Development Level

Tbio 368 | 11,445
Tdark 119 | 6,588
Tchem 55 | 1,598
Tclin 27 | 613

Collection

RFA-RM-18-021 8 | 328
Kinase: IDG Consortium (Target... 5 | 125
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 20 | 979
preweaning lethality, incomple... 15 | 499
decreased vertical activity 10 | 208
abnormal behavior 9 | 298
embryonic lethality prior to t... 9 | 278
increased or absent threshold ... 9 | 101
abnormal embryo size 7 | 220
decreased startle reflex 6 | 75
decreased threshold for audito... 6 | 26
abnormal seminal vesicle morph... 5 | 114
decreased body weight 5 | 161
decreased grip strength 5 | 116
decreased prepulse inhibition 5 | 82
embryonic growth retardation 5 | 106
male infertility 5 | 123
prenatal lethality prior to he... 5 | 87
abnormal behavioral response t... 4 | 66
abnormal bone structure 4 | 187
abnormal coat-hair pigmentatio... 4 | 64
decreased body length 4 | 101
decreased caudal vertebrae num... 4 | 53
decreased red blood cell distr... 4 | 41
decreased total body fat amoun... 4 | 207
enlarged heart 4 | 210
hypoactivity 4 | 132
impaired glucose tolerance 4 | 75
increased startle reflex 4 | 112
abnormal heart morphology 3 | 162
abnormal kidney morphology 3 | 65
abnormal retina morphology 3 | 71
abnormal sleep behavior 3 | 70
cataract 3 | 92
decreased circulating alanine ... 3 | 47
decreased circulating choleste... 3 | 93
decreased circulating creatini... 3 | 39
decreased circulating insulin ... 3 | 76
decreased circulating iron lev... 3 | 32
decreased erythrocyte cell num... 3 | 62
decreased leukocyte cell numbe... 3 | 73
decreased lymphocyte cell numb... 3 | 83
edema 3 | 59
embryonic lethality prior to o... 3 | 239
hyperactivity 3 | 148
improved glucose tolerance 3 | 79
increased body weight 3 | 25
increased circulating triglyce... 3 | 42
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
increased prepulse inhibition 3 | 32
short tibia 3 | 97
thrombocytopenia 3 | 56
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal head shape 2 | 10
abnormal joint morphology 2 | 23
abnormal locomotor behavior 2 | 24
abnormal pericardium morpholog... 2 | 26
abnormal retinal blood vessel ... 2 | 26
abnormal spleen morphology 2 | 55
abnormal urinary bladder morph... 2 | 11
absent startle reflex 2 | 24
anophthalmia 2 | 33
brachydactyly 2 | 19
convulsive seizures 2 | 13
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating aspartat... 2 | 34
decreased circulating phosphat... 2 | 27
decreased circulating potassiu... 2 | 20
increased anti-nuclear antigen... 2 | 19
increased blood urea nitrogen ... 2 | 48
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased circulating aspartat... 2 | 15
increased circulating fructosa... 2 | 13
increased erythrocyte cell num... 2 | 39
increased grip strength 2 | 41
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased vertical activity 2 | 24
long tibia 2 | 25
syndactyly 2 | 23
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal gait 1 | 69
abnormal vocalization 1 | 21
decreased circulating bilirubi... 1 | 19
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased total retina thickne... 1 | 17
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased cardiac muscle contr... 1 | 8
microphthalmia 1 | 26
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 420 | 11,493
ovarian cancer 278 | 8,520
osteosarcoma 266 | 7,950
medulloblastoma, large-cell 222 | 6,241
glioblastoma 217 | 5,792
psoriasis 211 | 6,694
atypical teratoid / rhabdoid tumor 199 | 5,112
ependymoma 186 | 4,679
lung cancer 170 | 4,740
adult high grade glioma 156 | 3,801
group 3 medulloblastoma 150 | 4,104
lung carcinoma 148 | 2,843
Breast cancer 145 | 3,578
Kidney cancer 145 | 2,613
Astrocytoma, Pilocytic 135 | 3,081
primitive neuroectodermal tumor 134 | 3,035
oligodendroglioma 130 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 121 | 2,955
malignant mesothelioma 120 | 3,232
lung adenocarcinoma 118 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 117 | 3,291
astrocytic glioma 113 | 2,597
interstitial cystitis 112 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 110 | 2,989
subependymal giant cell astrocytoma 110 | 2,287
invasive ductal carcinoma 107 | 2,951
non-small cell lung cancer 104 | 2,890
pituitary cancer 100 | 1,972
pancreatic cancer 85 | 2,398
ulcerative colitis 84 | 1,819
cystic fibrosis 83 | 1,696
Pick disease 81 | 1,894
ductal carcinoma in situ 73 | 1,745
breast carcinoma 68 | 1,638
group 4 medulloblastoma 67 | 1,855
tuberculosis 67 | 2,010
Cancer 66 | 2,499
Schizophrenia 66 | 1,160
colon cancer 64 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 63 | 1,962
diabetes mellitus 56 | 1,728
spina bifida 54 | 1,074
Autosomal recessive predisposition 51 | 1,442
adrenocortical carcinoma 51 | 1,428
nasopharyngeal carcinoma 46 | 1,058
Rheumatoid arthritis 45 | 1,191
Atopic dermatitis 44 | 952
Bipolar Disorder 41 | 666
Intellectual disability 41 | 1,016
pediatric high grade glioma 41 | 1,064
cutaneous lupus erythematosus 40 | 1,057
active Crohn's disease 39 | 922
Liver cancer 38 | 604
Melanoma 38 | 711
Multiple Sclerosis 37 | 540
Multiple myeloma 37 | 1,332
astrocytoma 35 | 1,146
gastric carcinoma 35 | 807
Epilepsy 34 | 792
primary pancreatic ductal adenocarcinoma 33 | 1,109
active ulcerative colitis 32 | 764
acute quadriplegic myopathy 31 | 1,158
fibroadenoma 31 | 559
non primary Sjogren syndrome sicca 31 | 891
Obesity 30 | 678
Skin cancer 29 | 469
dermatomyositis 29 | 966
medulloblastoma 29 | 720
Alzheimer's disease 28 | 658
Autistic Disorder 28 | 364
acute myeloid leukemia 28 | 783
Acquired metabolic disease 27 | 336
juvenile dermatomyositis 27 | 1,187
primary Sjogren syndrome 27 | 735
Type 2 diabetes mellitus 26 | 272
Crohn's disease 25 | 321
Dull intelligence 25 | 645
Low intelligence 25 | 645
Mental Retardation 25 | 645
Mental deficiency 25 | 645
Poor school performance 25 | 645
Seizures 25 | 596
Attention deficit hyperactivity disorder 24 | 278
aldosterone-producing adenoma 24 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 24 | 510
Duchenne muscular dystrophy 23 | 601
Endometrial cancer 23 | 311
Mental Depression 23 | 333
esophageal adenocarcinoma 23 | 737
progressive supranuclear palsy 23 | 676
Endometriosis 22 | 540
Liver Cirrhosis, Experimental 22 | 769
Osteoporosis 22 | 363
Vascular disease 22 | 319
Asthma 21 | 385
Muscle hypotonia 21 | 571
Short stature 21 | 531
Parkinson's disease 20 | 392
Prostatic Neoplasms 20 | 495
pancreatic carcinoma 20 | 562

