Development Level

Tbio 355 | 11,651
Tdark 93 | 6,593
Tchem 58 | 1,388
Tclin 27 | 612

Collection

RFA-RM-18-021 8 | 328
Ion Channel: IDG Consortium (T... 5 | 99
Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 31 | 979
preweaning lethality, incomple... 21 | 499
abnormal behavior 18 | 298
embryonic lethality prior to t... 11 | 278
abnormal embryo size 9 | 220
enlarged heart 9 | 210
hyperactivity 9 | 148
decreased grip strength 8 | 116
embryonic lethality prior to o... 8 | 239
abnormal bone structure 7 | 187
abnormal heart morphology 7 | 162
abnormal gait 6 | 69
decreased hemoglobin content 6 | 68
decreased lean body mass 6 | 135
decreased prepulse inhibition 6 | 82
decreased total body fat amoun... 6 | 207
increased or absent threshold ... 6 | 101
increased total body fat amoun... 6 | 134
short tibia 6 | 97
abnormal lens morphology 5 | 81
decreased body weight 5 | 161
decreased bone mineral content 5 | 151
decreased circulating choleste... 5 | 93
decreased erythrocyte cell num... 5 | 62
increased vertical activity 5 | 24
prenatal lethality prior to he... 5 | 87
abnormal eye morphology 4 | 68
abnormal locomotor behavior 4 | 24
abnormal seminal vesicle morph... 4 | 114
cataract 4 | 92
decreased bone mineral density 4 | 126
decreased circulating HDL chol... 4 | 68
decreased circulating insulin ... 4 | 76
decreased circulating serum al... 4 | 82
decreased circulating total pr... 4 | 49
decreased startle reflex 4 | 75
embryonic growth retardation 4 | 106
increased bone mineral content 4 | 108
increased bone mineral density 4 | 72
increased lean body mass 4 | 172
male infertility 4 | 123
thrombocytopenia 4 | 56
abnormal coat appearance 3 | 31
abnormal sleep behavior 3 | 70
abnormal spleen morphology 3 | 55
decreased body length 3 | 101
decreased circulating alkaline... 3 | 46
decreased circulating aspartat... 3 | 34
enlarged lymph nodes 3 | 37
enlarged spleen 3 | 41
hypoactivity 3 | 132
increased circulating alkaline... 3 | 122
increased circulating triglyce... 3 | 42
increased erythrocyte cell num... 3 | 39
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
increased mean platelet volume 3 | 45
small superior vagus ganglion 3 | 74
tremors 3 | 39
abnormal bone mineralization 2 | 38
abnormal cornea morphology 2 | 31
abnormal epididymis morphology 2 | 42
abnormal liver morphology 2 | 17
abnormal locomotor activation 2 | 16
abnormal motor capabilities-co... 2 | 5
abnormal pancreas morphology 2 | 13
abnormal placenta size 2 | 20
abnormal retina morphology 2 | 71
abnormal retinal blood vessel ... 2 | 26
abnormal startle reflex 2 | 15
abnormal vocalization 2 | 21
absent pinna reflex 2 | 23
brachydactyly 2 | 19
decreased blood urea nitrogen ... 2 | 51
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased eosinophil cell numb... 2 | 24
decreased fasted circulating g... 2 | 65
decreased heart left ventricle... 2 | 28
decreased threshold for audito... 2 | 26
decreased vertical activity 2 | 208
female infertility 2 | 60
hemorrhage 2 | 23
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased caudal vertebrae num... 2 | 7
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
increased heart rate 2 | 23
increased hematocrit 2 | 46
increased monocyte cell number 2 | 63
increased prepulse inhibition 2 | 32
increased startle reflex 2 | 112
long tibia 2 | 25
small testis 2 | 58
thin ventricular wall 2 | 24

