Development Level

Tbio 9,076 | 10,625
Tdark 4,295 | 7,003
Tchem 1,598 | 1,890
Tclin 460 | 602

Collection

Kinase: IDG Consortium (Targets) 112 | 125
Ion Channel: IDG Consortium (Targets) 76 | 102
GPCR: IDG Consortium (Targets) 61 | 127
Kinase: IDG Consortium (Complete/Control) 33 | 37
GPCR: IDG Consortium (Complete/Control) 18 | 26

IMPC Phenotype

preweaning lethality, complete... 607 | 633
preweaning lethality, incomple... 232 | 260
abnormal behavior 208 | 226
decreased lean body mass 183 | 195
embryonic lethality prior to t... 183 | 187
decreased total body fat amoun... 172 | 186
decreased body weight 163 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 145 | 157
abnormal bone structure 119 | 131
decreased bone mineral density 114 | 126
increased circulating alkaline... 110 | 119
increased or absent threshold ... 109 | 128
abnormal embryo size 107 | 112
decreased circulating glucose ... 101 | 121
decreased body length 100 | 108
decreased grip strength 100 | 123
hyperactivity 97 | 108
increased lean body mass 97 | 107
abnormal retina morphology 90 | 100
enlarged heart 87 | 111
increased bone mineral content 87 | 92
increased mean corpuscular hem... 87 | 93
increased mean corpuscular vol... 83 | 91
hypoactivity 81 | 89
decreased circulating choleste... 77 | 85
increased grip strength 74 | 83
short tibia 74 | 82
decreased circulating serum al... 72 | 79
decreased circulating triglyce... 72 | 83
decreased circulating HDL chol... 69 | 77
abnormal lens morphology 66 | 73
increased fasted circulating g... 64 | 68
decreased circulating insulin ... 63 | 75
prenatal lethality prior to he... 59 | 64
decreased lumbar vertebrae num... 57 | 62
abnormal retinal pigmentation 56 | 61
increased circulating sodium l... 56 | 71
increased sacral vertebrae num... 56 | 62
abnormal sleep behavior 54 | 63
decreased rib number 54 | 59
male infertility 53 | 62
abnormal bone mineralization 51 | 55
increased bone mineral density 50 | 52
increased circulating HDL chol... 50 | 63
increased total body fat amoun... 50 | 57
abnormal coat-hair pigmentatio... 49 | 54
decreased prepulse inhibition 47 | 52
decreased startle reflex 47 | 48
increased circulating choleste... 47 | 53
increased exploration in new e... 47 | 56
decreased hemoglobin content 46 | 53
decreased leukocyte cell numbe... 46 | 54
decreased mean corpuscular vol... 46 | 50
impaired glucose tolerance 46 | 52
improved glucose tolerance 46 | 56
abnormal behavioral response t... 45 | 52
abnormal gait 45 | 51
decreased circulating alanine ... 44 | 53
decreased caudal vertebrae num... 43 | 49
decreased fasted circulating g... 43 | 49
decreased circulating total pr... 41 | 41
decreased erythrocyte cell num... 41 | 43
thrombocytopenia 41 | 46
increased body weight 40 | 42
decreased heart weight 39 | 44
increased hemoglobin content 39 | 45
abnormal heart morphology 37 | 51
decreased circulating LDL chol... 36 | 37
decreased circulating alkaline... 36 | 41
increased blood urea nitrogen ... 36 | 44
abnormal eye morphology 35 | 38
abnormal neural tube closure 35 | 37
decreased eosinophil cell numb... 35 | 41
increased rib number 35 | 41
decreased neutrophil cell numb... 34 | 37
increased startle reflex 34 | 38
decreased circulating free fat... 33 | 39
increased circulating chloride... 33 | 43
increased leukocyte cell numbe... 33 | 37
small testis 33 | 37
increased hematocrit 32 | 36
abnormal cranium morphology 31 | 32
abnormal seminal vesicle morph... 31 | 47
decreased mean corpuscular hem... 31 | 34
increased heart weight 31 | 37
tremors 31 | 34
decreased circulating chloride... 30 | 32
decreased circulating fructosa... 30 | 31
limb grasping 30 | 35
female infertility 29 | 34
cardiovascular system phenotyp... 28 | 35
decreased circulating calcium ... 28 | 33
decreased circulating creatini... 28 | 31
decreased threshold for audito... 28 | 32
increased circulating potassiu... 28 | 31
abnormal spleen morphology 27 | 36
abnormal testis morphology 27 | 30
decreased T cell number 27 | 31
embryonic growth retardation 27 | 28