Tissue

Endocrine System 546 | 18,159
Female tissues 535 | 17,400
Digestive Tract 530 | 17,369
Male tissues 523 | 17,142
Skin and soft tissues 522 | 17,230
Nervous System 517 | 16,725
Urinary Tract 517 | 16,678
Blood and immune system 510 | 16,909
Liver and Pancreas 510 | 16,750
Respiratory system 500 | 16,393
Cardiovascular System 468 | 15,192

Target Family

Non-IDG 319 | 12,091
Enzyme 123 | 4,145
Transcription Factor 35 | 1,400
Kinase 26 | 634
Ion Channel 22 | 344
Transporter 16 | 473
GPCR 12 | 408
Epigenetic 7 | 242
oGPCR 7 | 421
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

GWAS Trait

Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein NipSnap homolog 3B NIPSNAP3B Tbio Non-IDG -1.06487 11.0 103
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Cytochrome c oxidase assembly protein COX15 homolog COX15 Tbio Enzyme -1.37513 23.0 104
Cysteine sulfinic acid decarboxylase CSAD Tbio Enzyme -2.16604 143.8 134
Zinc finger protein 446 ZNF446 Tdark Transcription Factor 0.09 1.28 80
Fibrocystin-L PKHD1L1 Tdark Non-IDG -0.48112 3.05 17
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Achaete-scute homolog 2 ASCL2 Tbio Transcription Factor -1.84293 66.0 190
Transcription factor-like 5 protein TCFL5 Tbio Transcription Factor -2.62447 404.7 161
Heparan sulfate glucosamine 3-O-sulfotransferase 4 HS3ST4 Tdark Enzyme -0.45852 2.98 18