Development Level

Tbio 9,854 | 11,178
Tdark 4,092 | 6,569
Tchem 1,668 | 1,885
Tclin 488 | 612

Collection

Kinase: IDG Consortium (Target... 118 | 125
Ion Channel: IDG Consortium (T... 75 | 99
GPCR: IDG Consortium (Targets) 71 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 944 | 979
preweaning lethality, incomple... 463 | 499
abnormal behavior 271 | 298
embryonic lethality prior to t... 268 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 179 | 210
abnormal bone structure 171 | 187
decreased vertical activity 158 | 208
increased lean body mass 155 | 172
decreased body weight 153 | 161
abnormal heart morphology 140 | 162
decreased bone mineral content 131 | 151
hyperactivity 131 | 148
decreased lean body mass 119 | 135
increased total body fat amoun... 118 | 134
hypoactivity 116 | 132
decreased bone mineral density 112 | 126
decreased circulating glucose ... 111 | 126
increased circulating alkaline... 110 | 122
male infertility 109 | 123
increased startle reflex 107 | 112
embryonic growth retardation 101 | 106
increased bone mineral content 100 | 108
decreased grip strength 98 | 116
increased or absent threshold ... 93 | 101
decreased body length 91 | 101
short tibia 91 | 97
increased mean corpuscular hem... 89 | 96
abnormal seminal vesicle morph... 88 | 114
cataract 88 | 92
increased mean corpuscular vol... 87 | 92
decreased circulating choleste... 86 | 93
prenatal lethality prior to he... 81 | 87
abnormal lens morphology 78 | 81
decreased lymphocyte cell numb... 76 | 83
decreased prepulse inhibition 75 | 82
decreased circulating serum al... 73 | 82
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 72 | 79
decreased circulating insulin ... 71 | 76
decreased startle reflex 69 | 75
increased bone mineral density 69 | 72
increased fasted circulating g... 69 | 76
improved glucose tolerance 68 | 79
increased circulating HDL chol... 68 | 80
impaired glucose tolerance 67 | 75
abnormal retina morphology 65 | 71
abnormal eye morphology 64 | 68
abnormal sleep behavior 64 | 70
decreased circulating HDL chol... 64 | 68
decreased leukocyte cell numbe... 64 | 73
small superior vagus ganglion 64 | 74
decreased hemoglobin content 62 | 68
increased circulating sodium l... 62 | 71
abnormal gait 60 | 69
increased circulating choleste... 59 | 66
increased heart weight 59 | 62
abnormal behavioral response t... 58 | 66
abnormal coat-hair pigmentatio... 58 | 64
decreased erythrocyte cell num... 58 | 62
increased monocyte cell number 57 | 63
edema 55 | 59
abnormal kidney morphology 54 | 65
decreased fasted circulating g... 54 | 65
small testis 53 | 58
thrombocytopenia 52 | 56
abnormal spleen morphology 51 | 55
decreased caudal vertebrae num... 51 | 53
decreased mean corpuscular hem... 47 | 50
female infertility 47 | 60
decreased blood urea nitrogen ... 46 | 51
hydrometra 46 | 53
abnormal neural tube closure 45 | 46
decreased circulating total pr... 45 | 49
decreased circulating alanine ... 44 | 47
decreased hematocrit 44 | 46
increased blood urea nitrogen ... 44 | 48
decreased circulating alkaline... 43 | 46
increased leukocyte cell numbe... 43 | 47
increased neutrophil cell numb... 43 | 46
abnormal skin morphology 42 | 50
increased hematocrit 41 | 46
enlarged spleen 40 | 41
increased hemoglobin content 40 | 45
decreased red blood cell distr... 39 | 41
increased mean platelet volume 39 | 45
abnormal testis morphology 38 | 43
increased circulating triglyce... 38 | 42
decreased neutrophil cell numb... 37 | 42
limb grasping 37 | 41
tremors 37 | 39
abnormal bone mineralization 36 | 38
decreased circulating LDL chol... 36 | 38
increased grip strength 36 | 41
abnormal cranium morphology 35 | 36
decreased circulating creatini... 35 | 39
increased circulating chloride... 35 | 41
prolonged QT interval 35 | 38

