Development Level

Tbio 9,363 | 10,625
Tdark 4,471 | 7,003
Tchem 1,641 | 1,890
Tclin 471 | 602

Collection

Kinase: IDG Consortium (Targets) 115 | 125
Ion Channel: IDG Consortium (Targets) 76 | 102
GPCR: IDG Consortium (Targets) 73 | 128
Kinase: IDG Consortium (Complete/Control) 32 | 37
GPCR: IDG Consortium (Complete/Control) 17 | 24

IMPC Phenotype

preweaning lethality, complete... 610 | 633
preweaning lethality, incomple... 239 | 260
abnormal behavior 208 | 226
decreased lean body mass 182 | 195
embryonic lethality prior to t... 182 | 187
decreased total body fat amoun... 176 | 186
decreased body weight 164 | 174
embryonic lethality prior to o... 147 | 148
decreased bone mineral content 145 | 157
abnormal bone structure 117 | 131
decreased bone mineral density 115 | 126
increased or absent threshold ... 115 | 128
increased circulating alkaline... 114 | 119
decreased grip strength 110 | 123
decreased body length 106 | 108
abnormal embryo size 105 | 112
decreased circulating glucose ... 104 | 121
hyperactivity 100 | 108
abnormal retina morphology 95 | 100
enlarged heart 94 | 111
increased lean body mass 93 | 107
increased mean corpuscular hem... 89 | 93
increased mean corpuscular vol... 85 | 91
increased bone mineral content 84 | 92
hypoactivity 81 | 89
decreased circulating choleste... 80 | 85
decreased circulating triglyce... 77 | 83
short tibia 75 | 82
increased grip strength 73 | 83
decreased circulating HDL chol... 72 | 77
decreased circulating serum al... 68 | 79
abnormal lens morphology 66 | 73
decreased circulating insulin ... 63 | 75
increased fasted circulating g... 63 | 68
prenatal lethality prior to he... 62 | 64
decreased lumbar vertebrae num... 60 | 62
increased circulating sodium l... 59 | 71
increased sacral vertebrae num... 59 | 62
abnormal retinal pigmentation 57 | 61
abnormal sleep behavior 55 | 63
decreased rib number 55 | 59
increased circulating HDL chol... 54 | 63
male infertility 54 | 62
abnormal bone mineralization 53 | 55
abnormal coat-hair pigmentatio... 51 | 54
increased total body fat amoun... 51 | 57
decreased mean corpuscular vol... 49 | 50
increased bone mineral density 49 | 52
decreased hemoglobin content 48 | 53
decreased prepulse inhibition 48 | 52
increased circulating choleste... 48 | 53
increased exploration in new e... 48 | 56
decreased leukocyte cell numbe... 47 | 54
improved glucose tolerance 47 | 56
impaired glucose tolerance 46 | 52
abnormal behavioral response t... 45 | 52
abnormal gait 45 | 51
decreased caudal vertebrae num... 45 | 49
decreased circulating alanine ... 45 | 53
decreased startle reflex 44 | 48
abnormal heart morphology 43 | 51
decreased erythrocyte cell num... 43 | 43
decreased fasted circulating g... 42 | 49
thrombocytopenia 42 | 46
increased body weight 41 | 42
increased blood urea nitrogen ... 40 | 44
increased hemoglobin content 39 | 45
decreased circulating total pr... 38 | 41
decreased eosinophil cell numb... 38 | 41
decreased heart weight 38 | 44
increased rib number 38 | 41
decreased circulating alkaline... 37 | 41
abnormal eye morphology 36 | 38
abnormal seminal vesicle morph... 36 | 47
increased circulating chloride... 36 | 43
decreased circulating free fat... 35 | 39
increased leukocyte cell numbe... 35 | 37
abnormal neural tube closure 34 | 37
decreased circulating LDL chol... 34 | 37
decreased neutrophil cell numb... 34 | 37
limb grasping 34 | 35
small testis 34 | 37
decreased mean corpuscular hem... 33 | 34
increased heart weight 32 | 37
tremors 32 | 34
abnormal cranium morphology 31 | 32
increased hematocrit 31 | 36
increased startle reflex 31 | 38
abnormal spleen morphology 30 | 36
decreased T cell number 30 | 31
decreased circulating chloride... 29 | 32
decreased circulating creatini... 29 | 31
decreased circulating fructosa... 29 | 31
abnormal testis morphology 28 | 30
cardiovascular system phenotyp... 28 | 35
decreased circulating calcium ... 28 | 33
abnormal epididymis morphology 27 | 31
embryonic growth retardation 27 | 28
female infertility 27 | 34
increased circulating calcium ... 27 | 32

