1. Home
  2. Targets
Target Filters...

Development Level

Tbio 53 | 11,445
Tdark 10 | 6,588
Tclin 5 | 613
Tchem 4 | 1,598

Collection

GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal embryo size 7 | 220
preweaning lethality, incomple... 5 | 499
abnormal eye morphology 4 | 68
hemorrhage 4 | 23
abnormal neural tube closure 3 | 46
decreased bone mineral content 3 | 151
decreased circulating HDL chol... 3 | 68
abnormal bone structure 2 | 187
abnormal facial morphology 2 | 17
abnormal heart morphology 2 | 162
abnormal limb bud morphology 2 | 17
abnormal limb morphology 2 | 13
decreased circulating choleste... 2 | 93
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased body length 2 | 32
pale yolk sac 2 | 25
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal head shape 1 | 10
abnormal heart shape 1 | 5
abnormal hindbrain development 1 | 16
abnormal incisor morphology 1 | 4
abnormal liver size 1 | 5
abnormal lymph node morphology 1 | 3
abnormal midbrain development 1 | 20
abnormal outer ear morphology 1 | 3
abnormal placenta size 1 | 20
abnormal radius morphology 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal stomach morphology 1 | 10
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
cleft palate 1 | 8
convulsive seizures 1 | 13
cyanosis 1 | 7
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
increased CD4-positive, CD25-p... 1 | 1
increased KLRG1-positive NK ce... 1 | 1
increased NK cell number 1 | 3
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased effector memory CD4-... 1 | 1
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
pale liver 1 | 6
pallor 1 | 34
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74
unresponsive to tactile stimul... 1 | 8
urinary bladder obstruction 1 | 4

Disease

Carcinoma 54 | 11,493
ovarian cancer 47 | 8,520
osteosarcoma 37 | 7,950
medulloblastoma, large-cell 36 | 6,241
glioblastoma 33 | 5,792
psoriasis 32 | 6,694
atypical teratoid / rhabdoid tumor 31 | 5,112
Acquired metabolic disease 30 | 336
ependymoma 29 | 4,679
lung cancer 27 | 4,740
Kidney cancer 24 | 2,613
group 3 medulloblastoma 22 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
malignant mesothelioma 21 | 3,232
adult high grade glioma 20 | 3,801
lung adenocarcinoma 20 | 2,716
lung carcinoma 20 | 2,843
non-small cell lung cancer 20 | 2,890
Cancer 19 | 2,499
invasive ductal carcinoma 19 | 2,951
Astrocytoma, Pilocytic 18 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
oligodendroglioma 18 | 2,850
Breast cancer 17 | 3,578
pancreatic cancer 16 | 2,398
adrenocortical carcinoma 15 | 1,428
cystic fibrosis 15 | 1,696
interstitial cystitis 15 | 2,312
primitive neuroectodermal tumor 14 | 3,035
ulcerative colitis 14 | 1,819
ductal carcinoma in situ 13 | 1,745
subependymal giant cell astrocytoma 13 | 2,287
tuberculosis 13 | 2,010
astrocytic glioma 12 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Pick disease 10 | 1,894
astrocytoma 10 | 1,146
pituitary cancer 10 | 1,972
Autosomal recessive predisposition 9 | 1,442
Rheumatoid arthritis 9 | 1,191
Crohn's disease 8 | 321
primary pancreatic ductal adenocarcinoma 8 | 1,109
spina bifida 8 | 1,074
Atopic dermatitis 7 | 952
Cleft Palate 7 | 271
Intellectual disability 7 | 1,016
Obesity 7 | 678
Orbital separation excessive 7 | 244
Type 2 diabetes mellitus 7 | 272
breast carcinoma 7 | 1,638
Acquired scoliosis 6 | 281
Cognitive delay 6 | 608
Curvature of spine 6 | 282
Diabetes Mellitus, Non-Insulin-Dependent 6 | 145
Endometriosis 6 | 540
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Short stature 6 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
diabetes mellitus 6 | 1,728
gastric cancer 6 | 459
gastric carcinoma 6 | 807
group 4 medulloblastoma 6 | 1,855
juvenile dermatomyositis 6 | 1,187
Amyotrophic lateral sclerosis 5 | 451
Big calvaria 5 | 147
Cataract 5 | 297
Chronic obstructive pulmonary disease 5 | 184
Coronary artery disease 5 | 268
Craniofacial Abnormalities 5 | 151
Diabetes Mellitus, Type 2 5 | 142
Frontal bossing 5 | 157
Glaucoma 5 | 239
Hypoplastic mandible condyle 5 | 275
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Liver cancer 5 | 604
Mandibular hypoplasia 5 | 275
Melanoma 5 | 711
Micrognathism 5 | 275
Polycystic ovary syndrome 5 | 360
Schizophrenia 5 | 1,160
Small head 5 | 374
Uranostaphyloschisis 5 | 167
acute myeloid leukemia 5 | 783
colon cancer 5 | 1,478
cutaneous lupus erythematosus 5 | 1,057
dermatomyositis 5 | 966
nasopharyngeal carcinoma 5 | 1,058
pancreatic carcinoma 5 | 562
progressive supranuclear palsy 5 | 676
Arthritis, Rheumatoid 4 | 174
Connective tissue disease 4 | 62
Dull intelligence 4 | 645
Prostatic Neoplasms 4 | 495
acute quadriplegic myopathy 4 | 1,158
limb girdle muscular dystrophy 2A 4 | 213
sonic hedgehog group medulloblastoma 4 | 467

Tissue

Blood and immune system 70 | 16,909
Digestive Tract 70 | 17,369
Endocrine System 70 | 18,159
Female tissues 70 | 17,400
Male tissues 70 | 17,142
Skin and soft tissues 70 | 17,230
Respiratory system 69 | 16,393
Urinary Tract 69 | 16,678
Liver and Pancreas 67 | 16,750
Nervous System 67 | 16,725
Cardiovascular System 61 | 15,192

Target Family

Non-IDG 40 | 12,091
Transcription Factor 13 | 1,400
Enzyme 10 | 4,145
Kinase 4 | 634
Epigenetic 2 | 242
Transporter 2 | 473
GPCR 1 | 408

GWAS Trait

Waist circumference adjusted f... 72 | 72
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hedgehog-interacting protein HHIP Tbio Non-IDG -1.83526 65.4 193
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Homeobox protein Hox-C5 HOXC5 Tbio Transcription Factor -1.08912 11.9 114
Vigilin HDLBP Tbio Non-IDG -2.01228 106.9 233
Putative uncharacterized protein C17orf82 C17orf82 Tdark Non-IDG 0.00000 0
Latent-transforming growth factor beta-binding protein 1 LTBP1 Tbio Non-IDG -1.97590 101.5 128
Dynein heavy chain 10, axonemal DNAH10 Tdark Non-IDG -0.45693 2.56 10
A disintegrin and metalloproteinase with thrombospondin motifs 3 ADAMTS3 Tbio Enzyme -0.75603 4.50 45
Gasdermin-C GSDMC Tdark Non-IDG -0.67744 3.26 108
Lysyl oxidase homolog 1 LOXL1 Tbio Enzyme -2.55611 364.6 174