Development Level

Tbio 235 | 10,625
Tdark 93 | 7,003
Tchem 37 | 1,890
Tclin 15 | 602

Collection

Eligible Ion Channel Proteins 4 | 117
Eligible Kinase Proteins 4 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 12 | 633
decreased caudal vertebrae num... 5 | 49
decreased grip strength 5 | 123
embryonic lethality prior to t... 5 | 187
abnormal behavior 4 | 226
abnormal bone structure 4 | 131
decreased body weight 4 | 174
decreased total body fat amoun... 4 | 186
increased or absent threshold ... 4 | 128
abnormal behavioral response t... 3 | 52
abnormal coat/hair pigmentatio... 3 | 54
abnormal retina morphology 3 | 100
abnormal sleep behavior 3 | 63
decreased CD4-positive, CD25-p... 3 | 24
decreased body length 3 | 108
decreased bone mineral content 3 | 157
decreased circulating choleste... 3 | 85
decreased circulating insulin ... 3 | 75
decreased effector memory CD8-... 3 | 24
decreased lean body mass 3 | 195
decreased startle reflex 3 | 48
hyperactivity 3 | 108
improved glucose tolerance 3 | 56
increased B cell number 3 | 23
increased body weight 3 | 42
preweaning lethality, incomple... 3 | 260
abnormal QRS complex 2 | 25
abnormal embryo size 2 | 112
abnormal kidney morphology 2 | 30
absent startle reflex 2 | 15
convulsive seizures 2 | 11
decreased CD8-positive, naive ... 2 | 5
decreased KLRG1-positive NK ce... 2 | 9
decreased Ly6C low monocyte nu... 2 | 23
decreased NK cell number 2 | 16
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating aspartat... 2 | 27
decreased circulating creatini... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating iron lev... 2 | 25
decreased circulating phosphat... 2 | 15
decreased circulating potassiu... 2 | 17
decreased eosinophil cell numb... 2 | 41
decreased exploration in new e... 2 | 9
decreased gamma-delta T cell n... 2 | 18
decreased heart weight 2 | 44
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
increased CD4-positive, alpha ... 2 | 15
increased Ly6C high monocyte n... 2 | 12
increased NK T cell number 2 | 11
increased circulating alkaline... 2 | 119
increased circulating aspartat... 2 | 17
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased mature B cell number 2 | 12
increased mean corpuscular hem... 2 | 93
increased neutrophil cell numb... 2 | 15
increased rib number 2 | 41
male infertility 2 | 62
prenatal lethality prior to he... 2 | 64
thrombocytopenia 2 | 46
abnormal cranium morphology 1 | 32
abnormal motor capabilities/co... 1 | 4
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal tail movements 1 | 12
corneal opacity 1 | 25
decreased CD11b-low dendritic ... 1 | 3
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased circulating sodium l... 1 | 18
decreased thoracic vertebrae n... 1 | 7
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
enlarged heart atrium 1 | 2
increased CD5-positive Ly6C-po... 1 | 4
increased KLRG1+ CD4 alpha bet... 1 | 5
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating iron lev... 1 | 25
increased effector memory CD4-... 1 | 15
increased eosinophil cell numb... 1 | 9
increased gamma-delta T cell n... 1 | 16
increased granulocyte number 1 | 8
increased mean corpuscular vol... 1 | 91
increased startle reflex 1 | 38
long tibia 1 | 13
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
tremors 1 | 34

