Development Level

Tbio 8,994 | 10,625
Tdark 4,211 | 7,003
Tchem 1,600 | 1,890
Tclin 449 | 602

Collection

Kinase: IDG Consortium (Targets) 116 | 125
Ion Channel: IDG Consortium (Targets) 70 | 102
GPCR: IDG Consortium (Targets) 63 | 127
Kinase: IDG Consortium (Complete/Control) 32 | 37
GPCR: IDG Consortium (Complete/Control) 18 | 26

IMPC Phenotype

preweaning lethality, complete... 607 | 633
preweaning lethality, incomple... 238 | 260
abnormal behavior 203 | 226
embryonic lethality prior to t... 182 | 187
decreased lean body mass 178 | 195
decreased total body fat amoun... 165 | 186
decreased body weight 160 | 174
embryonic lethality prior to o... 147 | 148
decreased bone mineral content 142 | 157
abnormal bone structure 116 | 131
increased or absent threshold ... 114 | 128
decreased bone mineral density 111 | 126
increased circulating alkaline... 108 | 119
abnormal embryo size 107 | 112
decreased circulating glucose ... 103 | 121
decreased grip strength 103 | 123
decreased body length 98 | 108
hyperactivity 97 | 108
enlarged heart 93 | 111
increased lean body mass 91 | 107
abnormal retina morphology 89 | 100
increased mean corpuscular hem... 87 | 93
increased mean corpuscular vol... 86 | 91
increased bone mineral content 85 | 92
decreased circulating choleste... 77 | 85
hypoactivity 76 | 89
decreased circulating triglyce... 73 | 83
short tibia 72 | 82
decreased circulating HDL chol... 69 | 77
decreased circulating serum al... 69 | 79
abnormal lens morphology 67 | 73
increased grip strength 67 | 83
decreased circulating insulin ... 64 | 75
increased fasted circulating g... 63 | 68
prenatal lethality prior to he... 62 | 64
increased circulating sodium l... 61 | 71
decreased lumbar vertebrae num... 59 | 62
increased sacral vertebrae num... 58 | 62
abnormal retinal pigmentation 56 | 61
abnormal sleep behavior 54 | 63
decreased rib number 54 | 59
abnormal bone mineralization 52 | 55
increased total body fat amoun... 52 | 57
increased circulating HDL chol... 51 | 63
abnormal coat-hair pigmentatio... 48 | 54
male infertility 48 | 62
decreased circulating alanine ... 47 | 53
increased bone mineral density 47 | 52
increased exploration in new e... 47 | 56
decreased hemoglobin content 46 | 53
decreased mean corpuscular vol... 46 | 50
improved glucose tolerance 46 | 56
increased circulating choleste... 46 | 53
impaired glucose tolerance 45 | 52
decreased caudal vertebrae num... 44 | 49
decreased leukocyte cell numbe... 44 | 54
abnormal behavioral response t... 43 | 52
decreased erythrocyte cell num... 43 | 43
decreased prepulse inhibition 43 | 52
thrombocytopenia 43 | 46
abnormal gait 42 | 51
decreased fasted circulating g... 42 | 49
decreased startle reflex 41 | 48
decreased circulating total pr... 40 | 41
increased hemoglobin content 40 | 45
abnormal heart morphology 39 | 51
decreased heart weight 38 | 44
increased body weight 38 | 42
abnormal seminal vesicle morph... 37 | 47
increased blood urea nitrogen ... 37 | 44
decreased circulating LDL chol... 36 | 37
decreased circulating alkaline... 36 | 41
increased circulating chloride... 36 | 43
increased rib number 36 | 41
abnormal eye morphology 35 | 38
decreased eosinophil cell numb... 35 | 41
decreased neutrophil cell numb... 35 | 37
increased startle reflex 35 | 38
abnormal neural tube closure 34 | 37
decreased circulating free fat... 34 | 39
abnormal cranium morphology 32 | 32
cardiovascular system phenotyp... 31 | 35
decreased circulating fructosa... 31 | 31
decreased mean corpuscular hem... 31 | 34
increased heart weight 31 | 37
abnormal spleen morphology 30 | 36
increased leukocyte cell numbe... 30 | 37
small testis 30 | 37
decreased T cell number 29 | 31
decreased circulating calcium ... 29 | 33
decreased circulating chloride... 29 | 32
decreased circulating creatini... 29 | 31
increased hematocrit 29 | 36
limb grasping 29 | 35
tremors 29 | 34
decreased blood urea nitrogen ... 28 | 31
decreased threshold for audito... 28 | 32
embryonic growth retardation 27 | 28
increased circulating potassiu... 27 | 31
decreased circulating aspartat... 26 | 27

