Development Level

Tbio 9,988 | 11,651
Tdark 3,943 | 6,593
Tchem 1,207 | 1,388
Tclin 471 | 612

Collection

Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 73 | 99
GPCR: IDG Consortium (Targets) 60 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 18 | 25

IMPC Phenotype

preweaning lethality, complete... 940 | 979
preweaning lethality, incomple... 453 | 499
embryonic lethality prior to t... 268 | 278
abnormal behavior 266 | 298
embryonic lethality prior to o... 237 | 239
abnormal embryo size 208 | 220
decreased total body fat amoun... 189 | 207
enlarged heart 173 | 210
abnormal bone structure 164 | 187
decreased vertical activity 161 | 208
increased lean body mass 155 | 172
decreased body weight 150 | 161
abnormal heart morphology 135 | 162
decreased bone mineral content 133 | 151
hyperactivity 131 | 148
decreased lean body mass 122 | 135
hypoactivity 118 | 132
increased total body fat amoun... 117 | 134
increased circulating alkaline... 113 | 122
decreased circulating glucose ... 111 | 126
decreased bone mineral density 108 | 126
male infertility 106 | 123
increased startle reflex 105 | 112
decreased grip strength 98 | 116
embryonic growth retardation 98 | 106
increased bone mineral content 96 | 108
abnormal seminal vesicle morph... 91 | 114
decreased body length 91 | 101
increased or absent threshold ... 88 | 101
short tibia 88 | 97
cataract 87 | 92
decreased circulating choleste... 86 | 93
increased mean corpuscular hem... 85 | 96
increased mean corpuscular vol... 84 | 92
prenatal lethality prior to he... 80 | 87
abnormal lens morphology 76 | 81
decreased circulating serum al... 76 | 82
decreased prepulse inhibition 76 | 82
decreased lymphocyte cell numb... 74 | 83
decreased mean corpuscular vol... 72 | 79
increased bone mineral density 70 | 72
decreased circulating triglyce... 69 | 79
decreased startle reflex 69 | 75
increased fasted circulating g... 69 | 76
increased circulating HDL chol... 68 | 80
abnormal retina morphology 65 | 71
improved glucose tolerance 65 | 79
small superior vagus ganglion 64 | 74
decreased circulating insulin ... 63 | 76
impaired glucose tolerance 63 | 75
abnormal eye morphology 62 | 68
abnormal sleep behavior 62 | 70
decreased circulating HDL chol... 62 | 68
decreased leukocyte cell numbe... 62 | 73
abnormal behavioral response t... 58 | 66
abnormal gait 58 | 69
decreased erythrocyte cell num... 58 | 62
decreased fasted circulating g... 58 | 65
decreased hemoglobin content 58 | 68
increased circulating choleste... 58 | 66
abnormal coat-hair pigmentatio... 57 | 64
abnormal kidney morphology 56 | 65
edema 56 | 59
increased circulating sodium l... 56 | 71
increased heart weight 55 | 62
increased monocyte cell number 55 | 63
small testis 52 | 58
decreased caudal vertebrae num... 51 | 53
female infertility 50 | 60
thrombocytopenia 50 | 56
decreased circulating total pr... 47 | 49
hydrometra 47 | 53
abnormal spleen morphology 46 | 55
decreased mean corpuscular hem... 46 | 50
abnormal neural tube closure 45 | 46
decreased blood urea nitrogen ... 43 | 51
decreased circulating alanine ... 43 | 47
increased hematocrit 43 | 46
abnormal skin morphology 42 | 50
decreased circulating alkaline... 42 | 46
increased leukocyte cell numbe... 42 | 47
increased neutrophil cell numb... 42 | 46
decreased hematocrit 41 | 46
increased blood urea nitrogen ... 40 | 48
increased hemoglobin content 40 | 45
abnormal testis morphology 39 | 43
enlarged spleen 39 | 41
increased circulating triglyce... 39 | 42
increased mean platelet volume 38 | 45
decreased circulating LDL chol... 37 | 38
decreased red blood cell distr... 37 | 41
increased grip strength 37 | 41
tremors 37 | 39
limb grasping 36 | 41
abnormal bone mineralization 35 | 38
decreased neutrophil cell numb... 35 | 42
abnormal epididymis morphology 34 | 42
decreased circulating creatini... 34 | 39
increased erythrocyte cell num... 34 | 39
increased mean corpuscular hem... 34 | 36

