Development Level

Tbio 122 | 11,445
Tdark 28 | 6,588
Tchem 20 | 1,598
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 7 | 499
abnormal bone structure 6 | 187
decreased body weight 5 | 161
decreased total body fat amoun... 5 | 207
increased heart weight 5 | 62
increased startle reflex 5 | 112
decreased mean corpuscular vol... 4 | 79
increased lean body mass 4 | 172
abnormal behavior 3 | 298
cardiovascular system phenotyp... 3 | 36
decreased erythrocyte cell num... 3 | 62
decreased mean corpuscular hem... 3 | 50
decreased vertical activity 3 | 208
increased total body fat amoun... 3 | 134
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
thrombocytopenia 3 | 56
abnormal bone mineralization 2 | 38
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 93
decreased circulating total pr... 2 | 49
decreased fasted circulating g... 2 | 65
decreased leukocyte cell numbe... 2 | 73
decreased threshold for audito... 2 | 26
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased erythrocyte cell num... 2 | 39
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
short tibia 2 | 97
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal eye anterior chamber ... 1 | 9
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vitreous body morphol... 1 | 10
absent startle reflex 1 | 24
decreased IgG1 level 1 | 8
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased T cell number 1 | 6
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased lactate dehydrogenas... 1 | 3
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
male infertility 1 | 123
microphthalmia 1 | 26
prenatal lethality 1 | 28
shortened RR interval 1 | 17
small seminal vesicle 1 | 10
small spleen 1 | 19
small superior vagus ganglion 1 | 74
small testis 1 | 58
vertebral transformation 1 | 12

Disease

Carcinoma 126 | 11,493
osteosarcoma 100 | 7,950
ovarian cancer 97 | 8,520
medulloblastoma, large-cell 72 | 6,241
glioblastoma 69 | 5,792
psoriasis 57 | 6,694
lung cancer 54 | 4,740
group 3 medulloblastoma 53 | 4,104
adult high grade glioma 51 | 3,801
atypical teratoid / rhabdoid tumor 51 | 5,112
ependymoma 51 | 4,679
Astrocytoma, Pilocytic 44 | 3,081
Breast cancer 43 | 3,578
pancreatic cancer 40 | 2,398
Cancer 39 | 2,499
Kidney cancer 39 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,955
subependymal giant cell astrocytoma 38 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,291
oligodendroglioma 37 | 2,850
lung carcinoma 36 | 2,843
invasive ductal carcinoma 35 | 2,951
primitive neuroectodermal tumor 33 | 3,035
tuberculosis 33 | 2,010
non-small cell lung cancer 32 | 2,890
astrocytic glioma 31 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,989
malignant mesothelioma 31 | 3,232
ulcerative colitis 31 | 1,819
interstitial cystitis 29 | 2,312
Pick disease 25 | 1,894
lung adenocarcinoma 22 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
Liver cancer 20 | 604
pituitary cancer 20 | 1,972
cystic fibrosis 19 | 1,696
spina bifida 19 | 1,074
ductal carcinoma in situ 18 | 1,745
group 4 medulloblastoma 18 | 1,855
gastric carcinoma 17 | 807
Liver Cirrhosis, Experimental 16 | 769
astrocytoma 16 | 1,146
diabetes mellitus 16 | 1,728
primary pancreatic ductal adenocarcinoma 16 | 1,109
Autosomal recessive predisposition 15 | 1,442
breast carcinoma 15 | 1,638
juvenile dermatomyositis 15 | 1,187
dermatomyositis 14 | 966
pancreatic carcinoma 14 | 562
Multiple myeloma 13 | 1,332
Schizophrenia 13 | 1,160
colon cancer 13 | 1,478
esophageal adenocarcinoma 13 | 737
pediatric high grade glioma 13 | 1,064
Rheumatoid arthritis 12 | 1,191
Thrombocytopenia 12 | 197
acute quadriplegic myopathy 12 | 1,158
cutaneous lupus erythematosus 12 | 1,057
primary Sjogren syndrome 12 | 735
Obesity 11 | 678
Waldenstrons macroglobulinemia 11 | 765
acute myeloid leukemia 11 | 783
gastric cancer 11 | 459
mucosa-associated lymphoid tissue lymphoma 11 | 484
progressive supranuclear palsy 11 | 676
active Crohn's disease 10 | 922
aldosterone-producing adenoma 10 | 665
Crohn's disease 9 | 321
Intellectual disability 9 | 1,016
Kidney disease 9 | 430
Melanoma 9 | 711
hepatocellular carcinoma 9 | 547
nasopharyngeal carcinoma 9 | 1,058
substance-related disorder 9 | 162
Atopic dermatitis 8 | 952
Bipolar Disorder 8 | 666
Brachydactyly 8 | 156
Cardiovascular system disease 8 | 246
Down syndrome 8 | 499
Hemolytic anemia 8 | 77
Hypertensive disease 8 | 292
Osteoporosis 8 | 363
Polycystic ovary syndrome 8 | 360
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
Alzheimer's disease 7 | 658
Amyotrophic lateral sclerosis 7 | 451
Duchenne muscular dystrophy 7 | 601
Epilepsy 7 | 792
Hypertension 7 | 396
Muscle hypotonia 7 | 571
active ulcerative colitis 7 | 764
adrenocortical carcinoma 7 | 1,428
Cognitive delay 6 | 608
Dull intelligence 6 | 645
Mental and motor retardation 6 | 608
Type 2 diabetes mellitus 6 | 272
Vascular disease 6 | 319
chronic lymphosyte leukemia 6 | 204
chronic rhinosinusitis 6 | 512
fibroadenoma 6 | 559

Tissue

Endocrine System 167 | 18,159
Digestive Tract 165 | 17,369
Respiratory system 165 | 16,393
Skin and soft tissues 165 | 17,230
Female tissues 164 | 17,400
Male tissues 164 | 17,142
Blood and immune system 163 | 16,909
Urinary Tract 162 | 16,678
Liver and Pancreas 160 | 16,750
Nervous System 159 | 16,725
Cardiovascular System 152 | 15,192

Target Family

Non-IDG 110 | 12,091
Enzyme 25 | 4,145
Transcription Factor 14 | 1,400
Kinase 9 | 634
Epigenetic 6 | 242
Transporter 5 | 473
GPCR 2 | 408
Ion Channel 1 | 344
TF/Epigenetic 1 | 38
oGPCR 1 | 421

GWAS Trait

Platelet distribution width 174 | 174
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase tousled-like 1 TLK1 Tchem Kinase -1.25235 19.2 305
Solute carrier family 12 member 7 SLC12A7 Tbio Transporter -1.46102 28.2 156
Homeobox protein orthopedia OTP Tbio Transcription Factor -2.26130 187.7 110
Putative protein phosphatase inhibitor 2-like protein 1 PPP1R2P1 Tdark Enzyme 0.00000 0
Tubulin delta chain TUBD1 Tbio Non-IDG -1.28681 18.5 57
Rotatin RTTN Tbio Non-IDG -0.87856 9.51 13
CD2-associated protein CD2AP Tbio Non-IDG -3.44533 2735.9 82
Zinc finger protein ZFPM2 ZFPM2 Tbio Transcription Factor -1.78912 62.9 93
ATP-binding cassette sub-family D member 3 ABCD3 Tbio Transporter -1.82051 64.2 166
Death-associated protein kinase 2 DAPK2 Tchem Kinase -1.39206 28.7 440