Development Level

Tbio 83 | 11,445
Tdark 28 | 6,588
Tchem 20 | 1,598
Tclin 9 | 613

Collection

Kinase: IDG Consortium (Target... 4 | 125

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
decreased circulating glucose ... 4 | 126
abnormal embryo size 3 | 220
decreased body weight 3 | 161
decreased circulating chloride... 3 | 30
decreased lean body mass 3 | 135
preweaning lethality, complete... 3 | 979
thrombocytopenia 3 | 56
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal coat- hair morphology 2 | 19
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal neural tube closure 2 | 46
anophthalmia 2 | 33
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
hyperactivity 2 | 148
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased circulating alanine ... 2 | 13
increased circulating calcium ... 2 | 34
increased circulating potassiu... 2 | 29
increased circulating total pr... 2 | 28
increased fasted circulating g... 2 | 76
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased prepulse inhibition 2 | 32
microphthalmia 2 | 26
prenatal lethality prior to he... 2 | 87
small superior vagus ganglion 2 | 74
abnormal craniofacial morpholo... 1 | 33
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal liver morphology 1 | 17
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal vibrissa morphology 1 | 25
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased circulating aspartat... 1 | 34
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
edema 1 | 59
embryonic lethality prior to o... 1 | 239
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased B cell number 1 | 9
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
small adrenal glands 1 | 16
small seminal vesicle 1 | 10
small testis 1 | 58
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 99 | 11,493
osteosarcoma 73 | 7,950
ovarian cancer 73 | 8,520
psoriasis 62 | 6,694
glioblastoma 53 | 5,792
lung cancer 52 | 4,740
medulloblastoma, large-cell 47 | 6,241
Cancer 39 | 2,499
lung carcinoma 38 | 2,843
non-small cell lung cancer 37 | 2,890
Kidney cancer 35 | 2,613
atypical teratoid / rhabdoid tumor 35 | 5,112
ependymoma 35 | 4,679
Rheumatoid arthritis 33 | 1,191
pancreatic cancer 33 | 2,398
adult high grade glioma 32 | 3,801
invasive ductal carcinoma 31 | 2,951
Breast cancer 30 | 3,578
lung adenocarcinoma 30 | 2,716
tuberculosis 30 | 2,010
interstitial cystitis 29 | 2,312
group 3 medulloblastoma 28 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,291
ulcerative colitis 28 | 1,819
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
Astrocytoma, Pilocytic 26 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
primitive neuroectodermal tumor 24 | 3,035
subependymal giant cell astrocytoma 22 | 2,287
group 4 medulloblastoma 21 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
cystic fibrosis 20 | 1,696
diabetes mellitus 20 | 1,728
malignant mesothelioma 20 | 3,232
cutaneous lupus erythematosus 17 | 1,057
pituitary cancer 17 | 1,972
Pick disease 16 | 1,894
ductal carcinoma in situ 16 | 1,745
juvenile dermatomyositis 16 | 1,187
astrocytic glioma 15 | 2,597
breast carcinoma 15 | 1,638
dermatomyositis 15 | 966
Melanoma 14 | 711
Multiple myeloma 14 | 1,332
colon cancer 14 | 1,478
oligodendroglioma 14 | 2,850
primary Sjogren syndrome 14 | 735
Acquired metabolic disease 13 | 336
Autosomal recessive predisposition 13 | 1,442
Intellectual disability 13 | 1,016
spina bifida 13 | 1,074
Crohn's disease 12 | 321
Type 2 diabetes mellitus 12 | 272
active Crohn's disease 12 | 922
active ulcerative colitis 12 | 764
esophageal adenocarcinoma 12 | 737
mucosa-associated lymphoid tissue lymphoma 12 | 484
Anemia 11 | 365
Arthritis, Rheumatoid 11 | 174
Bipolar Disorder 11 | 666
Skin cancer 11 | 469
Waldenstrons macroglobulinemia 11 | 765
acute myeloid leukemia 11 | 783
acute quadriplegic myopathy 11 | 1,158
non primary Sjogren syndrome sicca 11 | 891
periodontitis 11 | 293
Atherosclerosis 10 | 291
Breast Neoplasms 10 | 445
Coronary artery disease 10 | 268
Kidney disease 10 | 430
Mammary Neoplasms 10 | 425
Multiple Sclerosis 10 | 540
Prostatic Neoplasms 10 | 495
Schizophrenia 10 | 1,160
adrenocortical carcinoma 10 | 1,428
hepatocellular carcinoma 10 | 547
pediatric high grade glioma 10 | 1,064
Alzheimer's disease 9 | 658
Arthritis 9 | 290
Asthma 9 | 385
Chronic Lymphocytic Leukemia 9 | 262
Dull intelligence 9 | 645
Liver cancer 9 | 604
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Muscle hypotonia 9 | 571
Obesity 9 | 678
Poor school performance 9 | 645
gastric carcinoma 9 | 807
medulloblastoma 9 | 720
Autistic Disorder 8 | 364
Cognitive delay 8 | 608
Diarrhea 8 | 253
Global developmental delay 8 | 608
Hepatomegaly 8 | 285
Mental and motor retardation 8 | 608
Neutropenia 8 | 72
gastric cancer 8 | 459
primary pancreatic ductal adenocarcinoma 8 | 1,109

Tissue

Endocrine System 137 | 18,159
Female tissues 136 | 17,400
Nervous System 135 | 16,725
Digestive Tract 133 | 17,369
Liver and Pancreas 133 | 16,750
Skin and soft tissues 132 | 17,230
Male tissues 131 | 17,142
Blood and immune system 130 | 16,909
Respiratory system 130 | 16,393
Urinary Tract 129 | 16,678
Cardiovascular System 118 | 15,192

Target Family

Non-IDG 68 | 12,091
Enzyme 32 | 4,145
Kinase 12 | 634
Transcription Factor 12 | 1,400
GPCR 7 | 408
Transporter 5 | 473
Epigenetic 3 | 242
Nuclear Receptor 1 | 48

GWAS Trait

Sum basophil neutrophil counts 140 | 140
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclin-dependent kinase 6 CDK6 Tclin Kinase -2.71197 390.1 730
Tyrosine-protein kinase Lyn LYN Tclin Kinase -2.83644 683.2 589
Mast/stem cell growth factor receptor Kit KIT Tclin Kinase -3.80501 6371.9 4098
Protein C-ets-1 ETS1 Tbio Transcription Factor -2.89500 760.0 463
Transcription factor Sp1 SP1 Tbio Transcription Factor -3.01541 976.7 780
Beta-2 adrenergic receptor ADRB2 Tclin GPCR -3.22695 1680.9 829
Leptin receptor LEPR Tclin Non-IDG -3.01833 782.6 615
Alpha-enolase ENO1 Tchem Enzyme -2.83087 656.7 508
Adapter molecule crk CRK Tbio Non-IDG -2.55195 357.0 432
14-3-3 protein epsilon YWHAE Tbio Non-IDG -2.23108 170.5 348