Development Level

Tbio 9,690 | 10,625
Tdark 4,633 | 7,003
Tchem 1,703 | 1,890
Tclin 514 | 602

Collection

Kinase: IDG Consortium (Targets) 116 | 125
Ion Channel: IDG Consortium (Targets) 85 | 102
GPCR: IDG Consortium (Targets) 76 | 127
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 21 | 26

IMPC Phenotype

preweaning lethality, complete... 617 | 633
preweaning lethality, incomple... 251 | 260
abnormal behavior 219 | 226
decreased lean body mass 188 | 195
embryonic lethality prior to t... 185 | 187
decreased total body fat amoun... 178 | 186
decreased body weight 169 | 174
decreased bone mineral content 150 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 122 | 131
decreased bone mineral density 120 | 126
increased or absent threshold ... 118 | 128
decreased circulating glucose ... 113 | 121
decreased grip strength 112 | 123
increased circulating alkaline... 111 | 119
abnormal embryo size 106 | 112
decreased body length 105 | 108
hyperactivity 100 | 108
increased lean body mass 99 | 107
enlarged heart 98 | 111
abnormal retina morphology 93 | 100
increased bone mineral content 89 | 92
increased mean corpuscular hem... 89 | 93
increased mean corpuscular vol... 87 | 91
hypoactivity 81 | 89
decreased circulating choleste... 80 | 85
decreased circulating triglyce... 78 | 83
short tibia 75 | 82
decreased circulating HDL chol... 73 | 77
decreased circulating serum al... 72 | 79
increased grip strength 72 | 83
abnormal lens morphology 69 | 73
decreased circulating insulin ... 69 | 75
increased circulating sodium l... 67 | 71
increased fasted circulating g... 65 | 68
prenatal lethality prior to he... 62 | 64
decreased lumbar vertebrae num... 61 | 62
increased sacral vertebrae num... 59 | 62
male infertility 59 | 62
increased circulating HDL chol... 58 | 63
abnormal retinal pigmentation 57 | 61
abnormal sleep behavior 57 | 63
abnormal bone mineralization 55 | 55
decreased rib number 55 | 59
increased total body fat amoun... 53 | 57
abnormal coat-hair pigmentatio... 51 | 54
increased exploration in new e... 51 | 56
decreased hemoglobin content 50 | 53
decreased leukocyte cell numbe... 50 | 54
increased bone mineral density 50 | 52
increased circulating choleste... 50 | 53
decreased circulating alanine ... 49 | 53
decreased mean corpuscular vol... 49 | 50
decreased prepulse inhibition 48 | 52
impaired glucose tolerance 48 | 52
improved glucose tolerance 48 | 56
abnormal gait 47 | 51
decreased caudal vertebrae num... 47 | 49
decreased fasted circulating g... 45 | 49
abnormal heart morphology 44 | 51
decreased startle reflex 44 | 48
thrombocytopenia 44 | 46
abnormal behavioral response t... 43 | 52
decreased erythrocyte cell num... 42 | 43
increased blood urea nitrogen ... 42 | 44
increased circulating chloride... 42 | 43
increased body weight 40 | 42
increased hemoglobin content 40 | 45
increased rib number 40 | 41
decreased circulating total pr... 39 | 41
decreased heart weight 39 | 44
abnormal seminal vesicle morph... 38 | 47
decreased eosinophil cell numb... 38 | 41
decreased circulating alkaline... 37 | 41
increased startle reflex 37 | 38
abnormal eye morphology 36 | 38
abnormal neural tube closure 36 | 37
decreased circulating LDL chol... 36 | 37
decreased circulating free fat... 36 | 39
decreased neutrophil cell numb... 35 | 37
increased heart weight 35 | 37
increased leukocyte cell numbe... 34 | 37
abnormal spleen morphology 33 | 36
decreased mean corpuscular hem... 33 | 34
abnormal cranium morphology 32 | 32
cardiovascular system phenotyp... 32 | 35
limb grasping 32 | 35
small testis 32 | 37
tremors 32 | 34
decreased T cell number 31 | 31
decreased circulating fructosa... 31 | 31
decreased circulating calcium ... 30 | 33
decreased circulating creatini... 30 | 31
female infertility 30 | 34
decreased blood urea nitrogen ... 29 | 31
decreased threshold for audito... 29 | 32
increased circulating calcium ... 29 | 32
increased circulating potassiu... 29 | 31
increased hematocrit 29 | 36
decreased circulating chloride... 28 | 32

