Development Level

Tbio 116 | 11,651
Tdark 32 | 6,593
Tchem 18 | 1,388
Tclin 7 | 612

Collection

RFA-RM-18-021 3 | 328
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 6 | 499
decreased body weight 4 | 161
decreased circulating glucose ... 4 | 126
decreased total body fat amoun... 4 | 207
decreased mean corpuscular hem... 3 | 31
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
decreased lean body mass 2 | 135
decreased red blood cell distr... 2 | 41
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
increased prepulse inhibition 2 | 32
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal tail length 1 | 3
abnormal tail morphology 1 | 25
abnormal tail movements 1 | 12
abnormal vitreous body morphol... 1 | 10
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased circulating HDL chol... 1 | 68
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
decreased urine creatinine lev... 1 | 3
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
enlarged spleen 1 | 41
enlarged testis 1 | 6
head bobbing 1 | 5
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating creatine... 1 | 5
increased circulating magnesiu... 1 | 10
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small epididymis 1 | 3
small heart 1 | 10
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytosis 1 | 27
tremors 1 | 39
trunk curl 1 | 16
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 137 | 11,493
glioblastoma 76 | 5,792
ovarian cancer 76 | 8,520
medulloblastoma, large-cell 74 | 6,241
atypical teratoid / rhabdoid tumor 70 | 5,112
psoriasis 70 | 6,694
lung cancer 69 | 4,740
osteosarcoma 69 | 7,950
ependymoma 57 | 4,679
adult high grade glioma 50 | 3,801
Breast cancer 49 | 3,578
Kidney cancer 49 | 2,613
group 3 medulloblastoma 49 | 4,104
Astrocytoma, Pilocytic 47 | 3,081
primitive neuroectodermal tumor 46 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 40 | 2,955
invasive ductal carcinoma 40 | 2,951
lung carcinoma 40 | 2,843
non-small cell lung cancer 39 | 2,890
interstitial cystitis 38 | 2,312
malignant mesothelioma 37 | 3,232
oligodendroglioma 37 | 2,850
subependymal giant cell astrocytoma 37 | 2,287
Pick disease 36 | 1,894
astrocytic glioma 35 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
pancreatic cancer 33 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,291
cystic fibrosis 31 | 1,696
ductal carcinoma in situ 31 | 1,745
lung adenocarcinoma 29 | 2,716
pituitary cancer 28 | 1,972
Cancer 26 | 2,499
ulcerative colitis 24 | 1,819
group 4 medulloblastoma 23 | 1,855
Melanoma 22 | 711
colon cancer 19 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
Schizophrenia 18 | 1,160
tuberculosis 18 | 2,010
Skin cancer 17 | 469
Autosomal recessive predisposition 16 | 1,442
Chronic obstructive pulmonary disease 16 | 184
Liver cancer 16 | 604
Rheumatoid arthritis 16 | 1,191
diabetes mellitus 16 | 1,728
Bipolar Disorder 15 | 666
cutaneous lupus erythematosus 15 | 1,057
juvenile dermatomyositis 15 | 1,187
spina bifida 15 | 1,074
primary pancreatic ductal adenocarcinoma 14 | 1,109
breast carcinoma 13 | 1,638
nasopharyngeal carcinoma 13 | 1,058
primary Sjogren syndrome 13 | 735
substance-related disorder 13 | 162
Atopic dermatitis 12 | 952
acute quadriplegic myopathy 12 | 1,158
astrocytoma 12 | 1,146
gastric carcinoma 12 | 807
active Crohn's disease 11 | 922
adrenocortical carcinoma 11 | 1,428
aldosterone-producing adenoma 11 | 665
Acquired metabolic disease 10 | 336
Endometrial cancer 10 | 311
Multiple myeloma 10 | 1,332
active ulcerative colitis 10 | 764
Asthma 9 | 385
Intellectual disability 9 | 1,016
acute myeloid leukemia 9 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
dermatomyositis 9 | 966
pediatric high grade glioma 9 | 1,064
Alzheimer's disease 8 | 658
Attention deficit hyperactivity disorder 8 | 278
Duchenne muscular dystrophy 8 | 601
Epilepsy 8 | 792
Liver Cirrhosis, Experimental 8 | 769
Lung Neoplasms 8 | 232
Parkinson's disease 8 | 392
Prostatic Neoplasms 8 | 495
Seizures 8 | 596
esophageal adenocarcinoma 8 | 737
fibroadenoma 8 | 559
sonic hedgehog group medulloblastoma 8 | 467
Colorectal Neoplasms 7 | 243
Endometriosis 7 | 540
Hypersensitivity reaction type II disease 7 | 253
Liver Cirrhosis 7 | 181
Waldenstrons macroglobulinemia 7 | 765
facioscapulohumeral dystrophy 7 | 288
head and neck cancer and chronic obstructive pulmonary disease 7 | 239
medulloblastoma 7 | 720
mucosa-associated lymphoid tissue lymphoma 7 | 484
non primary Sjogren syndrome sicca 7 | 891
non-small cell lung carcinoma 7 | 317
progressive supranuclear palsy 7 | 676
Major Depressive Disorder 6 | 301
Vascular disease 6 | 319
pancreatic carcinoma 6 | 562
periodontitis 6 | 293

Tissue

Endocrine System 167 | 18,159
Female tissues 166 | 17,400
Skin and soft tissues 161 | 17,230
Digestive Tract 160 | 17,369
Male tissues 159 | 17,142
Liver and Pancreas 157 | 16,750
Blood and immune system 156 | 16,909
Urinary Tract 155 | 16,678
Nervous System 152 | 16,725
Respiratory system 152 | 16,393
Cardiovascular System 134 | 15,192

Target Family

Non-IDG 112 | 12,091
Enzyme 30 | 4,145
Ion Channel 8 | 344
Transcription Factor 7 | 1,400
Kinase 6 | 634
GPCR 3 | 408
Transporter 3 | 473
Epigenetic 2 | 242
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

GWAS Trait

Post bronchodilator FEV1 173 | 173
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Regulator of G-protein signaling 21 RGS21 Tdark Non-IDG -0.64910 3.57 54
Nephronectin NPNT Tbio Non-IDG -1.54450 37.2 104
Disks large homolog 2 DLG2 Tbio Non-IDG -1.75838 53.6 227
Periodic tryptophan protein 1 homolog PWP1 Tbio Non-IDG -0.80806 7.04 62
Protein Z-dependent protease inhibitor SERPINA10 Tbio Enzyme -1.87106 72.9 218
Paired immunoglobulin-like type 2 receptor beta PILRB Tdark Non-IDG -0.59058 3.83 79
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.82116 74.0 249
Leucine-rich repeat-containing protein 4C LRRC4C Tbio Non-IDG -2.22551 163.3 161
Defensin-6 DEFA6 Tbio Non-IDG -1.25739 19.3 70
Apoptosis-associated speck-like protein containing a CARD PYCARD Tbio Non-IDG -1.86744 55.9 477