Development Level

Tbio 9,907 | 11,651
Tdark 3,870 | 6,593
Tchem 1,202 | 1,388
Tclin 457 | 612

Collection

RFA-RM-18-021 240 | 328
Kinase: IDG Consortium (Target... 118 | 125
Ion Channel: IDG Consortium (T... 68 | 99
GPCR: IDG Consortium (Targets) 63 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 17 | 25

IMPC Phenotype

preweaning lethality, complete... 941 | 979
preweaning lethality, incomple... 454 | 499
abnormal behavior 268 | 298
embryonic lethality prior to t... 268 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 213 | 220
decreased total body fat amoun... 180 | 207
enlarged heart 174 | 210
abnormal bone structure 165 | 187
increased lean body mass 151 | 172
decreased vertical activity 150 | 208
decreased body weight 148 | 161
abnormal heart morphology 133 | 162
decreased bone mineral content 131 | 151
hyperactivity 128 | 148
decreased lean body mass 121 | 135
increased total body fat amoun... 120 | 134
decreased circulating glucose ... 112 | 126
hypoactivity 111 | 132
decreased bone mineral density 110 | 126
increased circulating alkaline... 109 | 122
embryonic growth retardation 102 | 106
increased startle reflex 102 | 112
decreased grip strength 100 | 116
increased bone mineral content 98 | 108
male infertility 96 | 123
abnormal seminal vesicle morph... 94 | 114
decreased body length 94 | 101
cataract 88 | 92
increased mean corpuscular hem... 88 | 96
increased mean corpuscular vol... 88 | 92
short tibia 88 | 97
increased or absent threshold ... 87 | 101
decreased circulating choleste... 83 | 93
prenatal lethality prior to he... 81 | 87
abnormal lens morphology 77 | 81
decreased circulating serum al... 73 | 82
decreased lymphocyte cell numb... 70 | 83
increased fasted circulating g... 70 | 76
decreased mean corpuscular vol... 69 | 79
decreased prepulse inhibition 69 | 82
decreased circulating triglyce... 68 | 79
abnormal retina morphology 67 | 71
decreased circulating insulin ... 67 | 76
improved glucose tolerance 67 | 79
increased bone mineral density 67 | 72
increased circulating HDL chol... 66 | 80
abnormal eye morphology 64 | 68
impaired glucose tolerance 64 | 75
small superior vagus ganglion 63 | 74
decreased circulating HDL chol... 62 | 68
decreased hemoglobin content 62 | 68
abnormal sleep behavior 61 | 70
decreased erythrocyte cell num... 61 | 62
decreased startle reflex 61 | 75
increased circulating sodium l... 61 | 71
decreased leukocyte cell numbe... 60 | 73
abnormal coat-hair pigmentatio... 58 | 64
edema 58 | 59
abnormal behavioral response t... 56 | 66
abnormal gait 56 | 69
increased circulating choleste... 56 | 66
increased monocyte cell number 56 | 63
decreased fasted circulating g... 54 | 65
increased heart weight 53 | 62
abnormal kidney morphology 52 | 65
thrombocytopenia 52 | 56
decreased caudal vertebrae num... 51 | 53
abnormal spleen morphology 49 | 55
small testis 49 | 58
decreased circulating total pr... 47 | 49
female infertility 46 | 60
hydrometra 46 | 53
decreased blood urea nitrogen ... 45 | 51
decreased hematocrit 45 | 46
decreased mean corpuscular hem... 45 | 50
abnormal neural tube closure 44 | 46
decreased circulating alanine ... 44 | 47
abnormal skin morphology 42 | 50
increased blood urea nitrogen ... 42 | 48
decreased circulating alkaline... 41 | 46
increased mean platelet volume 41 | 45
increased hemoglobin content 40 | 45
increased hematocrit 39 | 46
increased neutrophil cell numb... 39 | 46
decreased neutrophil cell numb... 38 | 42
decreased red blood cell distr... 38 | 41
increased leukocyte cell numbe... 38 | 47
decreased circulating LDL chol... 37 | 38
enlarged spleen 37 | 41
abnormal bone mineralization 36 | 38
abnormal cranium morphology 36 | 36
increased circulating triglyce... 36 | 42
abnormal testis morphology 35 | 43
increased grip strength 35 | 41
abnormal epididymis morphology 34 | 42
decreased circulating creatini... 34 | 39
increased mean corpuscular hem... 34 | 36
limb grasping 34 | 41
tremors 34 | 39

