Development Level

Tbio 28 | 11,178
Tchem 13 | 1,885
Tclin 5 | 612
Tdark 5 | 6,569

Collection

GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal locomotor behavior 2 | 24
abnormal seminal vesicle morph... 2 | 114
hypoactivity 2 | 132
increased mean corpuscular vol... 2 | 92
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal testis morphology 1 | 43
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged liver 1 | 2
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased caudal vertebrae num... 1 | 7
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
prolonged ST segment 1 | 36
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytopenia 1 | 56
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 38 | 11,192
psoriasis 25 | 6,514
osteosarcoma 19 | 7,766
ovarian cancer 15 | 8,297
Cancer 14 | 2,388
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,911
diabetes mellitus 13 | 1,683
lung cancer 13 | 4,607
ependymoma 12 | 4,559
Anemia 10 | 353
Astrocytoma, Pilocytic 10 | 3,006
Obesity 10 | 655
cystic fibrosis 10 | 1,629
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,902
Autosomal recessive predisposition 9 | 1,407
Bilirubin metabolic disorder 9 | 41
glioblastoma 9 | 5,635
malignant mesothelioma 9 | 3,135
non-small cell lung cancer 9 | 2,799
Cardiovascular system disease 8 | 240
Rheumatoid arthritis 8 | 1,156
Sickle Cell Anemia 8 | 50
group 3 medulloblastoma 8 | 4,002
interstitial cystitis 8 | 2,237
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,204
lung carcinoma 8 | 2,755
medulloblastoma, large-cell 8 | 6,086
oligodendroglioma 8 | 2,768
Acquired metabolic disease 7 | 329
Atherosclerosis 7 | 276
Metabolic syndrome X 7 | 52
Pericholangitis 7 | 8
Schizophrenia 7 | 1,136
Type 2 diabetes mellitus 7 | 268
adult high grade glioma 7 | 3,701
atypical teratoid / rhabdoid tumor 7 | 4,971
lung adenocarcinoma 7 | 2,627
primitive neuroectodermal tumor 7 | 2,957
Breast cancer 6 | 3,469
Crohn's disease 6 | 311
Epilepsy 6 | 775
Gout 6 | 103
Hyperglycemia 6 | 134
Hypertension 6 | 372
Lipid metabolism disorder 6 | 111
Liver cancer 6 | 589
astrocytic glioma 6 | 2,530
invasive ductal carcinoma 6 | 2,867
pancreatic cancer 6 | 2,322
subependymal giant cell astrocytoma 6 | 2,230
tuberculosis 6 | 1,963
ulcerative colitis 6 | 1,765
Atopic dermatitis 5 | 915
Attention deficit hyperactivity disorder 5 | 272
Coronary artery disease 5 | 253
Diabetes Mellitus, Non-Insulin-Dependent 5 | 140
Hyperinsulinism 5 | 128
Hypertensive disease 5 | 278
Kidney cancer 5 | 2,548
Kidney disease 5 | 411
Liver Cirrhosis, Experimental 5 | 733
Polycystic ovary syndrome 5 | 348
Seizures 5 | 584
Vascular disease 5 | 294
Vomiting 5 | 116
active ulcerative colitis 5 | 736
cutaneous lupus erythematosus 5 | 1,016
ductal carcinoma in situ 5 | 1,686
nasopharyngeal carcinoma 5 | 1,024
Breast Neoplasms 4 | 423
Diabetes Mellitus, Type 2 4 | 136
Fatty liver disease 4 | 102
Heart disease 4 | 288
Hypertriglyceridemia 4 | 17
Hyperuricemia 4 | 47
Mammary Neoplasms 4 | 403
Pick disease 4 | 1,856
Prostatic Neoplasms 4 | 472
Thrombocytopenia 4 | 193
active Crohn's disease 4 | 882
adrenocortical carcinoma 4 | 1,385
aldosterone-producing adenoma 4 | 646
colon cancer 4 | 1,428
pituitary cancer 4 | 1,915
spina bifida 4 | 1,053
Alzheimer's disease 3 | 640
Bipolar Disorder 3 | 646
Cardiovascular Diseases 3 | 57
Diarrhea 3 | 245
Disease of metabolism 3 | 17
Hepatomegaly 3 | 280
Melanoma 3 | 689
Myopathy 3 | 185
Neonatal Jaundice 3 | 30
acute quadriplegic myopathy 3 | 1,133
astrocytoma 3 | 1,113
breast carcinoma 3 | 1,589
chronic rhinosinusitis 3 | 505
dermatomyositis 3 | 941

Tissue

Liver and Pancreas 50 | 16,750
Digestive Tract 49 | 17,369
Skin and soft tissues 48 | 17,230
Urinary Tract 48 | 16,678
Endocrine System 46 | 18,159
Female tissues 45 | 17,400
Male tissues 44 | 17,142
Blood and immune system 43 | 16,909
Nervous System 42 | 16,725
Respiratory system 38 | 16,393
Cardiovascular System 37 | 15,192

Target Family

Enzyme 28 | 4,145
Non-IDG 12 | 12,091
Transporter 7 | 473
GPCR 1 | 408
Ion Channel 1 | 344
Kinase 1 | 634
Transcription Factor 1 | 1,400

GWAS Trait

Metabolic traits 51 | 51
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pantothenate kinase 1 PANK1 Tbio Kinase -1.80926 56.9 188
Polycystic kidney disease 2-like 1 protein PKD2L1 Tbio Ion Channel -1.95186 96.8 100
Carbamoyl-phosphate synthase [ammonia], mitochondrial CPS1 Tclin Enzyme -2.28267 188.9 238
UDP-glucuronosyltransferase 1-7 UGT1A7 Tbio Enzyme -1.87803 74.6 24
UDP-glucuronosyltransferase 1-8 UGT1A8 Tbio Enzyme -1.68933 43.9 5
Hepatocyte nuclear factor 1-alpha HNF1A Tbio Transcription Factor -2.87439 680.9 0
Glucose-6-phosphatase 2 G6PC2 Tbio Enzyme -1.88404 87.7 44
DNA polymerase zeta catalytic subunit REV3L Tbio Enzyme -2.20108 158.5 41
Cytochrome P450 4A11 CYP4A11 Tbio Non-IDG -1.97180 93.7 142
D-3-phosphoglycerate dehydrogenase PHGDH Tbio Enzyme -3.17330 1408.2 293