Development Level

Tbio 8,928 | 10,625
Tdark 4,230 | 7,003
Tchem 1,583 | 1,890
Tclin 440 | 602

Collection

Kinase: IDG Consortium (Targets) 111 | 125
Ion Channel: IDG Consortium (Targets) 71 | 102
GPCR: IDG Consortium (Targets) 63 | 127
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 19 | 26

IMPC Phenotype

preweaning lethality, complete... 604 | 633
preweaning lethality, incomple... 235 | 260
abnormal behavior 205 | 226
embryonic lethality prior to t... 186 | 187
decreased lean body mass 179 | 195
decreased total body fat amoun... 171 | 186
decreased body weight 162 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 142 | 157
abnormal bone structure 118 | 131
increased or absent threshold ... 115 | 128
decreased bone mineral density 112 | 126
increased circulating alkaline... 110 | 119
abnormal embryo size 105 | 112
decreased grip strength 105 | 123
decreased circulating glucose ... 103 | 121
decreased body length 101 | 108
increased lean body mass 97 | 107
hyperactivity 94 | 108
enlarged heart 93 | 111
abnormal retina morphology 88 | 100
increased mean corpuscular hem... 88 | 93
increased bone mineral content 86 | 92
increased mean corpuscular vol... 83 | 91
decreased circulating choleste... 79 | 85
hypoactivity 79 | 89
decreased circulating triglyce... 74 | 83
increased grip strength 73 | 83
short tibia 72 | 82
decreased circulating HDL chol... 70 | 77
decreased circulating serum al... 69 | 79
abnormal lens morphology 64 | 73
increased fasted circulating g... 64 | 68
decreased circulating insulin ... 62 | 75
prenatal lethality prior to he... 62 | 64
increased circulating sodium l... 57 | 71
abnormal retinal pigmentation 56 | 61
decreased lumbar vertebrae num... 55 | 62
abnormal bone mineralization 53 | 55
increased circulating HDL chol... 53 | 63
decreased rib number 52 | 59
increased sacral vertebrae num... 52 | 62
abnormal sleep behavior 51 | 63
increased total body fat amoun... 51 | 57
male infertility 51 | 62
increased bone mineral density 49 | 52
increased circulating choleste... 48 | 53
increased exploration in new e... 48 | 56
decreased mean corpuscular vol... 47 | 50
abnormal coat-hair pigmentatio... 46 | 54
decreased circulating alanine ... 46 | 53
decreased hemoglobin content 46 | 53
decreased prepulse inhibition 46 | 52
decreased leukocyte cell numbe... 45 | 54
decreased startle reflex 45 | 48
abnormal behavioral response t... 44 | 52
decreased caudal vertebrae num... 44 | 49
abnormal gait 43 | 51
impaired glucose tolerance 43 | 52
improved glucose tolerance 43 | 56
thrombocytopenia 43 | 46
abnormal heart morphology 42 | 51
decreased erythrocyte cell num... 41 | 43
increased body weight 41 | 42
decreased circulating total pr... 39 | 41
increased blood urea nitrogen ... 39 | 44
decreased fasted circulating g... 38 | 49
increased hemoglobin content 37 | 45
increased rib number 37 | 41
abnormal neural tube closure 36 | 37
decreased circulating free fat... 36 | 39
decreased heart weight 36 | 44
decreased circulating alkaline... 35 | 41
decreased eosinophil cell numb... 35 | 41
decreased neutrophil cell numb... 35 | 37
small testis 35 | 37
decreased circulating LDL chol... 34 | 37
increased startle reflex 34 | 38
abnormal eye morphology 33 | 38
increased heart weight 33 | 37
decreased mean corpuscular hem... 32 | 34
increased circulating chloride... 32 | 43
increased hematocrit 32 | 36
increased leukocyte cell numbe... 32 | 37
abnormal cranium morphology 31 | 32
abnormal seminal vesicle morph... 31 | 47
limb grasping 30 | 35
abnormal spleen morphology 29 | 36
decreased circulating creatini... 29 | 31
decreased circulating fructosa... 29 | 31
tremors 29 | 34
abnormal testis morphology 28 | 30
cardiovascular system phenotyp... 28 | 35
decreased T cell number 28 | 31
decreased circulating calcium ... 28 | 33
decreased circulating chloride... 28 | 32
embryonic growth retardation 28 | 28
increased circulating potassiu... 28 | 31
female infertility 27 | 34
increased circulating calcium ... 27 | 32

