Development Level

Tbio 119 | 11,445
Tdark 28 | 6,588
Tchem 23 | 1,598
Tclin 10 | 613

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Complete... 1 | 25
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 16 | 979
preweaning lethality, incomple... 9 | 499
abnormal bone structure 7 | 187
abnormal behavior 5 | 298
abnormal seminal vesicle morph... 5 | 114
enlarged heart 5 | 210
abnormal testis morphology 4 | 43
decreased body weight 4 | 161
increased bone mineral content 4 | 108
increased fasted circulating g... 4 | 76
small testis 4 | 58
abnormal heart morphology 3 | 162
decreased body length 3 | 101
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased lean body mass 3 | 135
embryonic lethality prior to t... 3 | 278
increased bone mineral density 3 | 72
increased lean body mass 3 | 172
small superior vagus ganglion 3 | 74
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo size 2 | 220
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
anophthalmia 2 | 33
cataract 2 | 92
decreased circulating calcium ... 2 | 36
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
enlarged epididymis 2 | 31
enlarged uterus 2 | 11
hydrometra 2 | 53
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
male infertility 2 | 123
microphthalmia 2 | 26
polycystic kidney 2 | 15
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal lens morphology 1 | 81
abnormal lip morphology 1 | 2
abnormal liver morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal rib morphology 1 | 10
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
absent startle reflex 1 | 24
corneal opacity 1 | 32
decreased anxiety-related resp... 1 | 12
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged cecum 1 | 5
enlarged spleen 1 | 41
female infertility 1 | 60
hydroencephaly 1 | 14
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased exploration in new e... 1 | 8
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
irregularly shaped pupil 1 | 7
long tibia 1 | 25
persistence of hyaloid vascula... 1 | 33
shortened RR interval 1 | 17
small spleen 1 | 19
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

Carcinoma 138 | 11,493
ovarian cancer 101 | 8,520
glioblastoma 96 | 5,792
medulloblastoma, large-cell 95 | 6,241
atypical teratoid / rhabdoid tumor 85 | 5,112
osteosarcoma 82 | 7,950
ependymoma 74 | 4,679
psoriasis 73 | 6,694
adult high grade glioma 65 | 3,801
group 3 medulloblastoma 60 | 4,104
Astrocytoma, Pilocytic 59 | 3,081
lung cancer 56 | 4,740
oligodendroglioma 54 | 2,850
Kidney cancer 51 | 2,613
astrocytic glioma 48 | 2,597
primitive neuroectodermal tumor 46 | 3,035
Breast cancer 42 | 3,578
lung carcinoma 42 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
invasive ductal carcinoma 39 | 2,951
subependymal giant cell astrocytoma 37 | 2,287
Pick disease 35 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,989
malignant mesothelioma 32 | 3,232
lung adenocarcinoma 31 | 2,716
Schizophrenia 30 | 1,160
non-small cell lung cancer 30 | 2,890
pancreatic cancer 30 | 2,398
pituitary cancer 29 | 1,972
tuberculosis 27 | 2,010
interstitial cystitis 24 | 2,312
Cancer 23 | 2,499
group 4 medulloblastoma 23 | 1,855
ulcerative colitis 23 | 1,819
Melanoma 21 | 711
breast carcinoma 20 | 1,638
Intellectual disability 19 | 1,016
ductal carcinoma in situ 19 | 1,745
Rheumatoid arthritis 18 | 1,191
adrenocortical carcinoma 18 | 1,428
astrocytoma 18 | 1,146
diabetes mellitus 18 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
Bipolar Disorder 16 | 666
colon cancer 16 | 1,478
cystic fibrosis 15 | 1,696
pediatric high grade glioma 15 | 1,064
Alzheimer's disease 14 | 658
Liver cancer 14 | 604
Skin cancer 14 | 469
Depressive disorder 13 | 409
juvenile dermatomyositis 13 | 1,187
non primary Sjogren syndrome sicca 13 | 891
spina bifida 13 | 1,074
Alcoholic Intoxication, Chronic 12 | 289
Autistic Disorder 12 | 364
Epilepsy 12 | 792
Obesity 12 | 678
Parkinson's disease 12 | 392
medulloblastoma 12 | 720
primary pancreatic ductal adenocarcinoma 12 | 1,109
Multiple myeloma 11 | 1,332
Acquired metabolic disease 10 | 336
active Crohn's disease 10 | 922
acute myeloid leukemia 10 | 783
acute quadriplegic myopathy 10 | 1,158
chronic rhinosinusitis 10 | 512
pancreatic carcinoma 10 | 562
substance-related disorder 10 | 162
Autosomal recessive predisposition 9 | 1,442
Cognitive disorder 9 | 50
Down syndrome 9 | 499
Type 2 diabetes mellitus 9 | 272
cutaneous lupus erythematosus 9 | 1,057
gastric carcinoma 9 | 807
Attention deficit hyperactivity disorder 8 | 278
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Muscle hypotonia 8 | 571
Osteoporosis 8 | 363
Seizures 8 | 596
dermatomyositis 8 | 966
interstitial lung disease 8 | 298
nasopharyngeal carcinoma 8 | 1,058
posterior fossa group A ependymoma 8 | 468
progressive supranuclear palsy 8 | 676
Atopic dermatitis 7 | 952
Chronic obstructive pulmonary disease 7 | 184
Crohn's disease 7 | 321
Endometriosis 7 | 540
Mental Depression 7 | 333
Multiple Sclerosis 7 | 540
Polycystic ovary syndrome 7 | 360
Waldenstrons macroglobulinemia 7 | 765
aldosterone-producing adenoma 7 | 665
esophageal adenocarcinoma 7 | 737
gastric cancer 7 | 459
primary Sjogren syndrome 7 | 735

Tissue

Endocrine System 177 | 18,159
Female tissues 172 | 17,400
Skin and soft tissues 172 | 17,230
Male tissues 170 | 17,142
Nervous System 170 | 16,725
Digestive Tract 168 | 17,369
Urinary Tract 166 | 16,678
Liver and Pancreas 165 | 16,750
Blood and immune system 163 | 16,909
Respiratory system 160 | 16,393
Cardiovascular System 151 | 15,192

Target Family

Non-IDG 95 | 12,091
Enzyme 36 | 4,145
Transcription Factor 15 | 1,400
Kinase 9 | 634
Ion Channel 8 | 344
Epigenetic 6 | 242
GPCR 6 | 408
Transporter 4 | 473
Nuclear Receptor 1 | 48

GWAS Trait

Neuroticism 180 | 180
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
Nuclear pore complex protein Nup160 NUP160 Tbio Non-IDG -1.13177 13.6 169
RNA-binding protein Nova-2 NOVA2 Tbio Non-IDG -1.57921 37.5 137
Caspase recruitment domain-containing protein 11 CARD11 Tbio Enzyme -2.17228 139.2 235
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Mitochondrial peptide methionine sulfoxide reductase MSRA Tbio Enzyme -1.92325 88.1 167
FERM, ARHGEF and pleckstrin domain-containing protein 1 FARP1 Tbio Non-IDG -1.56544 38.3 153
General transcription factor II-I repeat domain-containing protein 1 GTF2IRD1 Tbio Transcription Factor -1.74692 0.00000 281
Malignant fibrous histiocytoma-amplified sequence 1 MFHAS1 Tbio Non-IDG -0.75963 7.87 9