Disease

osteosarcoma 196 | 7,933
ovarian cancer 189 | 8,484
medulloblastoma, large-cell 166 | 6,234
glioblastoma 151 | 5,572
psoriasis 138 | 6,685
atypical teratoid / rhabdoid tumor 122 | 4,369
lung cancer 109 | 4,466
lung carcinoma 108 | 2,844
pilocytic astrocytoma 102 | 3,086
primitive neuroectodermal tumor 101 | 3,031
oligodendroglioma 100 | 2,849
Carcinoma 99 | 2,147
Obesity 94 | 616
intraductal papillary-mucinous adenoma (IPMA) 87 | 2,956
malignant mesothelioma 87 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 83 | 3,289
lung adenocarcinoma 83 | 2,713
subependymal giant cell astrocytoma 83 | 2,287
Breast cancer 81 | 3,094
pediatric high grade glioma 81 | 2,712
pituitary cancer 77 | 1,972
intraductal papillary-mucinous carcinoma (IPMC) 76 | 2,988
astrocytic glioma 74 | 2,241
interstitial cystitis 73 | 2,299
invasive ductal carcinoma 73 | 2,950
ependymoma 66 | 2,514
non-small cell lung cancer 65 | 2,798
ulcerative colitis 62 | 2,087
Pick disease 59 | 1,893
adult high grade glioma 58 | 2,148
cystic fibrosis 54 | 1,665
group 4 medulloblastoma 51 | 1,875
sonic hedgehog group medulloblastoma 50 | 1,482
ductal carcinoma in situ 49 | 1,745
posterior fossa group A ependymoma 49 | 1,511
group 3 medulloblastoma 48 | 2,254
pancreatic cancer 48 | 2,300
colon cancer 46 | 1,475
medulloblastoma 46 | 1,524
posterior fossa group B ependymoma 45 | 1,530
breast carcinoma 44 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 39 | 1,795
tuberculosis 38 | 1,557
atypical teratoid/rhabdoid tumor 36 | 1,095
spina bifida 35 | 1,064
Cancer 34 | 2,346
adrenocortical carcinoma 34 | 1,427
diabetes mellitus 34 | 1,663
nasopharyngeal carcinoma 33 | 1,056
Rheumatoid Arthritis 31 | 1,160
astrocytoma 31 | 1,493
primary pancreatic ductal adenocarcinoma 27 | 1,271
gastric carcinoma 26 | 832
Atopic dermatitis 24 | 944
Schizophrenia 24 | 501
Alzheimer's disease 23 | 644
Multiple Sclerosis 23 | 498
Multiple myeloma 23 | 1,327
Intellectual disability 22 | 573
active Crohn's disease 22 | 918
cutaneous lupus erythematosus 22 | 1,056
fibroadenoma 22 | 557
acute quadriplegic myopathy 21 | 1,157
Autistic Disorder 19 | 320
Acquired metabolic disease 18 | 267
active ulcerative colitis 18 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 499
dermatomyositis 18 | 933
juvenile dermatomyositis 18 | 1,189
Crohn's disease 17 | 304
primary Sjogren syndrome 17 | 789
progressive supranuclear palsy 17 | 674
Vascular disease 16 | 281
acute myeloid leukemia 16 | 780
non primary Sjogren syndrome sicca 16 | 840
non-small cell lung carcinoma 16 | 413
Asthma 15 | 349
Type 2 diabetes mellitus 15 | 189
Diabetes Mellitus, Non-Insulin-Dependent 14 | 157
Epilepsy 14 | 346
Parkinson's disease 14 | 364
aldosterone-producing adenoma 14 | 664
urothelial carcinoma 14 | 318
Duchenne muscular dystrophy 13 | 602
Waldenstrons macroglobulinemia 13 | 765
esophageal adenocarcinoma 13 | 737
Amyotrophic Lateral Sclerosis 12 | 431
Down syndrome 12 | 548
Endometriosis 12 | 535
Neurodegenerative disease 12 | 383
chronic rhinosinusitis 12 | 512
facioscapulohumeral dystrophy 12 | 286
tuberculosis and treatment for 6 months 12 | 686
Bipolar Disorder 11 | 266
Mammary Neoplasms 11 | 410
Osteoporosis 11 | 257
Peripheral Neuropathy 11 | 303
Prostate cancer 11 | 172
Prostatic Neoplasms 11 | 471
Atherosclerosis 10 | 275

Tissue

Female tissues 376 | 18,647
Nervous System 375 | 18,561
Digestive Tract 374 | 18,473
Blood and immune system 373 | 17,995
Cardiovascular System 373 | 17,958
Endocrine System 373 | 18,512
Liver and Pancreas 373 | 18,136
Male tissues 372 | 17,969
Urinary Tract 372 | 18,444
Skin and soft tissues 370 | 18,115
Respiratory system 361 | 17,484

Target Family

Non-IDG 221 | 11,971
Enzyme 80 | 4,146
Kinase 20 | 634
Transcription Factor 17 | 1,400
Ion Channel 16 | 341
Transporter 12 | 473
Epigenetic 6 | 242
GPCR 6 | 406
TF/Epigenetic 1 | 38
oGPCR 1 | 421

