Development Level

Tbio 10,065 | 11,445
Tdark 4,165 | 6,588
Tchem 1,424 | 1,598
Tclin 506 | 613

Collection

RFA-RM-18-021 268 | 328
Kinase: IDG Consortium (Target... 123 | 125
Ion Channel: IDG Consortium (T... 82 | 99
GPCR: IDG Consortium (Targets) 74 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 951 | 979
preweaning lethality, incomple... 469 | 499
abnormal behavior 280 | 298
embryonic lethality prior to t... 271 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 195 | 207
enlarged heart 178 | 210
abnormal bone structure 177 | 187
decreased vertical activity 165 | 208
increased lean body mass 162 | 172
decreased body weight 155 | 161
decreased bone mineral content 138 | 151
hyperactivity 138 | 148
abnormal heart morphology 136 | 162
decreased lean body mass 130 | 135
increased total body fat amoun... 128 | 134
hypoactivity 124 | 132
decreased bone mineral density 118 | 126
decreased circulating glucose ... 116 | 126
increased circulating alkaline... 116 | 122
increased startle reflex 112 | 112
male infertility 107 | 123
decreased grip strength 105 | 116
embryonic growth retardation 102 | 106
increased bone mineral content 101 | 108
abnormal seminal vesicle morph... 98 | 114
decreased body length 95 | 101
short tibia 94 | 97
cataract 90 | 92
increased or absent threshold ... 90 | 101
decreased circulating choleste... 89 | 93
increased mean corpuscular hem... 89 | 96
prenatal lethality prior to he... 85 | 87
increased mean corpuscular vol... 84 | 92
abnormal lens morphology 79 | 81
decreased lymphocyte cell numb... 77 | 83
decreased circulating serum al... 76 | 82
decreased prepulse inhibition 76 | 82
decreased mean corpuscular vol... 75 | 79
decreased circulating triglyce... 73 | 79
decreased startle reflex 71 | 75
impaired glucose tolerance 71 | 75
improved glucose tolerance 70 | 79
increased bone mineral density 70 | 72
increased circulating HDL chol... 70 | 80
increased fasted circulating g... 70 | 76
abnormal retina morphology 67 | 71
decreased circulating insulin ... 67 | 76
decreased leukocyte cell numbe... 67 | 73
decreased circulating HDL chol... 65 | 68
small superior vagus ganglion 65 | 74
abnormal eye morphology 64 | 68
abnormal sleep behavior 63 | 70
increased circulating sodium l... 62 | 71
abnormal gait 60 | 69
decreased fasted circulating g... 60 | 65
increased circulating choleste... 60 | 66
decreased hemoglobin content 59 | 68
abnormal behavioral response t... 58 | 66
abnormal coat-hair pigmentatio... 58 | 64
abnormal kidney morphology 58 | 65
decreased erythrocyte cell num... 57 | 62
edema 57 | 59
increased heart weight 55 | 62
increased monocyte cell number 55 | 63
abnormal spleen morphology 52 | 55
small testis 52 | 58
decreased caudal vertebrae num... 51 | 53
female infertility 50 | 60
thrombocytopenia 48 | 56
decreased blood urea nitrogen ... 47 | 51
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 46 | 50
abnormal neural tube closure 45 | 46
decreased circulating alanine ... 45 | 47
decreased circulating alkaline... 45 | 46
increased blood urea nitrogen ... 45 | 48
increased leukocyte cell numbe... 45 | 47
abnormal skin morphology 44 | 50
hydrometra 44 | 53
increased neutrophil cell numb... 43 | 46
decreased hematocrit 42 | 46
enlarged spleen 41 | 41
increased circulating triglyce... 40 | 42
increased hematocrit 40 | 46
increased hemoglobin content 40 | 45
increased mean platelet volume 40 | 45
abnormal testis morphology 39 | 43
decreased red blood cell distr... 39 | 41
limb grasping 39 | 41
tremors 39 | 39
decreased neutrophil cell numb... 38 | 42
increased circulating chloride... 38 | 41
abnormal bone mineralization 37 | 38
abnormal epididymis morphology 37 | 42
decreased circulating LDL chol... 37 | 38
increased grip strength 37 | 41
decreased circulating creatini... 36 | 39
increased mean corpuscular hem... 35 | 36

