Development Level

Tbio 64 | 11,445
Tchem 15 | 1,598
Tdark 6 | 6,588
Tclin 5 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Complete... 1 | 25
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 6 | 499
decreased caudal vertebrae num... 3 | 53
decreased circulating glucose ... 3 | 126
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal cornea morphology 2 | 31
abnormal lens morphology 2 | 81
cataract 2 | 92
corneal opacity 2 | 32
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased grip strength 2 | 116
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
enlarged heart 2 | 210
hypoactivity 2 | 132
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased fasted circulating g... 2 | 76
male infertility 2 | 123
polycystic kidney 2 | 15
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal iris morphology 1 | 13
abnormal male genitalia morpho... 1 | 3
abnormal optic disc morphology 1 | 10
abnormal placenta size 1 | 20
abnormal retinal outer nuclear... 1 | 3
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
absent external male genitalia 1 | 1
absent pinna reflex 1 | 23
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating lipase l... 1 | 3
decreased circulating phosphat... 1 | 27
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
decreased urine creatinine lev... 1 | 3
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
fused cornea and lens 1 | 5
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating creatini... 1 | 38
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
mydriasis 1 | 6
oligodactyly 1 | 1
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small kidney 1 | 16
small testis 1 | 58

Disease

Carcinoma 63 | 11,493
ovarian cancer 48 | 8,520
Parkinson's disease 46 | 392
medulloblastoma, large-cell 42 | 6,241
osteosarcoma 42 | 7,950
glioblastoma 32 | 5,792
psoriasis 32 | 6,694
atypical teratoid / rhabdoid tumor 31 | 5,112
ependymoma 29 | 4,679
lung cancer 28 | 4,740
group 3 medulloblastoma 26 | 4,104
lung carcinoma 25 | 2,843
Kidney cancer 23 | 2,613
adult high grade glioma 23 | 3,801
Astrocytoma, Pilocytic 22 | 3,081
Pick disease 21 | 1,894
invasive ductal carcinoma 21 | 2,951
subependymal giant cell astrocytoma 21 | 2,287
Breast cancer 20 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
malignant mesothelioma 20 | 3,232
interstitial cystitis 19 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
oligodendroglioma 17 | 2,850
pancreatic cancer 17 | 2,398
primitive neuroectodermal tumor 16 | 3,035
astrocytic glioma 15 | 2,597
lung adenocarcinoma 15 | 2,716
ulcerative colitis 15 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
group 4 medulloblastoma 13 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
non-small cell lung cancer 13 | 2,890
pituitary cancer 13 | 1,972
tuberculosis 13 | 2,010
Autosomal recessive predisposition 12 | 1,442
diabetes mellitus 12 | 1,728
cutaneous lupus erythematosus 10 | 1,057
cystic fibrosis 10 | 1,696
Bipolar Disorder 9 | 666
Cancer 9 | 2,499
Schizophrenia 9 | 1,160
adrenocortical carcinoma 9 | 1,428
breast carcinoma 9 | 1,638
Liver cancer 8 | 604
Rheumatoid arthritis 8 | 1,191
acute quadriplegic myopathy 8 | 1,158
Alzheimer's disease 7 | 658
Liver Cirrhosis, Experimental 7 | 769
Melanoma 7 | 711
Seizures 7 | 596
astrocytoma 7 | 1,146
colon cancer 7 | 1,478
ductal carcinoma in situ 7 | 1,745
gastric carcinoma 7 | 807
juvenile dermatomyositis 7 | 1,187
primary Sjogren syndrome 7 | 735
primary pancreatic ductal adenocarcinoma 7 | 1,109
Atopic dermatitis 6 | 952
Autistic Disorder 6 | 364
Epilepsy 6 | 792
Muscle hypotonia 6 | 571
Parkinson Disease 6 | 64
Short stature 6 | 531
active Crohn's disease 6 | 922
pancreatic carcinoma 6 | 562
progressive supranuclear palsy 6 | 676
spina bifida 6 | 1,074
Chronic Lymphocytic Leukemia 5 | 262
Chronic obstructive pulmonary disease 5 | 184
Dementia 5 | 175
Down syndrome 5 | 499
Endometriosis 5 | 540
Intellectual disability 5 | 1,016
Multiple Sclerosis 5 | 540
Multiple myeloma 5 | 1,332
Neurodegenerative disease 5 | 414
Parkinsonian Disorders 5 | 56
Skin cancer 5 | 469
Waldenstrons macroglobulinemia 5 | 765
atypical teratoid/rhabdoid tumor 5 | 357
fibroadenoma 5 | 559
pediatric high grade glioma 5 | 1,064
posterior fossa group A ependymoma 5 | 468
Alcoholic Intoxication, Chronic 4 | 289
Cocaine-Related Disorders 4 | 92
Depressive disorder 4 | 409
Endometrial cancer 4 | 311
Gastroesophageal reflux disease 4 | 110
Hyperreflexia 4 | 209
Hypokinesia 4 | 19
Low set ears 4 | 181
Major Depressive Disorder 4 | 301
Obesity 4 | 678
Orbital separation excessive 4 | 244
Osteoporosis 4 | 363
Unipolar Depression 4 | 250
aldosterone-producing adenoma 4 | 665
medulloblastoma 4 | 720
urothelial carcinoma 4 | 318

Tissue

Endocrine System 88 | 18,159
Digestive Tract 87 | 17,369
Male tissues 86 | 17,142
Skin and soft tissues 86 | 17,230
Female tissues 85 | 17,400
Nervous System 84 | 16,725
Urinary Tract 83 | 16,678
Liver and Pancreas 82 | 16,750
Blood and immune system 81 | 16,909
Respiratory system 80 | 16,393
Cardiovascular System 75 | 15,192

Target Family

Non-IDG 42 | 12,091
Enzyme 26 | 4,145
Kinase 9 | 634
GPCR 3 | 408
Ion Channel 3 | 344
Transcription Factor 3 | 1,400
Transporter 3 | 473
TF/Epigenetic 1 | 38

GWAS Trait

Parkinson's disease 90 | 90
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 Tbio Enzyme -1.91194 82.4 102
Transmembrane glycoprotein NMB GPNMB Tbio Non-IDG -2.05817 130.8 293
Pleckstrin homology domain-containing family M member 1 PLEKHM1 Tbio Non-IDG -1.44998 27.9 116
Sugar transporter SWEET1 SLC50A1 Tbio Transporter -2.23661 169.6 56
Kinectin KTN1 Tbio Non-IDG -1.93411 83.4 89
Mitogen-activated protein kinase kinase kinase kinase 4 MAP4K4 Tchem Kinase -2.19064 152.6 547
Endosomal/lysosomal potassium channel TMEM175 TMEM175 Tbio Non-IDG -0.65375 3.76 42
Semaphorin-5A SEMA5A Tbio Non-IDG -1.82162 69.8 238
GTP cyclohydrolase 1 GCH1 Tbio Enzyme -2.80099 639.3 247
Solute carrier family 41 member 1 SLC41A1 Tbio Transporter -1.94210 82.1 23