Development Level

Tbio 80 | 11,445
Tdark 21 | 6,588
Tchem 17 | 1,598
Tclin 4 | 613

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
abnormal cornea morphology 2 | 31
abnormal epididymis morphology 2 | 42
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
abnormal spleen morphology 2 | 55
decreased body length 2 | 101
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating aspartat... 2 | 34
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased total body fat amoun... 2 | 207
increased circulating HDL chol... 2 | 80
increased or absent threshold ... 2 | 101
long tibia 2 | 25
male infertility 2 | 123
preweaning lethality, complete... 2 | 979
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal allantois morphology 1 | 8
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart looping 1 | 5
abnormal hindbrain development 1 | 16
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal skin morphology 1 | 50
abnormal somite shape 1 | 5
abnormal tail bud morphology 1 | 8
abnormal tail movements 1 | 12
abnormal tibia morphology 1 | 14
abnormal visceral yolk sac mor... 1 | 6
absent pinna reflex 1 | 23
cataract 1 | 92
corneal opacity 1 | 32
decreased KLRG1+ CD8 alpha bet... 1 | 2
decreased body weight 1 | 161
decreased cardiac muscle contr... 1 | 11
decreased circulating alanine ... 1 | 47
decreased circulating bilirubi... 1 | 19
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased lactate dehydrogenas... 1 | 16
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
female infertility 1 | 60
fused cornea and lens 1 | 5
hydroencephaly 1 | 14
hydrometra 1 | 53
hyperactivity 1 | 148
increased anti-nuclear antigen... 1 | 19
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 8
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased vertical activity 1 | 24
pale yolk sac 1 | 25
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
shortened RR interval 1 | 17
small kidney 1 | 16

Disease

Carcinoma 97 | 11,493
ovarian cancer 57 | 8,520
medulloblastoma, large-cell 56 | 6,241
osteosarcoma 53 | 7,950
glioblastoma 51 | 5,792
atypical teratoid / rhabdoid tumor 48 | 5,112
psoriasis 46 | 6,694
ependymoma 44 | 4,679
group 3 medulloblastoma 43 | 4,104
adult high grade glioma 36 | 3,801
primitive neuroectodermal tumor 35 | 3,035
Kidney cancer 34 | 2,613
Astrocytoma, Pilocytic 31 | 3,081
Breast cancer 31 | 3,578
lung cancer 30 | 4,740
malignant mesothelioma 29 | 3,232
oligodendroglioma 28 | 2,850
lung adenocarcinoma 24 | 2,716
pituitary cancer 24 | 1,972
astrocytic glioma 23 | 2,597
lung carcinoma 22 | 2,843
non-small cell lung cancer 22 | 2,890
subependymal giant cell astrocytoma 22 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
group 4 medulloblastoma 19 | 1,855
Cancer 18 | 2,499
invasive ductal carcinoma 18 | 2,951
Schizophrenia 17 | 1,160
pancreatic cancer 17 | 2,398
Obesity 16 | 678
Pick disease 16 | 1,894
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
interstitial cystitis 15 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
Acquired metabolic disease 13 | 336
colon cancer 13 | 1,478
diabetes mellitus 13 | 1,728
Intellectual disability 12 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Liver cancer 11 | 604
adrenocortical carcinoma 11 | 1,428
pediatric high grade glioma 11 | 1,064
Alzheimer's disease 10 | 658
Autistic Disorder 10 | 364
Melanoma 10 | 711
ulcerative colitis 10 | 1,819
Autosomal recessive predisposition 9 | 1,442
Bipolar Disorder 9 | 666
Depressive disorder 9 | 409
active Crohn's disease 9 | 922
acute myeloid leukemia 9 | 783
aldosterone-producing adenoma 9 | 665
breast carcinoma 9 | 1,638
cystic fibrosis 9 | 1,696
dermatomyositis 9 | 966
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
astrocytoma 8 | 1,146
esophageal adenocarcinoma 8 | 737
tuberculosis 8 | 2,010
Cognitive delay 7 | 608
Epilepsy 7 | 792
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
Osteoporosis 7 | 363
Parkinson's disease 7 | 392
Skin cancer 7 | 469
Barrett's esophagus 6 | 182
Breast Neoplasms 6 | 445
Endometrial cancer 6 | 311
Mammary Neoplasms 6 | 425
Muscle hypotonia 6 | 571
Seizures 6 | 596
Short stature 6 | 531
Type 2 diabetes mellitus 6 | 272
active ulcerative colitis 6 | 764
cutaneous lupus erythematosus 6 | 1,057
ductal carcinoma in situ 6 | 1,745
hepatocellular carcinoma 6 | 547
medulloblastoma 6 | 720
nasopharyngeal carcinoma 6 | 1,058
posterior fossa group B ependymoma 6 | 416
Alcoholic Intoxication, Chronic 5 | 289
Amyotrophic lateral sclerosis 5 | 451
Asthma 5 | 385
Attention deficit hyperactivity disorder 5 | 278
Diabetes Mellitus, Type 2 5 | 142
Mood Disorders 5 | 184
Multiple Sclerosis 5 | 540
Multiple myeloma 5 | 1,332
Substance-Related Disorders 5 | 115
juvenile dermatomyositis 5 | 1,187
non primary Sjogren syndrome sicca 5 | 891
posterior fossa group A ependymoma 5 | 468
spina bifida 5 | 1,074
Prostatic Neoplasms 4 | 495
primary Sjogren syndrome 4 | 735

Tissue

Endocrine System 117 | 18,159
Female tissues 112 | 17,400
Skin and soft tissues 112 | 17,230
Digestive Tract 111 | 17,369
Male tissues 109 | 17,142
Nervous System 109 | 16,725
Respiratory system 109 | 16,393
Urinary Tract 109 | 16,678
Liver and Pancreas 108 | 16,750
Blood and immune system 106 | 16,909
Cardiovascular System 101 | 15,192

Target Family

Non-IDG 63 | 12,091
Enzyme 23 | 4,145
Transcription Factor 11 | 1,400
Epigenetic 9 | 242
Nuclear Receptor 4 | 48
GPCR 3 | 408
Kinase 3 | 634
Ion Channel 2 | 344
Transporter 2 | 473
TF/Epigenetic 1 | 38
oGPCR 1 | 421

GWAS Trait

Menarche (age at onset) 122 | 122
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Coronary artery disease 367 | 367
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Brain-derived neurotrophic factor BDNF Tbio Non-IDG -4.00507 10701.6 723
Aromatase CYP19A1 Tclin Enzyme -3.38322 2409.0 449
Alpha-ketoglutarate-dependent dioxygenase FTO FTO Tbio Enzyme -3.13021 1342.0 318
Lysine-specific demethylase 4A KDM4A Tchem Epigenetic -3.06159 1089.8 271
DNA-binding protein SATB2 SATB2 Tbio Transcription Factor -2.88608 726.3 200
Aryl hydrocarbon receptor nuclear translocator-like protein 1 ARNTL Tbio Transcription Factor -2.83548 672.9 330
Short transient receptor potential channel 6 TRPC6 Tchem Ion Channel -2.82303 661.6 320
Cell adhesion molecule 1 CADM1 Tbio Non-IDG -2.77749 549.7 479
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
NAD-dependent protein deacetylase sirtuin-3, mitochondrial SIRT3 Tchem Epigenetic -2.74514 583.3 550