Disease

Carcinoma 415 | 11,493
medulloblastoma, large-cell 270 | 6,241
ovarian cancer 263 | 8,520
glioblastoma 254 | 5,792
osteosarcoma 245 | 7,950
atypical teratoid / rhabdoid tumor 239 | 5,112
ependymoma 218 | 4,679
psoriasis 218 | 6,694
lung cancer 181 | 4,740
adult high grade glioma 177 | 3,801
group 3 medulloblastoma 167 | 4,104
Astrocytoma, Pilocytic 166 | 3,081
Kidney cancer 161 | 2,613
oligodendroglioma 149 | 2,850
Breast cancer 148 | 3,578
primitive neuroectodermal tumor 146 | 3,035
astrocytic glioma 136 | 2,597
Schizophrenia 131 | 1,160
lung carcinoma 114 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 113 | 2,955
subependymal giant cell astrocytoma 112 | 2,287
malignant mesothelioma 111 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 109 | 3,291
non-small cell lung cancer 107 | 2,890
lung adenocarcinoma 104 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 98 | 2,989
invasive ductal carcinoma 97 | 2,951
Pick disease 96 | 1,894
pituitary cancer 91 | 1,972
group 4 medulloblastoma 90 | 1,855
Cancer 89 | 2,499
interstitial cystitis 88 | 2,312
pancreatic cancer 84 | 2,398
cystic fibrosis 70 | 1,696
Bipolar Disorder 69 | 666
colon cancer 69 | 1,478
tuberculosis 68 | 2,010
Melanoma 57 | 711
ulcerative colitis 57 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 56 | 1,962
adrenocortical carcinoma 55 | 1,428
ductal carcinoma in situ 52 | 1,745
Liver cancer 51 | 604
breast carcinoma 51 | 1,638
Rheumatoid arthritis 47 | 1,191
acute quadriplegic myopathy 47 | 1,158
Epilepsy 45 | 792
Intellectual disability 45 | 1,016
Skin cancer 43 | 469
astrocytoma 43 | 1,146
pediatric high grade glioma 43 | 1,064
Autistic Disorder 40 | 364
diabetes mellitus 40 | 1,728
spina bifida 40 | 1,074
Autosomal recessive predisposition 38 | 1,442
Endometrial cancer 38 | 311
juvenile dermatomyositis 38 | 1,187
aldosterone-producing adenoma 37 | 665
Alzheimer's disease 36 | 658
Mental Depression 36 | 333
active Crohn's disease 33 | 922
Acquired metabolic disease 32 | 336
Depressive disorder 32 | 409
Obesity 32 | 678
progressive supranuclear palsy 32 | 676
Seizures 30 | 596
cutaneous lupus erythematosus 30 | 1,057
medulloblastoma 30 | 720
nasopharyngeal carcinoma 30 | 1,058
Multiple myeloma 29 | 1,332
acute myeloid leukemia 29 | 783
dermatomyositis 29 | 966
Amyotrophic lateral sclerosis 28 | 451
non primary Sjogren syndrome sicca 27 | 891
primary Sjogren syndrome 27 | 735
primary pancreatic ductal adenocarcinoma 27 | 1,109
Major Depressive Disorder 26 | 301
active ulcerative colitis 26 | 764
Muscle hypotonia 25 | 571
Waldenstrons macroglobulinemia 25 | 765
gastric carcinoma 25 | 807
Dull intelligence 23 | 645
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
Alcoholic Intoxication, Chronic 22 | 289
Atopic dermatitis 22 | 952
Cognitive delay 22 | 608
Global developmental delay 22 | 608
Liver Cirrhosis, Experimental 22 | 769
Mental and motor retardation 22 | 608
Down syndrome 21 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 21 | 510
Attention deficit hyperactivity disorder 20 | 278
Type 2 diabetes mellitus 20 | 272
Unipolar Depression 20 | 250
non-small cell lung carcinoma 20 | 317
Multiple Sclerosis 19 | 540
Parkinson's disease 19 | 392

Tissue

Endocrine System 517 | 18,159
Digestive Tract 505 | 17,369
Female tissues 504 | 17,400
Male tissues 497 | 17,142
Nervous System 497 | 16,725
Skin and soft tissues 497 | 17,230
Liver and Pancreas 490 | 16,750
Blood and immune system 488 | 16,909
Urinary Tract 488 | 16,678
Respiratory system 486 | 16,393
Cardiovascular System 459 | 15,192

Target Family

Non-IDG 285 | 12,091
Enzyme 111 | 4,145
Transcription Factor 48 | 1,400
Kinase 28 | 634
Ion Channel 21 | 344
Transporter 16 | 473
Epigenetic 11 | 242
GPCR 7 | 408
Nuclear Receptor 3 | 48
TF/Epigenetic 2 | 38
oGPCR 1 | 421

GWAS Trait

Schizophrenia 533 | 533
Obesity-related traits 569 | 569
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Disks large homolog 2 DLG2 Tbio Non-IDG -1.75838 53.6 227
POM121-like protein 2 POM121L2 Tdark Non-IDG 0.40 0.40 5
Protein tweety homolog 3 TTYH3 Tbio Ion Channel -0.17609 1.56 17
WD repeat-containing protein 82 WDR82 Tbio Non-IDG -1.00294 10.5 68
RNA-binding motif, single-stranded-interacting protein 3 RBMS3 Tbio Non-IDG -0.93602 12.0 95
RNA binding protein fox-1 homolog 1 RBFOX1 Tbio Non-IDG -2.00815 99.2 207
LIM domain kinase 2 LIMK2 Tchem Kinase -1.65006 41.3 405
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.91291 722.8 693