Development Level

Tbio 9,277 | 10,625
Tdark 4,552 | 7,003
Tchem 1,654 | 1,890
Tclin 495 | 602

Collection

Kinase: IDG Consortium (Targets) 120 | 125
Ion Channel: IDG Consortium (Targets) 85 | 102
GPCR: IDG Consortium (Targets) 75 | 128
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 22 | 24

IMPC Phenotype

preweaning lethality, complete... 615 | 633
preweaning lethality, incomple... 246 | 260
abnormal behavior 217 | 226
decreased lean body mass 190 | 195
embryonic lethality prior to t... 184 | 187
decreased total body fat amoun... 178 | 186
decreased body weight 167 | 174
decreased bone mineral content 150 | 157
embryonic lethality prior to o... 147 | 148
abnormal bone structure 125 | 131
decreased bone mineral density 120 | 126
increased or absent threshold ... 117 | 128
increased circulating alkaline... 114 | 119
decreased grip strength 111 | 123
abnormal embryo size 106 | 112
decreased body length 106 | 108
decreased circulating glucose ... 106 | 121
increased lean body mass 103 | 107
hyperactivity 102 | 108
abnormal retina morphology 97 | 100
enlarged heart 95 | 111
increased mean corpuscular hem... 90 | 93
increased bone mineral content 88 | 92
increased mean corpuscular vol... 85 | 91
decreased circulating choleste... 83 | 85
hypoactivity 83 | 89
short tibia 80 | 82
decreased circulating triglyce... 76 | 83
increased grip strength 74 | 83
decreased circulating HDL chol... 73 | 77
decreased circulating serum al... 73 | 79
abnormal lens morphology 68 | 73
decreased circulating insulin ... 65 | 75
prenatal lethality prior to he... 63 | 64
increased fasted circulating g... 62 | 68
increased circulating sodium l... 61 | 71
decreased lumbar vertebrae num... 60 | 62
increased sacral vertebrae num... 60 | 62
abnormal retinal pigmentation 58 | 61
male infertility 56 | 62
abnormal sleep behavior 55 | 63
decreased rib number 55 | 59
increased circulating HDL chol... 55 | 63
abnormal bone mineralization 54 | 55
increased total body fat amoun... 54 | 57
increased bone mineral density 50 | 52
abnormal coat-hair pigmentatio... 49 | 54
decreased circulating alanine ... 49 | 53
decreased leukocyte cell numbe... 49 | 54
decreased prepulse inhibition 49 | 52
impaired glucose tolerance 49 | 52
increased circulating choleste... 48 | 53
increased exploration in new e... 48 | 56
abnormal gait 47 | 51
decreased mean corpuscular vol... 47 | 50
decreased hemoglobin content 46 | 53
decreased startle reflex 46 | 48
improved glucose tolerance 46 | 56
abnormal behavioral response t... 44 | 52
decreased caudal vertebrae num... 44 | 49
decreased fasted circulating g... 44 | 49
abnormal heart morphology 42 | 51
abnormal seminal vesicle morph... 42 | 47
increased blood urea nitrogen ... 42 | 44
decreased erythrocyte cell num... 41 | 43
increased hemoglobin content 41 | 45
decreased circulating total pr... 40 | 41
decreased heart weight 40 | 44
decreased circulating alkaline... 39 | 41
increased body weight 39 | 42
increased circulating chloride... 39 | 43
thrombocytopenia 39 | 46
decreased eosinophil cell numb... 38 | 41
increased rib number 38 | 41
decreased neutrophil cell numb... 37 | 37
increased startle reflex 37 | 38
abnormal eye morphology 36 | 38
decreased circulating LDL chol... 36 | 37
abnormal neural tube closure 35 | 37
decreased circulating free fat... 35 | 39
increased leukocyte cell numbe... 35 | 37
tremors 34 | 34
abnormal spleen morphology 33 | 36
limb grasping 32 | 35
abnormal cranium morphology 31 | 32
decreased mean corpuscular hem... 31 | 34
increased heart weight 31 | 37
small testis 31 | 37
cardiovascular system phenotyp... 30 | 35
decreased blood urea nitrogen ... 30 | 31
decreased circulating calcium ... 30 | 33
decreased circulating creatini... 30 | 31
decreased circulating chloride... 29 | 32
decreased circulating fructosa... 29 | 31
increased circulating calcium ... 29 | 32
increased circulating potassiu... 29 | 31
increased hematocrit 29 | 36
decreased T cell number 28 | 31
decreased threshold for audito... 28 | 32
female infertility 28 | 34