Disease

Carcinoma 9,956 | 11,493
ovarian cancer 8,043 | 8,520
osteosarcoma 7,306 | 7,950
medulloblastoma, large-cell 5,870 | 6,241
psoriasis 5,634 | 6,694
glioblastoma 5,489 | 5,792
atypical teratoid / rhabdoid tumor 4,879 | 5,112
ependymoma 4,467 | 4,679
lung cancer 4,354 | 4,740
group 3 medulloblastoma 3,904 | 4,104
adult high grade glioma 3,515 | 3,801
Breast cancer 3,348 | 3,578
malignant mesothelioma 3,062 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,040 | 3,291
primitive neuroectodermal tumor 2,908 | 3,035
Astrocytoma, Pilocytic 2,882 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,766 | 2,989
invasive ductal carcinoma 2,740 | 2,951
oligodendroglioma 2,739 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 2,727 | 2,955
non-small cell lung cancer 2,585 | 2,890
lung carcinoma 2,525 | 2,843
astrocytic glioma 2,498 | 2,597
lung adenocarcinoma 2,420 | 2,716
Kidney cancer 2,398 | 2,613
pancreatic cancer 2,170 | 2,398
subependymal giant cell astrocytoma 2,155 | 2,287
Cancer 2,108 | 2,499
interstitial cystitis 1,977 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,848 | 1,962
Pick disease 1,842 | 1,894
pituitary cancer 1,836 | 1,972
tuberculosis 1,804 | 2,010
group 4 medulloblastoma 1,789 | 1,855
ductal carcinoma in situ 1,610 | 1,745
ulcerative colitis 1,599 | 1,819
cystic fibrosis 1,518 | 1,696
breast carcinoma 1,500 | 1,638
adrenocortical carcinoma 1,342 | 1,428
colon cancer 1,337 | 1,478
diabetes mellitus 1,315 | 1,728
Multiple myeloma 1,294 | 1,332
Autosomal recessive predisposition 1,290 | 1,442
juvenile dermatomyositis 1,136 | 1,187
acute quadriplegic myopathy 1,121 | 1,158
astrocytoma 1,100 | 1,146
Rheumatoid arthritis 1,048 | 1,191
primary pancreatic ductal adenocarcinoma 1,040 | 1,109
pediatric high grade glioma 1,022 | 1,064
Schizophrenia 1,010 | 1,160
spina bifida 993 | 1,074
Intellectual disability 977 | 1,016
nasopharyngeal carcinoma 934 | 1,058
dermatomyositis 899 | 966
cutaneous lupus erythematosus 871 | 1,057
active Crohn's disease 815 | 922
non primary Sjogren syndrome sicca 806 | 891
Atopic dermatitis 794 | 952
gastric carcinoma 755 | 807
acute myeloid leukemia 746 | 783
Epilepsy 744 | 792
Waldenstrons macroglobulinemia 730 | 765
Liver Cirrhosis, Experimental 690 | 769
medulloblastoma 690 | 720
active ulcerative colitis 665 | 764
progressive supranuclear palsy 653 | 676
primary Sjogren syndrome 639 | 735
aldosterone-producing adenoma 635 | 665
esophageal adenocarcinoma 632 | 737
Dull intelligence 615 | 645
Low intelligence 615 | 645
Mental Retardation 615 | 645
Mental deficiency 615 | 645
Poor school performance 615 | 645
Alzheimer's disease 604 | 658
Obesity 599 | 678
Cognitive delay 584 | 608
Global developmental delay 584 | 608
Melanoma 584 | 711
Mental and motor retardation 584 | 608
Bipolar Disorder 582 | 666
Duchenne muscular dystrophy 569 | 601
Seizures 563 | 596
Liver cancer 553 | 604
Muscle hypotonia 550 | 571
pancreatic carcinoma 523 | 562
hepatocellular carcinoma 510 | 547
fibroadenoma 506 | 559
Short stature 502 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 497 | 510
Endometriosis 477 | 540
Down syndrome 470 | 499
chronic rhinosinusitis 464 | 512
Prostatic Neoplasms 448 | 495
sonic hedgehog group medulloblastoma 444 | 467
Amyotrophic lateral sclerosis 435 | 451
posterior fossa group A ependymoma 435 | 468
gastric cancer 426 | 459
Multiple Sclerosis 416 | 540
Breast Neoplasms 404 | 445

Tissue

Endocrine System 15,967 | 18,159
Female tissues 15,712 | 17,400
Digestive Tract 15,691 | 17,369
Skin and soft tissues 15,645 | 17,230
Male tissues 15,585 | 17,142
Nervous System 15,520 | 16,725
Blood and immune system 15,441 | 16,909
Liver and Pancreas 15,379 | 16,750
Urinary Tract 15,339 | 16,678
Respiratory system 15,179 | 16,393
Cardiovascular System 14,349 | 15,192

Target Family

Non-IDG 9,352 | 12,091
Enzyme 3,683 | 4,145
Transcription Factor 1,214 | 1,400
Kinase 604 | 634
Transporter 414 | 473
Ion Channel 287 | 344
GPCR 272 | 408
Epigenetic 235 | 242
Nuclear Receptor 43 | 48
TF/Epigenetic 36 | 38
oGPCR 20 | 421

HCA RNA Cell Line

AF22 16,160 | 16,160
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39