Development Level

Tbio 8,994 | 10,625
Tdark 4,288 | 7,003
Tchem 1,584 | 1,890
Tclin 445 | 602

Collection

Kinase: IDG Consortium (Targets) 115 | 125
Ion Channel: IDG Consortium (Targets) 70 | 102
GPCR: IDG Consortium (Targets) 62 | 128
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 17 | 24

IMPC Phenotype

preweaning lethality, complete... 602 | 633
preweaning lethality, incomple... 233 | 260
abnormal behavior 206 | 226
decreased lean body mass 184 | 195
embryonic lethality prior to t... 181 | 187
decreased total body fat amoun... 171 | 186
decreased body weight 163 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 145 | 157
abnormal bone structure 119 | 131
decreased bone mineral density 115 | 126
increased or absent threshold ... 114 | 128
increased circulating alkaline... 112 | 119
abnormal embryo size 105 | 112
decreased body length 103 | 108
decreased grip strength 103 | 123
decreased circulating glucose ... 100 | 121
hyperactivity 98 | 108
abnormal retina morphology 92 | 100
increased lean body mass 92 | 107
enlarged heart 88 | 111
increased mean corpuscular hem... 87 | 93
increased bone mineral content 83 | 92
increased mean corpuscular vol... 81 | 91
decreased circulating choleste... 78 | 85
hypoactivity 78 | 89
increased grip strength 73 | 83
short tibia 73 | 82
decreased circulating triglyce... 72 | 83
decreased circulating serum al... 70 | 79
decreased circulating HDL chol... 69 | 77
abnormal lens morphology 66 | 73
increased fasted circulating g... 63 | 68
prenatal lethality prior to he... 61 | 64
abnormal retinal pigmentation 58 | 61
decreased circulating insulin ... 58 | 75
increased circulating sodium l... 57 | 71
decreased lumbar vertebrae num... 56 | 62
increased sacral vertebrae num... 55 | 62
abnormal sleep behavior 53 | 63
decreased rib number 53 | 59
increased circulating HDL chol... 52 | 63
abnormal bone mineralization 51 | 55
male infertility 51 | 62
increased total body fat amoun... 50 | 57
increased exploration in new e... 49 | 56
decreased prepulse inhibition 48 | 52
decreased startle reflex 48 | 48
increased bone mineral density 48 | 52
increased circulating choleste... 48 | 53
abnormal behavioral response t... 47 | 52
decreased caudal vertebrae num... 46 | 49
decreased circulating alanine ... 46 | 53
decreased hemoglobin content 46 | 53
decreased mean corpuscular vol... 46 | 50
abnormal coat-hair pigmentatio... 45 | 54
decreased leukocyte cell numbe... 45 | 54
improved glucose tolerance 45 | 56
abnormal gait 42 | 51
impaired glucose tolerance 42 | 52
decreased fasted circulating g... 41 | 49
decreased circulating total pr... 40 | 41
thrombocytopenia 40 | 46
increased body weight 39 | 42
increased hemoglobin content 39 | 45
abnormal heart morphology 38 | 51
decreased heart weight 38 | 44
decreased erythrocyte cell num... 37 | 43
increased blood urea nitrogen ... 37 | 44
abnormal neural tube closure 36 | 37
decreased circulating LDL chol... 36 | 37
decreased neutrophil cell numb... 36 | 37
increased rib number 36 | 41
decreased circulating alkaline... 35 | 41
increased circulating chloride... 35 | 43
abnormal eye morphology 34 | 38
decreased circulating free fat... 34 | 39
decreased eosinophil cell numb... 34 | 41
increased leukocyte cell numbe... 34 | 37
increased hematocrit 33 | 36
small testis 33 | 37
increased startle reflex 32 | 38
abnormal seminal vesicle morph... 31 | 47
cardiovascular system phenotyp... 31 | 35
decreased mean corpuscular hem... 31 | 34
tremors 31 | 34
abnormal cranium morphology 30 | 32
abnormal spleen morphology 29 | 36
decreased circulating creatini... 29 | 31
decreased circulating fructosa... 29 | 31
increased heart weight 29 | 37
decreased circulating calcium ... 28 | 33
decreased threshold for audito... 28 | 32
limb grasping 28 | 35
abnormal testis morphology 27 | 30
decreased T cell number 27 | 31
decreased blood urea nitrogen ... 27 | 31
decreased circulating chloride... 27 | 32
embryonic growth retardation 27 | 28
increased circulating potassiu... 27 | 31

