Development Level

Tbio 9,579 | 11,651
Tdark 3,689 | 6,593
Tchem 1,134 | 1,388
Tclin 440 | 612

Collection

RFA-RM-18-021 214 | 328
Kinase: IDG Consortium (Target... 104 | 125
Ion Channel: IDG Consortium (T... 66 | 99
GPCR: IDG Consortium (Targets) 51 | 126
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 14 | 25

IMPC Phenotype

preweaning lethality, complete... 919 | 979
preweaning lethality, incomple... 441 | 499
embryonic lethality prior to t... 264 | 278
abnormal behavior 257 | 298
embryonic lethality prior to o... 235 | 239
abnormal embryo size 205 | 220
decreased total body fat amoun... 179 | 207
enlarged heart 167 | 210
abnormal bone structure 160 | 187
decreased body weight 148 | 161
decreased vertical activity 148 | 208
increased lean body mass 148 | 172
abnormal heart morphology 131 | 162
hyperactivity 126 | 148
decreased bone mineral content 125 | 151
decreased lean body mass 116 | 135
hypoactivity 109 | 132
increased circulating alkaline... 109 | 122
increased total body fat amoun... 109 | 134
decreased circulating glucose ... 103 | 126
increased startle reflex 103 | 112
decreased bone mineral density 102 | 126
embryonic growth retardation 100 | 106
male infertility 96 | 123
decreased grip strength 94 | 116
increased bone mineral content 92 | 108
decreased body length 91 | 101
increased or absent threshold ... 87 | 101
abnormal seminal vesicle morph... 85 | 114
decreased circulating choleste... 84 | 93
short tibia 84 | 97
cataract 82 | 92
increased mean corpuscular hem... 81 | 96
prenatal lethality prior to he... 81 | 87
increased mean corpuscular vol... 79 | 92
abnormal lens morphology 73 | 81
decreased prepulse inhibition 72 | 82
decreased circulating serum al... 69 | 82
decreased mean corpuscular vol... 69 | 79
decreased lymphocyte cell numb... 68 | 83
decreased circulating triglyce... 67 | 79
decreased startle reflex 67 | 75
increased bone mineral density 67 | 72
abnormal retina morphology 65 | 71
increased fasted circulating g... 65 | 76
decreased leukocyte cell numbe... 61 | 73
increased circulating HDL chol... 61 | 80
abnormal eye morphology 60 | 68
decreased circulating HDL chol... 59 | 68
improved glucose tolerance 58 | 79
small superior vagus ganglion 58 | 74
abnormal sleep behavior 57 | 70
decreased circulating insulin ... 57 | 76
edema 57 | 59
impaired glucose tolerance 57 | 75
abnormal coat-hair pigmentatio... 56 | 64
increased heart weight 56 | 62
abnormal gait 55 | 69
increased circulating sodium l... 55 | 71
abnormal behavioral response t... 54 | 66
decreased hemoglobin content 54 | 68
decreased erythrocyte cell num... 53 | 62
decreased fasted circulating g... 53 | 65
increased circulating choleste... 53 | 66
small testis 53 | 58
decreased caudal vertebrae num... 50 | 53
abnormal kidney morphology 49 | 65
thrombocytopenia 49 | 56
increased monocyte cell number 47 | 63
decreased mean corpuscular hem... 46 | 50
decreased circulating total pr... 44 | 49
decreased blood urea nitrogen ... 43 | 51
female infertility 43 | 60
hydrometra 43 | 53
abnormal spleen morphology 42 | 55
decreased circulating alanine ... 42 | 47
abnormal neural tube closure 41 | 46
decreased circulating alkaline... 41 | 46
increased hematocrit 41 | 46
abnormal skin morphology 40 | 50
increased blood urea nitrogen ... 40 | 48
increased leukocyte cell numbe... 40 | 47
increased hemoglobin content 39 | 45
increased neutrophil cell numb... 39 | 46
abnormal testis morphology 38 | 43
decreased red blood cell distr... 37 | 41
enlarged spleen 37 | 41
increased mean platelet volume 37 | 45
decreased circulating LDL chol... 36 | 38
decreased hematocrit 36 | 46
increased erythrocyte cell num... 35 | 39
tremors 35 | 39
abnormal bone mineralization 34 | 38
abnormal cranium morphology 34 | 36
increased circulating triglyce... 34 | 42
increased grip strength 34 | 41
decreased neutrophil cell numb... 33 | 42
increased mean corpuscular hem... 33 | 36
enlarged lymph nodes 32 | 37
limb grasping 32 | 41