Disease

ovarian cancer 8,068 | 8,491
osteosarcoma 7,401 | 7,933
psoriasis 5,849 | 6,685
medulloblastoma, large-cell 5,804 | 6,234
glioblastoma 5,258 | 5,572
lung cancer 4,242 | 4,473
atypical teratoid / rhabdoid tumor 4,098 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,145 | 3,289
malignant mesothelioma 3,027 | 3,163
Breast cancer 2,946 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 2,856 | 2,988
pilocytic astrocytoma 2,851 | 3,086
primitive neuroectodermal tumor 2,836 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 2,820 | 2,956
invasive ductal carcinoma 2,794 | 2,950
oligodendroglioma 2,658 | 2,849
non-small cell lung cancer 2,642 | 2,798
lung carcinoma 2,582 | 2,844
pediatric high grade glioma 2,557 | 2,712
lung adenocarcinoma 2,510 | 2,714
ependymoma 2,372 | 2,514
pancreatic cancer 2,187 | 2,300
subependymal giant cell astrocytoma 2,172 | 2,287
Cancer 2,154 | 2,346
interstitial cystitis 2,122 | 2,299
group 3 medulloblastoma 2,106 | 2,254
astrocytic glioma 2,092 | 2,241
adult high grade glioma 1,953 | 2,148
ulcerative colitis 1,943 | 2,087
Carcinoma 1,898 | 2,147
pituitary cancer 1,825 | 1,972
Pick disease 1,795 | 1,893
group 4 medulloblastoma 1,780 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,714 | 1,795
ductal carcinoma in situ 1,649 | 1,745
cystic fibrosis 1,558 | 1,670
breast carcinoma 1,530 | 1,614
tuberculosis 1,459 | 1,563
astrocytoma 1,441 | 1,493
medulloblastoma 1,424 | 1,524
posterior fossa group B ependymoma 1,401 | 1,530
diabetes mellitus 1,398 | 1,663
sonic hedgehog group medulloblastoma 1,392 | 1,482
posterior fossa group A ependymoma 1,383 | 1,511
colon cancer 1,378 | 1,475
adrenocortical carcinoma 1,362 | 1,427
Multiple myeloma 1,297 | 1,327
primary pancreatic ductal adenocarcinoma 1,238 | 1,271
juvenile dermatomyositis 1,151 | 1,189
acute quadriplegic myopathy 1,122 | 1,157
Rheumatoid Arthritis 1,101 | 1,170
atypical teratoid/rhabdoid tumor 1,041 | 1,095
spina bifida 1,019 | 1,064
nasopharyngeal carcinoma 963 | 1,056
cutaneous lupus erythematosus 955 | 1,056
dermatomyositis 949 | 966
active Crohn's disease 870 | 918
Atopic dermatitis 835 | 944
gastric carcinoma 791 | 832
non primary Sjogren syndrome sicca 758 | 840
acute myeloid leukemia 752 | 785
Waldenstrons macroglobulinemia 745 | 764
primary Sjogren syndrome 733 | 788
esophageal adenocarcinoma 696 | 737
tuberculosis and treatment for 6 months 664 | 686
progressive supranuclear palsy 647 | 674
aldosterone-producing adenoma 644 | 664
Alzheimer's disease 579 | 644
Duchenne muscular dystrophy 573 | 602
Obesity 553 | 616
Intellectual disability 544 | 573
pancreatic carcinoma 542 | 567
fibroadenoma 531 | 557
hepatocellular carcinoma 531 | 550
Down syndrome 521 | 548
Endometriosis 492 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 484 | 499
chronic rhinosinusitis 468 | 512
Prostatic Neoplasms 447 | 471
active ulcerative colitis 443 | 477
IGA Glomerulonephritis 439 | 454
Schizophrenia 429 | 503
Multiple Sclerosis 423 | 498
mucosa-associated lymphoid tissue lymphoma 423 | 480
gastric cancer 419 | 436
Amyotrophic Lateral Sclerosis 411 | 432
Mammary Neoplasms 383 | 410
inflammatory breast cancer 374 | 404
Neurodegenerative disease 361 | 383
non-small cell lung carcinoma 358 | 413
Kidney disease 347 | 397
sarcoidosis 340 | 368
Parkinson's disease 325 | 364
glioblastoma multiforme 322 | 347
Polycystic Ovary Syndrome 319 | 334
tuberculosis and treatment for 3 months 308 | 327
hereditary spastic paraplegia 304 | 313
nephrosclerosis 304 | 329
urothelial carcinoma 304 | 318
Epilepsy 299 | 346

Tissue

Nervous System 16,289 | 18,560
Female tissues 16,273 | 18,646
Endocrine System 16,260 | 18,511
Digestive Tract 16,258 | 18,472
Urinary Tract 16,202 | 18,443
Liver and Pancreas 16,154 | 18,135
Male tissues 16,106 | 17,968
Blood and immune system 16,086 | 17,994
Cardiovascular System 16,085 | 17,957
Skin and soft tissues 16,071 | 18,114
Respiratory system 15,867 | 17,483

Target Family

Non-IDG 9,612 | 11,969
Enzyme 3,736 | 4,146
Transcription Factor 1,275 | 1,400
Kinase 602 | 634
Transporter 416 | 473
GPCR 285 | 408
Ion Channel 273 | 341
Epigenetic 229 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 34 | 38
oGPCR 31 | 421

HCA RNA Cell Line

BEWO 16,540 | 16,540
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131