GWAS Trait

Obesity-related traits 380 | 380
Schizophrenia 334 | 334
Height 250 | 250
Post bronchodilator FEV1/FVC r... 192 | 192
Body mass index 180 | 180
IgG glycosylation 162 | 162
Inflammatory bowel disease 117 | 117
Post bronchodilator FEV1 112 | 112
Crohn's disease 110 | 110
Blood metabolite levels 103 | 103
Type 2 diabetes 94 | 94
3-hydroxy-1-methylpropylmercap... 93 | 93
3-hydroxypropylmercapturic aci... 92 | 92
Ulcerative colitis 89 | 89
Platelet count 79 | 79
Systemic lupus erythematosus 78 | 78
HDL cholesterol 76 | 76
Rheumatoid arthritis 74 | 74
Cholesterol, total 73 | 73
Menarche (age at onset) 73 | 73
Diisocyanate-induced asthma 72 | 72
Multiple sclerosis 68 | 68
LDL cholesterol 67 | 67
QT interval 58 | 58
Metabolite levels 55 | 55
Atopic dermatitis 54 | 54
Bipolar disorder and schizophr... 54 | 54
Breast cancer 54 | 54
Prostate cancer 54 | 54
Triglycerides 53 | 53
Bipolar disorder 52 | 52
HIV-1 control 50 | 50
Post bronchodilator FEV1/FVC r... 50 | 50
HIV-1 viral setpoint 49 | 49
Cognitive performance 48 | 48
Amyotrophic lateral sclerosis ... 46 | 46
Bone mineral density 46 | 46
Clozapine-induced agranulocyto... 46 | 46
Attention deficit hyperactivit... 44 | 44
Blood pressure 44 | 44
Coronary heart disease 43 | 43
Glomerular filtration rate (cr... 43 | 43
Parkinson's disease 43 | 43
Type 1 diabetes 42 | 42
PR interval in Tripanosoma cru... 40 | 40
Post bronchodilator FEV1 in CO... 39 | 39
Alzheimer's disease (cognitive... 38 | 38
Educational attainment 38 | 38
Pulmonary function 38 | 38
Diffuse large B cell lymphoma 37 | 37
Inflammatory skin disease 37 | 37
Beta-2 microglubulin plasma le... 36 | 36
Glucose homeostasis traits 36 | 36
Urate levels 36 | 36
Blood metabolite ratios 35 | 35
Psoriasis 35 | 35
Autism spectrum disorder, atte... 34 | 34
Migraine 33 | 33
Coronary artery disease 32 | 32
Metabolic traits 32 | 32
Waist-to-hip ratio adjusted fo... 32 | 32
Cognitive function 31 | 31
Colorectal cancer 31 | 31
Amyotrophic lateral sclerosis 30 | 30
Myopia (pathological) 30 | 30
Obesity 30 | 30
Response to amphetamines 30 | 30
Systolic blood pressure 30 | 30
Alzheimer's disease (late onse... 29 | 29
Celiac disease 29 | 29
Phospholipid levels (plasma) 29 | 29
Red blood cell traits 29 | 29
Advanced age-related macular d... 28 | 28
Dental caries 28 | 28
Fibrinogen levels 28 | 28
Parental extreme longevity (95... 28 | 28
Pulmonary function (interactio... 28 | 28
Asthma 27 | 27
Cognitive decline rate in late... 27 | 27
Glomerular filtration rate in ... 27 | 27
Longevity 27 | 27
Mean platelet volume 27 | 27
Chronic kidney disease 26 | 26
Diabetic kidney disease 26 | 26
Diastolic blood pressure 26 | 26
Coronary artery calcification 25 | 25
Metabolic syndrome 25 | 25
Pancreatic cancer 25 | 25
Protein quantitative trait loc... 25 | 25
Hypertension 24 | 24
Migraine - clinic-based 24 | 24
Parental longevity (combined p... 24 | 24
Primary biliary cirrhosis 24 | 24
Thiazide-induced adverse metab... 24 | 24
Menopause (age at onset) 23 | 23
Response to antipsychotic trea... 23 | 23
Age-related macular degenerati... 22 | 22
Immune response to smallpox va... 22 | 22
Mild influenza (H1N1) infectio... 22 | 22
Sudden cardiac arrest 22 | 22

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box only protein 47 FBXO47 Tdark Non-IDG 0.08 0.95 47
Transmembrane protein 229B TMEM229B Tdark Non-IDG 1.34 0.03 3
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Plasma kallikrein KLKB1 Tclin Enzyme -2.88472 708.0 231
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Equilibrative nucleoside transporter 3 SLC29A3 Tbio Transporter -2.36515 247.3 58
Interleukin enhancer-binding factor 3 ILF3 Tbio Non-IDG -2.09543 135.8 239
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Zinc finger CCCH domain-containing protein 4 ZC3H4 Tdark Non-IDG 0.54 0.30 53
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542