Development Level

Tbio 9,989 | 11,651
Tdark 4,012 | 6,593
Tchem 1,182 | 1,388
Tclin 465 | 612

Collection

RFA-RM-18-021 233 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 70 | 99
GPCR: IDG Consortium (Targets) 56 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 940 | 979
preweaning lethality, incomple... 454 | 499
embryonic lethality prior to t... 268 | 278
abnormal behavior 266 | 298
embryonic lethality prior to o... 237 | 239
abnormal embryo size 209 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 177 | 210
decreased vertical activity 169 | 208
abnormal bone structure 168 | 187
increased lean body mass 156 | 172
decreased body weight 147 | 161
abnormal heart morphology 140 | 162
hyperactivity 132 | 148
decreased bone mineral content 126 | 151
decreased lean body mass 122 | 135
hypoactivity 117 | 132
increased total body fat amoun... 116 | 134
increased circulating alkaline... 114 | 122
decreased bone mineral density 110 | 126
decreased circulating glucose ... 108 | 126
male infertility 105 | 123
embryonic growth retardation 101 | 106
increased startle reflex 101 | 112
decreased grip strength 99 | 116
increased bone mineral content 95 | 108
abnormal seminal vesicle morph... 93 | 114
decreased body length 93 | 101
increased or absent threshold ... 89 | 101
decreased circulating choleste... 87 | 93
short tibia 86 | 97
increased mean corpuscular hem... 85 | 96
increased mean corpuscular vol... 84 | 92
cataract 83 | 92
prenatal lethality prior to he... 83 | 87
abnormal lens morphology 76 | 81
decreased prepulse inhibition 75 | 82
decreased circulating serum al... 74 | 82
decreased lymphocyte cell numb... 71 | 83
decreased circulating triglyce... 70 | 79
decreased mean corpuscular vol... 70 | 79
increased bone mineral density 68 | 72
abnormal retina morphology 67 | 71
impaired glucose tolerance 67 | 75
increased fasted circulating g... 67 | 76
abnormal eye morphology 66 | 68
decreased startle reflex 66 | 75
increased circulating HDL chol... 66 | 80
decreased circulating HDL chol... 65 | 68
decreased leukocyte cell numbe... 65 | 73
improved glucose tolerance 64 | 79
abnormal sleep behavior 63 | 70
decreased circulating insulin ... 62 | 76
small superior vagus ganglion 62 | 74
decreased hemoglobin content 59 | 68
abnormal behavioral response t... 58 | 66
increased circulating choleste... 58 | 66
abnormal coat-hair pigmentatio... 56 | 64
abnormal gait 56 | 69
decreased erythrocyte cell num... 56 | 62
edema 56 | 59
increased circulating sodium l... 56 | 71
increased heart weight 56 | 62
abnormal kidney morphology 55 | 65
decreased fasted circulating g... 55 | 65
increased monocyte cell number 54 | 63
small testis 54 | 58
female infertility 51 | 60
abnormal spleen morphology 50 | 55
decreased caudal vertebrae num... 50 | 53
thrombocytopenia 48 | 56
hydrometra 47 | 53
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
abnormal neural tube closure 45 | 46
decreased blood urea nitrogen ... 45 | 51
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 44 | 46
increased blood urea nitrogen ... 44 | 48
increased leukocyte cell numbe... 43 | 47
abnormal skin morphology 42 | 50
increased hematocrit 41 | 46
increased hemoglobin content 41 | 45
increased neutrophil cell numb... 40 | 46
decreased hematocrit 39 | 46
decreased neutrophil cell numb... 39 | 42
enlarged spleen 39 | 41
abnormal testis morphology 38 | 43
decreased red blood cell distr... 38 | 41
increased grip strength 38 | 41
increased mean platelet volume 38 | 45
tremors 37 | 39
abnormal bone mineralization 36 | 38
abnormal epididymis morphology 36 | 42
decreased circulating LDL chol... 36 | 38
increased circulating triglyce... 36 | 42
limb grasping 36 | 41
enlarged lymph nodes 35 | 37
increased erythrocyte cell num... 35 | 39
increased circulating chloride... 34 | 41