Disease

Carcinoma 9,142 | 11,493
ovarian cancer 7,751 | 8,520
osteosarcoma 6,985 | 7,950
medulloblastoma, large-cell 5,418 | 6,241
psoriasis 5,161 | 6,694
glioblastoma 5,118 | 5,792
atypical teratoid / rhabdoid tumor 4,485 | 5,112
lung cancer 4,179 | 4,740
ependymoma 4,039 | 4,679
group 3 medulloblastoma 3,594 | 4,104
adult high grade glioma 3,199 | 3,801
Breast cancer 3,166 | 3,578
malignant mesothelioma 2,962 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,896 | 3,291
primitive neuroectodermal tumor 2,643 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,620 | 2,989
invasive ductal carcinoma 2,620 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,582 | 2,955
Astrocytoma, Pilocytic 2,562 | 3,081
oligodendroglioma 2,466 | 2,850
non-small cell lung cancer 2,450 | 2,890
lung carcinoma 2,290 | 2,843
astrocytic glioma 2,272 | 2,597
lung adenocarcinoma 2,249 | 2,716
Kidney cancer 2,164 | 2,613
pancreatic cancer 2,085 | 2,398
Cancer 2,051 | 2,499
subependymal giant cell astrocytoma 2,005 | 2,287
interstitial cystitis 1,816 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,793 | 1,962
tuberculosis 1,772 | 2,010
Pick disease 1,713 | 1,894
group 4 medulloblastoma 1,669 | 1,855
pituitary cancer 1,659 | 1,972
ulcerative colitis 1,542 | 1,819
ductal carcinoma in situ 1,535 | 1,745
cystic fibrosis 1,484 | 1,696
breast carcinoma 1,433 | 1,638
adrenocortical carcinoma 1,296 | 1,428
Multiple myeloma 1,295 | 1,332
colon cancer 1,274 | 1,478
diabetes mellitus 1,264 | 1,728
Autosomal recessive predisposition 1,191 | 1,442
juvenile dermatomyositis 1,128 | 1,187
acute quadriplegic myopathy 1,097 | 1,158
astrocytoma 1,055 | 1,146
Rheumatoid arthritis 1,037 | 1,191
primary pancreatic ductal adenocarcinoma 1,015 | 1,109
pediatric high grade glioma 963 | 1,064
spina bifida 940 | 1,074
dermatomyositis 931 | 966
Intellectual disability 911 | 1,016
Schizophrenia 870 | 1,160
nasopharyngeal carcinoma 868 | 1,058
cutaneous lupus erythematosus 819 | 1,057
active Crohn's disease 784 | 922
non primary Sjogren syndrome sicca 763 | 891
Atopic dermatitis 762 | 952
acute myeloid leukemia 736 | 783
Waldenstrons macroglobulinemia 723 | 765
gastric carcinoma 721 | 807
Epilepsy 673 | 792
Liver Cirrhosis, Experimental 648 | 769
medulloblastoma 642 | 720
active ulcerative colitis 624 | 764
primary Sjogren syndrome 624 | 735
progressive supranuclear palsy 623 | 676
aldosterone-producing adenoma 612 | 665
esophageal adenocarcinoma 605 | 737
Dull intelligence 580 | 645
Low intelligence 580 | 645
Mental Retardation 580 | 645
Mental deficiency 580 | 645
Poor school performance 580 | 645
Cognitive delay 562 | 608
Global developmental delay 562 | 608
Mental and motor retardation 562 | 608
Alzheimer's disease 559 | 658
Duchenne muscular dystrophy 552 | 601
Muscle hypotonia 528 | 571
Obesity 525 | 678
Seizures 511 | 596
pancreatic carcinoma 504 | 562
hepatocellular carcinoma 500 | 547
Melanoma 495 | 711
Bipolar Disorder 485 | 666
autosomal dominant Emery-Dreifuss muscular dystrophy 481 | 510
fibroadenoma 476 | 559
Liver cancer 473 | 604
Short stature 472 | 531
Endometriosis 454 | 540
Down syndrome 446 | 499
chronic rhinosinusitis 421 | 512
gastric cancer 418 | 459
Prostatic Neoplasms 417 | 495
sonic hedgehog group medulloblastoma 414 | 467
posterior fossa group A ependymoma 412 | 468
Amyotrophic lateral sclerosis 407 | 451
tuberculosis and treatment for 6 months 399 | 409
Multiple Sclerosis 393 | 540

Tissue

Endocrine System 14,639 | 18,159
Female tissues 14,540 | 17,400
Skin and soft tissues 14,516 | 17,230
Digestive Tract 14,507 | 17,369
Male tissues 14,467 | 17,142
Blood and immune system 14,399 | 16,909
Nervous System 14,384 | 16,725
Liver and Pancreas 14,360 | 16,750
Urinary Tract 14,329 | 16,678
Respiratory system 14,243 | 16,393
Cardiovascular System 13,646 | 15,192

Target Family

Non-IDG 8,603 | 12,091
Enzyme 3,450 | 4,145
Transcription Factor 1,132 | 1,400
Kinase 555 | 634
Transporter 364 | 473
Epigenetic 221 | 242
Ion Channel 219 | 344
GPCR 204 | 408
Nuclear Receptor 39 | 48
TF/Epigenetic 35 | 38
oGPCR 20 | 421

HCA RNA Cell Line

ASC TERT1 14,842 | 14,842
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50