Development Level

Tbio 8,844 | 10,625
Tdark 4,154 | 7,003
Tchem 1,558 | 1,890
Tclin 438 | 602

Collection

Kinase: IDG Consortium (Targets) 112 | 125
Ion Channel: IDG Consortium (Targets) 68 | 102
GPCR: IDG Consortium (Targets) 61 | 127
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 18 | 26

IMPC Phenotype

preweaning lethality, complete... 604 | 633
preweaning lethality, incomple... 236 | 260
abnormal behavior 204 | 226
embryonic lethality prior to t... 183 | 187
decreased lean body mass 177 | 195
decreased total body fat amoun... 170 | 186
decreased body weight 162 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 141 | 157
increased or absent threshold ... 114 | 128
abnormal bone structure 113 | 131
decreased bone mineral density 109 | 126
increased circulating alkaline... 108 | 119
abnormal embryo size 104 | 112
decreased grip strength 103 | 123
decreased body length 102 | 108
decreased circulating glucose ... 96 | 121
hyperactivity 96 | 108
enlarged heart 94 | 111
increased lean body mass 94 | 107
abnormal retina morphology 90 | 100
increased bone mineral content 86 | 92
increased mean corpuscular hem... 86 | 93
increased mean corpuscular vol... 85 | 91
decreased circulating choleste... 78 | 85
short tibia 76 | 82
hypoactivity 74 | 89
decreased circulating serum al... 72 | 79
increased grip strength 72 | 83
decreased circulating triglyce... 71 | 83
decreased circulating HDL chol... 70 | 77
increased fasted circulating g... 62 | 68
abnormal lens morphology 61 | 73
prenatal lethality prior to he... 61 | 64
increased circulating sodium l... 60 | 71
decreased lumbar vertebrae num... 56 | 62
abnormal retinal pigmentation 55 | 61
decreased circulating insulin ... 55 | 75
decreased rib number 54 | 59
increased sacral vertebrae num... 54 | 62
abnormal bone mineralization 52 | 55
increased total body fat amoun... 51 | 57
abnormal sleep behavior 50 | 63
male infertility 49 | 62
decreased prepulse inhibition 48 | 52
abnormal coat-hair pigmentatio... 47 | 54
increased bone mineral density 47 | 52
increased circulating HDL chol... 47 | 63
decreased mean corpuscular vol... 46 | 50
decreased circulating alanine ... 45 | 53
decreased hemoglobin content 45 | 53
increased exploration in new e... 45 | 56
decreased leukocyte cell numbe... 44 | 54
decreased startle reflex 44 | 48
impaired glucose tolerance 44 | 52
improved glucose tolerance 44 | 56
increased circulating choleste... 44 | 53
abnormal behavioral response t... 43 | 52
abnormal gait 42 | 51
abnormal heart morphology 42 | 51
decreased caudal vertebrae num... 42 | 49
decreased fasted circulating g... 42 | 49
thrombocytopenia 42 | 46
decreased circulating total pr... 40 | 41
decreased erythrocyte cell num... 40 | 43
increased body weight 40 | 42
increased circulating chloride... 39 | 43
increased blood urea nitrogen ... 38 | 44
increased hemoglobin content 37 | 45
decreased circulating alkaline... 36 | 41
decreased eosinophil cell numb... 36 | 41
decreased heart weight 36 | 44
increased rib number 36 | 41
decreased circulating LDL chol... 35 | 37
abnormal eye morphology 34 | 38
abnormal neural tube closure 34 | 37
abnormal seminal vesicle morph... 34 | 47
decreased circulating free fat... 34 | 39
increased startle reflex 34 | 38
decreased neutrophil cell numb... 33 | 37
increased leukocyte cell numbe... 33 | 37
decreased mean corpuscular hem... 31 | 34
small testis 31 | 37
tremors 31 | 34
abnormal cranium morphology 30 | 32
abnormal spleen morphology 30 | 36
decreased circulating fructosa... 30 | 31
increased heart weight 30 | 37
decreased T cell number 29 | 31
decreased circulating calcium ... 29 | 33
increased hematocrit 29 | 36
limb grasping 29 | 35
cardiovascular system phenotyp... 28 | 35
decreased blood urea nitrogen ... 27 | 31
embryonic growth retardation 27 | 28
abnormal testis morphology 26 | 30
decreased circulating chloride... 26 | 32
decreased circulating creatini... 26 | 31
female infertility 26 | 34
increased circulating potassiu... 26 | 31

