Development Level

Tbio 81 | 11,445
Tchem 21 | 1,598
Tdark 18 | 6,588
Tclin 13 | 613

Collection

Kinase: IDG Consortium (Target... 4 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

decreased circulating glucose ... 4 | 126
preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 4 | 499
decreased body weight 3 | 161
decreased circulating chloride... 3 | 30
decreased lean body mass 3 | 135
hypoactivity 3 | 132
improved glucose tolerance 3 | 79
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
anophthalmia 2 | 33
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
hyperactivity 2 | 148
increased circulating alanine ... 2 | 13
increased circulating calcium ... 2 | 34
increased circulating potassiu... 2 | 29
increased circulating total pr... 2 | 28
increased fasted circulating g... 2 | 76
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
microphthalmia 2 | 26
thrombocytopenia 2 | 56
abnormal craniofacial morpholo... 1 | 33
abnormal facial morphology 1 | 17
abnormal forebrain morphology 1 | 10
abnormal head shape 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal locomotor behavior 1 | 24
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased B cell number 1 | 9
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased heart rate 1 | 23
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
irregularly shaped pupil 1 | 7
limb grasping 1 | 41
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
tremors 1 | 39
trunk curl 1 | 16
vertebral transformation 1 | 12

Disease

Carcinoma 91 | 11,493
osteosarcoma 74 | 7,950
ovarian cancer 73 | 8,520
glioblastoma 59 | 5,792
psoriasis 59 | 6,694
medulloblastoma, large-cell 53 | 6,241
lung cancer 48 | 4,740
lung carcinoma 45 | 2,843
Cancer 41 | 2,499
atypical teratoid / rhabdoid tumor 41 | 5,112
non-small cell lung cancer 41 | 2,890
tuberculosis 39 | 2,010
pancreatic cancer 38 | 2,398
adult high grade glioma 37 | 3,801
ependymoma 37 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,291
invasive ductal carcinoma 34 | 2,951
lung adenocarcinoma 34 | 2,716
Rheumatoid arthritis 33 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,989
Breast cancer 30 | 3,578
interstitial cystitis 30 | 2,312
Astrocytoma, Pilocytic 29 | 3,081
group 3 medulloblastoma 28 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
ulcerative colitis 27 | 1,819
cystic fibrosis 26 | 1,696
subependymal giant cell astrocytoma 25 | 2,287
primitive neuroectodermal tumor 24 | 3,035
group 4 medulloblastoma 23 | 1,855
Kidney cancer 22 | 2,613
diabetes mellitus 22 | 1,728
malignant mesothelioma 22 | 3,232
ductal carcinoma in situ 18 | 1,745
juvenile dermatomyositis 18 | 1,187
breast carcinoma 17 | 1,638
cutaneous lupus erythematosus 16 | 1,057
mucosa-associated lymphoid tissue lymphoma 16 | 484
pituitary cancer 16 | 1,972
primary Sjogren syndrome 16 | 735
colon cancer 15 | 1,478
oligodendroglioma 15 | 2,850
Anemia 14 | 365
Multiple myeloma 14 | 1,332
Pick disease 14 | 1,894
astrocytic glioma 14 | 2,597
dermatomyositis 14 | 966
Autosomal recessive predisposition 13 | 1,442
Intellectual disability 13 | 1,016
Type 2 diabetes mellitus 13 | 272
active Crohn's disease 13 | 922
acute myeloid leukemia 13 | 783
spina bifida 13 | 1,074
Acquired metabolic disease 12 | 336
Arthritis, Rheumatoid 12 | 174
Asthma 12 | 385
Atherosclerosis 12 | 291
Coronary artery disease 12 | 268
Crohn's disease 12 | 321
Kidney disease 12 | 430
adrenocortical carcinoma 12 | 1,428
astrocytoma 12 | 1,146
esophageal adenocarcinoma 12 | 737
Atopic dermatitis 11 | 952
Bipolar Disorder 11 | 666
Multiple Sclerosis 11 | 540
Obesity 11 | 678
Prostatic Neoplasms 11 | 495
active ulcerative colitis 11 | 764
acute quadriplegic myopathy 11 | 1,158
gastric carcinoma 11 | 807
pediatric high grade glioma 11 | 1,064
Arthritis 10 | 290
Dull intelligence 10 | 645
Hypersensitivity reaction type II disease 10 | 253
Low intelligence 10 | 645
Melanoma 10 | 711
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
Waldenstrons macroglobulinemia 10 | 765
non primary Sjogren syndrome sicca 10 | 891
non-small cell lung carcinoma 10 | 317
pancreatic carcinoma 10 | 562
periodontitis 10 | 293
Alzheimer's disease 9 | 658
Breast Neoplasms 9 | 445
Duchenne muscular dystrophy 9 | 601
Hypertension 9 | 396
Mammary Neoplasms 9 | 425
Neutropenia 9 | 72
gastric cancer 9 | 459
hepatocellular carcinoma 9 | 547
Heart disease 8 | 306
Lung disease 8 | 142
Muscle hypotonia 8 | 571
Schizophrenia 8 | 1,160
medulloblastoma 8 | 720
primary pancreatic ductal adenocarcinoma 8 | 1,109

Tissue

Endocrine System 129 | 18,159
Digestive Tract 128 | 17,369
Blood and immune system 127 | 16,909
Female tissues 127 | 17,400
Nervous System 127 | 16,725
Respiratory system 127 | 16,393
Skin and soft tissues 127 | 17,230
Liver and Pancreas 126 | 16,750
Urinary Tract 126 | 16,678
Male tissues 125 | 17,142
Cardiovascular System 120 | 15,192

Target Family

Non-IDG 68 | 12,091
Enzyme 29 | 4,145
Kinase 13 | 634
Transcription Factor 8 | 1,400
GPCR 7 | 408
Transporter 5 | 473
Epigenetic 2 | 242
Nuclear Receptor 1 | 48

GWAS Trait

Myeloid white cell count 133 | 133
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Solute carrier family 45 member 4 SLC45A4 Tdark Transporter 0.30 0.50 12
Solute carrier family 12 member 7 SLC12A7 Tbio Transporter -1.46102 28.2 156
5-hydroxytryptamine receptor 4 HTR4 Tclin GPCR -2.87235 796.4 248
Chondroitin sulfate synthase 1 CHSY1 Tbio Enzyme -1.69082 48.5 101
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.29685 1936.6 519
GTP:AMP phosphotransferase AK3, mitochondrial AK3 Tbio Kinase -1.37969 23.5 249
Polycomb group RING finger protein 3 PCGF3 Tdark Non-IDG -0.48328 1.97 115
TBC1 domain family member 8 TBC1D8 Tdark Non-IDG 0.21 0.48 69
Histo-blood group ABO system transferase ABO Tbio Enzyme 0.00000 0
Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 Tbio Enzyme -1.02570 11.0 0