Development Level

Tbio 41 | 11,445
Tdark 12 | 6,588
Tchem 5 | 1,598
Tclin 1 | 613

Collection

GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
hyperactivity 3 | 148
preweaning lethality, complete... 3 | 979
abnormal embryo size 2 | 220
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased circulating serum al... 2 | 82
decreased lean body mass 2 | 135
increased circulating alkaline... 2 | 122
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal limb bud morphology 1 | 17
abnormal maxilla morphology 1 | 17
abnormal nail morphology 1 | 8
abnormal pelvic girdle bone mo... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal placenta morphology 1 | 5
abnormal seminal vesicle morph... 1 | 114
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
abnormal zygomatic bone morpho... 1 | 3
cardiovascular system phenotyp... 1 | 36
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased anxiety-related resp... 1 | 12
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased fluid intake 1 | 3
decreased granulocyte number 1 | 6
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lumbar vertebrae num... 1 | 2
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
hypoactivity 1 | 132
increased body length 1 | 32
increased caudal vertebrae num... 1 | 7
increased circulating choleste... 1 | 66
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

Carcinoma 43 | 11,493
osteosarcoma 33 | 7,950
ovarian cancer 30 | 8,520
medulloblastoma, large-cell 24 | 6,241
psoriasis 24 | 6,694
glioblastoma 22 | 5,792
group 3 medulloblastoma 22 | 4,104
Breast cancer 20 | 3,578
lung cancer 19 | 4,740
ependymoma 17 | 4,679
Kidney cancer 16 | 2,613
atypical teratoid / rhabdoid tumor 16 | 5,112
primitive neuroectodermal tumor 16 | 3,035
malignant mesothelioma 15 | 3,232
invasive ductal carcinoma 14 | 2,951
non-small cell lung cancer 13 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
pancreatic cancer 11 | 2,398
astrocytic glioma 10 | 2,597
ductal carcinoma in situ 10 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
lung adenocarcinoma 10 | 2,716
oligodendroglioma 10 | 2,850
adult high grade glioma 9 | 3,801
breast carcinoma 9 | 1,638
Astrocytoma, Pilocytic 8 | 3,081
Cancer 8 | 2,499
cystic fibrosis 8 | 1,696
interstitial cystitis 8 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung carcinoma 8 | 2,843
colon cancer 7 | 1,478
group 4 medulloblastoma 7 | 1,855
pediatric high grade glioma 7 | 1,064
subependymal giant cell astrocytoma 7 | 2,287
Autosomal recessive predisposition 6 | 1,442
Pick disease 6 | 1,894
Intellectual disability 5 | 1,016
Muscle hypotonia 5 | 571
Schizophrenia 5 | 1,160
adrenocortical carcinoma 5 | 1,428
aldosterone-producing adenoma 5 | 665
juvenile dermatomyositis 5 | 1,187
nasopharyngeal carcinoma 5 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
primary Sjogren syndrome 5 | 735
progressive supranuclear palsy 5 | 676
tuberculosis 5 | 2,010
Depressive disorder 4 | 409
Dull intelligence 4 | 645
Endometrial cancer 4 | 311
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple myeloma 4 | 1,332
Poor school performance 4 | 645
acute quadriplegic myopathy 4 | 1,158
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109
ulcerative colitis 4 | 1,819
Abdominal Pain 3 | 98
Attention deficit hyperactivity disorder 3 | 278
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 3 | 13
Cerebellar Ataxia 3 | 304
Congenital pes cavus 3 | 88
Constipation 3 | 181
Decreased tendon reflex 3 | 122
Deglutition Disorders 3 | 132
Distal sensory impairment 3 | 52
Dyschezia 3 | 135
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Highly variable clinical phenotype 3 | 150
Highly variable phenotype and severity 3 | 150
Highly variable phenotype, even within families 3 | 150
Lynch syndrome 3 | 35
Neurodegenerative disease 3 | 414
Neuropathy 3 | 261
Pediatric failure to thrive 3 | 365
Phenotypic variability 3 | 150
Premature Menopause 3 | 31
Premature ovarian failure 3 | 65
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Small head 3 | 374
Waldenstrons macroglobulinemia 3 | 765
cutaneous lupus erythematosus 3 | 1,057
medulloblastoma 3 | 720
non primary Sjogren syndrome sicca 3 | 891
spina bifida 3 | 1,074
Adenoid Cystic Carcinoma 2 | 99
Concave bridge of nose 2 | 195
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Hepatomegaly 2 | 285
Melanoma 2 | 711
Multiple Sclerosis 2 | 540
Schizoaffective Disorder 2 | 55
Secondary physiologic amenorrhea 2 | 32
tuberculosis and treatment for 3 months 2 | 179

Tissue

Endocrine System 59 | 18,159
Female tissues 58 | 17,400
Urinary Tract 58 | 16,678
Blood and immune system 57 | 16,909
Digestive Tract 57 | 17,369
Male tissues 57 | 17,142
Liver and Pancreas 56 | 16,750
Nervous System 56 | 16,725
Respiratory system 56 | 16,393
Skin and soft tissues 56 | 17,230
Cardiovascular System 53 | 15,192

Target Family

Non-IDG 31 | 12,091
Enzyme 16 | 4,145
Epigenetic 4 | 242
Kinase 3 | 634
Transcription Factor 2 | 1,400
Transporter 2 | 473
GPCR 1 | 408

GWAS Trait

Menopause (age at onset) 59 | 59
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rhomboid-related protein 2 RHBDL2 Tbio Enzyme -0.71201 6.19 56
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A GSPT1 Tbio Enzyme -1.35573 22.8 99
Adhesion G protein-coupled receptor A2 ADGRA2 Tbio GPCR -1.45203 30.0 211
Leucine-rich repeat neuronal protein 4 LRRN4 Tdark Non-IDG -0.29273 2.21 123
Glutamate receptor-interacting protein 1 GRIP1 Tbio Non-IDG -2.18570 152.7 157
Protein BANP BANP Tbio Non-IDG -1.67812 53.3 92
DNA mismatch repair protein Msh6 MSH6 Tbio Epigenetic -2.72594 572.3 479
Membrane-associated phosphatidylinositol transfer protein 2 PITPNM2 Tdark Non-IDG -0.73640 4.35 66
Modulator of macroautophagy TMEM150B TMEM150B Tdark Non-IDG -0.08659 0.99 50
NF-kappa-B inhibitor-like protein 1 NFKBIL1 Tbio Non-IDG -1.41875 29.3 137