Development Level

Tbio 9,839 | 11,651
Tdark 3,875 | 6,593
Tchem 1,190 | 1,388
Tclin 449 | 612

Collection

RFA-RM-18-021 236 | 328
Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 68 | 99
GPCR: IDG Consortium (Targets) 62 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 938 | 979
preweaning lethality, incomple... 452 | 499
embryonic lethality prior to t... 270 | 278
abnormal behavior 265 | 298
embryonic lethality prior to o... 236 | 239
abnormal embryo size 208 | 220
decreased total body fat amoun... 188 | 207
enlarged heart 178 | 210
abnormal bone structure 165 | 187
decreased vertical activity 161 | 208
increased lean body mass 159 | 172
decreased body weight 151 | 161
abnormal heart morphology 140 | 162
decreased bone mineral content 132 | 151
hyperactivity 127 | 148
decreased lean body mass 122 | 135
increased total body fat amoun... 120 | 134
hypoactivity 114 | 132
decreased circulating glucose ... 112 | 126
increased circulating alkaline... 110 | 122
decreased bone mineral density 109 | 126
increased startle reflex 106 | 112
male infertility 102 | 123
embryonic growth retardation 100 | 106
decreased grip strength 97 | 116
increased bone mineral content 95 | 108
decreased body length 93 | 101
increased or absent threshold ... 89 | 101
abnormal seminal vesicle morph... 88 | 114
increased mean corpuscular hem... 87 | 96
cataract 86 | 92
decreased circulating choleste... 86 | 93
increased mean corpuscular vol... 86 | 92
short tibia 84 | 97
prenatal lethality prior to he... 83 | 87
abnormal lens morphology 78 | 81
decreased lymphocyte cell numb... 77 | 83
decreased prepulse inhibition 75 | 82
decreased circulating serum al... 72 | 82
decreased circulating triglyce... 72 | 79
decreased mean corpuscular vol... 70 | 79
increased fasted circulating g... 70 | 76
increased bone mineral density 68 | 72
increased circulating HDL chol... 68 | 80
decreased startle reflex 67 | 75
small superior vagus ganglion 66 | 74
abnormal retina morphology 64 | 71
decreased circulating insulin ... 63 | 76
abnormal eye morphology 62 | 68
decreased circulating HDL chol... 61 | 68
decreased leukocyte cell numbe... 61 | 73
impaired glucose tolerance 61 | 75
abnormal sleep behavior 60 | 70
improved glucose tolerance 60 | 79
increased circulating choleste... 59 | 66
abnormal gait 58 | 69
decreased erythrocyte cell num... 58 | 62
abnormal kidney morphology 57 | 65
increased circulating sodium l... 57 | 71
increased monocyte cell number 57 | 63
abnormal behavioral response t... 56 | 66
decreased hemoglobin content 56 | 68
increased heart weight 56 | 62
abnormal coat-hair pigmentatio... 55 | 64
edema 55 | 59
decreased fasted circulating g... 54 | 65
small testis 53 | 58
decreased caudal vertebrae num... 51 | 53
thrombocytopenia 51 | 56
female infertility 48 | 60
hydrometra 47 | 53
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
abnormal neural tube closure 45 | 46
abnormal spleen morphology 44 | 55
decreased blood urea nitrogen ... 43 | 51
decreased circulating alanine ... 43 | 47
increased blood urea nitrogen ... 43 | 48
increased hematocrit 43 | 46
abnormal skin morphology 42 | 50
decreased circulating alkaline... 41 | 46
increased neutrophil cell numb... 41 | 46
abnormal testis morphology 40 | 43
increased leukocyte cell numbe... 40 | 47
decreased hematocrit 38 | 46
enlarged spleen 38 | 41
increased circulating triglyce... 38 | 42
increased hemoglobin content 38 | 45
increased mean platelet volume 38 | 45
decreased red blood cell distr... 37 | 41
abnormal bone mineralization 36 | 38
limb grasping 36 | 41
decreased circulating LDL chol... 35 | 38
increased erythrocyte cell num... 35 | 39
increased grip strength 35 | 41
tremors 35 | 39
abnormal epididymis morphology 34 | 42
decreased circulating creatini... 34 | 39
increased mean corpuscular hem... 34 | 36
pallor 34 | 34

