Development Level

Tbio 186 | 11,445
Tdark 40 | 6,588
Tchem 32 | 1,598
Tclin 17 | 613

Collection

RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Target... 4 | 125
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 16 | 979
preweaning lethality, incomple... 13 | 499
decreased body weight 6 | 161
decreased erythrocyte cell num... 6 | 62
decreased vertical activity 6 | 208
abnormal lens morphology 5 | 81
cataract 5 | 92
improved glucose tolerance 5 | 79
increased startle reflex 5 | 112
abnormal behavior 4 | 298
abnormal bone structure 4 | 187
abnormal embryo size 4 | 220
decreased circulating choleste... 4 | 93
decreased prepulse inhibition 4 | 82
decreased total body fat amoun... 4 | 207
embryonic lethality prior to t... 4 | 278
hyperactivity 4 | 148
increased lean body mass 4 | 172
increased mean corpuscular hem... 4 | 96
increased or absent threshold ... 4 | 101
increased total body fat amoun... 4 | 134
abnormal epididymis morphology 3 | 42
abnormal gait 3 | 69
abnormal startle reflex 3 | 15
abnormal testis morphology 3 | 43
absent startle reflex 3 | 24
cardiovascular system phenotyp... 3 | 36
decreased bone mineral density 3 | 126
decreased circulating glucose ... 3 | 126
decreased circulating total pr... 3 | 49
decreased leukocyte cell numbe... 3 | 73
decreased threshold for audito... 3 | 26
enlarged heart 3 | 210
hypoactivity 3 | 132
increased circulating alkaline... 3 | 122
limb grasping 3 | 41
prolonged QT interval 3 | 38
abnormal bone mineralization 2 | 38
abnormal eye morphology 2 | 68
abnormal locomotor activation 2 | 16
abnormal seminal vesicle morph... 2 | 114
abnormal snout morphology 2 | 23
abnormal tooth morphology 2 | 24
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating alkaline... 2 | 46
decreased circulating iron lev... 2 | 32
decreased circulating serum al... 2 | 82
decreased circulating sodium l... 2 | 22
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased mean corpuscular vol... 2 | 79
embryonic growth retardation 2 | 106
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating amylase ... 2 | 25
increased circulating free fat... 2 | 20
increased circulating glucose ... 2 | 24
increased circulating iron lev... 2 | 30
increased circulating total pr... 2 | 28
increased heart rate 2 | 23
increased lymphocyte cell numb... 2 | 32
male infertility 2 | 123
prenatal lethality prior to he... 2 | 87
prolonged ST segment 2 | 36
short tibia 2 | 97
small testis 2 | 58
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
corneal opacity 1 | 32
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
hydrometra 1 | 53
increased body length 1 | 32
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased red blood cell distr... 1 | 34
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small spleen 1 | 19
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Carcinoma 190 | 11,493
ovarian cancer 157 | 8,520
osteosarcoma 155 | 7,950
medulloblastoma, large-cell 125 | 6,241
glioblastoma 122 | 5,792
psoriasis 96 | 6,694
atypical teratoid / rhabdoid tumor 93 | 5,112
lung cancer 89 | 4,740
ependymoma 84 | 4,679
adult high grade glioma 72 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 71 | 3,291
Cancer 70 | 2,499
Breast cancer 69 | 3,578
group 3 medulloblastoma 67 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 66 | 2,955
primitive neuroectodermal tumor 64 | 3,035
Astrocytoma, Pilocytic 63 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 63 | 2,989
pancreatic cancer 61 | 2,398
non-small cell lung cancer 60 | 2,890
oligodendroglioma 56 | 2,850
subependymal giant cell astrocytoma 53 | 2,287
malignant mesothelioma 52 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 52 | 1,962
invasive ductal carcinoma 51 | 2,951
lung carcinoma 51 | 2,843
tuberculosis 50 | 2,010
Kidney cancer 49 | 2,613
astrocytic glioma 47 | 2,597
interstitial cystitis 44 | 2,312
group 4 medulloblastoma 42 | 1,855
ulcerative colitis 42 | 1,819
cystic fibrosis 41 | 1,696
lung adenocarcinoma 39 | 2,716
juvenile dermatomyositis 38 | 1,187
Pick disease 37 | 1,894
diabetes mellitus 36 | 1,728
pituitary cancer 36 | 1,972
Multiple myeloma 33 | 1,332
acute quadriplegic myopathy 31 | 1,158
ductal carcinoma in situ 31 | 1,745
spina bifida 31 | 1,074
Autosomal recessive predisposition 28 | 1,442
Rheumatoid arthritis 27 | 1,191
colon cancer 26 | 1,478
Schizophrenia 25 | 1,160
active Crohn's disease 25 | 922
breast carcinoma 25 | 1,638
astrocytoma 24 | 1,146
dermatomyositis 23 | 966
esophageal adenocarcinoma 23 | 737
pediatric high grade glioma 23 | 1,064
primary Sjogren syndrome 23 | 735
Waldenstrons macroglobulinemia 22 | 765
active ulcerative colitis 22 | 764
adrenocortical carcinoma 22 | 1,428
gastric carcinoma 22 | 807
pancreatic carcinoma 22 | 562
Liver Cirrhosis, Experimental 21 | 769
primary pancreatic ductal adenocarcinoma 21 | 1,109
Thrombocytopenia 20 | 197
hepatocellular carcinoma 20 | 547
cutaneous lupus erythematosus 19 | 1,057
gastric cancer 19 | 459
Obesity 18 | 678
Liver cancer 17 | 604
Multiple Sclerosis 17 | 540
Prostatic Neoplasms 17 | 495
Duchenne muscular dystrophy 16 | 601
Hemolytic anemia 16 | 77
Melanoma 16 | 711
medulloblastoma 16 | 720
progressive supranuclear palsy 16 | 676
Anemia 15 | 365
Crohn's disease 15 | 321
Intellectual disability 14 | 1,016
Kidney disease 14 | 430
Liver carcinoma 14 | 240
acute myeloid leukemia 14 | 783
Alzheimer's disease 13 | 658
Amyotrophic lateral sclerosis 13 | 451
Bipolar Disorder 13 | 666
Carcinoma, Hepatocellular 13 | 228
Colorectal Neoplasms 13 | 243
Coronary artery disease 13 | 268
Down syndrome 13 | 499
Lymphoid leukemia 13 | 160
Muscle hypotonia 13 | 571
Osteoporosis 13 | 363
fibroadenoma 13 | 559
Acquired metabolic disease 12 | 336
Atopic dermatitis 12 | 952
Cardiovascular system disease 12 | 246
Epilepsy 12 | 792
Hypertensive disease 12 | 292
Short stature 12 | 531
Splenomegaly 12 | 190
aldosterone-producing adenoma 12 | 665
Low intelligence 11 | 645
Mental Retardation 11 | 645