Disease

ovarian cancer 7,696 | 8,491
osteosarcoma 6,985 | 7,933
medulloblastoma, large-cell 5,459 | 6,234
psoriasis 5,232 | 6,685
glioblastoma 4,930 | 5,572
lung cancer 3,974 | 4,473
atypical teratoid / rhabdoid tumor 3,878 | 4,369
malignant mesothelioma 2,938 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 2,911 | 3,289
Breast cancer 2,752 | 3,098
primitive neuroectodermal tumor 2,675 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,610 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,600 | 2,956
pilocytic astrocytoma 2,582 | 3,086
invasive ductal carcinoma 2,560 | 2,950
oligodendroglioma 2,483 | 2,849
pediatric high grade glioma 2,410 | 2,712
non-small cell lung cancer 2,376 | 2,798
lung carcinoma 2,296 | 2,844
ependymoma 2,256 | 2,514
lung adenocarcinoma 2,246 | 2,714
pancreatic cancer 2,015 | 2,300
subependymal giant cell astrocytoma 2,013 | 2,287
group 3 medulloblastoma 1,989 | 2,254
astrocytic glioma 1,954 | 2,241
Cancer 1,930 | 2,346
interstitial cystitis 1,815 | 2,299
adult high grade glioma 1,778 | 2,148
ulcerative colitis 1,747 | 2,087
Carcinoma 1,713 | 2,147
Pick disease 1,710 | 1,893
group 4 medulloblastoma 1,710 | 1,875
pituitary cancer 1,674 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,654 | 1,795
ductal carcinoma in situ 1,495 | 1,745
cystic fibrosis 1,444 | 1,670
breast carcinoma 1,369 | 1,614
astrocytoma 1,354 | 1,493
tuberculosis 1,346 | 1,563
medulloblastoma 1,321 | 1,524
posterior fossa group B ependymoma 1,308 | 1,530
sonic hedgehog group medulloblastoma 1,304 | 1,482
Multiple myeloma 1,280 | 1,327
posterior fossa group A ependymoma 1,270 | 1,511
adrenocortical carcinoma 1,249 | 1,427
colon cancer 1,240 | 1,475
diabetes mellitus 1,203 | 1,663
primary pancreatic ductal adenocarcinoma 1,161 | 1,271
juvenile dermatomyositis 1,097 | 1,189
acute quadriplegic myopathy 1,081 | 1,157
Rheumatoid Arthritis 983 | 1,170
spina bifida 982 | 1,064
atypical teratoid/rhabdoid tumor 967 | 1,095
dermatomyositis 881 | 966
nasopharyngeal carcinoma 870 | 1,056
cutaneous lupus erythematosus 809 | 1,056
active Crohn's disease 782 | 918
Atopic dermatitis 739 | 944
non primary Sjogren syndrome sicca 730 | 840
gastric carcinoma 724 | 832
acute myeloid leukemia 723 | 785
Waldenstrons macroglobulinemia 711 | 764
tuberculosis and treatment for 6 months 644 | 686
primary Sjogren syndrome 636 | 788
esophageal adenocarcinoma 635 | 737
progressive supranuclear palsy 628 | 674
aldosterone-producing adenoma 604 | 664
Alzheimer's disease 541 | 644
Intellectual disability 519 | 573
Duchenne muscular dystrophy 517 | 602
pancreatic carcinoma 508 | 567
hepatocellular carcinoma 497 | 550
Obesity 489 | 616
Down syndrome 478 | 548
fibroadenoma 467 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 454 | 499
Endometriosis 452 | 535
chronic rhinosinusitis 424 | 512
Prostatic Neoplasms 413 | 471
active ulcerative colitis 406 | 477
gastric cancer 396 | 436
IGA Glomerulonephritis 395 | 454
Amyotrophic Lateral Sclerosis 394 | 432
Schizophrenia 371 | 503
Mammary Neoplasms 368 | 410
mucosa-associated lymphoid tissue lymphoma 365 | 480
Multiple Sclerosis 363 | 498
Neurodegenerative disease 349 | 383
inflammatory breast cancer 332 | 404
non-small cell lung carcinoma 318 | 413
Kidney disease 301 | 397
hereditary spastic paraplegia 301 | 313
Parkinson's disease 299 | 364
glioblastoma multiforme 297 | 347
tuberculosis and treatment for 3 months 293 | 327
Polycystic Ovary Syndrome 290 | 334
sarcoidosis 283 | 368
Epilepsy 279 | 346
urothelial carcinoma 263 | 318
nephrosclerosis 253 | 329

Tissue

Nervous System 14,837 | 18,560
Female tissues 14,817 | 18,646
Digestive Tract 14,815 | 18,472
Endocrine System 14,796 | 18,511
Urinary Tract 14,765 | 18,443
Liver and Pancreas 14,761 | 18,135
Male tissues 14,742 | 17,968
Blood and immune system 14,741 | 17,994
Cardiovascular System 14,717 | 17,957
Skin and soft tissues 14,663 | 18,114
Respiratory system 14,589 | 17,483

Target Family

Non-IDG 8,637 | 11,969
Enzyme 3,490 | 4,146
Transcription Factor 1,163 | 1,400
Kinase 567 | 634
Transporter 375 | 473
GPCR 228 | 408
Ion Channel 228 | 341
Epigenetic 219 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 34 | 38
oGPCR 11 | 421

HCA RNA Cell Line

A549 14,994 | 14,994
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66