Development Level

Tbio 120 | 11,445
Tchem 24 | 1,598
Tdark 18 | 6,588
Tclin 11 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal embryo size 5 | 220
embryonic lethality prior to t... 4 | 278
enlarged heart 4 | 210
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
abnormal behavior 2 | 298
abnormal coat-hair pigmentatio... 2 | 64
abnormal cornea morphology 2 | 31
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal hindbrain development 2 | 16
abnormal midbrain development 2 | 20
abnormal neural tube closure 2 | 46
decreased blood urea nitrogen ... 2 | 51
decreased circulating amylase ... 2 | 28
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
hydrometra 2 | 53
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased anti-nuclear antigen... 2 | 19
increased circulating alkaline... 2 | 122
increased circulating free fat... 2 | 20
increased fasted circulating g... 2 | 76
increased grip strength 2 | 41
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
increased total body fat amoun... 2 | 134
pale yolk sac 2 | 25
preweaning lethality, incomple... 2 | 499
small superior vagus ganglion 2 | 74
abnormal coat- hair morphology 1 | 19
abnormal eye anterior chamber ... 1 | 9
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retinal blood vessel ... 1 | 26
abnormal skin condition 1 | 6
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
abnormal vitelline vasculature... 1 | 6
cataract 1 | 92
corneal opacity 1 | 32
cystolithiasis 1 | 3
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged testis 1 | 6
head bobbing 1 | 5
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
long tibia 1 | 25
pale liver 1 | 6
pallor 1 | 34
polycystic kidney 1 | 15
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small testis 1 | 58
thick skin 1 | 4
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 117 | 11,493
osteosarcoma 101 | 7,950
ovarian cancer 98 | 8,520
medulloblastoma, large-cell 70 | 6,241
psoriasis 63 | 6,694
glioblastoma 62 | 5,792
lung cancer 60 | 4,740
Cancer 47 | 2,499
atypical teratoid / rhabdoid tumor 46 | 5,112
group 3 medulloblastoma 46 | 4,104
ependymoma 44 | 4,679
tuberculosis 42 | 2,010
adult high grade glioma 40 | 3,801
Breast cancer 39 | 3,578
Astrocytoma, Pilocytic 37 | 3,081
ulcerative colitis 37 | 1,819
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,291
malignant mesothelioma 36 | 3,232
non-small cell lung cancer 35 | 2,890
interstitial cystitis 34 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,955
invasive ductal carcinoma 34 | 2,951
lung carcinoma 34 | 2,843
Kidney cancer 33 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
primitive neuroectodermal tumor 31 | 3,035
subependymal giant cell astrocytoma 31 | 2,287
lung adenocarcinoma 29 | 2,716
oligodendroglioma 28 | 2,850
pancreatic cancer 28 | 2,398
astrocytic glioma 25 | 2,597
Rheumatoid arthritis 24 | 1,191
diabetes mellitus 23 | 1,728
Asthma 22 | 385
Crohn's disease 22 | 321
Pick disease 21 | 1,894
cystic fibrosis 21 | 1,696
pituitary cancer 21 | 1,972
Atopic dermatitis 20 | 952
Multiple myeloma 20 | 1,332
Schizophrenia 20 | 1,160
astrocytoma 20 | 1,146
group 4 medulloblastoma 20 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
acute quadriplegic myopathy 18 | 1,158
breast carcinoma 18 | 1,638
primary pancreatic ductal adenocarcinoma 18 | 1,109
Autosomal recessive predisposition 17 | 1,442
ductal carcinoma in situ 17 | 1,745
primary Sjogren syndrome 16 | 735
spina bifida 16 | 1,074
Waldenstrons macroglobulinemia 15 | 765
colon cancer 15 | 1,478
juvenile dermatomyositis 15 | 1,187
Multiple Sclerosis 14 | 540
adrenocortical carcinoma 14 | 1,428
Alzheimer's disease 13 | 658
Breast Neoplasms 13 | 445
Leukemia, Myelocytic, Acute 13 | 120
Liver cancer 13 | 604
Mammary Neoplasms 13 | 425
Prostatic Neoplasms 13 | 495
cutaneous lupus erythematosus 13 | 1,057
dermatomyositis 13 | 966
Intellectual disability 12 | 1,016
Leukemia, Myeloid, Acute 12 | 105
Lymphoid leukemia 12 | 160
gastric carcinoma 12 | 807
non primary Sjogren syndrome sicca 11 | 891
Autistic Disorder 10 | 364
Celiac disease 10 | 116
Chronic Lymphocytic Leukemia 10 | 262
Inflammatory bowel disease 10 | 151
Kidney disease 10 | 430
Liver Cirrhosis, Experimental 10 | 769
active Crohn's disease 10 | 922
acute myeloid leukemia 10 | 783
medulloblastoma 10 | 720
nasopharyngeal carcinoma 10 | 1,058
pediatric high grade glioma 10 | 1,064
Allergic rhinitis 9 | 94
Arthritis, Rheumatoid 9 | 174
Hypereosinophilic syndrome 9 | 71
Hypersensitivity reaction type II disease 9 | 253
Immune system cancer 9 | 140
Muscle hypotonia 9 | 571
Polycystic ovary syndrome 9 | 360
progressive supranuclear palsy 9 | 676
Duchenne muscular dystrophy 8 | 601
Dull intelligence 8 | 645
Low intelligence 8 | 645
Melanoma 8 | 711
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Obesity 8 | 678
Poor school performance 8 | 645
Short stature 8 | 531
Splenomegaly 8 | 190
Vascular disease 8 | 319
fibroadenoma 8 | 559

Tissue

Digestive Tract 165 | 17,369
Endocrine System 165 | 18,159
Female tissues 164 | 17,400
Blood and immune system 163 | 16,909
Skin and soft tissues 163 | 17,230
Urinary Tract 162 | 16,678
Liver and Pancreas 161 | 16,750
Respiratory system 161 | 16,393
Male tissues 159 | 17,142
Nervous System 159 | 16,725
Cardiovascular System 153 | 15,192

Target Family

Non-IDG 91 | 12,091
Transcription Factor 32 | 1,400
Enzyme 25 | 4,145
Kinase 11 | 634
GPCR 6 | 408
Epigenetic 4 | 242
Transporter 3 | 473
TF/Epigenetic 1 | 38

GWAS Trait

Sum eosinophil basophil counts 173 | 173
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein Helios IKZF2 Tbio Transcription Factor -1.26324 15.8 221
Krueppel-like factor 2 KLF2 Tbio Transcription Factor -2.30630 216.2 308
Tetraspanin-32 TSPAN32 Tbio Non-IDG -0.97140 8.31 153
T-box transcription factor TBX6 TBX6 Tbio Transcription Factor -1.78720 63.0 315
Transcriptional-regulating factor 1 TRERF1 Tbio Transcription Factor -0.69436 6.18 146
5-hydroxytryptamine receptor 4 HTR4 Tclin GPCR -2.87235 796.4 248
Glucocorticoid-induced transcript 1 protein GLCCI1 Tbio Non-IDG -1.39326 24.3 158
Serpin B12 SERPINB12 Tbio Non-IDG -0.56624 4.27 155
Serine/threonine-protein kinase SIK3 SIK3 Tchem Kinase -1.18286 18.2 0
Suppressor of tumorigenicity 20 protein ST20 Tdark Non-IDG -1.66163 0.71 0