Disease

Carcinoma 9,504 | 11,493
ovarian cancer 7,875 | 8,520
osteosarcoma 7,157 | 7,950
medulloblastoma, large-cell 5,598 | 6,241
psoriasis 5,464 | 6,694
glioblastoma 5,244 | 5,792
atypical teratoid / rhabdoid tumor 4,642 | 5,112
lung cancer 4,202 | 4,740
ependymoma 4,190 | 4,679
group 3 medulloblastoma 3,716 | 4,104
adult high grade glioma 3,321 | 3,801
Breast cancer 3,223 | 3,578
malignant mesothelioma 3,014 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,965 | 3,291
primitive neuroectodermal tumor 2,751 | 3,035
Astrocytoma, Pilocytic 2,686 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,665 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,623 | 2,955
invasive ductal carcinoma 2,623 | 2,951
oligodendroglioma 2,554 | 2,850
non-small cell lung cancer 2,498 | 2,890
lung carcinoma 2,347 | 2,843
astrocytic glioma 2,324 | 2,597
lung adenocarcinoma 2,321 | 2,716
Kidney cancer 2,195 | 2,613
Cancer 2,160 | 2,499
pancreatic cancer 2,124 | 2,398
subependymal giant cell astrocytoma 2,062 | 2,287
interstitial cystitis 1,880 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,818 | 1,962
tuberculosis 1,778 | 2,010
Pick disease 1,755 | 1,894
pituitary cancer 1,725 | 1,972
group 4 medulloblastoma 1,698 | 1,855
ductal carcinoma in situ 1,536 | 1,745
ulcerative colitis 1,536 | 1,819
cystic fibrosis 1,478 | 1,696
breast carcinoma 1,448 | 1,638
diabetes mellitus 1,344 | 1,728
Multiple myeloma 1,298 | 1,332
colon cancer 1,290 | 1,478
adrenocortical carcinoma 1,281 | 1,428
Autosomal recessive predisposition 1,251 | 1,442
juvenile dermatomyositis 1,125 | 1,187
acute quadriplegic myopathy 1,096 | 1,158
astrocytoma 1,074 | 1,146
Rheumatoid arthritis 1,060 | 1,191
primary pancreatic ductal adenocarcinoma 1,027 | 1,109
spina bifida 993 | 1,074
pediatric high grade glioma 987 | 1,064
Intellectual disability 938 | 1,016
Schizophrenia 933 | 1,160
dermatomyositis 927 | 966
nasopharyngeal carcinoma 894 | 1,058
cutaneous lupus erythematosus 842 | 1,057
active Crohn's disease 812 | 922
non primary Sjogren syndrome sicca 782 | 891
Atopic dermatitis 749 | 952
acute myeloid leukemia 737 | 783
gastric carcinoma 726 | 807
Waldenstrons macroglobulinemia 723 | 765
Epilepsy 709 | 792
active ulcerative colitis 669 | 764
medulloblastoma 659 | 720
Liver Cirrhosis, Experimental 657 | 769
esophageal adenocarcinoma 641 | 737
progressive supranuclear palsy 632 | 676
aldosterone-producing adenoma 608 | 665
primary Sjogren syndrome 606 | 735
Dull intelligence 599 | 645
Low intelligence 599 | 645
Mental Retardation 599 | 645
Mental deficiency 599 | 645
Poor school performance 599 | 645
Cognitive delay 572 | 608
Global developmental delay 572 | 608
Mental and motor retardation 572 | 608
Alzheimer's disease 562 | 658
Duchenne muscular dystrophy 542 | 601
Muscle hypotonia 542 | 571
Obesity 542 | 678
Seizures 540 | 596
Bipolar Disorder 535 | 666
Melanoma 511 | 711
hepatocellular carcinoma 507 | 547
pancreatic carcinoma 507 | 562
Short stature 494 | 531
fibroadenoma 486 | 559
Liver cancer 482 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 475 | 510
Endometriosis 468 | 540
Down syndrome 456 | 499
Prostatic Neoplasms 449 | 495
chronic rhinosinusitis 434 | 512
Multiple Sclerosis 425 | 540
sonic hedgehog group medulloblastoma 423 | 467
gastric cancer 420 | 459
posterior fossa group A ependymoma 417 | 468
Amyotrophic lateral sclerosis 415 | 451
Breast Neoplasms 402 | 445

Tissue

Endocrine System 15,393 | 18,159
Female tissues 15,159 | 17,400
Digestive Tract 15,155 | 17,369
Skin and soft tissues 15,131 | 17,230
Male tissues 15,072 | 17,142
Blood and immune system 15,000 | 16,909
Nervous System 14,985 | 16,725
Liver and Pancreas 14,900 | 16,750
Urinary Tract 14,849 | 16,678
Respiratory system 14,745 | 16,393
Cardiovascular System 13,981 | 15,192

Target Family

Non-IDG 9,089 | 12,091
Enzyme 3,567 | 4,145
Transcription Factor 1,218 | 1,400
Kinase 578 | 634
Transporter 385 | 473
Ion Channel 246 | 344
GPCR 233 | 408
Epigenetic 228 | 242
Nuclear Receptor 41 | 48
TF/Epigenetic 36 | 38
oGPCR 27 | 421

HCA RNA Cell Line

AN3-CA 15,648 | 15,648
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50