Development Level

Tbio 58 | 11,445
Tchem 13 | 1,598
Tdark 12 | 6,588
Tclin 4 | 613

Collection

GPCR: IDG Consortium (Targets) 2 | 126

IMPC Phenotype

preweaning lethality, complete... 5 | 979
hyperactivity 3 | 148
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased circulating choleste... 2 | 93
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
increased anti-nuclear antigen... 2 | 19
increased circulating alkaline... 2 | 122
preweaning lethality, incomple... 2 | 499
vertebral transformation 2 | 12
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal humerus morphology 1 | 11
abnormal outer ear morphology 1 | 3
abnormal response to tactile s... 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
absent optic nerve 1 | 2
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
anophthalmia 1 | 33
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart rate 1 | 18
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased CD4-positive, CD25-p... 1 | 1
increased KLRG1-positive NK ce... 1 | 1
increased NK cell number 1 | 3
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased effector memory CD4-... 1 | 1
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
male infertility 1 | 123
microphthalmia 1 | 26
mydriasis 1 | 6
prenatal lethality prior to he... 1 | 87
prolonged RR interval 1 | 8
small testis 1 | 58

Disease

Carcinoma 64 | 11,493
ovarian cancer 45 | 8,520
osteosarcoma 41 | 7,950
medulloblastoma, large-cell 36 | 6,241
psoriasis 35 | 6,694
glioblastoma 32 | 5,792
lung cancer 29 | 4,740
atypical teratoid / rhabdoid tumor 27 | 5,112
Cardiovascular system disease 26 | 246
diabetes mellitus 24 | 1,728
ependymoma 24 | 4,679
Breast cancer 23 | 3,578
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
Lipid metabolism disorder 20 | 114
group 3 medulloblastoma 20 | 4,104
malignant mesothelioma 20 | 3,232
oligodendroglioma 19 | 2,850
Obesity 18 | 678
primitive neuroectodermal tumor 18 | 3,035
Cancer 17 | 2,499
subependymal giant cell astrocytoma 17 | 2,287
Coronary artery disease 16 | 268
invasive ductal carcinoma 16 | 2,951
lung adenocarcinoma 16 | 2,716
non-small cell lung cancer 16 | 2,890
Atherosclerosis 15 | 291
adult high grade glioma 15 | 3,801
astrocytic glioma 15 | 2,597
Kidney cancer 14 | 2,613
pancreatic cancer 14 | 2,398
Type 2 diabetes mellitus 13 | 272
Acquired metabolic disease 12 | 336
breast carcinoma 12 | 1,638
ductal carcinoma in situ 12 | 1,745
interstitial cystitis 12 | 2,312
lung carcinoma 12 | 2,843
Astrocytoma, Pilocytic 11 | 3,081
Autosomal recessive predisposition 11 | 1,442
Metabolic syndrome X 11 | 52
astrocytoma 11 | 1,146
ulcerative colitis 11 | 1,819
Intellectual disability 10 | 1,016
Kidney disease 10 | 430
Schizophrenia 10 | 1,160
adrenocortical carcinoma 10 | 1,428
cystic fibrosis 10 | 1,696
Liver Cirrhosis, Experimental 9 | 769
Pick disease 9 | 1,894
Vascular disease 9 | 319
pediatric high grade glioma 9 | 1,064
Diabetes Mellitus, Non-Insulin-Dependent 8 | 145
Multiple myeloma 8 | 1,332
Rheumatoid arthritis 8 | 1,191
esophageal adenocarcinoma 8 | 737
group 4 medulloblastoma 8 | 1,855
tuberculosis 8 | 2,010
Hypertension 7 | 396
Hypertriglyceridemia 7 | 17
Liver cancer 7 | 604
Macular degeneration 7 | 65
dermatomyositis 7 | 966
fibroadenoma 7 | 559
hepatocellular carcinoma 7 | 547
pituitary cancer 7 | 1,972
Alcoholic Intoxication, Chronic 6 | 289
Alzheimer's disease 6 | 658
Bipolar Disorder 6 | 666
Cerebrovascular disease 6 | 238
Diabetes Mellitus, Type 2 6 | 142
Dull intelligence 6 | 645
Dyslipidemias 6 | 27
Hypercholesterolemia, Familial 6 | 23
Hyperglycemia 6 | 137
Hyperlipoproteinemia Type II 6 | 12
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Proteinuria 6 | 144
Short stature 6 | 531
active ulcerative colitis 6 | 764
interstitial lung disease 6 | 298
medulloblastoma 6 | 720
pancreatic carcinoma 6 | 562
spina bifida 6 | 1,074
Asthma 5 | 385
Cardiovascular Diseases 5 | 59
Depressive disorder 5 | 409
Heart disease 5 | 306
Hypercholesterolemia 5 | 44
Short nose 5 | 132
Small nose 5 | 132
active Crohn's disease 5 | 922
colon cancer 5 | 1,478
cutaneous lupus erythematosus 5 | 1,057
gastric cancer 5 | 459
juvenile dermatomyositis 5 | 1,187

Tissue

Endocrine System 86 | 18,159
Female tissues 84 | 17,400
Liver and Pancreas 84 | 16,750
Male tissues 83 | 17,142
Skin and soft tissues 83 | 17,230
Digestive Tract 82 | 17,369
Urinary Tract 82 | 16,678
Blood and immune system 81 | 16,909
Nervous System 79 | 16,725
Respiratory system 79 | 16,393
Cardiovascular System 73 | 15,192

Target Family

Non-IDG 47 | 12,091
Enzyme 22 | 4,145
Transcription Factor 8 | 1,400
Kinase 4 | 634
Epigenetic 3 | 242
GPCR 3 | 408

GWAS Trait

Triglycerides 87 | 87
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Hepatocyte growth factor receptor MET Tclin Kinase -3.32232 2013.7 1982
Vascular endothelial growth factor A VEGFA Tclin Non-IDG -4.27197 19076.6 1809
Tyrosine-protein kinase BAZ1B BAZ1B Tbio Epigenetic -1.45627 32.0 155
Apolipoprotein E APOE Tbio Non-IDG -4.20176 15904.9 976
Aldehyde dehydrogenase, mitochondrial ALDH2 Tclin Enzyme -2.97865 1004.9 470