Development Level

Tbio 9,911 | 11,651
Tdark 3,936 | 6,593
Tchem 1,193 | 1,388
Tclin 453 | 612

Collection

RFA-RM-18-021 237 | 328
Kinase: IDG Consortium (Target... 117 | 125
Ion Channel: IDG Consortium (T... 68 | 99
GPCR: IDG Consortium (Targets) 61 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 18 | 25

IMPC Phenotype

preweaning lethality, complete... 934 | 979
preweaning lethality, incomple... 448 | 499
abnormal behavior 266 | 298
embryonic lethality prior to t... 264 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 209 | 220
decreased total body fat amoun... 183 | 207
enlarged heart 170 | 210
abnormal bone structure 167 | 187
increased lean body mass 155 | 172
decreased vertical activity 154 | 208
decreased body weight 151 | 161
decreased bone mineral content 136 | 151
abnormal heart morphology 133 | 162
hyperactivity 130 | 148
decreased lean body mass 119 | 135
increased total body fat amoun... 116 | 134
hypoactivity 114 | 132
decreased bone mineral density 112 | 126
increased circulating alkaline... 112 | 122
decreased circulating glucose ... 108 | 126
increased startle reflex 104 | 112
male infertility 103 | 123
embryonic growth retardation 99 | 106
decreased grip strength 98 | 116
increased bone mineral content 96 | 108
decreased body length 92 | 101
increased or absent threshold ... 90 | 101
abnormal seminal vesicle morph... 89 | 114
short tibia 88 | 97
increased mean corpuscular hem... 86 | 96
cataract 85 | 92
decreased circulating choleste... 85 | 93
increased mean corpuscular vol... 82 | 92
prenatal lethality prior to he... 81 | 87
decreased prepulse inhibition 78 | 82
abnormal lens morphology 77 | 81
decreased circulating serum al... 74 | 82
decreased mean corpuscular vol... 73 | 79
decreased lymphocyte cell numb... 72 | 83
decreased circulating triglyce... 70 | 79
increased fasted circulating g... 69 | 76
decreased startle reflex 68 | 75
increased bone mineral density 67 | 72
abnormal retina morphology 66 | 71
increased circulating HDL chol... 66 | 80
improved glucose tolerance 64 | 79
small superior vagus ganglion 63 | 74
decreased circulating HDL chol... 61 | 68
decreased circulating insulin ... 61 | 76
decreased leukocyte cell numbe... 61 | 73
abnormal behavioral response t... 60 | 66
abnormal eye morphology 60 | 68
abnormal sleep behavior 60 | 70
impaired glucose tolerance 58 | 75
increased circulating choleste... 58 | 66
abnormal gait 57 | 69
increased circulating sodium l... 57 | 71
decreased fasted circulating g... 56 | 65
decreased hemoglobin content 56 | 68
edema 56 | 59
abnormal kidney morphology 54 | 65
decreased erythrocyte cell num... 54 | 62
small testis 54 | 58
abnormal coat-hair pigmentatio... 53 | 64
increased monocyte cell number 53 | 63
decreased caudal vertebrae num... 52 | 53
increased heart weight 52 | 62
thrombocytopenia 50 | 56
female infertility 48 | 60
abnormal spleen morphology 47 | 55
abnormal neural tube closure 46 | 46
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
decreased circulating alanine ... 45 | 47
hydrometra 44 | 53
increased hematocrit 44 | 46
decreased blood urea nitrogen ... 43 | 51
increased leukocyte cell numbe... 43 | 47
increased blood urea nitrogen ... 42 | 48
decreased circulating alkaline... 41 | 46
increased neutrophil cell numb... 41 | 46
abnormal skin morphology 40 | 50
abnormal testis morphology 40 | 43
increased hemoglobin content 40 | 45
decreased hematocrit 38 | 46
increased circulating triglyce... 38 | 42
increased mean platelet volume 38 | 45
decreased circulating LDL chol... 37 | 38
decreased red blood cell distr... 37 | 41
enlarged spleen 37 | 41
increased grip strength 37 | 41
tremors 37 | 39
abnormal bone mineralization 35 | 38
decreased circulating creatini... 35 | 39
decreased neutrophil cell numb... 35 | 42
increased erythrocyte cell num... 35 | 39
abnormal epididymis morphology 34 | 42
increased mean corpuscular hem... 34 | 36
limb grasping 34 | 41