Disease

ovarian cancer 7,806 | 8,491
osteosarcoma 7,116 | 7,933
medulloblastoma, large-cell 5,585 | 6,234
psoriasis 5,437 | 6,685
glioblastoma 5,060 | 5,572
lung cancer 4,076 | 4,473
atypical teratoid / rhabdoid tumor 3,969 | 4,369
malignant mesothelioma 3,001 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 2,954 | 3,289
Breast cancer 2,832 | 3,098
primitive neuroectodermal tumor 2,741 | 3,031
pilocytic astrocytoma 2,692 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 2,672 | 2,988
invasive ductal carcinoma 2,664 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,641 | 2,956
oligodendroglioma 2,555 | 2,849
non-small cell lung cancer 2,473 | 2,798
pediatric high grade glioma 2,463 | 2,712
lung carcinoma 2,402 | 2,844
lung adenocarcinoma 2,329 | 2,714
ependymoma 2,310 | 2,514
subependymal giant cell astrocytoma 2,060 | 2,287
group 3 medulloblastoma 2,050 | 2,254
pancreatic cancer 2,050 | 2,300
Cancer 2,013 | 2,346
astrocytic glioma 2,009 | 2,241
interstitial cystitis 1,916 | 2,299
adult high grade glioma 1,848 | 2,148
ulcerative colitis 1,817 | 2,087
Carcinoma 1,793 | 2,147
Pick disease 1,749 | 1,893
pituitary cancer 1,726 | 1,972
group 4 medulloblastoma 1,715 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,651 | 1,795
ductal carcinoma in situ 1,564 | 1,745
cystic fibrosis 1,512 | 1,670
breast carcinoma 1,438 | 1,614
astrocytoma 1,387 | 1,493
tuberculosis 1,386 | 1,563
posterior fossa group B ependymoma 1,363 | 1,530
medulloblastoma 1,353 | 1,524
sonic hedgehog group medulloblastoma 1,348 | 1,482
posterior fossa group A ependymoma 1,307 | 1,511
adrenocortical carcinoma 1,295 | 1,427
colon cancer 1,292 | 1,475
Multiple myeloma 1,284 | 1,327
diabetes mellitus 1,256 | 1,663
primary pancreatic ductal adenocarcinoma 1,184 | 1,271
juvenile dermatomyositis 1,128 | 1,189
acute quadriplegic myopathy 1,103 | 1,157
Rheumatoid Arthritis 1,044 | 1,170
atypical teratoid/rhabdoid tumor 988 | 1,095
spina bifida 967 | 1,064
dermatomyositis 927 | 966
nasopharyngeal carcinoma 894 | 1,056
cutaneous lupus erythematosus 863 | 1,056
active Crohn's disease 810 | 918
Atopic dermatitis 774 | 944
gastric carcinoma 759 | 832
non primary Sjogren syndrome sicca 737 | 840
acute myeloid leukemia 734 | 785
Waldenstrons macroglobulinemia 729 | 764
primary Sjogren syndrome 673 | 788
tuberculosis and treatment for 6 months 648 | 686
esophageal adenocarcinoma 638 | 737
progressive supranuclear palsy 633 | 674
aldosterone-producing adenoma 614 | 664
Alzheimer's disease 563 | 644
Duchenne muscular dystrophy 545 | 602
Intellectual disability 522 | 573
pancreatic carcinoma 517 | 567
hepatocellular carcinoma 506 | 550
Obesity 504 | 616
Down syndrome 499 | 548
fibroadenoma 488 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 474 | 499
Endometriosis 465 | 535
chronic rhinosinusitis 438 | 512
Prostatic Neoplasms 415 | 471
active ulcerative colitis 411 | 477
IGA Glomerulonephritis 410 | 454
Amyotrophic Lateral Sclerosis 398 | 432
gastric cancer 397 | 436
Schizophrenia 393 | 503
mucosa-associated lymphoid tissue lymphoma 383 | 480
Multiple Sclerosis 382 | 498
Mammary Neoplasms 369 | 410
Neurodegenerative disease 357 | 383
inflammatory breast cancer 355 | 404
non-small cell lung carcinoma 343 | 413
Parkinson's disease 310 | 364
glioblastoma multiforme 309 | 347
hereditary spastic paraplegia 305 | 313
Kidney disease 300 | 397
Polycystic Ovary Syndrome 298 | 334
sarcoidosis 297 | 368
tuberculosis and treatment for 3 months 289 | 327
urothelial carcinoma 280 | 318
Epilepsy 271 | 346
interstitial lung disease 265 | 292

Tissue

Nervous System 15,244 | 18,560
Female tissues 15,225 | 18,646
Digestive Tract 15,219 | 18,472
Endocrine System 15,199 | 18,511
Urinary Tract 15,166 | 18,443
Liver and Pancreas 15,152 | 18,135
Blood and immune system 15,120 | 17,994
Cardiovascular System 15,118 | 17,957
Male tissues 15,116 | 17,968
Skin and soft tissues 15,060 | 18,114
Respiratory system 14,966 | 17,483

Target Family

Non-IDG 8,929 | 11,969
Enzyme 3,550 | 4,146
Transcription Factor 1,195 | 1,400
Kinase 582 | 634
Transporter 377 | 473
GPCR 244 | 408
Ion Channel 241 | 341
Epigenetic 219 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 33 | 38
oGPCR 17 | 421

HCA RNA Cell Line

BJ hTERT+ SV40 Large T+ 15,429 | 15,429
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50