Development Level

Tbio 9,739 | 11,651
Tdark 3,811 | 6,593
Tchem 1,177 | 1,388
Tclin 447 | 612

Collection

Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 67 | 99
GPCR: IDG Consortium (Targets) 61 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 17 | 25

IMPC Phenotype

preweaning lethality, complete... 936 | 979
preweaning lethality, incomple... 459 | 499
embryonic lethality prior to t... 267 | 278
abnormal behavior 264 | 298
embryonic lethality prior to o... 236 | 239
abnormal embryo size 209 | 220
decreased total body fat amoun... 181 | 207
enlarged heart 175 | 210
abnormal bone structure 163 | 187
increased lean body mass 154 | 172
decreased vertical activity 152 | 208
decreased body weight 148 | 161
abnormal heart morphology 135 | 162
decreased bone mineral content 130 | 151
hyperactivity 129 | 148
decreased lean body mass 119 | 135
increased total body fat amoun... 115 | 134
hypoactivity 110 | 132
increased circulating alkaline... 109 | 122
decreased bone mineral density 108 | 126
decreased circulating glucose ... 105 | 126
increased startle reflex 105 | 112
embryonic growth retardation 102 | 106
decreased grip strength 97 | 116
male infertility 96 | 123
increased bone mineral content 95 | 108
abnormal seminal vesicle morph... 92 | 114
decreased body length 92 | 101
increased or absent threshold ... 89 | 101
short tibia 88 | 97
increased mean corpuscular hem... 85 | 96
increased mean corpuscular vol... 85 | 92
decreased circulating choleste... 82 | 93
cataract 80 | 92
prenatal lethality prior to he... 80 | 87
decreased circulating serum al... 74 | 82
decreased prepulse inhibition 73 | 82
decreased lymphocyte cell numb... 72 | 83
decreased mean corpuscular vol... 71 | 79
abnormal lens morphology 70 | 81
decreased circulating triglyce... 67 | 79
increased bone mineral density 67 | 72
increased fasted circulating g... 67 | 76
decreased startle reflex 66 | 75
improved glucose tolerance 64 | 79
increased circulating HDL chol... 64 | 80
abnormal retina morphology 63 | 71
impaired glucose tolerance 63 | 75
decreased circulating HDL chol... 61 | 68
abnormal eye morphology 60 | 68
decreased leukocyte cell numbe... 60 | 73
small superior vagus ganglion 60 | 74
decreased circulating insulin ... 59 | 76
increased circulating sodium l... 58 | 71
abnormal behavioral response t... 57 | 66
abnormal sleep behavior 57 | 70
abnormal coat-hair pigmentatio... 56 | 64
abnormal kidney morphology 56 | 65
edema 56 | 59
abnormal gait 55 | 69
decreased erythrocyte cell num... 55 | 62
decreased hemoglobin content 55 | 68
increased heart weight 55 | 62
decreased fasted circulating g... 54 | 65
increased circulating choleste... 54 | 66
increased monocyte cell number 54 | 63
small testis 51 | 58
thrombocytopenia 51 | 56
abnormal spleen morphology 49 | 55
decreased caudal vertebrae num... 49 | 53
decreased circulating total pr... 46 | 49
female infertility 46 | 60
decreased mean corpuscular hem... 45 | 50
abnormal neural tube closure 44 | 46
decreased blood urea nitrogen ... 44 | 51
hydrometra 44 | 53
decreased circulating alanine ... 42 | 47
decreased circulating alkaline... 42 | 46
increased neutrophil cell numb... 42 | 46
increased blood urea nitrogen ... 41 | 48
increased leukocyte cell numbe... 41 | 47
abnormal skin morphology 40 | 50
increased hematocrit 40 | 46
increased mean platelet volume 40 | 45
decreased hematocrit 39 | 46
enlarged spleen 39 | 41
increased hemoglobin content 39 | 45
abnormal testis morphology 38 | 43
tremors 37 | 39
abnormal bone mineralization 36 | 38
decreased circulating LDL chol... 36 | 38
decreased neutrophil cell numb... 36 | 42
decreased red blood cell distr... 36 | 41
increased circulating triglyce... 36 | 42
increased grip strength 36 | 41
abnormal epididymis morphology 35 | 42
abnormal cranium morphology 34 | 36
enlarged lymph nodes 34 | 37
increased circulating chloride... 34 | 41
limb grasping 34 | 41