Tissue

Endocrine System 265 | 18,159
Digestive Tract 262 | 17,369
Female tissues 262 | 17,400
Blood and immune system 261 | 16,909
Male tissues 260 | 17,142
Liver and Pancreas 259 | 16,750
Skin and soft tissues 258 | 17,230
Urinary Tract 257 | 16,678
Nervous System 256 | 16,725
Respiratory system 252 | 16,393
Cardiovascular System 245 | 15,192

Target Family

Non-IDG 154 | 12,091
Enzyme 56 | 4,145
Transcription Factor 30 | 1,400
Kinase 17 | 634
Transporter 5 | 473
Epigenetic 4 | 242
GPCR 4 | 408
Ion Channel 3 | 344
TF/Epigenetic 2 | 38

GWAS Trait

Platelet count 275 | 275
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tropomyosin alpha-4 chain TPM4 Tbio Non-IDG -1.57899 37.4 120
Ras association domain-containing protein 3 RASSF3 Tbio Non-IDG 0.00000 130
CD2-associated protein CD2AP Tbio Non-IDG -3.44533 2735.9 82
Thrombopoietin THPO Tbio Non-IDG -3.23551 1632.3 440
Transcriptional activator protein Pur-beta PURB Tbio Non-IDG -1.49692 30.7 79
G patch domain-containing protein 8 GPATCH8 Tbio Non-IDG -0.13830 1.47 20
Insulin-like growth factor 2 mRNA-binding protein 2 IGF2BP2 Tbio Non-IDG -1.77792 57.3 400
Stonin-2 STON2 Tbio Non-IDG -1.43585 30.0 11
Monoacylglycerol lipase ABHD6 ABHD6 Tchem Enzyme -1.37418 26.1 71
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 ASAP1 Tbio Non-IDG -1.76454 62.6 183