Disease

Carcinoma 9,539 | 11,493
ovarian cancer 7,916 | 8,520
osteosarcoma 7,202 | 7,950
medulloblastoma, large-cell 5,641 | 6,241
psoriasis 5,484 | 6,694
glioblastoma 5,307 | 5,792
atypical teratoid / rhabdoid tumor 4,685 | 5,112
lung cancer 4,276 | 4,740
ependymoma 4,243 | 4,679
group 3 medulloblastoma 3,741 | 4,104
adult high grade glioma 3,368 | 3,801
Breast cancer 3,258 | 3,578
malignant mesothelioma 3,083 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,984 | 3,291
primitive neuroectodermal tumor 2,775 | 3,035
Astrocytoma, Pilocytic 2,717 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,695 | 2,989
invasive ductal carcinoma 2,693 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,658 | 2,955
oligodendroglioma 2,580 | 2,850
non-small cell lung cancer 2,570 | 2,890
lung carcinoma 2,416 | 2,843
lung adenocarcinoma 2,349 | 2,716
astrocytic glioma 2,347 | 2,597
Kidney cancer 2,244 | 2,613
Cancer 2,162 | 2,499
pancreatic cancer 2,145 | 2,398
subependymal giant cell astrocytoma 2,079 | 2,287
interstitial cystitis 1,933 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,830 | 1,962
tuberculosis 1,802 | 2,010
Pick disease 1,764 | 1,894
pituitary cancer 1,738 | 1,972
group 4 medulloblastoma 1,709 | 1,855
ulcerative colitis 1,582 | 1,819
ductal carcinoma in situ 1,579 | 1,745
cystic fibrosis 1,548 | 1,696
breast carcinoma 1,472 | 1,638
diabetes mellitus 1,315 | 1,728
adrenocortical carcinoma 1,313 | 1,428
colon cancer 1,304 | 1,478
Multiple myeloma 1,299 | 1,332
Autosomal recessive predisposition 1,242 | 1,442
juvenile dermatomyositis 1,136 | 1,187
acute quadriplegic myopathy 1,112 | 1,158
astrocytoma 1,082 | 1,146
Rheumatoid arthritis 1,067 | 1,191
primary pancreatic ductal adenocarcinoma 1,035 | 1,109
pediatric high grade glioma 990 | 1,064
spina bifida 986 | 1,074
Schizophrenia 938 | 1,160
dermatomyositis 935 | 966
Intellectual disability 933 | 1,016
nasopharyngeal carcinoma 901 | 1,058
cutaneous lupus erythematosus 871 | 1,057
active Crohn's disease 820 | 922
non primary Sjogren syndrome sicca 789 | 891
Atopic dermatitis 787 | 952
acute myeloid leukemia 745 | 783
gastric carcinoma 740 | 807
Waldenstrons macroglobulinemia 736 | 765
Epilepsy 686 | 792
Liver Cirrhosis, Experimental 674 | 769
active ulcerative colitis 672 | 764
medulloblastoma 661 | 720
esophageal adenocarcinoma 641 | 737
progressive supranuclear palsy 639 | 676
primary Sjogren syndrome 635 | 735
aldosterone-producing adenoma 619 | 665
Dull intelligence 592 | 645
Low intelligence 592 | 645
Mental Retardation 592 | 645
Mental deficiency 592 | 645
Poor school performance 592 | 645
Alzheimer's disease 569 | 658
Cognitive delay 563 | 608
Global developmental delay 563 | 608
Mental and motor retardation 563 | 608
Obesity 562 | 678
Duchenne muscular dystrophy 551 | 601
Bipolar Disorder 541 | 666
Muscle hypotonia 535 | 571
Seizures 533 | 596
Melanoma 529 | 711
pancreatic carcinoma 516 | 562
hepatocellular carcinoma 506 | 547
Liver cancer 504 | 604
fibroadenoma 492 | 559
Short stature 486 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 486 | 510
Endometriosis 476 | 540
Down syndrome 458 | 499
chronic rhinosinusitis 441 | 512
Prostatic Neoplasms 439 | 495
sonic hedgehog group medulloblastoma 430 | 467
gastric cancer 424 | 459
posterior fossa group A ependymoma 421 | 468
Multiple Sclerosis 420 | 540
Amyotrophic lateral sclerosis 417 | 451
Breast Neoplasms 404 | 445

Tissue

Endocrine System 15,359 | 18,159
Digestive Tract 15,203 | 17,369
Female tissues 15,198 | 17,400
Skin and soft tissues 15,153 | 17,230
Male tissues 15,102 | 17,142
Blood and immune system 15,011 | 16,909
Nervous System 14,983 | 16,725
Liver and Pancreas 14,963 | 16,750
Urinary Tract 14,916 | 16,678
Respiratory system 14,818 | 16,393
Cardiovascular System 14,101 | 15,192

Target Family

Non-IDG 9,061 | 12,091
Enzyme 3,576 | 4,145
Transcription Factor 1,199 | 1,400
Kinase 588 | 634
Transporter 377 | 473
Ion Channel 245 | 344
GPCR 244 | 408
Epigenetic 225 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 34 | 38
oGPCR 18 | 421

HCA RNA Cell Line

BJ hTERT+ SV40 Large T+ 15,609 | 15,609
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50