Development Level

Tbio 9,741 | 11,445
Tdark 3,919 | 6,588
Tchem 1,335 | 1,598
Tclin 453 | 613

Collection

RFA-RM-18-021 235 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 72 | 99
GPCR: IDG Consortium (Targets) 52 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 937 | 979
preweaning lethality, incomple... 451 | 499
embryonic lethality prior to t... 269 | 278
abnormal behavior 267 | 298
embryonic lethality prior to o... 237 | 239
abnormal embryo size 210 | 220
decreased total body fat amoun... 181 | 207
enlarged heart 172 | 210
abnormal bone structure 163 | 187
decreased vertical activity 157 | 208
increased lean body mass 153 | 172
decreased body weight 151 | 161
abnormal heart morphology 137 | 162
decreased bone mineral content 133 | 151
hyperactivity 133 | 148
decreased lean body mass 122 | 135
increased total body fat amoun... 119 | 134
hypoactivity 112 | 132
decreased bone mineral density 108 | 126
decreased circulating glucose ... 108 | 126
increased circulating alkaline... 106 | 122
increased startle reflex 106 | 112
decreased grip strength 100 | 116
embryonic growth retardation 100 | 106
male infertility 98 | 123
increased bone mineral content 94 | 108
decreased body length 91 | 101
short tibia 88 | 97
abnormal seminal vesicle morph... 87 | 114
increased mean corpuscular hem... 87 | 96
decreased circulating choleste... 86 | 93
increased mean corpuscular vol... 86 | 92
increased or absent threshold ... 85 | 101
cataract 84 | 92
prenatal lethality prior to he... 83 | 87
decreased prepulse inhibition 76 | 82
abnormal lens morphology 74 | 81
decreased lymphocyte cell numb... 74 | 83
decreased circulating serum al... 71 | 82
decreased circulating triglyce... 71 | 79
decreased mean corpuscular vol... 71 | 79
increased bone mineral density 69 | 72
decreased startle reflex 68 | 75
increased fasted circulating g... 65 | 76
abnormal eye morphology 64 | 68
abnormal retina morphology 64 | 71
decreased leukocyte cell numbe... 63 | 73
improved glucose tolerance 63 | 79
increased circulating HDL chol... 63 | 80
decreased circulating HDL chol... 62 | 68
small superior vagus ganglion 62 | 74
abnormal sleep behavior 61 | 70
decreased circulating insulin ... 61 | 76
impaired glucose tolerance 61 | 75
increased circulating sodium l... 59 | 71
abnormal behavioral response t... 58 | 66
decreased erythrocyte cell num... 58 | 62
decreased hemoglobin content 58 | 68
abnormal coat-hair pigmentatio... 57 | 64
abnormal gait 56 | 69
edema 56 | 59
increased monocyte cell number 56 | 63
abnormal kidney morphology 55 | 65
increased circulating choleste... 54 | 66
increased heart weight 54 | 62
decreased caudal vertebrae num... 52 | 53
small testis 52 | 58
thrombocytopenia 52 | 56
decreased fasted circulating g... 51 | 65
decreased mean corpuscular hem... 47 | 50
abnormal spleen morphology 46 | 55
decreased circulating total pr... 46 | 49
abnormal neural tube closure 45 | 46
female infertility 45 | 60
hydrometra 44 | 53
decreased circulating alanine ... 43 | 47
decreased circulating alkaline... 43 | 46
decreased blood urea nitrogen ... 41 | 51
decreased hematocrit 41 | 46
increased hematocrit 41 | 46
increased neutrophil cell numb... 41 | 46
abnormal skin morphology 40 | 50
increased blood urea nitrogen ... 40 | 48
increased hemoglobin content 39 | 45
increased leukocyte cell numbe... 39 | 47
enlarged spleen 38 | 41
increased mean platelet volume 38 | 45
abnormal testis morphology 37 | 43
decreased circulating LDL chol... 37 | 38
decreased red blood cell distr... 37 | 41
increased circulating triglyce... 37 | 42
tremors 37 | 39
abnormal bone mineralization 36 | 38
increased grip strength 36 | 41
limb grasping 36 | 41
abnormal cranium morphology 34 | 36
enlarged lymph nodes 34 | 37
increased erythrocyte cell num... 33 | 39
increased mean corpuscular hem... 33 | 36
pallor 33 | 34