Disease

Carcinoma 9,262 | 11,493
ovarian cancer 7,804 | 8,520
osteosarcoma 7,067 | 7,950
medulloblastoma, large-cell 5,516 | 6,241
psoriasis 5,278 | 6,694
glioblastoma 5,167 | 5,792
atypical teratoid / rhabdoid tumor 4,583 | 5,112
lung cancer 4,178 | 4,740
ependymoma 4,120 | 4,679
group 3 medulloblastoma 3,651 | 4,104
adult high grade glioma 3,259 | 3,801
Breast cancer 3,150 | 3,578
malignant mesothelioma 3,014 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,938 | 3,291
primitive neuroectodermal tumor 2,709 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,633 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,615 | 2,955
Astrocytoma, Pilocytic 2,608 | 3,081
invasive ductal carcinoma 2,590 | 2,951
oligodendroglioma 2,506 | 2,850
non-small cell lung cancer 2,465 | 2,890
lung carcinoma 2,311 | 2,843
astrocytic glioma 2,284 | 2,597
lung adenocarcinoma 2,266 | 2,716
Kidney cancer 2,151 | 2,613
pancreatic cancer 2,109 | 2,398
Cancer 2,073 | 2,499
subependymal giant cell astrocytoma 2,031 | 2,287
interstitial cystitis 1,832 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,832 | 1,962
tuberculosis 1,761 | 2,010
Pick disease 1,724 | 1,894
group 4 medulloblastoma 1,689 | 1,855
pituitary cancer 1,688 | 1,972
ulcerative colitis 1,513 | 1,819
ductal carcinoma in situ 1,512 | 1,745
cystic fibrosis 1,479 | 1,696
breast carcinoma 1,406 | 1,638
Multiple myeloma 1,295 | 1,332
adrenocortical carcinoma 1,267 | 1,428
diabetes mellitus 1,261 | 1,728
colon cancer 1,252 | 1,478
Autosomal recessive predisposition 1,237 | 1,442
juvenile dermatomyositis 1,105 | 1,187
acute quadriplegic myopathy 1,090 | 1,158
astrocytoma 1,056 | 1,146
primary pancreatic ductal adenocarcinoma 1,013 | 1,109
Rheumatoid arthritis 1,007 | 1,191
spina bifida 1,001 | 1,074
pediatric high grade glioma 977 | 1,064
Intellectual disability 928 | 1,016
Schizophrenia 899 | 1,160
dermatomyositis 889 | 966
nasopharyngeal carcinoma 877 | 1,058
cutaneous lupus erythematosus 816 | 1,057
active Crohn's disease 792 | 922
non primary Sjogren syndrome sicca 775 | 891
Atopic dermatitis 749 | 952
acute myeloid leukemia 733 | 783
Waldenstrons macroglobulinemia 718 | 765
gastric carcinoma 705 | 807
Epilepsy 687 | 792
active ulcerative colitis 664 | 764
Liver Cirrhosis, Experimental 645 | 769
medulloblastoma 645 | 720
esophageal adenocarcinoma 638 | 737
progressive supranuclear palsy 634 | 676
aldosterone-producing adenoma 609 | 665
primary Sjogren syndrome 604 | 735
Dull intelligence 589 | 645
Low intelligence 589 | 645
Mental Retardation 589 | 645
Mental deficiency 589 | 645
Poor school performance 589 | 645
Cognitive delay 570 | 608
Global developmental delay 570 | 608
Mental and motor retardation 570 | 608
Alzheimer's disease 557 | 658
Obesity 537 | 678
Muscle hypotonia 535 | 571
Duchenne muscular dystrophy 524 | 601
Seizures 524 | 596
pancreatic carcinoma 508 | 562
Melanoma 501 | 711
hepatocellular carcinoma 498 | 547
Bipolar Disorder 497 | 666
Liver cancer 478 | 604
Short stature 475 | 531
fibroadenoma 471 | 559
autosomal dominant Emery-Dreifuss muscular dystrophy 466 | 510
Endometriosis 462 | 540
Down syndrome 442 | 499
Prostatic Neoplasms 436 | 495
chronic rhinosinusitis 427 | 512
gastric cancer 422 | 459
Amyotrophic lateral sclerosis 417 | 451
sonic hedgehog group medulloblastoma 416 | 467
posterior fossa group A ependymoma 408 | 468
Breast Neoplasms 400 | 445
tuberculosis and treatment for 6 months 399 | 409

Tissue

Endocrine System 14,973 | 18,159
Digestive Tract 14,838 | 17,369
Female tissues 14,828 | 17,400
Skin and soft tissues 14,793 | 17,230
Male tissues 14,728 | 17,142
Blood and immune system 14,664 | 16,909
Nervous System 14,632 | 16,725
Liver and Pancreas 14,623 | 16,750
Urinary Tract 14,586 | 16,678
Respiratory system 14,485 | 16,393
Cardiovascular System 13,762 | 15,192

Target Family

Non-IDG 8,768 | 12,091
Enzyme 3,517 | 4,145
Transcription Factor 1,168 | 1,400
Kinase 574 | 634
Transporter 375 | 473
Ion Channel 231 | 344
GPCR 228 | 408
Epigenetic 225 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 35 | 38
oGPCR 11 | 421

HCA RNA Cell Line

A549 15,174 | 15,174
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50