Development Level

Tbio 82 | 11,445
Tchem 19 | 1,598
Tdark 18 | 6,588
Tclin 5 | 613

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased vertical activity 5 | 208
abnormal embryo size 4 | 220
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
abnormal spleen morphology 3 | 55
enlarged heart 3 | 210
improved glucose tolerance 3 | 79
increased heart rate 3 | 23
increased lymphocyte cell numb... 3 | 32
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
abnormal testis morphology 2 | 43
decreased bone mineral content 2 | 151
decreased circulating insulin ... 2 | 76
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
embryonic lethality prior to o... 2 | 239
enlarged lymph nodes 2 | 37
enlarged spleen 2 | 41
hypoactivity 2 | 132
increased basophil cell number 2 | 7
increased eosinophil cell numb... 2 | 11
increased leukocyte cell numbe... 2 | 47
increased total body fat amoun... 2 | 134
prenatal lethality prior to he... 2 | 87
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal colon morphology 1 | 3
abnormal duodenum morphology 1 | 4
abnormal epididymis morphology 1 | 42
abnormal eye anterior chamber ... 1 | 9
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal head shape 1 | 10
abnormal limb morphology 1 | 13
abnormal outer ear morphology 1 | 3
abnormal response to tactile s... 1 | 17
abnormal retinal vasculature m... 1 | 27
abnormal skin appearance 1 | 3
abnormal vertebrae morphology 1 | 18
absent pinna reflex 1 | 23
cataract 1 | 92
cyanosis 1 | 7
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased KLRG1+ CD8 alpha bet... 1 | 2
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased monocyte cell number 1 | 8
edema 1 | 59
enlarged epididymis 1 | 31
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
increased B cell number 1 | 9
increased body length 1 | 32
increased caudal vertebrae num... 1 | 7
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 36
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
limb grasping 1 | 41
pallor 1 | 34
short tibia 1 | 97
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74
small testis 1 | 58
syndactyly 1 | 23
thick ventricular wall 1 | 7
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

Carcinoma 93 | 11,493
Multiple Sclerosis 83 | 540
ovarian cancer 67 | 8,520
osteosarcoma 65 | 7,950
psoriasis 57 | 6,694
glioblastoma 50 | 5,792
medulloblastoma, large-cell 48 | 6,241
lung cancer 38 | 4,740
atypical teratoid / rhabdoid tumor 34 | 5,112
adult high grade glioma 31 | 3,801
ependymoma 29 | 4,679
group 3 medulloblastoma 29 | 4,104
Breast cancer 26 | 3,578
Cancer 26 | 2,499
interstitial cystitis 26 | 2,312
lung carcinoma 26 | 2,843
malignant mesothelioma 25 | 3,232
Kidney cancer 24 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
non-small cell lung cancer 24 | 2,890
Astrocytoma, Pilocytic 22 | 3,081
primitive neuroectodermal tumor 22 | 3,035
ulcerative colitis 22 | 1,819
invasive ductal carcinoma 21 | 2,951
subependymal giant cell astrocytoma 21 | 2,287
Rheumatoid arthritis 20 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
pancreatic cancer 20 | 2,398
pituitary cancer 20 | 1,972
tuberculosis 20 | 2,010
astrocytic glioma 19 | 2,597
lung adenocarcinoma 19 | 2,716
oligodendroglioma 19 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
Crohn's disease 17 | 321
group 4 medulloblastoma 17 | 1,855
Pick disease 16 | 1,894
cystic fibrosis 16 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
primary Sjogren syndrome 15 | 735
Celiac disease 14 | 116
Melanoma 14 | 711
Asthma 13 | 385
cutaneous lupus erythematosus 13 | 1,057
diabetes mellitus 13 | 1,728
Atopic dermatitis 12 | 952
astrocytoma 12 | 1,146
Hypersensitivity reaction type II disease 11 | 253
Skin cancer 10 | 469
breast carcinoma 10 | 1,638
pediatric high grade glioma 10 | 1,064
Autosomal recessive predisposition 9 | 1,442
Primary biliary cirrhosis 9 | 51
Schizophrenia 9 | 1,160
adrenocortical carcinoma 9 | 1,428
gastric carcinoma 9 | 807
juvenile dermatomyositis 9 | 1,187
non primary Sjogren syndrome sicca 9 | 891
pancreatic carcinoma 9 | 562
Vascular disease 8 | 319
ductal carcinoma in situ 8 | 1,745
esophageal adenocarcinoma 8 | 737
sarcoidosis 8 | 370
Alzheimer's disease 7 | 658
Arthritis 7 | 290
Bipolar Disorder 7 | 666
Liver Cirrhosis, Experimental 7 | 769
Liver cancer 7 | 604
active Crohn's disease 7 | 922
acute myeloid leukemia 7 | 783
acute quadriplegic myopathy 7 | 1,158
nasopharyngeal carcinoma 7 | 1,058
periodontitis 7 | 293
primary pancreatic ductal adenocarcinoma 7 | 1,109
progressive supranuclear palsy 7 | 676
Acquired metabolic disease 6 | 336
Human immunodeficiency virus infectious disease 6 | 138
Kidney disease 6 | 430
Multiple myeloma 6 | 1,332
Parkinson's disease 6 | 392
Type 1 diabetes mellitus 6 | 109
Waldenstrons macroglobulinemia 6 | 765
colon cancer 6 | 1,478
Arthritis, Rheumatoid 5 | 174
Atherosclerosis 5 | 291
Dermatitis 5 | 157
Dull intelligence 5 | 645
Inflammatory bowel disease 5 | 151
Low intelligence 5 | 645
Mental deficiency 5 | 645
Neurodegenerative disease 5 | 414
Poor school performance 5 | 645
Type 2 diabetes mellitus 5 | 272
active ulcerative colitis 5 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
dermatomyositis 5 | 966
fibroadenoma 5 | 559
gastric cancer 5 | 459
medulloblastoma 5 | 720
nephrosclerosis 5 | 333

Tissue

Endocrine System 119 | 18,159
Digestive Tract 117 | 17,369
Skin and soft tissues 116 | 17,230
Blood and immune system 115 | 16,909
Female tissues 115 | 17,400
Male tissues 115 | 17,142
Liver and Pancreas 114 | 16,750
Urinary Tract 112 | 16,678
Nervous System 111 | 16,725
Cardiovascular System 110 | 15,192
Respiratory system 110 | 16,393

Target Family

Non-IDG 75 | 12,091
Enzyme 20 | 4,145
Transcription Factor 14 | 1,400
Kinase 7 | 634
GPCR 3 | 408
Epigenetic 2 | 242
Transporter 2 | 473
TF/Epigenetic 1 | 38

GWAS Trait

Multiple sclerosis 124 | 124
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Butyrophilin-like protein 2 BTNL2 Tbio Non-IDG -2.57312 369.3 73
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 DDAH1 Tchem Enzyme -2.13636 144.4 205
von Willebrand factor A domain-containing protein 8 VWA8 Tbio Non-IDG -0.36798 2.42 8
Eomesodermin homolog EOMES Tbio Transcription Factor -2.37902 230.4 333
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 ASAP1 Tbio Non-IDG -1.76454 62.6 183
NEDD4 family-interacting protein 1 NDFIP1 Tbio Non-IDG -1.24333 24.3 147
CUB and sushi domain-containing protein 1 CSMD1 Tbio Non-IDG -1.68684 47.7 0
Outer dense fiber protein 3B ODF3B Tdark Non-IDG 0.11 0.63 66
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
Tyrosine-protein kinase Mer MERTK Tchem Kinase -2.27276 199.1 609