Disease

Carcinoma 9,442 | 11,493
ovarian cancer 7,890 | 8,520
osteosarcoma 7,143 | 7,950
medulloblastoma, large-cell 5,611 | 6,241
psoriasis 5,410 | 6,694
glioblastoma 5,287 | 5,792
atypical teratoid / rhabdoid tumor 4,677 | 5,112
lung cancer 4,253 | 4,740
ependymoma 4,216 | 4,679
group 3 medulloblastoma 3,722 | 4,104
adult high grade glioma 3,351 | 3,801
Breast cancer 3,238 | 3,578
malignant mesothelioma 3,080 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,971 | 3,291
primitive neuroectodermal tumor 2,765 | 3,035
Astrocytoma, Pilocytic 2,699 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,691 | 2,989
invasive ductal carcinoma 2,688 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,653 | 2,955
oligodendroglioma 2,581 | 2,850
non-small cell lung cancer 2,535 | 2,890
lung carcinoma 2,377 | 2,843
astrocytic glioma 2,352 | 2,597
lung adenocarcinoma 2,328 | 2,716
Kidney cancer 2,235 | 2,613
pancreatic cancer 2,142 | 2,398
Cancer 2,126 | 2,499
subependymal giant cell astrocytoma 2,061 | 2,287
interstitial cystitis 1,899 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,810 | 1,962
tuberculosis 1,785 | 2,010
Pick disease 1,766 | 1,894
pituitary cancer 1,730 | 1,972
group 4 medulloblastoma 1,719 | 1,855
ductal carcinoma in situ 1,572 | 1,745
ulcerative colitis 1,563 | 1,819
cystic fibrosis 1,536 | 1,696
breast carcinoma 1,464 | 1,638
adrenocortical carcinoma 1,315 | 1,428
diabetes mellitus 1,310 | 1,728
Multiple myeloma 1,295 | 1,332
colon cancer 1,295 | 1,478
Autosomal recessive predisposition 1,226 | 1,442
juvenile dermatomyositis 1,127 | 1,187
acute quadriplegic myopathy 1,111 | 1,158
astrocytoma 1,076 | 1,146
Rheumatoid arthritis 1,051 | 1,191
primary pancreatic ductal adenocarcinoma 1,034 | 1,109
pediatric high grade glioma 990 | 1,064
spina bifida 982 | 1,074
Intellectual disability 933 | 1,016
dermatomyositis 932 | 966
Schizophrenia 924 | 1,160
nasopharyngeal carcinoma 881 | 1,058
cutaneous lupus erythematosus 834 | 1,057
active Crohn's disease 802 | 922
Atopic dermatitis 790 | 952
non primary Sjogren syndrome sicca 784 | 891
acute myeloid leukemia 740 | 783
Waldenstrons macroglobulinemia 732 | 765
gastric carcinoma 728 | 807
Epilepsy 682 | 792
Liver Cirrhosis, Experimental 667 | 769
medulloblastoma 659 | 720
active ulcerative colitis 651 | 764
esophageal adenocarcinoma 632 | 737
progressive supranuclear palsy 629 | 676
primary Sjogren syndrome 617 | 735
aldosterone-producing adenoma 608 | 665
Dull intelligence 593 | 645
Low intelligence 593 | 645
Mental Retardation 593 | 645
Mental deficiency 593 | 645
Poor school performance 593 | 645
Alzheimer's disease 572 | 658
Cognitive delay 566 | 608
Global developmental delay 566 | 608
Mental and motor retardation 566 | 608
Obesity 555 | 678
Duchenne muscular dystrophy 550 | 601
Muscle hypotonia 536 | 571
Melanoma 530 | 711
Bipolar Disorder 527 | 666
Seizures 523 | 596
pancreatic carcinoma 508 | 562
Liver cancer 504 | 604
hepatocellular carcinoma 501 | 547
fibroadenoma 493 | 559
autosomal dominant Emery-Dreifuss muscular dystrophy 484 | 510
Short stature 482 | 531
Endometriosis 465 | 540
Down syndrome 456 | 499
Prostatic Neoplasms 434 | 495
chronic rhinosinusitis 430 | 512
sonic hedgehog group medulloblastoma 424 | 467
gastric cancer 420 | 459
posterior fossa group A ependymoma 419 | 468
Amyotrophic lateral sclerosis 418 | 451
Multiple Sclerosis 408 | 540
tuberculosis and treatment for 6 months 402 | 409

Tissue

Endocrine System 15,189 | 18,159
Female tissues 15,061 | 17,400
Digestive Tract 15,060 | 17,369
Skin and soft tissues 15,006 | 17,230
Male tissues 14,963 | 17,142
Blood and immune system 14,904 | 16,909
Nervous System 14,863 | 16,725
Liver and Pancreas 14,825 | 16,750
Urinary Tract 14,806 | 16,678
Respiratory system 14,710 | 16,393
Cardiovascular System 13,999 | 15,192

Target Family

Non-IDG 8,995 | 12,091
Enzyme 3,527 | 4,145
Transcription Factor 1,189 | 1,400
Kinase 582 | 634
Transporter 370 | 473
Ion Channel 238 | 344
GPCR 226 | 408
Epigenetic 225 | 242
Nuclear Receptor 38 | 48
TF/Epigenetic 35 | 38
oGPCR 23 | 421

HCA RNA Cell Line

BJ 15,448 | 15,448
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endosomal/lysosomal potassium channel TMEM175 TMEM175 Tbio Non-IDG -0.65375 3.76 42
WASH complex subunit 2C WASHC2C Tbio Non-IDG -0.83634 0.00000 45
Transmembrane protein 170A TMEM170A Tdark Non-IDG 0.00000 1.18 3
Protein AF-9 MLLT3 Tbio Non-IDG -1.99555 93.8 210
Scm-like with four MBT domains protein 1 SFMBT1 Tbio Epigenetic -2.06810 112.0 113
Guanine deaminase GDA Tbio Enzyme -1.48687 32.3 196
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.18 96
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.24396 15.5 189
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.72004 3.69 184
Solute carrier organic anion transporter family member 3A1 SLCO3A1 Tbio Transporter -1.39614 24.1 46