Disease

ovarian cancer 7,755 | 8,491
osteosarcoma 7,072 | 7,933
medulloblastoma, large-cell 5,532 | 6,234
psoriasis 5,360 | 6,685
glioblastoma 5,009 | 5,572
lung cancer 4,054 | 4,473
atypical teratoid / rhabdoid tumor 3,930 | 4,369
malignant mesothelioma 2,997 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 2,937 | 3,289
Breast cancer 2,799 | 3,098
primitive neuroectodermal tumor 2,712 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,663 | 2,988
pilocytic astrocytoma 2,649 | 3,086
invasive ductal carcinoma 2,632 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,625 | 2,956
oligodendroglioma 2,522 | 2,849
non-small cell lung cancer 2,427 | 2,798
pediatric high grade glioma 2,426 | 2,712
lung carcinoma 2,377 | 2,844
lung adenocarcinoma 2,297 | 2,714
ependymoma 2,290 | 2,514
subependymal giant cell astrocytoma 2,038 | 2,287
pancreatic cancer 2,037 | 2,300
group 3 medulloblastoma 2,019 | 2,254
astrocytic glioma 1,991 | 2,241
Cancer 1,986 | 2,346
interstitial cystitis 1,890 | 2,299
adult high grade glioma 1,827 | 2,148
ulcerative colitis 1,803 | 2,087
Carcinoma 1,772 | 2,147
Pick disease 1,743 | 1,893
pituitary cancer 1,707 | 1,972
group 4 medulloblastoma 1,703 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,631 | 1,795
ductal carcinoma in situ 1,545 | 1,745
cystic fibrosis 1,506 | 1,670
breast carcinoma 1,417 | 1,614
tuberculosis 1,374 | 1,563
astrocytoma 1,370 | 1,493
medulloblastoma 1,353 | 1,524
posterior fossa group B ependymoma 1,333 | 1,530
sonic hedgehog group medulloblastoma 1,327 | 1,482
posterior fossa group A ependymoma 1,294 | 1,511
Multiple myeloma 1,282 | 1,327
colon cancer 1,281 | 1,475
adrenocortical carcinoma 1,278 | 1,427
diabetes mellitus 1,248 | 1,663
primary pancreatic ductal adenocarcinoma 1,179 | 1,271
juvenile dermatomyositis 1,124 | 1,189
acute quadriplegic myopathy 1,092 | 1,157
Rheumatoid Arthritis 1,032 | 1,170
atypical teratoid/rhabdoid tumor 980 | 1,095
spina bifida 959 | 1,064
dermatomyositis 925 | 966
nasopharyngeal carcinoma 885 | 1,056
cutaneous lupus erythematosus 843 | 1,056
active Crohn's disease 805 | 918
Atopic dermatitis 758 | 944
gastric carcinoma 757 | 832
non primary Sjogren syndrome sicca 732 | 840
acute myeloid leukemia 730 | 785
Waldenstrons macroglobulinemia 725 | 764
primary Sjogren syndrome 660 | 788
tuberculosis and treatment for 6 months 654 | 686
esophageal adenocarcinoma 626 | 737
progressive supranuclear palsy 626 | 674
aldosterone-producing adenoma 607 | 664
Alzheimer's disease 549 | 644
Duchenne muscular dystrophy 537 | 602
pancreatic carcinoma 514 | 567
hepatocellular carcinoma 504 | 550
Intellectual disability 503 | 573
Obesity 494 | 616
Down syndrome 491 | 548
fibroadenoma 484 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 470 | 499
Endometriosis 457 | 535
chronic rhinosinusitis 442 | 512
Prostatic Neoplasms 418 | 471
IGA Glomerulonephritis 416 | 454
active ulcerative colitis 407 | 477
Amyotrophic Lateral Sclerosis 400 | 432
gastric cancer 398 | 436
Multiple Sclerosis 381 | 498
Schizophrenia 377 | 503
mucosa-associated lymphoid tissue lymphoma 375 | 480
Mammary Neoplasms 368 | 410
Neurodegenerative disease 352 | 383
inflammatory breast cancer 348 | 404
non-small cell lung carcinoma 337 | 413
glioblastoma multiforme 310 | 347
hereditary spastic paraplegia 301 | 313
Parkinson's disease 298 | 364
sarcoidosis 296 | 368
Kidney disease 293 | 397
Polycystic Ovary Syndrome 293 | 334
tuberculosis and treatment for 3 months 292 | 327
urothelial carcinoma 276 | 318
Epilepsy 269 | 346
interstitial lung disease 265 | 292

Tissue

Nervous System 15,135 | 18,560
Female tissues 15,113 | 18,646
Digestive Tract 15,111 | 18,472
Endocrine System 15,094 | 18,511
Urinary Tract 15,064 | 18,443
Liver and Pancreas 15,061 | 18,135
Male tissues 15,031 | 17,968
Cardiovascular System 15,023 | 17,957
Blood and immune system 15,018 | 17,994
Skin and soft tissues 14,954 | 18,114
Respiratory system 14,885 | 17,483

Target Family

Non-IDG 8,859 | 11,969
Enzyme 3,540 | 4,146
Transcription Factor 1,179 | 1,400
Kinase 580 | 634
Transporter 371 | 473
Ion Channel 240 | 341
GPCR 228 | 408
Epigenetic 219 | 242
Nuclear Receptor 38 | 48
TF/Epigenetic 36 | 38
oGPCR 21 | 421

HCA RNA Cell Line

BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66