Disease

ovarian cancer 7,711 | 8,491
osteosarcoma 7,019 | 7,933
medulloblastoma, large-cell 5,470 | 6,234
psoriasis 5,337 | 6,685
glioblastoma 4,905 | 5,572
lung cancer 3,991 | 4,473
atypical teratoid / rhabdoid tumor 3,865 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,943 | 3,289
malignant mesothelioma 2,906 | 3,163
Breast cancer 2,776 | 3,098
primitive neuroectodermal tumor 2,671 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,632 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,617 | 2,956
pilocytic astrocytoma 2,568 | 3,086
invasive ductal carcinoma 2,564 | 2,950
oligodendroglioma 2,477 | 2,849
non-small cell lung cancer 2,385 | 2,798
pediatric high grade glioma 2,356 | 2,712
lung carcinoma 2,293 | 2,844
lung adenocarcinoma 2,279 | 2,714
ependymoma 2,247 | 2,514
pancreatic cancer 2,047 | 2,300
group 3 medulloblastoma 2,003 | 2,254
subependymal giant cell astrocytoma 1,999 | 2,287
Cancer 1,979 | 2,346
astrocytic glioma 1,959 | 2,241
interstitial cystitis 1,859 | 2,299
adult high grade glioma 1,811 | 2,148
ulcerative colitis 1,780 | 2,087
Carcinoma 1,711 | 2,147
Pick disease 1,702 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,682 | 1,795
group 4 medulloblastoma 1,673 | 1,875
pituitary cancer 1,655 | 1,972
ductal carcinoma in situ 1,514 | 1,745
cystic fibrosis 1,430 | 1,670
breast carcinoma 1,381 | 1,614
tuberculosis 1,358 | 1,563
astrocytoma 1,355 | 1,493
medulloblastoma 1,343 | 1,524
sonic hedgehog group medulloblastoma 1,302 | 1,482
colon cancer 1,285 | 1,475
Multiple myeloma 1,282 | 1,327
posterior fossa group A ependymoma 1,269 | 1,511
posterior fossa group B ependymoma 1,269 | 1,530
adrenocortical carcinoma 1,243 | 1,427
diabetes mellitus 1,242 | 1,663
primary pancreatic ductal adenocarcinoma 1,167 | 1,271
juvenile dermatomyositis 1,092 | 1,189
acute quadriplegic myopathy 1,080 | 1,157
Rheumatoid Arthritis 1,005 | 1,170
spina bifida 983 | 1,064
atypical teratoid/rhabdoid tumor 969 | 1,095
nasopharyngeal carcinoma 885 | 1,056
dermatomyositis 883 | 966
cutaneous lupus erythematosus 819 | 1,056
active Crohn's disease 815 | 918
gastric carcinoma 734 | 832
Atopic dermatitis 724 | 944
non primary Sjogren syndrome sicca 717 | 840
Waldenstrons macroglobulinemia 715 | 764
acute myeloid leukemia 714 | 785
esophageal adenocarcinoma 653 | 737
tuberculosis and treatment for 6 months 647 | 686
primary Sjogren syndrome 636 | 788
progressive supranuclear palsy 625 | 674
aldosterone-producing adenoma 597 | 664
Alzheimer's disease 537 | 644
Duchenne muscular dystrophy 520 | 602
Intellectual disability 520 | 573
Obesity 505 | 616
pancreatic carcinoma 500 | 567
hepatocellular carcinoma 496 | 550
Down syndrome 480 | 548
Endometriosis 461 | 535
fibroadenoma 454 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 447 | 499
chronic rhinosinusitis 429 | 512
Prostatic Neoplasms 427 | 471
active ulcerative colitis 414 | 477
IGA Glomerulonephritis 398 | 454
gastric cancer 390 | 436
Amyotrophic Lateral Sclerosis 385 | 432
Multiple Sclerosis 378 | 498
Schizophrenia 378 | 503
Mammary Neoplasms 367 | 410
mucosa-associated lymphoid tissue lymphoma 361 | 480
inflammatory breast cancer 345 | 404
Neurodegenerative disease 341 | 383
non-small cell lung carcinoma 323 | 413
Kidney disease 309 | 397
Parkinson's disease 304 | 364
sarcoidosis 303 | 368
glioblastoma multiforme 300 | 347
hereditary spastic paraplegia 297 | 313
Polycystic Ovary Syndrome 296 | 334
tuberculosis and treatment for 3 months 289 | 327
nephrosclerosis 272 | 329
urothelial carcinoma 272 | 318
Epilepsy 270 | 346

Tissue

Nervous System 15,076 | 18,560
Digestive Tract 15,060 | 18,472
Female tissues 15,046 | 18,646
Endocrine System 15,038 | 18,511
Urinary Tract 14,998 | 18,443
Liver and Pancreas 14,992 | 18,135
Blood and immune system 14,949 | 17,994
Male tissues 14,947 | 17,968
Cardiovascular System 14,935 | 17,957
Skin and soft tissues 14,894 | 18,114
Respiratory system 14,773 | 17,483

Target Family

Non-IDG 8,784 | 11,969
Enzyme 3,554 | 4,146
Transcription Factor 1,189 | 1,400
Kinase 572 | 634
Transporter 381 | 473
GPCR 235 | 408
Ion Channel 235 | 341
Epigenetic 220 | 242
Nuclear Receptor 41 | 48
TF/Epigenetic 33 | 38
oGPCR 10 | 421

HCA RNA Cell Line

CACO-2 15,254 | 15,254
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66