Disease

Carcinoma 9,475 | 11,493
ovarian cancer 7,865 | 8,520
osteosarcoma 7,156 | 7,950
medulloblastoma, large-cell 5,589 | 6,241
psoriasis 5,407 | 6,694
glioblastoma 5,249 | 5,792
atypical teratoid / rhabdoid tumor 4,636 | 5,112
lung cancer 4,267 | 4,740
ependymoma 4,191 | 4,679
group 3 medulloblastoma 3,694 | 4,104
adult high grade glioma 3,321 | 3,801
Breast cancer 3,223 | 3,578
malignant mesothelioma 3,079 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,965 | 3,291
primitive neuroectodermal tumor 2,745 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,686 | 2,989
Astrocytoma, Pilocytic 2,675 | 3,081
invasive ductal carcinoma 2,662 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,642 | 2,955
oligodendroglioma 2,547 | 2,850
non-small cell lung cancer 2,524 | 2,890
lung carcinoma 2,391 | 2,843
astrocytic glioma 2,318 | 2,597
lung adenocarcinoma 2,316 | 2,716
Kidney cancer 2,216 | 2,613
pancreatic cancer 2,132 | 2,398
Cancer 2,128 | 2,499
subependymal giant cell astrocytoma 2,056 | 2,287
interstitial cystitis 1,908 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,808 | 1,962
tuberculosis 1,796 | 2,010
Pick disease 1,757 | 1,894
pituitary cancer 1,721 | 1,972
group 4 medulloblastoma 1,706 | 1,855
ulcerative colitis 1,573 | 1,819
ductal carcinoma in situ 1,561 | 1,745
cystic fibrosis 1,542 | 1,696
breast carcinoma 1,453 | 1,638
diabetes mellitus 1,308 | 1,728
Multiple myeloma 1,297 | 1,332
adrenocortical carcinoma 1,296 | 1,428
colon cancer 1,294 | 1,478
Autosomal recessive predisposition 1,230 | 1,442
juvenile dermatomyositis 1,132 | 1,187
acute quadriplegic myopathy 1,101 | 1,158
astrocytoma 1,076 | 1,146
Rheumatoid arthritis 1,058 | 1,191
primary pancreatic ductal adenocarcinoma 1,033 | 1,109
spina bifida 978 | 1,074
pediatric high grade glioma 977 | 1,064
dermatomyositis 934 | 966
Schizophrenia 924 | 1,160
Intellectual disability 915 | 1,016
nasopharyngeal carcinoma 891 | 1,058
cutaneous lupus erythematosus 851 | 1,057
active Crohn's disease 815 | 922
non primary Sjogren syndrome sicca 782 | 891
Atopic dermatitis 771 | 952
acute myeloid leukemia 740 | 783
gastric carcinoma 737 | 807
Waldenstrons macroglobulinemia 733 | 765
Epilepsy 682 | 792
active ulcerative colitis 665 | 764
medulloblastoma 661 | 720
Liver Cirrhosis, Experimental 660 | 769
progressive supranuclear palsy 632 | 676
esophageal adenocarcinoma 629 | 737
primary Sjogren syndrome 623 | 735
aldosterone-producing adenoma 612 | 665
Dull intelligence 581 | 645
Low intelligence 581 | 645
Mental Retardation 581 | 645
Mental deficiency 581 | 645
Poor school performance 581 | 645
Cognitive delay 559 | 608
Global developmental delay 559 | 608
Mental and motor retardation 559 | 608
Alzheimer's disease 558 | 658
Obesity 555 | 678
Duchenne muscular dystrophy 543 | 601
Melanoma 534 | 711
Muscle hypotonia 527 | 571
Seizures 527 | 596
Bipolar Disorder 516 | 666
pancreatic carcinoma 513 | 562
hepatocellular carcinoma 505 | 547
Liver cancer 502 | 604
fibroadenoma 488 | 559
autosomal dominant Emery-Dreifuss muscular dystrophy 482 | 510
Short stature 478 | 531
Endometriosis 465 | 540
Down syndrome 447 | 499
chronic rhinosinusitis 445 | 512
Prostatic Neoplasms 442 | 495
gastric cancer 425 | 459
posterior fossa group A ependymoma 420 | 468
Amyotrophic lateral sclerosis 419 | 451
sonic hedgehog group medulloblastoma 419 | 467
Multiple Sclerosis 415 | 540
Breast Neoplasms 400 | 445

Tissue

Endocrine System 15,261 | 18,159
Female tissues 15,110 | 17,400
Digestive Tract 15,102 | 17,369
Skin and soft tissues 15,053 | 17,230
Male tissues 15,005 | 17,142
Blood and immune system 14,931 | 16,909
Nervous System 14,879 | 16,725
Liver and Pancreas 14,870 | 16,750
Urinary Tract 14,831 | 16,678
Respiratory system 14,726 | 16,393
Cardiovascular System 14,001 | 15,192

Target Family

Non-IDG 8,994 | 12,091
Enzyme 3,566 | 4,145
Transcription Factor 1,183 | 1,400
Kinase 586 | 634
Transporter 371 | 473
Ion Channel 243 | 344
GPCR 228 | 408
Epigenetic 225 | 242
Nuclear Receptor 38 | 48
TF/Epigenetic 37 | 38
oGPCR 22 | 421

HCA RNA Cell Line

BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50