolerance 68 | 79
increased circulating HDL chol... 68 | 80
impaired glucose tolerance 67 | 75
abnormal retina morphology 65 | 71
abnormal eye morphology 64 | 68
abnormal sleep behavior 64 | 70
decreased circulating HDL chol... 64 | 68
decreased leukocyte cell numbe... 64 | 73
small superior vagus ganglion 64 | 74
decreased hemoglobin content 62 | 68
increased circulating sodium l... 62 | 71
abnormal gait 60 | 69
increased circulating choleste... 59 | 66
increased heart weight 59 | 62
abnormal behavioral response t... 58 | 66
abnormal coat-hair pigmentatio... 58 | 64
decreased erythrocyte cell num... 58 | 62
increased monocyte cell number 57 | 63
edema 55 | 59
abnormal kidney morphology 54 | 65
decreased fasted circulating g... 54 | 65
small testis 53 | 58
thrombocytopenia 52 | 56
abnormal spleen morphology 51 | 55
decreased caudal vertebrae num... 51 | 53
decreased mean corpuscular hem... 47 | 50
female infertility 47 | 60
decreased blood urea nitrogen ... 46 | 51
hydrometra 46 | 53
abnormal neural tube closure 45 | 46
decreased circulating total pr... 45 | 49
decreased circulating alanine ... 44 | 47
decreased hematocrit 44 | 46
increased blood urea nitrogen ... 44 | 48
decreased circulating alkaline... 43 | 46
increased leukocyte cell numbe... 43 | 47
increased neutrophil cell numb... 43 | 46
abnormal skin morphology 42 | 50
increased hematocrit 41 | 46
enlarged spleen 40 | 41
increased hemoglobin content 40 | 45
decreased red blood cell distr... 39 | 41
increased mean platelet volume 39 | 45
abnormal testis morphology 38 | 43
increased circulating triglyce... 38 | 42
decreased neutrophil cell numb... 37 | 42
limb grasping 37 | 41
tremors 37 | 39
abnormal bone mineralization 36 | 38
decreased circulating LDL chol... 36 | 38
increased grip strength 36 | 41
abnormal cranium morphology 35 | 36
decreased circulating creatini... 35 | 39
increased circulating chloride... 35 | 41
prolonged QT interval 35 | 38

Disease

Carcinoma 9,765 | 11,493
ovarian cancer 8,027 | 8,520
osteosarcoma 7,331 | 7,950
medulloblastoma, large-cell 5,709 | 6,241
psoriasis 5,658 | 6,694
glioblastoma 5,329 | 5,792
atypical teratoid / rhabdoid tumor 4,715 | 5,112
lung cancer 4,363 | 4,740
ependymoma 4,284 | 4,679
group 3 medulloblastoma 3,796 | 4,104
adult high grade glioma 3,404 | 3,801
Breast cancer 3,302 | 3,578
malignant mesothelioma 3,083 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,077 | 3,291
primitive neuroectodermal tumor 2,793 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,762 | 2,989
Astrocytoma, Pilocytic 2,747 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 2,732 | 2,955
invasive ductal carcinoma 2,725 | 2,951
non-small cell lung cancer 2,634 | 2,890
oligodendroglioma 2,593 | 2,850
lung carcinoma 2,492 | 2,843
lung adenocarcinoma 2,431 | 2,716
astrocytic glioma 2,362 | 2,597
Kidney cancer 2,270 | 2,613
pancreatic cancer 2,227 | 2,398
Cancer 2,212 | 2,499
subependymal giant cell astrocytoma 2,096 | 2,287
interstitial cystitis 2,035 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,869 | 1,962
tuberculosis 1,858 | 2,010
pituitary cancer 1,776 | 1,972
Pick disease 1,771 | 1,894
group 4 medulloblastoma 1,724 | 1,855
ulcerative colitis 1,640 | 1,819
ductal carcinoma in situ 1,610 | 1,745
cystic fibrosis 1,575 | 1,696
breast carcinoma 1,502 | 1,638
diabetes mellitus 1,376 | 1,728
colon cancer 1,328 | 1,478
adrenocortical carcinoma 1,321 | 1,428
Multiple myeloma 1,305 | 1,332
Autosomal recessive predisposition 1,272 | 1,442
juvenile dermatomyositis 1,140 | 1,187
acute quadriplegic myopathy 1,110 | 1,158
Rheumatoid arthritis 1,100 | 1,191
astrocytoma 1,094 | 1,146
primary pancreatic ductal adenocarcinoma 1,046 | 1,109
spina bifida 1,031 | 1,074
pediatric high grade glioma 996 | 1,064
Schizophrenia 969 | 1,160
nasopharyngeal carcinoma 965 | 1,058
Intellectual disability 947 | 1,016
dermatomyositis 939 | 966
cutaneous lupus erythematosus 899 | 1,057
active Crohn's disease 856 | 922
non primary Sjogren syndrome sicca 804 | 891
Atopic dermatitis 802 | 952
acute myeloid leukemia 752 | 783
gastric carcinoma 750 | 807
Waldenstrons macroglobulinemia 741 | 765
active ulcerative colitis 713 | 764
Epilepsy 711 | 792
esophageal adenocarcinoma 700 | 737
Liver Cirrhosis, Experimental 688 | 769
medulloblastoma 667 | 720
primary Sjogren syndrome 656 | 735
progressive supranuclear palsy 645 | 676
aldosterone-producing adenoma 625 | 665
Dull intelligence 605 | 645
Low intelligence 605 | 645
Mental Retardation 605 | 645
Mental deficiency 605 | 645
Poor school performance 605 | 645
Obesity 579 | 678
Cognitive delay 578 | 608
Global developmental delay 578 | 608
Mental and motor retardation 578 | 608
Alzheimer's disease 573 | 658
Bipolar Disorder 557 | 666
Duchenne muscular dystrophy 554 | 601
Melanoma 543 | 711
Seizures 538 | 596
Muscle hypotonia 536 | 571
pancreatic carcinoma 526 | 562
hepatocellular carcinoma 521 | 547
fibroadenoma 506 | 559
Liver cancer 497 | 604
Short stature 490 | 531
Endometriosis 486 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 479 | 510
chronic rhinosinusitis 469 | 512
Down syndrome 467 | 499
Prostatic Neoplasms 464 | 495
Multiple Sclerosis 449 | 540
gastric cancer 433 | 459
sonic hedgehog group medulloblastoma 427 | 467
posterior fossa group A ependymoma 423 | 468
Amyotrophic lateral sclerosis 419 | 451
Breast Neoplasms 419 | 445

Tissue

Endocrine System 15,814 | 18,159
Female tissues 15,641 | 17,400
Digestive Tract 15,634 | 17,369
Skin and soft tissues 15,570 | 17,230
Male tissues 15,490 | 17,142
Blood and immune system 15,397 | 16,909
Liver and Pancreas 15,345 | 16,750
Nervous System 15,317 | 16,725
Urinary Tract 15,260 | 16,678
Respiratory system 15,138 | 16,393
Cardiovascular System 14,262 | 15,192

Target Family

Non-IDG 9,365 | 12,091
Enzyme 3,679 | 4,145
Transcription Factor 1,215 | 1,400
Kinase 595 | 634
Transporter 400 | 473
GPCR 260 | 408
Ion Channel 260 | 344
Epigenetic 228 | 242
Nuclear Receptor 43 | 48
TF/Epigenetic 37 | 38
oGPCR 20 | 421

HCA RNA Cell Line

CAPAN-2 16,102 | 16,102
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164