Disease

ovarian cancer 7,748 | 8,491
osteosarcoma 7,047 | 7,933
medulloblastoma, large-cell 5,497 | 6,234
psoriasis 5,317 | 6,685
glioblastoma 4,961 | 5,572
lung cancer 4,053 | 4,473
atypical teratoid / rhabdoid tumor 3,886 | 4,369
malignant mesothelioma 2,956 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 2,928 | 3,289
Breast cancer 2,796 | 3,098
primitive neuroectodermal tumor 2,674 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,652 | 2,988
invasive ductal carcinoma 2,640 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,624 | 2,956
pilocytic astrocytoma 2,613 | 3,086
oligodendroglioma 2,496 | 2,849
non-small cell lung cancer 2,445 | 2,798
pediatric high grade glioma 2,401 | 2,712
lung carcinoma 2,360 | 2,844
lung adenocarcinoma 2,325 | 2,714
ependymoma 2,267 | 2,514
pancreatic cancer 2,026 | 2,300
subependymal giant cell astrocytoma 1,998 | 2,287
group 3 medulloblastoma 1,983 | 2,254
Cancer 1,982 | 2,346
astrocytic glioma 1,979 | 2,241
interstitial cystitis 1,893 | 2,299
adult high grade glioma 1,817 | 2,148
ulcerative colitis 1,810 | 2,087
Carcinoma 1,746 | 2,147
Pick disease 1,724 | 1,893
group 4 medulloblastoma 1,694 | 1,875
pituitary cancer 1,684 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,639 | 1,795
ductal carcinoma in situ 1,552 | 1,745
cystic fibrosis 1,491 | 1,670
breast carcinoma 1,419 | 1,614
tuberculosis 1,376 | 1,563
astrocytoma 1,348 | 1,493
medulloblastoma 1,330 | 1,524
sonic hedgehog group medulloblastoma 1,327 | 1,482
posterior fossa group B ependymoma 1,321 | 1,530
adrenocortical carcinoma 1,290 | 1,427
Multiple myeloma 1,284 | 1,327
posterior fossa group A ependymoma 1,280 | 1,511
colon cancer 1,276 | 1,475
diabetes mellitus 1,260 | 1,663
primary pancreatic ductal adenocarcinoma 1,172 | 1,271
juvenile dermatomyositis 1,132 | 1,189
acute quadriplegic myopathy 1,093 | 1,157
Rheumatoid Arthritis 1,021 | 1,170
spina bifida 971 | 1,064
atypical teratoid/rhabdoid tumor 953 | 1,095
dermatomyositis 924 | 966
nasopharyngeal carcinoma 895 | 1,056
cutaneous lupus erythematosus 856 | 1,056
active Crohn's disease 796 | 918
Atopic dermatitis 771 | 944
gastric carcinoma 744 | 832
acute myeloid leukemia 729 | 785
non primary Sjogren syndrome sicca 728 | 840
Waldenstrons macroglobulinemia 726 | 764
primary Sjogren syndrome 673 | 788
tuberculosis and treatment for 6 months 656 | 686
esophageal adenocarcinoma 621 | 737
progressive supranuclear palsy 621 | 674
aldosterone-producing adenoma 606 | 664
Alzheimer's disease 546 | 644
Duchenne muscular dystrophy 543 | 602
hepatocellular carcinoma 511 | 550
pancreatic carcinoma 511 | 567
Intellectual disability 510 | 573
Obesity 495 | 616
Down syndrome 483 | 548
fibroadenoma 479 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 473 | 499
Endometriosis 463 | 535
chronic rhinosinusitis 434 | 512
IGA Glomerulonephritis 420 | 454
Prostatic Neoplasms 407 | 471
active ulcerative colitis 401 | 477
gastric cancer 401 | 436
Amyotrophic Lateral Sclerosis 393 | 432
mucosa-associated lymphoid tissue lymphoma 387 | 480
Schizophrenia 377 | 503
Mammary Neoplasms 367 | 410
Multiple Sclerosis 364 | 498
inflammatory breast cancer 355 | 404
Neurodegenerative disease 353 | 383
non-small cell lung carcinoma 328 | 413
glioblastoma multiforme 309 | 347
sarcoidosis 305 | 368
hereditary spastic paraplegia 303 | 313
Parkinson's disease 295 | 364
Polycystic Ovary Syndrome 295 | 334
tuberculosis and treatment for 3 months 295 | 327
Kidney disease 294 | 397
urothelial carcinoma 278 | 318
interstitial lung disease 264 | 292
nephrosclerosis 259 | 329

Tissue

Nervous System 15,003 | 18,560
Digestive Tract 14,981 | 18,472
Female tissues 14,978 | 18,646
Endocrine System 14,964 | 18,511
Urinary Tract 14,938 | 18,443
Liver and Pancreas 14,915 | 18,135
Cardiovascular System 14,902 | 17,957
Male tissues 14,885 | 17,968
Blood and immune system 14,884 | 17,994
Skin and soft tissues 14,836 | 18,114
Respiratory system 14,750 | 17,483

Target Family

Non-IDG 8,806 | 11,969
Enzyme 3,511 | 4,146
Transcription Factor 1,142 | 1,400
Kinase 578 | 634
Transporter 366 | 473
GPCR 237 | 408
Ion Channel 223 | 341
Epigenetic 219 | 242
Nuclear Receptor 40 | 48
TF/Epigenetic 33 | 38
oGPCR 26 | 421

HCA RNA Cell Line

BJ hTERT+ 15,181 | 15,181
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66