Disease

Carcinoma 9,403 | 11,493
ovarian cancer 7,857 | 8,520
osteosarcoma 7,129 | 7,950
medulloblastoma, large-cell 5,552 | 6,241
psoriasis 5,365 | 6,694
glioblastoma 5,200 | 5,792
atypical teratoid / rhabdoid tumor 4,577 | 5,112
lung cancer 4,261 | 4,740
ependymoma 4,145 | 4,679
group 3 medulloblastoma 3,646 | 4,104
adult high grade glioma 3,290 | 3,801
Breast cancer 3,212 | 3,578
malignant mesothelioma 3,036 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,957 | 3,291
primitive neuroectodermal tumor 2,706 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,677 | 2,989
invasive ductal carcinoma 2,671 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,640 | 2,955
Astrocytoma, Pilocytic 2,638 | 3,081
non-small cell lung cancer 2,545 | 2,890
oligodendroglioma 2,520 | 2,850
lung carcinoma 2,373 | 2,843
lung adenocarcinoma 2,348 | 2,716
astrocytic glioma 2,294 | 2,597
Kidney cancer 2,199 | 2,613
Cancer 2,126 | 2,499
pancreatic cancer 2,118 | 2,398
subependymal giant cell astrocytoma 2,015 | 2,287
interstitial cystitis 1,911 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,817 | 1,962
tuberculosis 1,802 | 2,010
Pick disease 1,738 | 1,894
pituitary cancer 1,698 | 1,972
group 4 medulloblastoma 1,688 | 1,855
ulcerative colitis 1,581 | 1,819
ductal carcinoma in situ 1,569 | 1,745
cystic fibrosis 1,525 | 1,696
breast carcinoma 1,456 | 1,638
diabetes mellitus 1,321 | 1,728
adrenocortical carcinoma 1,308 | 1,428
Multiple myeloma 1,299 | 1,332
colon cancer 1,290 | 1,478
Autosomal recessive predisposition 1,224 | 1,442
juvenile dermatomyositis 1,140 | 1,187
acute quadriplegic myopathy 1,102 | 1,158
astrocytoma 1,065 | 1,146
Rheumatoid arthritis 1,045 | 1,191
primary pancreatic ductal adenocarcinoma 1,024 | 1,109
spina bifida 988 | 1,074
pediatric high grade glioma 973 | 1,064
dermatomyositis 932 | 966
Intellectual disability 918 | 1,016
nasopharyngeal carcinoma 901 | 1,058
Schizophrenia 894 | 1,160
cutaneous lupus erythematosus 864 | 1,057
active Crohn's disease 806 | 922
Atopic dermatitis 782 | 952
non primary Sjogren syndrome sicca 778 | 891
acute myeloid leukemia 742 | 783
Waldenstrons macroglobulinemia 733 | 765
gastric carcinoma 724 | 807
Liver Cirrhosis, Experimental 673 | 769
Epilepsy 670 | 792
active ulcerative colitis 658 | 764
medulloblastoma 646 | 720
primary Sjogren syndrome 636 | 735
progressive supranuclear palsy 626 | 676
esophageal adenocarcinoma 624 | 737
aldosterone-producing adenoma 611 | 665
Dull intelligence 584 | 645
Low intelligence 584 | 645
Mental Retardation 584 | 645
Mental deficiency 584 | 645
Poor school performance 584 | 645
Cognitive delay 558 | 608
Global developmental delay 558 | 608
Mental and motor retardation 558 | 608
Alzheimer's disease 552 | 658
Duchenne muscular dystrophy 549 | 601
Obesity 544 | 678
Muscle hypotonia 524 | 571
Seizures 515 | 596
hepatocellular carcinoma 511 | 547
pancreatic carcinoma 511 | 562
Bipolar Disorder 510 | 666
Melanoma 506 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 485 | 510
Liver cancer 483 | 604
fibroadenoma 483 | 559
Short stature 475 | 531
Endometriosis 472 | 540
Down syndrome 443 | 499
chronic rhinosinusitis 437 | 512
Prostatic Neoplasms 431 | 495
sonic hedgehog group medulloblastoma 429 | 467
gastric cancer 428 | 459
posterior fossa group A ependymoma 417 | 468
Amyotrophic lateral sclerosis 411 | 451
Multiple Sclerosis 403 | 540
tuberculosis and treatment for 6 months 402 | 409

Tissue

Endocrine System 15,117 | 18,159
Female tissues 15,008 | 17,400
Digestive Tract 14,968 | 17,369
Skin and soft tissues 14,954 | 17,230
Male tissues 14,897 | 17,142
Blood and immune system 14,817 | 16,909
Liver and Pancreas 14,768 | 16,750
Nervous System 14,754 | 16,725
Urinary Tract 14,726 | 16,678
Respiratory system 14,634 | 16,393
Cardiovascular System 13,943 | 15,192

Target Family

Non-IDG 8,934 | 12,091
Enzyme 3,536 | 4,145
Transcription Factor 1,145 | 1,400
Kinase 585 | 634
Transporter 366 | 473
GPCR 237 | 408
Epigenetic 225 | 242
Ion Channel 225 | 344
Nuclear Receptor 40 | 48
TF/Epigenetic 34 | 38
oGPCR 26 | 421

HCA RNA Cell Line

BJ hTERT+ 15,353 | 15,353
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50