Disease

ovarian cancer 7,929 | 8,491
osteosarcoma 7,221 | 7,933
medulloblastoma, large-cell 5,812 | 6,234
psoriasis 5,585 | 6,685
glioblastoma 5,241 | 5,572
atypical teratoid / rhabdoid tumor 4,129 | 4,369
lung cancer 4,121 | 4,473
intraductal papillary-mucinous neoplasm (IPMN) 3,012 | 3,289
malignant mesothelioma 2,981 | 3,163
Breast cancer 2,895 | 3,098
primitive neuroectodermal tumor 2,874 | 3,031
pilocytic astrocytoma 2,853 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 2,743 | 2,988
oligodendroglioma 2,714 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 2,711 | 2,956
invasive ductal carcinoma 2,711 | 2,950
pediatric high grade glioma 2,574 | 2,712
lung carcinoma 2,510 | 2,844
non-small cell lung cancer 2,488 | 2,798
lung adenocarcinoma 2,401 | 2,714
ependymoma 2,396 | 2,514
astrocytic glioma 2,143 | 2,241
subependymal giant cell astrocytoma 2,136 | 2,287
group 3 medulloblastoma 2,112 | 2,254
pancreatic cancer 2,061 | 2,300
interstitial cystitis 1,959 | 2,299
Cancer 1,956 | 2,346
Carcinoma 1,925 | 2,147
adult high grade glioma 1,916 | 2,148
Pick disease 1,828 | 1,893
ulcerative colitis 1,828 | 2,087
pituitary cancer 1,822 | 1,972
group 4 medulloblastoma 1,798 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,672 | 1,795
ductal carcinoma in situ 1,594 | 1,745
cystic fibrosis 1,484 | 1,670
breast carcinoma 1,465 | 1,614
medulloblastoma 1,434 | 1,524
posterior fossa group B ependymoma 1,432 | 1,530
astrocytoma 1,422 | 1,493
sonic hedgehog group medulloblastoma 1,406 | 1,482
posterior fossa group A ependymoma 1,405 | 1,511
tuberculosis 1,399 | 1,563
adrenocortical carcinoma 1,325 | 1,427
colon cancer 1,324 | 1,475
Multiple myeloma 1,278 | 1,327
diabetes mellitus 1,254 | 1,663
primary pancreatic ductal adenocarcinoma 1,185 | 1,271
juvenile dermatomyositis 1,128 | 1,189
acute quadriplegic myopathy 1,112 | 1,157
atypical teratoid/rhabdoid tumor 1,036 | 1,095
Rheumatoid Arthritis 1,019 | 1,170
spina bifida 975 | 1,064
nasopharyngeal carcinoma 928 | 1,056
dermatomyositis 891 | 966
cutaneous lupus erythematosus 863 | 1,056
active Crohn's disease 805 | 918
Atopic dermatitis 781 | 944
gastric carcinoma 774 | 832
non primary Sjogren syndrome sicca 752 | 840
acute myeloid leukemia 736 | 785
Waldenstrons macroglobulinemia 723 | 764
primary Sjogren syndrome 679 | 788
tuberculosis and treatment for 6 months 659 | 686
progressive supranuclear palsy 647 | 674
aldosterone-producing adenoma 630 | 664
esophageal adenocarcinoma 629 | 737
Alzheimer's disease 587 | 644
Duchenne muscular dystrophy 563 | 602
Intellectual disability 552 | 573
Obesity 545 | 616
pancreatic carcinoma 524 | 567
Down syndrome 511 | 548
hepatocellular carcinoma 511 | 550
fibroadenoma 502 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 485 | 499
Endometriosis 467 | 535
chronic rhinosinusitis 461 | 512
Schizophrenia 434 | 503
Prostatic Neoplasms 424 | 471
IGA Glomerulonephritis 416 | 454
Amyotrophic Lateral Sclerosis 415 | 432
active ulcerative colitis 407 | 477
gastric cancer 401 | 436
mucosa-associated lymphoid tissue lymphoma 384 | 480
Multiple Sclerosis 378 | 498
Mammary Neoplasms 373 | 410
Neurodegenerative disease 365 | 383
non-small cell lung carcinoma 359 | 413
inflammatory breast cancer 348 | 404
Parkinson's disease 327 | 364
glioblastoma multiforme 323 | 347
Epilepsy 313 | 346
Polycystic Ovary Syndrome 307 | 334
hereditary spastic paraplegia 303 | 313
sarcoidosis 302 | 368
tuberculosis and treatment for 3 months 300 | 327
Kidney disease 295 | 397
urothelial carcinoma 287 | 318
nephrosclerosis 282 | 329

Tissue

Nervous System 15,839 | 18,560
Female tissues 15,807 | 18,646
Digestive Tract 15,803 | 18,472
Endocrine System 15,794 | 18,511
Urinary Tract 15,748 | 18,443
Liver and Pancreas 15,720 | 18,135
Male tissues 15,679 | 17,968
Blood and immune system 15,670 | 17,994
Cardiovascular System 15,670 | 17,957
Skin and soft tissues 15,636 | 18,114
Respiratory system 15,503 | 17,483

Target Family

Non-IDG 9,217 | 11,969
Enzyme 3,656 | 4,146
Transcription Factor 1,211 | 1,400
Kinase 597 | 634
Transporter 414 | 473
Ion Channel 284 | 341
GPCR 272 | 408
Epigenetic 229 | 242
Nuclear Receptor 43 | 48
TF/Epigenetic 35 | 38
oGPCR 20 | 421

HCA RNA Cell Line

AF22 15,978 | 15,978
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66