Disease

Carcinoma 9,377 | 11,493
ovarian cancer 7,827 | 8,520
osteosarcoma 7,107 | 7,950
medulloblastoma, large-cell 5,529 | 6,241
psoriasis 5,388 | 6,694
glioblastoma 5,148 | 5,792
atypical teratoid / rhabdoid tumor 4,567 | 5,112
lung cancer 4,183 | 4,740
ependymoma 4,085 | 4,679
group 3 medulloblastoma 3,665 | 4,104
adult high grade glioma 3,250 | 3,801
Breast cancer 3,200 | 3,578
malignant mesothelioma 2,989 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,973 | 3,291
primitive neuroectodermal tumor 2,706 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,656 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,633 | 2,955
Astrocytoma, Pilocytic 2,597 | 3,081
invasive ductal carcinoma 2,593 | 2,951
oligodendroglioma 2,501 | 2,850
non-small cell lung cancer 2,483 | 2,890
lung carcinoma 2,307 | 2,843
lung adenocarcinoma 2,301 | 2,716
astrocytic glioma 2,287 | 2,597
Kidney cancer 2,150 | 2,613
pancreatic cancer 2,140 | 2,398
Cancer 2,124 | 2,499
subependymal giant cell astrocytoma 2,018 | 2,287
interstitial cystitis 1,876 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,864 | 1,962
tuberculosis 1,772 | 2,010
Pick disease 1,716 | 1,894
group 4 medulloblastoma 1,676 | 1,855
pituitary cancer 1,667 | 1,972
ulcerative colitis 1,541 | 1,819
ductal carcinoma in situ 1,530 | 1,745
cystic fibrosis 1,464 | 1,696
breast carcinoma 1,417 | 1,638
diabetes mellitus 1,305 | 1,728
Multiple myeloma 1,297 | 1,332
colon cancer 1,297 | 1,478
adrenocortical carcinoma 1,261 | 1,428
Autosomal recessive predisposition 1,256 | 1,442
juvenile dermatomyositis 1,100 | 1,187
acute quadriplegic myopathy 1,089 | 1,158
astrocytoma 1,059 | 1,146
Rheumatoid arthritis 1,036 | 1,191
primary pancreatic ductal adenocarcinoma 1,016 | 1,109
spina bifida 1,003 | 1,074
pediatric high grade glioma 965 | 1,064
Intellectual disability 933 | 1,016
Schizophrenia 915 | 1,160
nasopharyngeal carcinoma 892 | 1,058
dermatomyositis 888 | 966
cutaneous lupus erythematosus 828 | 1,057
active Crohn's disease 825 | 922
non primary Sjogren syndrome sicca 770 | 891
Atopic dermatitis 734 | 952
acute myeloid leukemia 725 | 783
Waldenstrons macroglobulinemia 722 | 765
gastric carcinoma 715 | 807
Epilepsy 697 | 792
active ulcerative colitis 680 | 764
Liver Cirrhosis, Experimental 674 | 769
esophageal adenocarcinoma 656 | 737
medulloblastoma 641 | 720
progressive supranuclear palsy 631 | 676
aldosterone-producing adenoma 602 | 665
Dull intelligence 598 | 645
Low intelligence 598 | 645
Mental Retardation 598 | 645
Mental deficiency 598 | 645
Poor school performance 598 | 645
primary Sjogren syndrome 597 | 735
Cognitive delay 575 | 608
Global developmental delay 575 | 608
Mental and motor retardation 575 | 608
Obesity 563 | 678
Alzheimer's disease 554 | 658
Seizures 536 | 596
Muscle hypotonia 535 | 571
Melanoma 529 | 711
Bipolar Disorder 527 | 666
Duchenne muscular dystrophy 526 | 601
pancreatic carcinoma 500 | 562
hepatocellular carcinoma 496 | 547
Short stature 492 | 531
Endometriosis 471 | 540
Liver cancer 466 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 459 | 510
fibroadenoma 458 | 559
Prostatic Neoplasms 452 | 495
Down syndrome 443 | 499
chronic rhinosinusitis 432 | 512
sonic hedgehog group medulloblastoma 419 | 467
gastric cancer 417 | 459
Multiple Sclerosis 413 | 540
Amyotrophic lateral sclerosis 409 | 451
posterior fossa group A ependymoma 409 | 468
Breast Neoplasms 401 | 445

Tissue

Endocrine System 15,193 | 18,159
Digestive Tract 15,032 | 17,369
Female tissues 15,004 | 17,400
Skin and soft tissues 14,961 | 17,230
Male tissues 14,907 | 17,142
Blood and immune system 14,822 | 16,909
Liver and Pancreas 14,790 | 16,750
Urinary Tract 14,739 | 16,678
Nervous System 14,737 | 16,725
Respiratory system 14,587 | 16,393
Cardiovascular System 13,817 | 15,192

Target Family

Non-IDG 8,919 | 12,091
Enzyme 3,581 | 4,145
Transcription Factor 1,192 | 1,400
Kinase 578 | 634
Transporter 381 | 473
Ion Channel 239 | 344
GPCR 235 | 408
Epigenetic 226 | 242
Nuclear Receptor 41 | 48
TF/Epigenetic 34 | 38
oGPCR 10 | 421

HCA RNA Cell Line

CACO-2 15,436 | 15,436
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50