Disease

Carcinoma 9,512 | 11,192
ovarian cancer 7,817 | 8,297
osteosarcoma 7,159 | 7,766
medulloblastoma, large-cell 5,566 | 6,086
psoriasis 5,504 | 6,514
glioblastoma 5,184 | 5,635
atypical teratoid / rhabdoid tumor 4,583 | 4,971
lung cancer 4,244 | 4,607
ependymoma 4,172 | 4,559
group 3 medulloblastoma 3,701 | 4,002
adult high grade glioma 3,315 | 3,701
Breast cancer 3,206 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 2,997 | 3,204
malignant mesothelioma 2,991 | 3,135
primitive neuroectodermal tumor 2,720 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,682 | 2,902
Astrocytoma, Pilocytic 2,675 | 3,006
intraductal papillary-mucinous adenoma (IPMA) 2,655 | 2,872
invasive ductal carcinoma 2,648 | 2,867
non-small cell lung cancer 2,551 | 2,799
oligodendroglioma 2,515 | 2,768
lung carcinoma 2,411 | 2,755
lung adenocarcinoma 2,350 | 2,627
astrocytic glioma 2,298 | 2,530
Kidney cancer 2,217 | 2,548
pancreatic cancer 2,157 | 2,322
Cancer 2,114 | 2,388
subependymal giant cell astrocytoma 2,045 | 2,230
interstitial cystitis 1,967 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,824 | 1,911
tuberculosis 1,816 | 1,963
Pick disease 1,735 | 1,856
pituitary cancer 1,722 | 1,915
group 4 medulloblastoma 1,681 | 1,806
ulcerative colitis 1,590 | 1,765
ductal carcinoma in situ 1,555 | 1,686
cystic fibrosis 1,515 | 1,629
breast carcinoma 1,457 | 1,589
diabetes mellitus 1,337 | 1,683
colon cancer 1,283 | 1,428
adrenocortical carcinoma 1,279 | 1,385
Multiple myeloma 1,269 | 1,296
Autosomal recessive predisposition 1,241 | 1,407
juvenile dermatomyositis 1,103 | 1,147
acute quadriplegic myopathy 1,086 | 1,133
Rheumatoid arthritis 1,066 | 1,156
astrocytoma 1,062 | 1,113
spina bifida 1,012 | 1,053
primary pancreatic ductal adenocarcinoma 1,009 | 1,071
pediatric high grade glioma 967 | 1,035
Schizophrenia 948 | 1,136
nasopharyngeal carcinoma 935 | 1,024
Intellectual disability 930 | 998
dermatomyositis 914 | 941
cutaneous lupus erythematosus 866 | 1,016
active Crohn's disease 823 | 882
non primary Sjogren syndrome sicca 779 | 861
Atopic dermatitis 768 | 915
acute myeloid leukemia 729 | 760
gastric carcinoma 725 | 781
Waldenstrons macroglobulinemia 718 | 742
Epilepsy 694 | 775
active ulcerative colitis 688 | 736
esophageal adenocarcinoma 662 | 696
Liver Cirrhosis, Experimental 655 | 733
medulloblastoma 649 | 702
primary Sjogren syndrome 633 | 710
progressive supranuclear palsy 628 | 656
aldosterone-producing adenoma 608 | 646
Dull intelligence 595 | 634
Low intelligence 595 | 634
Mental Retardation 595 | 634
Mental deficiency 595 | 634
Poor school performance 595 | 634
Cognitive delay 567 | 596
Global developmental delay 567 | 596
Mental and motor retardation 567 | 596
Obesity 559 | 655
Alzheimer's disease 556 | 640
Duchenne muscular dystrophy 541 | 587
Bipolar Disorder 538 | 646
Melanoma 529 | 689
Muscle hypotonia 528 | 562
Seizures 526 | 584
pancreatic carcinoma 520 | 555
hepatocellular carcinoma 510 | 536
fibroadenoma 487 | 538
Liver cancer 485 | 589
Short stature 475 | 514
Endometriosis 467 | 521
autosomal dominant Emery-Dreifuss muscular dystrophy 462 | 492
chronic rhinosinusitis 462 | 505
Down syndrome 450 | 480
Prostatic Neoplasms 443 | 472
Multiple Sclerosis 438 | 527
gastric cancer 419 | 445
sonic hedgehog group medulloblastoma 419 | 459
posterior fossa group A ependymoma 411 | 456
Amyotrophic lateral sclerosis 405 | 437
Breast Neoplasms 398 | 423

Tissue

Endocrine System 15,814 | 18,159
Female tissues 15,641 | 17,400
Digestive Tract 15,634 | 17,369
Skin and soft tissues 15,570 | 17,230
Male tissues 15,490 | 17,142
Blood and immune system 15,397 | 16,909
Liver and Pancreas 15,345 | 16,750
Nervous System 15,317 | 16,725
Urinary Tract 15,260 | 16,678
Respiratory system 15,138 | 16,393
Cardiovascular System 14,262 | 15,192

Target Family

Non-IDG 9,365 | 12,091
Enzyme 3,679 | 4,145
Transcription Factor 1,215 | 1,400
Kinase 595 | 634
Transporter 400 | 473
GPCR 260 | 408
Ion Channel 260 | 344
Epigenetic 228 | 242
Nuclear Receptor 43 | 48
TF/Epigenetic 37 | 38
oGPCR 20 | 421

HCA RNA Cell Line

CAPAN-2 16,102 | 16,102
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101