Disease

ovarian cancer 7,887 | 8,491
osteosarcoma 7,266 | 7,933
medulloblastoma, large-cell 5,614 | 6,234
psoriasis 5,609 | 6,685
glioblastoma 5,082 | 5,572
lung cancer 4,149 | 4,473
atypical teratoid / rhabdoid tumor 3,963 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,025 | 3,289
malignant mesothelioma 3,001 | 3,163
Breast cancer 2,841 | 3,098
primitive neuroectodermal tumor 2,737 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,726 | 2,988
pilocytic astrocytoma 2,711 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 2,690 | 2,956
invasive ductal carcinoma 2,682 | 2,950
non-small cell lung cancer 2,533 | 2,798
oligodendroglioma 2,533 | 2,849
pediatric high grade glioma 2,457 | 2,712
lung carcinoma 2,453 | 2,844
lung adenocarcinoma 2,389 | 2,714
ependymoma 2,300 | 2,514
pancreatic cancer 2,120 | 2,300
subependymal giant cell astrocytoma 2,089 | 2,287
Cancer 2,086 | 2,346
group 3 medulloblastoma 2,048 | 2,254
interstitial cystitis 2,017 | 2,299
astrocytic glioma 2,010 | 2,241
adult high grade glioma 1,888 | 2,148
ulcerative colitis 1,882 | 2,087
Carcinoma 1,751 | 2,147
Pick disease 1,743 | 1,893
pituitary cancer 1,735 | 1,972
group 4 medulloblastoma 1,719 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,668 | 1,795
ductal carcinoma in situ 1,574 | 1,745
cystic fibrosis 1,517 | 1,670
breast carcinoma 1,450 | 1,614
tuberculosis 1,434 | 1,563
astrocytoma 1,389 | 1,493
medulloblastoma 1,375 | 1,524
sonic hedgehog group medulloblastoma 1,346 | 1,482
posterior fossa group B ependymoma 1,337 | 1,530
posterior fossa group A ependymoma 1,329 | 1,511
diabetes mellitus 1,314 | 1,663
colon cancer 1,307 | 1,475
adrenocortical carcinoma 1,304 | 1,427
Multiple myeloma 1,295 | 1,327
primary pancreatic ductal adenocarcinoma 1,198 | 1,271
juvenile dermatomyositis 1,128 | 1,189
acute quadriplegic myopathy 1,093 | 1,157
Rheumatoid Arthritis 1,084 | 1,170
spina bifida 1,016 | 1,064
atypical teratoid/rhabdoid tumor 986 | 1,095
nasopharyngeal carcinoma 939 | 1,056
dermatomyositis 935 | 966
cutaneous lupus erythematosus 930 | 1,056
active Crohn's disease 829 | 918
Atopic dermatitis 786 | 944
gastric carcinoma 766 | 832
non primary Sjogren syndrome sicca 751 | 840
Waldenstrons macroglobulinemia 748 | 764
acute myeloid leukemia 748 | 785
primary Sjogren syndrome 726 | 788
esophageal adenocarcinoma 685 | 737
tuberculosis and treatment for 6 months 665 | 686
progressive supranuclear palsy 633 | 674
aldosterone-producing adenoma 603 | 664
Alzheimer's disease 558 | 644
Duchenne muscular dystrophy 537 | 602
Intellectual disability 529 | 573
pancreatic carcinoma 528 | 567
hepatocellular carcinoma 524 | 550
Obesity 506 | 616
Down syndrome 501 | 548
fibroadenoma 488 | 557
Endometriosis 474 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 457 | 499
chronic rhinosinusitis 444 | 512
Prostatic Neoplasms 431 | 471
active ulcerative colitis 429 | 477
IGA Glomerulonephritis 427 | 454
gastric cancer 411 | 436
Multiple Sclerosis 410 | 498
mucosa-associated lymphoid tissue lymphoma 404 | 480
Amyotrophic Lateral Sclerosis 397 | 432
Schizophrenia 388 | 503
Mammary Neoplasms 374 | 410
inflammatory breast cancer 363 | 404
Neurodegenerative disease 354 | 383
non-small cell lung carcinoma 339 | 413
sarcoidosis 333 | 368
glioblastoma multiforme 316 | 347
Kidney disease 311 | 397
Parkinson's disease 310 | 364
Polycystic Ovary Syndrome 305 | 334
tuberculosis and treatment for 3 months 304 | 327
hereditary spastic paraplegia 301 | 313
urothelial carcinoma 289 | 318
Asthma 277 | 349
nephrosclerosis 272 | 329

Tissue

Nervous System 15,712 | 18,560
Female tissues 15,698 | 18,646
Endocrine System 15,679 | 18,511
Digestive Tract 15,677 | 18,472
Urinary Tract 15,616 | 18,443
Liver and Pancreas 15,598 | 18,135
Male tissues 15,574 | 17,968
Cardiovascular System 15,537 | 17,957
Blood and immune system 15,535 | 17,994
Skin and soft tissues 15,502 | 18,114
Respiratory system 15,365 | 17,483

Target Family

Non-IDG 9,303 | 11,969
Enzyme 3,617 | 4,146
Transcription Factor 1,211 | 1,400
Kinase 590 | 634
Transporter 387 | 473
GPCR 265 | 408
Ion Channel 244 | 341
Epigenetic 223 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 35 | 38
oGPCR 29 | 421

HCA RNA Cell Line

A-431 15,946 | 15,946
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Interleukin-9 IL9 Tbio Non-IDG -2.46520 301.6 339
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131